lopine-k eye drop - Ketorolac (0.4% w/v) + Olopatadine (0.1% w/v) medicine

Eylac-O Eye Drop: Complete Guide to Uses, Side Effects, and Safety

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🏭 Nitro Organics 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Evidence: Moderate to well-established for approved indications.
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Severe eye pain or a feeling that something is stuck in your eye.
  • Sudden decrease or loss of vision.
  • Increased redness, swelling, or discharge from the eye.
  • Development of a white spot on the cornea.
  • Signs of allergic reaction such as rash, itching, swelling of face, lips, or throat, or difficulty breathing.
  • Eye injury or infection that worsens despite treatment.

If experiencing severe symptoms, call emergency services immediately.

What is lopine-k eye drop used for?

This medicine is a prescription eye drop combining ketorolac and olopatadine. It treats allergic conjunctivitis and post-operative eye inflammation by reducing histamine and prostaglandins.

  • Generic Name: Ketorolac (0.4% w/v) + Olopatadine (0.1% w/v)
  • Manufacturer: Nitro Organics
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 lopine-k eye drop के बारे में (Hindi Summary)

उपयोग: यह दवा आंखों की एलर्जी, लालिमा, खुजली और सूजन के इलाज के लिए इस्तेमाल की जाती है। यह मोतियाबिंद या अन्य आंखों की सर्जरी के बाद होने वाली सूजन और दर्द को कम करने में भी मदद करती है। इसे आंखों में डालने वाली बूंदों के रूप में इस्तेमाल किया जाता है और यह केवल डॉक्टर के पर्चे पर ही मिलती है।

साइड इफेक्ट्स: इस दवा का उपयोग करने पर आंखों में जलन, खुजली, धुंधली दृष्टि, लालिमा या अस्थायी रूप से चुभन महसूस हो सकती है। कुछ लोगों को सिरदर्द या मुंह में कड़वा स्वाद भी महसूस हो सकता है। ये आमतौर पर हल्के और अस्थायी होते हैं। अगर आंखों में तेज दर्द, सूजन या दृष्टि में बदलाव हो तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा का इस्तेमाल केवल आंखों में करें और डॉक्टर के बताए अनुसार ही करें। उपयोग से पहले और बाद में हाथ धोएं। ड्रॉपर की नोक को आंख या किसी सतह से न छुएं। सॉफ्ट कॉन्टैक्ट लेंस पहनने से पहले इसे हटा दें और दवा डालने के 10 मिनट बाद ही दोबारा पहनें। धुंधली दृष्टि होने पर वाहन न चलाएं। दवा को बच्चों की पहुंच से दूर रखें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 lopine-k eye drop Uses & Benefits

[{"condition":"Allergic conjunctivitis","description":"Relieves itching, redness, tearing, and inflammation" class="semantic-link" title="Medicines for swelling">swelling of the conjunctiva caused by seasonal or perennial allergies.","evidence":"Well-established"},{"condition":"Post-operative ocular inflammation and pain","description":"Reduces inflammation and pain after cataract surgery, refractive surgery, or other ocular procedures.","evidence":"Well-established"},{"condition":"Vernal keratoconjunctivitis","description":"Helps control severe allergic eye inflammation, especially in children and young adults.","evidence":"Moderate"},{"condition":"Giant papillary conjunctivitis","description":"May reduce papillary reaction and discomfort associated with contact lens wear or ocular prostheses.","evidence":"Limited"}]

Off-label uses: [{"condition":"Dry eye syndrome with inflammatory component","description":"Sometimes prescribed off-label to reduce ocular surface inflammation in dry eye disease.","evidence":"Limited"},{"condition":"Prevention of intraoperative miosis","description":"Ketorolac component may help maintain pupil dilation during eye surgery, though this is not a primary approved use.","evidence":"Limited"}]

Primary treatment for: Allergic conjunctivitis

Also treats: Post-operative ocular inflammation, Vernal keratoconjunctivitis, Giant papillary conjunctivitis

📋 Drug Information

Generic Name(s)Ketorolac (0.4% w/v) + Olopatadine (0.1% w/v)
Brand Namelopine-k eye drop
ManufacturerNitro Organics
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassOPHTHAL
Action Class
Route of AdministrationOphthalmic
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep the bottle tightly closed when not in use. Do not freeze.
Shelf Life24 months from the date of manufacture, or as printed on the packaging.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always wash your hands before and after applying this medicine to prevent contamination.
2
Do not touch the dropper tip to your eye or any surface, as this can introduce bacteria.
3
If you wear soft contact lenses, remove them before use and wait at least 10 minutes before reinserting.
4
Use this medicine exactly as prescribed; do not increase the frequency or duration without consulting your eye doctor.
5
Report any persistent eye pain, vision changes, or signs of infection to your ophthalmologist immediately.
6
Keep the bottle tightly closed and store it at room temperature, away from direct sunlight.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Eye itching and redness
This medicine is commonly prescribed for allergic conjunctivitis.
Likely Use
Eye pain after surgery
It helps reduce post-operative inflammation and pain.
Likely Use
Dry eyes
This medicine is not a primary treatment for dry eye syndrome.
Not Primary
Eye infection with discharge
It is not an antibiotic and should not be used for infections.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionSystemic absorption after topical ocular administration is minimal. Small amounts may be absorbed through the nasolacrimal duct and gastrointestinal tract, but plasma concentrations are generally very low.
DistributionNot established from the available information.
Protein BindingKetorolac is highly protein-bound (greater than 99%), primarily to albumin. Olopatadine is approximately 55% bound to plasma proteins.
MetabolismKetorolac is metabolized in the liver primarily by glucuronidation and hydroxylation. Olopatadine undergoes limited hepatic metabolism, mainly by N-demethylation and glucuronidation.
Half-LifeThe elimination half-life of ketorolac is approximately 5 to 6 hours. The elimination half-life of olopatadine is approximately 3 hours after topical ocular administration.
ExcretionKetorolac and its metabolites are excreted primarily in urine (about 91%) and feces (about 6%). Olopatadine is excreted mainly in urine as unchanged drug and metabolites.
BioavailabilitySystemic bioavailability after ocular administration is low and not clinically significant for topical effects.
Onset of ActionSymptom relief may begin within minutes to hours after instillation, with maximal effect developing over several days of regular use.
Peak Plasma TimePeak plasma concentrations after ocular administration are typically very low and reached within 1 to 2 hours.
Duration of ActionThe effect of a single dose lasts approximately 4 to 8 hours for olopatadine and up to 6 hours for ketorolac, but clinical relief with regular dosing is continuous.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Ketorolac is a nonsteroidal anti-inflammatory drug that reversibly inhibits cyclooxygenase enzymes (COX-1 and COX-2), reducing the synthesis of prostaglandins and thromboxanes that mediate pain, inflammation, and fever. Olopatadine is an antihistamine and mast cell stabilizer that selectively antagonizes histamine H1 receptors and prevents the release of histamine and other inflammatory mediators from mast cells. Together, they reduce allergic and inflammatory responses in the eye.

Mechanism Steps

1
COX enzyme inhibition by ketorolac: Ketorolac binds reversibly to cyclooxygenase enzymes, blocking the conversion of arachidonic acid to prostaglandin H2.
2
Reduced prostaglandin synthesis: Decreased prostaglandin levels lead to less pain, vasodilation, and vascular permeability in ocular tissues.
3
Histamine H1 receptor blockade by olopatadine: Olopatadine competes with histamine for H1 receptors on blood vessels and nerve endings, preventing itching and redness.
4
Mast cell stabilization: Olopatadine prevents mast cell degranulation, reducing the release of histamine and other allergic mediators.
5
Combined anti-inflammatory and anti-allergic effect: The dual action provides broader relief from allergic and inflammatory ocular symptoms than either agent alone.

💡 How to Take lopine-k eye drop

Strength: Ketorolac 0.4% w/v + Olopatadine 0.1% w/v ophthalmic solution

1Wash your hands thoroughly with soap and water.
2Shake the bottle gently before use.
3Tilt your head back and pull down your lower eyelid to form a small pocket.
4Hold the dropper above the eye and squeeze one drop into the pocket.
5Close your eye gently and press the inner corner of your eye with your finger for 1-2 minutes to prevent drainage.
6Repeat in the other eye if prescribed.
7Replace the cap tightly and wash your hands again.

Dosage Information

Adult DosageThe usual adult dose is one drop in the affected eye(s) four times daily or as directed by your ophthalmologist. For post-operative use, dosing may be one drop four times daily starting before or after surgery. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician or ophthalmologist.
Elderly DosageNo specific dose adjustment is required for elderly patients, but use with caution and under medical supervision.
Renal ImpairmentNo dose adjustment is typically required for topical ocular use, but consult your doctor if you have severe renal impairment.
Hepatic ImpairmentNo dose adjustment is typically required for topical ocular use, but consult your doctor if you have severe hepatic impairment.
Maximum Daily DoseThe maximum recommended daily dose is one drop in the affected eye(s) four times daily, unless otherwise directed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of lopine-k eye drop

✅ Common Side Effects

Transient burning or stinging (Common (5-10%))
Usually resolves within minutes. If persistent or severe, consult your eye doctor.
Eye redness (Common (5-10%))
May decrease with continued use. If it worsens, contact your doctor.
Blurred vision (Common (5-10%))
Avoid driving until vision clears. If persistent, consult your doctor.
Foreign body sensation (Common (5-10%))
Usually temporary. If it continues, speak to your eye care provider.
Headache (Uncommon (1-5%))
Rest and stay hydrated. Consult a doctor if severe or persistent.

🚨 Serious Side Effects

Corneal ulceration or melting (Rare (<0.1%))
Seek immediate ophthalmologic care if you experience severe eye pain, vision loss, or a white spot on the cornea.
Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek emergency medical help if you develop swelling of face, lips, throat, or difficulty breathing.
Bronchospasm (Rare (<0.1%))
If you have asthma or aspirin sensitivity, stop use and seek medical attention immediately if wheezing occurs.
Delayed wound healing (Rare (<0.1%))
Inform your surgeon if you are using this medicine before or after eye surgery.

⚠️ Rare Side Effects

Punctate keratitis
Consult your eye doctor if you notice increased eye discomfort or light sensitivity.
Corneal edema
Report any decrease in vision or halos around lights to your doctor.
Ocular hypertension
Regular eye pressure checks may be needed if used long-term.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Other topical NSAIDs Major
Topical corticosteroids Major
Oral NSAIDs Moderate
Warfarin Moderate
Other eye drops Minor

🚨 Major Interactions

  • Other topical NSAIDs
  • Topical corticosteroids

⚡ Moderate Interactions

  • Oral NSAIDs
  • Anticoagulants (e.g., warfarin)

🍷 Alcohol Interaction

No significant interaction is expected with alcohol when this medicine is used as an eye drop, as systemic absorption is minimal. However, alcohol may worsen dehydration or dizziness if you are also taking other medications.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to ketorolac, olopatadine, or any component of the formulation.","Active corneal epithelial herpes simplex infection.","Untreated ocular infections (bacterial, fungal, or viral). ","Use in patients wearing soft contact lenses during treatment.","Cross-sensitivity to aspirin or other NSAIDs."]

⚠️ Warnings & Precautions

["For topical ocular use only. Do not inject or swallow.","Prolonged use may increase the risk of corneal adverse effects.","Remove soft contact lenses before use and wait 10 minutes before reinsertion.","Avoid touching the dropper tip to any surface to prevent contamination.","Use with caution in patients with a history of asthma or aspirin sensitivity.","Do not use if the solution is discolored or contains particles.","Keep out of reach of children."]

🤱 Lactation Safety

It is not known whether this medicine is excreted in human breast milk. Caution is advised when used by breastfeeding mothers. Consult your doctor before use.

💊 Overdose Management

Overdose with this medicine is unlikely due to its topical ocular route. If accidental ingestion occurs, seek medical attention. In case of excessive eye exposure, flush the eye with lukewarm water and consult a doctor if irritation persists.

⏰ Missed Dose

If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Use this medicine only in the affected eye(s) and exactly as prescribed by your eye doctor. Wash your hands thoroughly before and after each use. Do not touch the dropper tip to your eye, eyelid, or any surface to avoid contamination. Remove soft contact lenses before applying the drops and wait at least 10 minutes before reinserting them, unless your doctor advises otherwise. Do not use this medicine while wearing contact lenses if you have an active eye infection. Avoid driving or operating heavy machinery if your vision is temporarily blurred after instillation. Do not use this medicine for longer than your doctor recommends, as prolonged use may increase the risk of corneal problems. Keep the bottle tightly closed when not in use and store it out of reach of children. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before using this medicine. Do not use this medicine if the solution changes color or contains particles.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more susceptible to corneal adverse effects and should be monitored closely if using this medicine for prolonged periods.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy or are pregnant, consult your doctor before using this medicine. It should be used only if clearly needed.

🏥 Post-Surgery Considerations

This medicine is often prescribed after eye surgery to reduce inflammation and pain. Use exactly as directed by your surgeon and attend all follow-up appointments.

🦷 Dental Procedures

No specific precautions are required for dental procedures while using this medicine, but inform your dentist about all medications you are taking.

💚 Lifestyle Tips for Better Results

🏃
Avoid rubbing your eyes, as this can worsen irritation and introduce infection.
🥗
Use cool compresses to soothe allergic eyes.
😴
Identify and avoid allergens that trigger your symptoms.
💧
Maintain good hand hygiene, especially before touching your eyes.
🧘
Follow a healthy diet rich in omega-3 fatty acids to support eye health.
🌞
Get adequate sleep to help your eyes recover.

🏋️ Exercise Considerations

No specific exercise restrictions are required while using this medicine. However, if your vision is blurred after application, avoid activities that require clear vision, such as swimming or cycling, until it clears.

🥗 Diet Recommendations

Include omega-3 rich foods like flaxseeds and walnuts.
Eat plenty of fruits and vegetables rich in antioxidants.
Stay well hydrated to maintain tear production.
Limit processed foods and excess sugar.

💼 Impact on Daily Work & Life

This medicine may cause temporary blurred vision after instillation. Avoid driving or operating heavy machinery until your vision is clear. It should not affect your ability to work at a desk or perform other non-visually demanding tasks.

🛑 When to Stop This Medicine

Stop using this medicine and consult your doctor if you experience severe eye pain, vision changes, signs of infection, or allergic reactions. Do not stop abruptly if you are using it post-operatively without consulting your surgeon.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of corneal adverse effects such as corneal erosion, ulceration, or delayed healing. Regular monitoring by an ophthalmologist is recommended if prolonged use is necessary. Do not use for longer than prescribed without medical supervision.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Cold compresses

Can help reduce eye itching and swelling in allergic conjunctivitis.

Evidence: Well-established
Avoidance of allergens

Reducing exposure to pollen, dust, or pet dander can prevent symptoms.

Evidence: Well-established
Artificial tears

Can help flush allergens and soothe irritation.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are known with this medicine. Continue routine vaccinations as scheduled.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid extreme temperatures. Store at room temperature and protect from direct sunlight. If traveling across time zones, continue your regular dosing schedule as prescribed. Check customs regulations for carrying prescription eye drops.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 32-year-old woman with seasonal allergic conjunctivitis
She experienced severe eye itching and redness every spring. Her ophthalmologist prescribed this medicine four times daily. Within two days, her itching reduced significantly, and after a week, her eyes looked clear. She was advised to remove her contact lenses during treatment and to use preservative-free artificial tears for dryness.
💡 Lesson: Consistent use as prescribed and avoiding contact lenses during treatment leads to better outcomes.
👤 A 65-year-old man after cataract surgery
He was prescribed this medicine after cataract surgery to control inflammation and pain. He used it four times daily for two weeks. His post-operative recovery was smooth, with minimal discomfort. He was monitored for corneal healing and intraocular pressure.
💡 Lesson: Post-operative use under medical supervision helps reduce inflammation and supports recovery.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: You may feel relief within minutes to hours, but full effect may take a few days of regular use.

Q: Can I use this medicine for dry eyes?

A: No, this medicine is not intended for dry eyes unless specifically prescribed by your doctor for an inflammatory component.

Q: Is it safe to use with contact lenses?

A: Remove soft contact lenses before use and wait at least 10 minutes before reinserting them.

Q: What should I do if I miss a dose?

A: Apply it as soon as you remember, but if it is almost time for the next dose, skip the missed dose and continue your regular schedule.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I use this medicine long-term?
  • Will it affect my vision?
  • Can I drive after using this medicine?
  • Does it interact with my other eye drops?
  • What if I miss a dose?
  • Can I wear contact lenses while using this?

🔄 Substitutes for lopine-k eye drop

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be used for any eye redness.
    Fact: It is specifically for allergic and inflammatory conditions and should not be used for infections or dry eye without medical advice.
  • Myth: More drops mean faster relief.
    Fact: Using more than prescribed does not speed up recovery and may increase side effects.
  • Myth: It is safe to use indefinitely.
    Fact: Prolonged use can cause corneal problems and should be monitored by an eye doctor.

🔄 Alternative Options

Generic Alternatives

  • Ketorolac 0.4% ophthalmic solution
  • Olopatadine 0.1% ophthalmic solution

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Ketorolac 0.4% + Olopatadine 0.1%","primary_use":"Allergic conjunctivitis and post-operative inflammation","route":"Ophthalmic"},{"medicine":"Ketorolac eye drops","composition":"Ketorolac 0.4%","primary_use":"Post-operative inflammation and pain","route":"Ophthalmic"},{"medicine":"Olopatadine eye drops","composition":"Olopatadine 0.1%","primary_use":"Allergic conjunctivitis","route":"Ophthalmic"}]

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