Admero 250mg Injection (meropenem): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, or throat
- Severe rash or blistering of skin
- Seizures or convulsions
- Severe, persistent diarrhea or abdominal pain
- Decreased urine output or swelling in legs
- Yellowing of skin or eyes
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is macron 250mg injection used for?
This medicine is a carbapenem antibiotic injection containing meropenem 250 mg. It is used to treat serious bacterial infections in hospitals. It works by killing bacteria and is given intravenously by a healthcare professional.
- Generic Name: Meropenem (250mg)
- Manufacturer: I.I.F.A Health Care
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 macron 250mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा मेरोपेनम नामक एंटीबायोटिक का इंजेक्शन है, जिसका उपयोग अस्पताल में गंभीर बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। यह पेट, फेफड़े, त्वचा, मस्तिष्क और रक्त के संक्रमण में प्रभावी है। यह दवा केवल डॉक्टर या नर्स द्वारा नस के माध्यम से दी जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दस्त, जी मिचलाना, उल्टी, सिरदर्द, चकत्ते और इंजेक्शन की जगह पर दर्द या सूजन शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, दौरे और आंतों का गंभीर संक्रमण हो सकता है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल में डॉक्टर की देखरेख में दी जानी चाहिए। इससे पहले कि आपको यह दवा दी जाए, अपनी सभी एलर्जी, खासकर पेनिसिलिन से, और अपनी किडनी, लीवर या दौरे की बीमारी के बारे में डॉक्टर को बताएं। इलाज के दौरान शराब न पिएं। अगर सांस लेने में तकलीफ, चेहरे या गले में सूजन, या गंभीर चकत्ते दिखें तो तुरंत आपातकालीन सहायता लें।
💊 macron 250mg injection Uses & Benefits
[{"condition":"Complicated intra-abdominal infections","description":"Used to treat serious infections within the abdomen, such as peritonitis and abscesses, often caused by mixed bacteria.","evidence":"Well-established"},{"condition":"Bacterial meningitis","description":"Effective against meningitis caused by susceptible bacteria, including in pediatric patients.","evidence":"Well-established"},{"condition":"Hospital-acquired pneumonia","description":"Used for pneumonia acquired during hospital stay, including ventilator-associated pneumonia.","evidence":"Well-established"},{"condition":"Complicated skin and soft tissue infections","description":"Treats severe skin infections like necrotizing fasciitis and diabetic foot infections.","evidence":"Well-established"},{"condition":"Febrile neutropenia","description":"Used as empirical therapy in cancer patients with fever and low white blood cell counts.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Cystic fibrosis exacerbations","description":"Sometimes used to treat lung infections in cystic fibrosis patients when other antibiotics are not effective.","evidence":"Limited"},{"condition":"Nocardiosis","description":"May be used as an alternative treatment for Nocardia infections in patients who cannot tolerate standard therapy.","evidence":"Limited"}]
Primary treatment for: Serious bacterial infections
Also treats: Complicated intra-abdominal infections, Bacterial meningitis, Hospital-acquired pneumonia, Complicated skin and soft tissue infections, Febrile neutropenia
📋 Drug Information
| Generic Name(s) | Meropenem (250mg) |
| Brand Name | macron 250mg injection |
| Manufacturer | I.I.F.A Health Care |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cell wall active agent -Carbapenems |
| Route of Administration | Parenteral (intravenous) |
| Storage | Store unopened vials at room temperature (20-25°C). Once reconstituted, the solution should be used immediately or stored as per the manufacturer's instructions, typically refrigerated (2-8°C) and used within 24 hours. |
| Shelf Life | The shelf life of the unopened vial is typically 24 months from the date of manufacture. Refer to the product label for the exact expiry date. |
| WHO Guideline | Meropenem is included in the WHO Model List of Essential Medicines for the treatment of serious bacterial infections. It is recommended for use in hospitals with appropriate stewardship programs. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) recommends meropenem as a reserve antibiotic for the treatment of infections caused by multidrug-resistant organisms, to be used judiciously to prevent resistance. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine exerts its bactericidal effect by inhibiting the synthesis of the bacterial cell wall. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which are enzymes involved in cross-linking peptidoglycan chains. This inhibition prevents the formation of a functional cell wall, leading to bacterial cell lysis and death. Meropenem has a broad spectrum of activity against gram-positive and gram-negative bacteria, including many that produce beta-lactamases.
Mechanism Steps
💡 How to Take macron 250mg injection
Strength: 250 mg sterile powder for injection
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 500 mg to 1 g administered intravenously every 8 hours, depending on the type and severity of infection. For meningitis, the recommended dose is 2 g every 8 hours. For complicated skin and soft tissue infections, 500 mg every 8 hours is often sufficient. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | For pediatric patients, the dose is based on body weight. The usual dose is 10-20 mg/kg every 8 hours for most infections, and 40 mg/kg every 8 hours for meningitis. The maximum dose should not exceed 2 g every 8 hours. Pediatric dosing is not established from available information for all indications. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function, and dose adjustment may be necessary based on creatinine clearance. No specific dose adjustment is recommended for elderly patients with normal renal function. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. For patients with creatinine clearance (CrCl) 26-50 mL/min, the usual dose is given every 12 hours. For CrCl 10-25 mL/min, the usual dose is given every 24 hours. For CrCl less than 10 mL/min, the usual dose is given every 24 hours, and the patient should be monitored closely. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | No dose adjustment is necessary for patients with hepatic impairment alone. However, if both hepatic and renal impairment are present, dose adjustment based on renal function is recommended. |
| Maximum Daily Dose | The maximum daily dose is 6 g (2 g every 8 hours) for adults with normal renal function. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of macron 250mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Probenecid | Major | |
| Valproic acid | Major | |
| Aminoglycosides | Moderate | |
| Warfarin | Moderate | |
| Oral contraceptives | Minor |
🚨 Major Interactions
- Probenecid
- Valproic acid
⚡ Moderate Interactions
- Aminoglycosides
- Warfarin
🍷 Alcohol Interaction
Alcohol may exacerbate certain side effects of this medicine, such as nausea, dizziness, and gastrointestinal upset. It is advisable to avoid alcohol during treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to meropenem or other carbapenem antibiotics","Known severe allergy to penicillins or cephalosporins (due to potential cross-reactivity)","Concurrent use with valproic acid (due to significant interaction)"]
⚠️ Warnings & Precautions
["Serious allergic reactions, including anaphylaxis, have been reported. Discontinue immediately if allergic reaction occurs.","Clostridium difficile-associated diarrhea may occur. Use caution in patients with a history of colitis.","Seizures have been reported, especially in patients with renal impairment or central nervous system disorders. Use with caution.","Dose adjustment is required in patients with renal impairment.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.","Not effective against viral infections."]
🤱 Lactation Safety
Meropenem is excreted in human breast milk in low concentrations. It is generally considered safe during breastfeeding, but consult your doctor to weigh the benefits and risks.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, diarrhea, and seizures. There is no specific antidote. Treatment is symptomatic and supportive. Meropenem is removed by hemodialysis. In case of overdose, seek immediate medical attention.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional, missed doses are unlikely. If you miss a scheduled dose, contact your healthcare provider as soon as possible. Do not attempt to self-administer a double dose.
Additional Safety Advice
This medicine should only be administered by a qualified healthcare professional in a hospital or clinic setting. Before receiving this medicine, inform your doctor about any allergies, especially to penicillin or other antibiotics, and about any medical conditions such as kidney disease, liver disease, or a history of seizures. Do not use this medicine if you are allergic to meropenem or other carbapenem antibiotics. While receiving this medicine, your doctor may monitor your kidney function, liver function, and blood counts. Avoid alcohol during treatment as it may worsen side effects. If you experience signs of a severe allergic reaction such as difficulty breathing, swelling of the face or throat, or a severe rash, seek emergency medical help immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced renal function and may require dose adjustment. They are also at higher risk of seizures and should be monitored closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before starting this medicine. It should be used during pregnancy only if clearly needed. Discuss the risks and benefits with your healthcare provider.
🏥 Post-Surgery Considerations
This medicine is often used after surgery to prevent or treat infections. Follow your surgeon's instructions regarding wound care and monitoring for signs of infection.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. It may be used prophylactically before dental procedures in patients at risk of infective endocarditis, but this should be determined by your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While receiving this medicine, you may feel weak or dizzy. Avoid strenuous exercise until you feel fully recovered. Consult your doctor before resuming exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital setting, so you will likely need to take time off work during treatment. You may experience fatigue or dizziness; avoid driving or operating machinery until you feel fully alert.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping early may lead to incomplete treatment and resistance. Your doctor will determine when to stop based on your clinical response.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance and overgrowth of non-susceptible organisms. Prolonged therapy may also increase the risk of Clostridium difficile infection and fungal infections. Regular monitoring of renal and liver function is advised during prolonged use.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the infection and susceptibility, other antibiotics like cephalosporins or fluoroquinolones may be used.
Evidence: Well-establishedFor certain infections like abscesses, surgical drainage may be necessary in addition to antibiotics.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, ensure you are up to date with recommended vaccinations to prevent infections.
📦 Storage Guide
✅ DO
Store unopened vials at room temperature (20-25°C)
❌ DON'T
Do not freeze the unopened vials
✅ DO
Use reconstituted solution immediately or refrigerate (2-8°C) and use within 24 hours
❌ DON'T
Do not use if the solution is cloudy or contains particles
✅ DO
Keep out of reach of children
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
This medicine is administered in a healthcare setting, so travel is not applicable. If you are traveling after treatment, carry a copy of your prescription and medical records. Store any remaining medication as directed, and declare it at customs if required.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 30 minutes to 1 hour after administration, but you may not feel better immediately. Improvement in symptoms usually occurs within 24-48 hours.
A: No, this medicine must be administered by a healthcare professional in a hospital or clinic setting.
A: Report any side effects to your doctor immediately. Mild side effects like nausea may resolve on their own, but serious effects require medical attention.
🤔 Common Patient Concerns
🔄 Substitutes for macron 250mg injection
View AllAlternative brands with exact same active ingredient:
-
merotus 250mg injectionTusker Pharma Pvt Ltd ₹143.44 31.7% CHEAPER
-
mexico 250mg injectionReco Drugs ₹150.00 28.6% CHEAPER
-
meract 250mg injectionZenacts Pharma ₹209.00 0.5% CHEAPER
-
admero 250mg injectionAdjener Pharmaceuticals Pvt Ltd ₹220.00 4.8% COSTLIER
-
merosure 250mg injectionAlkem Laboratories Ltd ₹239.06 13.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken orally.
Fact: This medicine is an injection and must be given intravenously by a healthcare professional. - Myth: This medicine is safe for viral infections like cold and flu.
Fact: This medicine is an antibiotic and is only effective against bacterial infections. It does not treat viral infections. - Myth: This medicine can be stopped as soon as you feel better.
Fact: You must complete the full course as prescribed by your doctor to prevent recurrence and resistance.
🔄 Alternative Options
Generic Alternatives
- Meropenem 250 mg injection (various manufacturers)
Brand Alternatives
- Meronem
- Mepenem
- Merotec