Axylox PD 125mg/125mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Severe or persistent diarrhea, especially with blood or mucus
- Yellowing of the skin or eyes (jaundice)
- Severe abdominal pain or cramping
- Unusual bleeding or bruising
- Decreased urine output or swelling in the legs
- Seizures or confusion
- Skin rash with blisters or peeling
If experiencing severe symptoms, call emergency services immediately.
What is megamox 125mg/125mg tablet dt used for?
This medicine is a combination antibiotic containing amoxycillin and cloxacillin, used to treat bacterial infections of the skin, respiratory tract, and other areas. It works by killing bacteria and is available only by prescription.
- Generic Name: Amoxycillin (125mg) + Cloxacillin (125mg)
- Manufacturer: Max Life Science
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 megamox 125mg/125mg tablet dt के बारे में (Hindi Summary)
उपयोग: यह दवा एमोक्सिसिलिन और क्लोक्सासिलिन का संयोजन है, जिसका उपयोग बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। यह त्वचा, श्वसन तंत्र, दांतों और हड्डियों के संक्रमण में प्रभावी है। यह केवल डॉक्टर के पर्चे पर ही ली जानी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट दर्द और त्वचा पर चकत्ते शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, गंभीर दस्त, या यकृत की समस्या हो सकती है। किसी भी असामान्य लक्षण पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी दवाओं और एलर्जी के बारे में बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। दवा का पूरा कोर्स करें, भले ही आप बेहतर महसूस करें। शराब से बचें। दवा को ठंडी और सूखी जगह पर रखें।
💊 megamox 125mg/125mg tablet dt Uses & Benefits
[{"condition":"Skin and soft tissue infections","description":"This medicine is used to treat bacterial infections of the skin and underlying tissues, such as cellulitis, impetigo, and wound infections, caused by susceptible organisms including staphylococci and streptococci.","evidence":"Well-established"},{"condition":"Respiratory tract infections","description":"It may be prescribed for upper and lower respiratory tract infections, such as sinusitis, pharyngitis, and pneumonia, when caused by bacteria susceptible to both amoxycillin and cloxacillin.","evidence":"Established"},{"condition":"Dental infections","description":"This combination can be used for dental abscesses and other odontogenic infections where a penicillinase-resistant penicillin is needed.","evidence":"Established"},{"condition":"Bone and joint infections","description":"In some cases, it may be used for osteomyelitis or septic arthritis caused by susceptible gram-positive bacteria.","evidence":"Limited"}]
Off-label uses: [{"condition":"Prophylaxis in certain surgical procedures","description":"Occasionally used off-label for prevention of surgical site infections in patients with specific risk factors, though standard guidelines may recommend other agents.","evidence":"Limited"}]
Primary treatment for: Bacterial infections susceptible to amoxycillin and cloxacillin
Also treats: Skin and soft tissue infections, Respiratory tract infections, Dental infections, Bone and joint infections
📋 Drug Information
| Generic Name(s) | Amoxycillin (125mg) + Cloxacillin (125mg) |
| Brand Name | megamox 125mg/125mg tablet dt |
| Manufacturer | Max Life Science |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and light. Keep in the original container, tightly closed. Do not refrigerate unless specifically instructed. Keep out of reach of children and pets. |
| Shelf Life | Typically 24 months from the date of manufacture, but check the expiry date on the packaging. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two penicillin antibiotics that inhibit bacterial cell wall synthesis. Amoxycillin is a broad-spectrum aminopenicillin that binds to penicillin-binding proteins, preventing cross-linking of peptidoglycan in the bacterial cell wall, leading to cell lysis and death. Cloxacillin is a semisynthetic penicillinase-resistant penicillin that also binds to penicillin-binding proteins but is specifically designed to resist degradation by beta-lactamase enzymes produced by certain bacteria, such as Staphylococcus aureus. Together, they provide coverage against a wider range of gram-positive and some gram-negative bacteria.
Mechanism Steps
💡 How to Take megamox 125mg/125mg tablet dt
Strength: Each tablet contains amoxycillin 125 mg and cloxacillin 125 mg. This is an immediate-release oral tablet.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally every 6 to 8 hours, depending on the severity of the infection and the prescribing doctor's judgment. The dose may need to be adjusted in patients with kidney or liver impairment. The duration of treatment is typically 5 to 10 days, but this can vary based on the type of infection and clinical response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-medicate or alter the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have reduced renal function, which can increase the risk of side effects. Dose adjustment may be necessary based on creatinine clearance. Consult a doctor for appropriate dosing. |
| Renal Impairment | In patients with renal impairment, dose reduction or extended dosing intervals may be required. For creatinine clearance between 10 and 30 mL/min, the dose may need to be reduced. For creatinine clearance less than 10 mL/min, further reduction is advised. Consult a nephrologist or clinical pharmacist for guidance. |
| Hepatic Impairment | No specific dose adjustment is typically required for mild to moderate hepatic impairment. However, in severe liver disease, caution is advised and monitoring may be necessary. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose for adults is not firmly established for this specific combination, but typical maximum for amoxycillin is 4 grams per day and for cloxacillin is 4 grams per day. However, this combination product should not exceed the prescribed dose. Always follow your doctor's instructions. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of megamox 125mg/125mg tablet dt
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Allopurinol | Moderate | |
| Oral contraceptives | Moderate | |
| Probenecid | Moderate | |
| Tetracyclines | Moderate | |
| Antacids | Minor | |
| Food | Minor |
🚨 Major Interactions
- Warfarin
- Methotrexate
- Allopurinol
⚡ Moderate Interactions
- Oral contraceptives
- Probenecid
- Tetracyclines
🍷 Alcohol Interaction
Alcohol does not directly interact with amoxycillin or cloxacillin, but it can worsen stomach upset and may increase the risk of liver side effects. It is advisable to avoid or limit alcohol while taking this medicine, especially if you have an underlying liver condition.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to penicillins, cephalosporins, or any component of this medicine.","History of severe allergic reaction (e.g., anaphylaxis) to any beta-lactam antibiotic.","Infectious mononucleosis (due to high risk of rash).","Concurrent use with live typhoid vaccine (may reduce efficacy)."]
⚠️ Warnings & Precautions
["Before starting therapy, inquire about previous allergic reactions to penicillins or cephalosporins.","Use with caution in patients with renal impairment; dose adjustment may be necessary.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.","May cause false-positive results in certain urine glucose tests and urine protein tests.","Patients with phenylketonuria should check the formulation for phenylalanine content.","Not effective against viral infections; do not use for colds or flu.","Ensure adequate hydration during treatment to prevent crystalluria."]
🤱 Lactation Safety
Amoxycillin and cloxacillin are excreted in breast milk in small amounts. They are generally considered compatible with breastfeeding, but monitor the infant for diarrhea, thrush, or rash. Consult your doctor before use.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, diarrhea, and abdominal pain. In severe cases, especially in patients with renal impairment, neurotoxicity and seizures may occur. There is no specific antidote. Treatment is supportive and symptomatic. Maintain adequate hydration. In case of overdose, contact a poison control center or emergency room immediately. Hemodialysis may be considered to remove amoxycillin from the blood in severe cases.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Before taking this medicine, inform your doctor if you are allergic to penicillins, cephalosporins, or any other antibiotics. Tell your doctor about all other medicines you are taking, especially blood thinners like warfarin, methotrexate, and allopurinol. This medicine may reduce the effectiveness of oral contraceptives, so use additional birth control methods while taking it. Do not share this medicine with others, even if they have similar symptoms. Complete the full prescribed course, even if you feel better after a few days. If you miss a dose, take it as soon as you remember, but skip it if it is almost time for your next dose. Do not double the dose. Store this medicine at room temperature, away from moisture and heat. Keep out of reach of children. If you are pregnant or breastfeeding, consult your doctor before using this medicine. If you develop a rash, itching, or difficulty breathing, stop the medicine and seek emergency medical help immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function, which can increase the risk of side effects. Dose adjustment may be necessary based on renal function. Monitor for signs of toxicity and ensure adequate hydration.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Penicillins are generally considered safe, but the need for the medicine should be evaluated.
🏥 Post-Surgery Considerations
This medicine may be prescribed after surgery to prevent or treat surgical site infections. Follow your surgeon's instructions carefully. Inform your surgeon if you have any allergies to antibiotics.
🦷 Dental Procedures
This medicine may be used before or after dental procedures to prevent or treat dental infections. Inform your dentist if you are allergic to penicillins. It may interact with other medications used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you can continue with light to moderate exercise if you feel up to it. However, if you experience dizziness, fatigue, or muscle pain, avoid strenuous activities and consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. If you experience these effects, avoid driving or operating heavy machinery. Otherwise, you can continue your normal daily activities as tolerated.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor, even if you feel better. Stopping early can lead to incomplete treatment and antibiotic resistance. If you experience severe side effects, contact your doctor immediately for advice.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to overgrowth of non-susceptible organisms, such as fungi, and may increase the risk of antibiotic resistance. Rarely, prolonged use can cause liver or kidney problems. Regular monitoring may be required if used for extended periods. It is important to use this medicine only for the prescribed duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the infection and susceptibility, other antibiotics such as amoxicillin-clavulanate or cephalosporins may be used.
Evidence: Well-establishedFor minor skin infections, topical antibiotics may be sufficient.
Evidence: Established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the efficacy of live bacterial vaccines, such as the typhoid vaccine. Avoid vaccination with live organisms during treatment. Inactivated vaccines are generally safe to administer.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid temperature extremes. If crossing time zones, adjust dosing times gradually to maintain even intervals. Check customs regulations for carrying prescription medicines. Store away from direct sunlight and moisture.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 72 hours, but it is important to complete the full course as prescribed.
A: Yes, taking it with food can help reduce stomach upset.
A: Take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: Penicillins are generally considered safe during pregnancy, but you should consult your doctor before taking any medicine.
A: It is best to avoid alcohol as it can worsen stomach upset and may increase the risk of liver side effects.
🤔 Common Patient Concerns
🔄 Substitutes for megamox 125mg/125mg tablet dt
View AllAlternative brands with exact same active ingredient:
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osoclox 125mg/125mg injectionOsper Formulations Pvt Ltd ₹8.50 71% CHEAPER
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imox clo 125 mg/125 mg tablet dtIpca Laboratories Ltd ₹8.75 70.1% CHEAPER
-
closomox kid 125mg/125mg tabletOsho Pharma Pvt Ltd ₹11.00 62.5% CHEAPER
-
Rayclox Kid TabletRaphael Pharmaceuticals Pvt Ltd ₹11.04 62.3% CHEAPER
-
nexclox 125mg/125mg injectionNexus India ₹11.48 60.8% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Antibiotics can cure viral infections like the common cold.
Fact: This medicine is effective only against bacterial infections. It does not treat viral infections. - Myth: You can stop taking antibiotics once you feel better.
Fact: You must complete the full prescribed course to prevent bacterial resistance and ensure the infection is fully treated. - Myth: Antibiotics can be shared with others who have similar symptoms.
Fact: Never share antibiotics. They are prescribed for a specific infection and person. Sharing can cause harm and promote resistance.
🔄 Alternative Options
Generic Alternatives
- Amoxycillin and cloxacillin combination generic tablets
Brand Alternatives
- Axylox PD 125mg/125mg Tablet