Avicus F 10mg/145mg Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe muscle pain, tenderness, or weakness, especially with dark urine.
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain.
- Severe upper abdominal pain that radiates to the back, with nausea and vomiting.
- Swelling of the face, lips, tongue, or throat, or difficulty breathing.
- Unusual bleeding or bruising.
- Signs of liver problems such as persistent nausea, loss of appetite, or jaundice.
- Decreased urine output or swelling in the legs.
If experiencing severe symptoms, call emergency services immediately.
What is medistatin f 10mg/145mg tablet used for?
This medicine is a combination of atorvastatin and fenofibrate used to treat mixed dyslipidemia by lowering LDL cholesterol and triglycerides while raising HDL cholesterol.
- Generic Name: Atorvastatin (10mg) + Fenofibrate (145mg)
- Manufacturer: Xemex Life Sciences
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 medistatin f 10mg/145mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एटोरवास्टेटिन और फेनोफाइब्रेट का संयोजन है, जिसका उपयोग मिश्रित डिस्लिपिडेमिया के इलाज के लिए किया जाता है। यह खराब कोलेस्ट्रॉल (LDL) और ट्राइग्लिसराइड्स को कम करने में मदद करती है और अच्छे कोलेस्ट्रॉल (HDL) को बढ़ाती है। यह दवा उन रोगियों के लिए है जिनका कोलेस्ट्रॉल और ट्राइग्लिसराइड स्तर आहार और व्यायाम से नियंत्रित नहीं होता। यह दवा डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, मतली, पेट दर्द, कब्ज और मांसपेशियों में दर्द शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें मांसपेशियों की गंभीर क्षति (रैब्डोमायोलिसिस), यकृत की क्षति और अग्न्याशय की सूजन शामिल हो सकती है। यदि आपको असामान्य मांसपेशियों में दर्द, कमजोरी या गहरे रंग का मूत्र दिखाई दे, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे भोजन के साथ लें ताकि अवशोषण बेहतर हो और पेट की परेशानी कम हो। अंगूर का रस न पिएं क्योंकि यह दवा के स्तर को बढ़ा सकता है। शराब का सेवन न करें क्योंकि इससे यकृत की समस्या का खतरा बढ़ सकता है। नियमित रूप से रक्त परीक्षण कराएं। यदि आप गर्भवती हैं या स्तनपान करा रही हैं, तो इस दवा का उपयोग न करें।
💊 medistatin f 10mg/145mg tablet Uses & Benefits
[{"condition":"Mixed dyslipidemia","description":"This medicine is used to lower elevated LDL cholesterol and triglycerides while raising HDL cholesterol in patients with mixed dyslipidemia.","evidence":"Well-established"},{"condition":"Hypertriglyceridemia","description":"The fenofibrate component effectively reduces very high triglyceride levels, reducing the risk of pancreatitis.","evidence":"Well-established"},{"condition":"Hypercholesterolemia","description":"The atorvastatin component lowers LDL cholesterol and reduces cardiovascular risk.","evidence":"Well-established"},{"condition":"Combined hyperlipidemia","description":"This combination is used when both cholesterol and triglyceride levels are elevated and not controlled by single agents.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Non-alcoholic fatty liver disease","description":"Sometimes prescribed off-label to improve liver enzymes and lipid profile in patients with NAFLD.","evidence":"Limited"},{"condition":"Diabetic dyslipidemia","description":"May be used off-label in patients with type 2 diabetes and atherogenic dyslipidemia.","evidence":"Moderate"}]
Primary treatment for: Mixed dyslipidemia
Also treats: Hypertriglyceridemia, Hypercholesterolemia, Combined hyperlipidemia, Diabetic dyslipidemia
📋 Drug Information
| Generic Name(s) | Atorvastatin (10mg) + Fenofibrate (145mg) |
| Brand Name | medistatin f 10mg/145mg tablet |
| Manufacturer | Xemex Life Sciences |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two lipid-lowering agents with complementary mechanisms. Atorvastatin selectively inhibits HMG-CoA reductase, the rate-limiting enzyme in hepatic cholesterol synthesis, leading to upregulation of LDL receptors and increased clearance of LDL cholesterol from the blood. Fenofibrate activates peroxisome proliferator-activated receptor alpha (PPAR-alpha), which increases the expression of genes involved in fatty acid oxidation and lipoprotein lipase activity, thereby reducing triglyceride levels and increasing HDL cholesterol. Together, these actions improve the overall lipid profile.
Mechanism Steps
💡 How to Take medistatin f 10mg/145mg tablet
Strength: Atorvastatin 10 mg and Fenofibrate 145 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once daily with food. The dose may be adjusted by your doctor based on your lipid levels, kidney function, and response to treatment. The maximum recommended dose of atorvastatin in this combination is 10 mg, and fenofibrate is 145 mg. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Start with a lower dose and monitor renal and hepatic function closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with mild to moderate renal impairment, no dose adjustment is required for atorvastatin. However, fenofibrate dose should be reduced in patients with renal impairment. This medicine is contraindicated in severe renal impairment (eGFR <30 mL/min/1.73 m²). Consult your doctor for dose adjustment. |
| Hepatic Impairment | This medicine is contraindicated in patients with active liver disease or unexplained persistent elevations of serum transaminases. Use with caution in patients with a history of liver disease. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose of this medicine is one tablet containing atorvastatin 10 mg and fenofibrate 145 mg. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of medistatin f 10mg/145mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Cyclosporine | Major | |
| Gemfibrozil | Major | |
| Clarithromycin | Major | |
| Itraconazole | Major | |
| Colchicine | Moderate | |
| Rifampin | Moderate | |
| Antacids | Minor | |
| Grapefruit juice | Minor | |
| Alcohol | Moderate |
🚨 Major Interactions
- Warfarin
- Cyclosporine
- Gemfibrozil
- Strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole)
⚡ Moderate Interactions
- Fenofibrate
- Colchicine
- Rifampin
🍷 Alcohol Interaction
Avoid excessive alcohol consumption while taking this medicine, as it can increase the risk of liver damage and may worsen triglyceride levels. Moderate alcohol intake should be discussed with your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active liver disease or unexplained persistent elevations of serum transaminases.","Known hypersensitivity to atorvastatin, fenofibrate, or any component of the formulation.","Gallbladder disease.","Severe renal impairment (eGFR
⚠️ Warnings & Precautions
["This medicine may cause myopathy and rhabdomyolysis. Advise patients to report unexplained muscle pain, tenderness, or weakness.","Liver function should be monitored before and during treatment. Discontinue if serious liver injury occurs.","Fenofibrate may increase the risk of gallstones. Advise patients to report right upper abdominal pain.","This medicine may increase the risk of pancreatitis. Monitor triglyceride levels and advise patients to report severe abdominal pain.","Use with caution in patients with diabetes, as fenofibrate may affect blood glucose levels.","Avoid in patients with severe renal impairment. Dose adjustment is required for moderate renal impairment.","This medicine may interact with other drugs. Review all concomitant medications.","Do not use during pregnancy or breastfeeding.","Patients should be advised to follow a standard cholesterol-lowering diet and exercise program."]
🤱 Lactation Safety
This medicine is not recommended during breastfeeding. It is not known whether atorvastatin and fenofibrate are excreted in human milk. Potential risks to the infant cannot be excluded. Consult your doctor for alternative treatments.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. In case of suspected overdose, seek immediate medical attention. Treatment should be symptomatic and supportive. Monitor liver function, renal function, and creatine kinase levels. Hemodialysis is not expected to significantly enhance clearance of atorvastatin or fenofibrate.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without medical advice. Take the tablet with food to help absorption and reduce stomach upset. Avoid drinking grapefruit juice while on this medicine, as it can increase the levels of atorvastatin in your blood. Do not drink alcohol heavily, as it can increase the risk of liver problems. Inform your doctor if you have a history of liver disease, kidney disease, diabetes, or thyroid problems. Tell your doctor about all other medicines you are taking, especially blood thinners, other cholesterol medicines, and certain antibiotics. Regular blood tests are important to check your liver, kidney, and muscle health. If you experience unexplained muscle pain, weakness, or dark urine, contact your doctor immediately. Do not take this medicine if you are pregnant or planning to become pregnant. Use effective contraception while taking this medicine. Keep this medicine out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to the side effects of this medicine, especially muscle and liver problems. Regular monitoring of liver and kidney function is recommended. Dose adjustments may be necessary based on renal function.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy. Both atorvastatin and fenofibrate may harm the developing fetus. Women of childbearing potential should use effective contraception and discuss alternative treatments with their doctor.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may need to be temporarily stopped before surgery due to potential interactions with other medications and effects on liver and muscle. Follow your doctor's instructions.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. No specific precautions are usually required, but your dentist may need to know about your medication history.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is generally safe while taking this medicine. However, if you experience muscle pain, weakness, or fatigue during exercise, stop and consult your doctor. Avoid strenuous exercise if you have muscle symptoms.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is unlikely to affect your ability to drive or operate machinery. However, if you experience dizziness, muscle weakness, or fatigue, avoid driving or operating heavy machinery until you feel better. Most people can continue their normal daily activities while taking this medicine.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as severe muscle pain, liver problems, or allergic reactions, seek immediate medical attention. Your doctor may adjust the dose or switch to an alternative treatment.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe and effective for managing mixed dyslipidemia. However, it requires regular monitoring of liver enzymes, kidney function, and muscle enzymes. Rarely, long-term use may be associated with an increased risk of gallstones, myopathy, or liver injury. Patients should continue lifestyle modifications and attend regular follow-up appointments.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A heart-healthy diet low in saturated fats and refined sugars can help lower cholesterol and triglycerides.
Evidence: Well-establishedPhysical activity can improve lipid profile and cardiovascular health.
Evidence: Well-establishedLosing excess weight can significantly improve cholesterol and triglyceride levels.
Evidence: Well-establishedMay help lower triglycerides, but should be discussed with your doctor.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, inform your healthcare provider about all medicines you are taking before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. Store at room temperature and protect from light and moisture. If crossing time zones, continue taking your dose at the same time each day as close as possible. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 2 to 4 weeks, with maximum effects seen after 4 to 6 weeks. Regular blood tests will monitor your progress.
A: Do not take other cholesterol-lowering medicines without consulting your doctor, as this may increase the risk of side effects.
A: Report any unexplained muscle pain, tenderness, or weakness to your doctor immediately. It may be a sign of a rare but serious side effect.
A: This medicine can affect liver enzymes. Your doctor will monitor your liver function with blood tests before and during treatment.
🤔 Common Patient Concerns
🔄 Substitutes for medistatin f 10mg/145mg tablet
View AllAlternative brands with exact same active ingredient:
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bettor plus tabletBrilliant Lifesciences Pvt Ltd ₹91.88 1.6% CHEAPER
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atrowell f 10mg/145mg tabletMaxnova Healthcare ₹110.00 17.8% COSTLIER
-
atornet f 10mg/145mg tabletAkesiss Pharma Pvt Ltd ₹110.63 18.5% COSTLIER
-
atovib f tabletVibcare Pharma Pvt Ltd ₹111.56 19.5% COSTLIER
-
atortrue f 10mg/145mg tabletTruecure Healthcare Private Limited ₹117.19 25.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be stopped once cholesterol levels are normal.
Fact: This medicine is usually a long-term treatment. Stopping it without medical advice can cause cholesterol levels to rise again. - Myth: This medicine causes diabetes.
Fact: This medicine may slightly increase blood sugar levels, but the cardiovascular benefits usually outweigh this risk. Monitor blood sugar if you have diabetes. - Myth: You can eat anything while taking this medicine.
Fact: A healthy diet and exercise are essential for the best results. This medicine is not a substitute for lifestyle changes.
🔄 Alternative Options
Generic Alternatives
- Atorvastatin 10 mg + Fenofibrate 145 mg tablet (generic)
Brand Alternatives
- Avicus F 10mg/145mg Tablet