Augocare 1000 Duo Tablet: Complete Information
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Severe or bloody diarrhoea, even weeks after finishing the antibiotic
- Yellowing of the skin or eyes, dark urine, or severe itching
- Painful rash with blisters or peeling skin
- Decreased urine output or swelling in the legs
- Seizures or severe confusion
- Persistent high fever not improving after 48-72 hours
If experiencing severe symptoms, call emergency services immediately.
What is metclav 1000 duo tablet used for?
This medicine is a combination antibiotic containing amoxycillin and clavulanic acid. It is used to treat various bacterial infections by killing bacteria and preventing their growth. It is taken orally, usually every 12 hours with food, and the full course must be completed as prescribed.
- Generic Name: Amoxycillin (875mg) + Clavulanic Acid (125mg)
- Manufacturer: Medishri Healthcare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 metclav 1000 duo tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एक संयोजन एंटीबायोटिक है जिसमें अमोक्सिसिलिन और क्लैवुलैनिक एसिड होता है। इसका उपयोग विभिन्न जीवाणु संक्रमणों जैसे श्वसन तंत्र संक्रमण, मूत्र मार्ग संक्रमण, त्वचा संक्रमण और दांतों के संक्रमण के इलाज के लिए किया जाता है। यह दवा बैक्टीरिया को मारती है और उनके विकास को रोकती है। इसे आमतौर पर हर 12 घंटे में भोजन के साथ लिया जाता है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दस्त, जी मिचलाना, उल्टी, त्वचा पर दाने और मुँह या योनि में फंगल संक्रमण शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें एलर्जी, गंभीर दस्त, यकृत की समस्या और त्वचा की गंभीर प्रतिक्रियाएँ शामिल हो सकती हैं। यदि आपको कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। पूरा कोर्स पूरा करें, भले ही आप बेहतर महसूस करें। इसे भोजन के साथ लें ताकि पेट की परेशानी कम हो। यदि आपको दाने, खुजली या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से मिलें। शराब का सेवन न करें। इस दवा को दूसरों के साथ साझा न करें।
💊 metclav 1000 duo tablet Uses & Benefits
[{"condition":"Respiratory tract infections","description":"Used to treat community-acquired pneumonia, acute bacterial sinusitis, and acute exacerbations of chronic bronchitis caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Effective against uncomplicated and complicated urinary tract infections caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats cellulitis, abscesses, and wound infections caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Dental infections","description":"Used for dental abscesses and pericoronitis when caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Bone and joint infections","description":"May be used for osteomyelitis and septic arthritis as part of a broader treatment plan.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Helicobacter pylori eradication","description":"Sometimes used as part of combination therapy for H. pylori eradication, though not a first-line agent in all guidelines.","evidence":"Limited"},{"condition":"Lyme disease","description":"May be used off-label for early Lyme disease in patients who cannot take doxycycline.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Respiratory tract infections, Urinary tract infections, Skin infections, Dental infections
📋 Drug Information
| Generic Name(s) | Amoxycillin (875mg) + Clavulanic Acid (125mg) |
| Brand Name | metclav 1000 duo tablet |
| Manufacturer | Medishri Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store below 25°C in a dry place, protected from light. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines amoxycillin, a beta-lactam antibiotic, with clavulanic acid, a beta-lactamase inhibitor. Amoxycillin works by binding to penicillin-binding proteins (PBPs) on the bacterial cell wall, inhibiting the cross-linking of peptidoglycan, which is essential for cell wall integrity. This leads to bacterial cell lysis and death. Clavulanic acid has little intrinsic antibacterial activity but irreversibly inhibits beta-lactamase enzymes produced by certain bacteria, thereby protecting amoxycillin from degradation and extending its spectrum of activity against beta-lactamase-producing organisms.
Mechanism Steps
💡 How to Take metclav 1000 duo tablet
Strength: Tablet containing 875 mg amoxycillin and 125 mg clavulanic acid.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet (875 mg amoxycillin + 125 mg clavulanic acid) taken orally every 12 hours, with food. For severe infections, the dose may be increased or the frequency changed to every 8 hours, as determined by your doctor. The duration of treatment depends on the type and severity of infection, typically 5 to 14 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function and are at higher risk of side effects. Dose adjustment may be necessary based on renal function. Consult your doctor for appropriate dosing. |
| Renal Impairment | In patients with renal impairment, dose adjustment is required. For creatinine clearance 10-30 mL/min, the usual dose is one tablet every 12 hours. For creatinine clearance less than 10 mL/min, one tablet every 24 hours is recommended. Not recommended for patients on hemodialysis. Consult your doctor for personalized dosing. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Monitor liver function regularly. Dose adjustment may be needed. Consult your doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is 1750 mg amoxycillin and 250 mg clavulanic acid (two tablets of 875/125 mg per day). |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of metclav 1000 duo tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Allopurinol | Moderate | |
| Oral contraceptives | Moderate | |
| Probenecid | Moderate | |
| Mycophenolate mofetil | Moderate | |
| Antacids | Minor | |
| Iron supplements | Minor |
🚨 Major Interactions
- Warfarin
- Methotrexate
- Allopurinol
⚡ Moderate Interactions
- Oral contraceptives
- Probenecid
- Mycophenolate mofetil
🍷 Alcohol Interaction
Alcohol may worsen gastrointestinal side effects such as nausea and diarrhoea. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to penicillins, cephalosporins, or beta-lactam antibiotics","History of cholestatic jaundice or hepatic dysfunction associated with amoxycillin/clavulanic acid","Infectious mononucleosis (increased risk of rash)"]
⚠️ Warnings & Precautions
["Use with caution in patients with renal impairment; dose adjustment may be needed.","May cause Clostridium difficile-associated diarrhoea; report severe or bloody diarrhoea.","Serious allergic reactions can occur; stop and seek emergency help if suspected.","May reduce efficacy of oral contraceptives; use additional precautions.","Prolonged use may lead to fungal or bacterial superinfections.","Not effective against viral infections."]
🤱 Lactation Safety
Amoxycillin and clavulanic acid are excreted in breast milk in small amounts. This medicine is generally considered safe during breastfeeding, but monitor the infant for diarrhoea or thrush. Consult your doctor before use.
💊 Overdose Management
Overdose may cause gastrointestinal symptoms such as nausea, vomiting, and diarrhoea, and may lead to fluid and electrolyte imbalance. In severe cases, crystalluria and renal failure may occur. Treatment is symptomatic and supportive. Maintain adequate hydration. Hemodialysis may be considered in patients with renal impairment. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop treatment early, even if you feel better, as this can lead to antibiotic resistance and recurrence of infection. Complete the full course as directed. Take this medicine with food to reduce stomach upset. Swallow the tablet whole with a glass of water; do not crush or chew it. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. Inform your doctor if you have kidney or liver problems, or if you are allergic to penicillin or other antibiotics. Avoid alcohol while taking this medicine, as it may worsen side effects. If you develop a rash, itching, or difficulty breathing, stop the medicine and seek immediate medical help. Do not share this medicine with others, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of liver and kidney side effects. Dose adjustment may be needed based on renal function. Monitor closely for signs of toxicity.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. It is generally considered safe but should be used only when clearly needed.
🏥 Post-Surgery Considerations
This medicine may be prescribed to prevent or treat surgical site infections. Follow your surgeon's instructions regarding dosing and duration.
🦷 Dental Procedures
This medicine is often prescribed before or after dental procedures to prevent or treat infection. Inform your dentist if you are taking it.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Mild exercise is generally safe, but if you experience dizziness, fatigue, or joint pain, avoid strenuous activities. Listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. If affected, avoid driving or operating heavy machinery. Otherwise, it usually does not significantly impact daily activities.
🛑 When to Stop This Medicine
Stop taking this medicine only after completing the full prescribed course or as directed by your doctor. If you experience severe side effects, stop and seek medical advice immediately. Do not stop early without consulting your doctor, as it may lead to recurrence of infection.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance, fungal superinfections, and rarely liver or kidney problems. It is not intended for prolonged use unless directed by a doctor. Regular monitoring of liver and kidney function may be required if used for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help prevent antibiotic-associated diarrhoea.
Evidence: ModerateFor symptomatic relief of pain and fever, but do not treat the infection.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the efficacy of live bacterial vaccines like typhoid vaccine. Avoid vaccination during treatment and for a few days after.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature, away from direct sunlight and moisture. If crossing time zones, adjust dosing times gradually, but maintain the 12-hour interval as closely as possible. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours, but it is important to complete the full course as prescribed.
A: Yes, it is recommended to take this medicine with food to reduce stomach upset and improve absorption.
A: It is FDA Pregnancy Category B. Use only if clearly needed, as advised by your doctor.
A: It is advisable to avoid alcohol as it may worsen side effects like nausea and diarrhoea.
🤔 Common Patient Concerns
🔄 Substitutes for metclav 1000 duo tablet
View AllAlternative brands with exact same active ingredient:
-
flemiclav lb 875mg/125mg tabletFDC Ltd ₹123.28 56.7% CHEAPER
-
lacom-cv tabletComed Chemicals Ltd ₹253.13 11.1% CHEAPER
-
augpen lb 1000 mg tabletZuventus Healthcare Ltd ₹396.56 39.3% COSTLIER
-
indclav lb 875mg/125mg tabletIndchemie Health Specialities Pvt Ltd ₹487.50 71.2% COSTLIER
-
augpen lb 1g bid tabletZuventus Healthcare Ltd ₹607.35 113.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the common cold.
Fact: This medicine is an antibiotic and is only effective against bacterial infections. It does not treat viral infections. - Myth: You can stop taking this medicine as soon as you feel better.
Fact: You must complete the full course as prescribed, even if symptoms improve, to prevent recurrence and antibiotic resistance. - Myth: This medicine is safe to take without a prescription.
Fact: This is a prescription-only medicine and should only be taken under a doctor's supervision.
🔄 Alternative Options
Generic Alternatives
- Amoxycillin + Clavulanic Acid 875/125 mg tablet (various manufacturers)
Brand Alternatives
- Augmentin 1000 Duo
- Clavam 1000 Duo
- Moxikind-CV 1000
- Advent 1000 Duo