ktl-plus eye drops - Ofloxacin (0.3% w/v) + Ketorolac (0.5% w/v) medicine

Aflox K Eye Drop: Complete Guide to Uses, Side Effects, and Safety

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🏭 Sapient Laboratories Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 26, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Evidence: Well-established for approved indications.
Reviewed by
SaathiMed Expert Panel | Sep 26, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Severe eye pain or sudden vision loss
  • Swelling of the face, lips, or throat
  • Difficulty breathing or swallowing
  • Severe rash or hives
  • New or worsening eye discharge
  • Increased redness or swelling in the eye
  • Symptoms that do not improve within 3-5 days

If experiencing severe symptoms, call emergency services immediately.

What is ktl-plus eye drops used for?

This medicine is a combination eye drop containing ofloxacin (an antibiotic) and ketorolac (an anti-inflammatory), used to treat bacterial eye infections and reduce post-operative inflammation and pain.

  • Generic Name: Ofloxacin (0.3% w/v) + Ketorolac (0.5% w/v)
  • Manufacturer: Sapient Laboratories Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 ktl-plus eye drops के बारे में (Hindi Summary)

उपयोग: यह दवा आंखों के बैक्टीरियल संक्रमण जैसे कंजंक्टिवाइटिस (आंख आना) के इलाज के लिए इस्तेमाल की जाती है। यह आंखों की सूजन और दर्द को भी कम करती है, खासकर आंखों की सर्जरी के बाद। इसमें ऑफ्लोक्सासिन नामक एंटीबायोटिक और कीटोरोलैक नामक दर्द निवारक दवा होती है। यह दवा केवल बैक्टीरिया से होने वाले संक्रमण में प्रभावी है, वायरल या फंगल संक्रमण में नहीं।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में आंखों में जलन, खुजली, धुंधली दृष्टि, और आंखों में कुछ महसूस होना शामिल है। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर आंखों में तेज दर्द, सूजन, या दाने हों तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा का उपयोग करने से पहले अपने डॉक्टर को अपनी एलर्जी और दवाओं के बारे में बताएं। कॉन्टैक्ट लेंस पहनने से पहले उन्हें निकाल लें और दवा डालने के 15 मिनट बाद ही वापस पहनें। ड्रॉपर की नोक को किसी भी सतह से न छुएं। आंखों में लगाने से पहले और बाद में हाथ धोएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। दवा को बच्चों की पहुंच से दूर रखें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 ktl-plus eye drops Uses & Benefits

[{"condition":"Bacterial conjunctivitis","description":"This medicine is used to treat bacterial conjunctivitis caused by susceptible organisms, reducing infection and associated inflammation.","evidence":"Well-established"},{"condition":"Post-operative ocular inflammation and pain","description":"It is commonly prescribed after cataract surgery or other ocular procedures to prevent infection and reduce inflammation and pain.","evidence":"Well-established"},{"condition":"Corneal ulcers","description":"In some cases, it may be used to treat corneal ulcers caused by susceptible bacteria, but use must be supervised by an ophthalmologist.","evidence":"Limited"},{"condition":"Blepharitis","description":"May be used to treat bacterial blepharitis when caused by susceptible organisms, though other treatments are often preferred.","evidence":"Limited"}]

Off-label uses: [{"condition":"Traumatic corneal abrasion","description":"Sometimes prescribed off-label to prevent infection and reduce pain in corneal abrasions, but evidence is limited.","evidence":"Limited"},{"condition":"Ocular rosacea","description":"Rarely used off-label for ocular rosacea to reduce inflammation, but not a standard treatment.","evidence":"Limited"}]

Primary treatment for: Bacterial conjunctivitis

Also treats: Post-operative ocular inflammation, Corneal ulcers, Blepharitis

📋 Drug Information

Generic Name(s)Ofloxacin (0.3% w/v) + Ketorolac (0.5% w/v)
Brand Namektl-plus eye drops
ManufacturerSapient Laboratories Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassOPHTHAL
Action Class
Route of AdministrationOphthalmic
StorageStore at room temperature (15-30°C). Protect from light and freezing. Keep the bottle tightly closed when not in use.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always wash your hands before and after applying this medicine to prevent contamination.
2
Do not touch the dropper tip to your eye or any surface, as this can introduce bacteria.
3
If you wear contact lenses, remove them before application and wait at least 15 minutes before reinserting.
4
Use this medicine exactly as prescribed and complete the full course, even if symptoms improve.
5
If you are using other eye drops, wait at least 5 minutes between applications to avoid dilution.
6
Report any signs of allergic reaction, such as swelling, rash, or difficulty breathing, immediately.
7
Do not use this medicine for longer than prescribed, as it may lead to secondary infections or resistance.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Red, itchy eyes with discharge
This medicine is commonly prescribed for bacterial conjunctivitis.
Likely Use
✅
Eye pain and swelling after surgery
This medicine is used post-operatively to reduce inflammation and prevent infection.
Likely Use
❌
Blurred vision without infection
This medicine is not for simple blurred vision; consult an eye specialist.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionOfloxacin and ketorolac are absorbed systemically to a limited extent after topical ocular administration. Systemic absorption is generally low but can occur, especially if the nasolacrimal duct is not compressed after instillation.
DistributionNot established from the available information.
Protein BindingOfloxacin is approximately 20-30% bound to plasma proteins. Ketorolac is greater than 99% bound to plasma proteins.
MetabolismOfloxacin is minimally metabolized in the liver. Ketorolac is metabolized in the liver primarily by glucuronic acid conjugation and hydroxylation.
Half-LifeThe elimination half-life of ofloxacin is approximately 4-5 hours. The elimination half-life of ketorolac is approximately 5-6 hours.
ExcretionOfloxacin is primarily excreted unchanged in the urine. Ketorolac is excreted mainly in the urine as metabolites and unchanged drug.
BioavailabilitySystemic bioavailability following topical ocular administration is not well established but is considered low.
Onset of ActionThe anti-inflammatory and analgesic effects of ketorolac may begin within 30 minutes after instillation. The antibacterial effect of ofloxacin starts immediately upon contact with susceptible bacteria.
Peak Plasma TimeNot established from the available information.
Duration of ActionThe anti-inflammatory effect of ketorolac lasts approximately 4-6 hours. The antibacterial effect of ofloxacin persists as long as effective concentrations are maintained in the eye.

How It Works

This medicine combines two active ingredients with distinct mechanisms. Ofloxacin, a fluoroquinolone antibiotic, inhibits bacterial DNA gyrase and topoisomerase IV, enzymes necessary for DNA replication, transcription, repair, and recombination. This inhibition leads to the inability of bacteria to replicate and ultimately causes bacterial cell death. Ketorolac, a nonsteroidal anti-inflammatory drug, reversibly inhibits cyclooxygenase enzymes (COX-1 and COX-2), which are responsible for the conversion of arachidonic acid to prostaglandins. Prostaglandins are mediators of inflammation, pain, and fever. By blocking their production, ketorolac reduces ocular inflammation and pain. The combination provides both antibacterial and anti-inflammatory effects, which is particularly useful in post-operative settings or in infections where inflammation contributes to symptoms.

Mechanism Steps

1
Ofloxacin enters bacterial cell: Ofloxacin penetrates the bacterial cell wall and reaches the cytoplasm.
2
Inhibition of DNA gyrase: Ofloxacin binds to DNA gyrase, preventing the supercoiling of DNA necessary for replication.
3
Inhibition of topoisomerase IV: Ofloxacin also inhibits topoisomerase IV, interfering with DNA segregation during cell division.
4
Bacterial cell death: The disruption of DNA processes leads to bacterial cell death.
5
Ketorolac inhibits cyclooxygenase: Ketorolac blocks COX-1 and COX-2 enzymes, reducing prostaglandin synthesis.
6
Reduction of inflammation and pain: Decreased prostaglandins lead to less inflammation, pain, and swelling in the eye.

💡 How to Take ktl-plus eye drops

Strength: Ofloxacin 0.3% w/v + Ketorolac 0.5% w/v ophthalmic solution.

1Wash your hands thoroughly with soap and water.
2Shake the bottle gently before use.
3Tilt your head back and pull down your lower eyelid to form a pouch.
4Hold the dropper above your eye and squeeze one drop into the pouch.
5Close your eye gently and press your finger against the inner corner of your eye for 1-2 minutes to prevent the medicine from draining into your throat.
6Repeat for the other eye if directed.
7Replace the cap tightly after use.
8Wash your hands again to remove any medicine.

Dosage Information

Adult DosageThe usual adult dosage for bacterial conjunctivitis is 1-2 drops instilled into the affected eye(s) every 2-4 hours for the first 2 days, then 1-2 drops four times daily for the next 5 days. For post-operative inflammation, 1 drop four times daily is often used, starting 24 hours after surgery and continuing for 2 weeks. The dose must be individualized by a qualified clinician based on the indication, severity of infection, and patient response.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageNo specific dosage adjustments are required for elderly patients, but caution is advised due to potential increased sensitivity to side effects.
Renal ImpairmentNo dosage adjustment is required for topical ophthalmic use, as systemic absorption is minimal. However, use with caution in patients with severe renal impairment.
Hepatic ImpairmentNo dosage adjustment is required for topical ophthalmic use, as systemic absorption is minimal. However, use with caution in patients with severe hepatic impairment.
Maximum Daily DoseNot established from the available information. Use as prescribed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of ktl-plus eye drops

✅ Common Side Effects

Transient stinging or burning upon instillation (Common (5-10%))
Usually resolves within minutes. If persistent, consult your doctor.
Blurred vision (Common (5-10%))
Avoid driving or operating machinery until vision clears. If persistent, consult your doctor.
Eye discomfort or foreign body sensation (Common (5-10%))
Usually temporary. If severe or persistent, contact your doctor.
Eye redness or itching (Common (5-10%))
May resolve with continued use. If worsens, consult your doctor.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience swelling of face, lips, throat, difficulty breathing, or severe rash.
Secondary eye infection (Rare (<0.1%))
Contact your doctor if you notice new or worsening eye pain, swelling, or discharge.
Corneal deposits (Rare (<0.1%))
Consult an ophthalmologist if you experience persistent blurred vision or eye pain.

⚠️ Rare Side Effects

Corneal perforation
Seek immediate ophthalmologic care.
Systemic effects like nausea or headache
Consult your doctor if symptoms persist.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Aspirin Major
Ibuprofen Major
Other eye drops Moderate
Corticosteroid eye drops Moderate

🚨 Major Interactions

  • Other NSAIDs (e.g., aspirin, ibuprofen)
  • Anticoagulants (e.g., warfarin)

⚡ Moderate Interactions

  • Other ophthalmic solutions
  • Corticosteroids (ophthalmic)

🍷 Alcohol Interaction

No known interaction with alcohol when used topically in the eye. However, alcohol may increase the risk of gastrointestinal bleeding if the medicine is absorbed systemically in significant amounts.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to ofloxacin, ketorolac, or any component of the formulation.","Hypersensitivity to other fluoroquinolones or NSAIDs.","History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.","Viral, fungal, or mycobacterial eye infections.","Use in children under 1 year of age (safety not established)."]

⚠️ Warnings & Precautions

["Prolonged use may result in overgrowth of non-susceptible organisms, including fungi.","Do not touch dropper tip to any surface to avoid contamination.","Remove contact lenses before use and wait 15 minutes before reinserting.","May cause temporary blurred vision; avoid driving or operating machinery until vision clears.","Use with caution in patients with a history of bleeding disorders or those taking anticoagulants.","Safety and efficacy in pediatric patients below 1 year of age have not been established.","Use in pregnancy only if clearly needed.","Caution in breastfeeding women."]

🤱 Lactation Safety

It is not known whether ofloxacin or ketorolac are excreted in human milk after topical ocular administration. Systemically administered ofloxacin is excreted in breast milk. Caution should be exercised when this medicine is used by a nursing woman.

💊 Overdose Management

Overdose with this medicine is unlikely due to its topical ophthalmic route. If accidental ingestion occurs, contact a poison control center or seek medical attention. Symptoms of systemic ofloxacin overdose may include nausea, vomiting, and dizziness. Systemic ketorolac overdose may cause abdominal pain, nausea, vomiting, and gastrointestinal bleeding. Treatment is supportive and symptomatic.

⏰ Missed Dose

If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Before using this medicine, inform your doctor if you are allergic to ofloxacin, ketorolac, other fluoroquinolones, or other NSAIDs. Do not use this medicine while wearing contact lenses, as the preservative may be absorbed by soft contact lenses and cause irritation. Remove contact lenses before applying the drops and wait at least 15 minutes before reinserting them. To avoid contamination, do not touch the dropper tip to any surface, including your eye. Wash your hands thoroughly before and after using the drops. If you are pregnant or breastfeeding, consult your doctor before using this medicine, as the safety of this combination has not been fully established in these populations. Do not use this medicine for longer than prescribed, as prolonged use may increase the risk of secondary infections or antibiotic resistance. If you are using other eye drops, wait at least 5 minutes between applications to prevent dilution. Keep this medicine out of the reach of children. Do not drive or operate heavy machinery if you experience temporary blurred vision after applying the drops. If your symptoms do not improve within a few days or if they worsen, contact your doctor immediately.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more susceptible to the side effects of NSAIDs, including gastrointestinal bleeding and renal impairment, if systemic absorption occurs. Use with caution and monitor for any adverse effects.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before using this medicine. It is not recommended during pregnancy unless clearly needed.

🏥 Post-Surgery Considerations

This medicine is often prescribed after eye surgery to prevent infection and reduce inflammation. Use exactly as directed by your surgeon. Do not stop early unless instructed.

🦷 Dental Procedures

No specific precautions are required for dental procedures while using this medicine. However, inform your dentist about all medications you are taking.

💚 Lifestyle Tips for Better Results

🏃
Avoid touching or rubbing your eyes to prevent worsening of infection.
🥗
Wash your hands frequently, especially before and after applying the drops.
😴
Do not share towels or pillows with others to prevent spread of infection.
💧
Follow good hygiene practices, such as cleaning your eyeglasses regularly.
🧘
Get adequate rest to support your immune system.
🌞
Avoid wearing eye makeup until the infection clears.

🏋️ Exercise Considerations

No specific exercise restrictions are required while using this medicine. However, if you experience blurred vision after application, avoid activities that require clear vision, such as swimming or contact sports, until vision returns to normal.

🥗 Diet Recommendations

Stay well hydrated to maintain overall eye health.
Include foods rich in vitamin A and omega-3 fatty acids, such as carrots and fish.
Avoid excessive caffeine and alcohol, which can contribute to dehydration.

💼 Impact on Daily Work & Life

This medicine may cause temporary blurred vision after application, which can affect your ability to drive or operate machinery. It is advisable to wait until your vision is clear before resuming such activities. Otherwise, it does not significantly impact your daily work life.

🛑 When to Stop This Medicine

Stop using this medicine only after completing the prescribed course or as directed by your doctor. If you experience serious side effects, stop immediately and seek medical attention. Do not stop prematurely, as it may lead to recurrence of infection.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to secondary eye infections due to overgrowth of non-susceptible organisms, including fungi. Prolonged use of antibiotics can also contribute to antibiotic resistance. Regular monitoring by an ophthalmologist is recommended if extended therapy is required. Systemic effects are unlikely with topical use, but long-term use of NSAIDs may increase the risk of cardiovascular or gastrointestinal issues if significant systemic absorption occurs.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Warm compresses

Can help relieve discomfort and reduce swelling in conjunctivitis.

Evidence: Well-established
Artificial tears

Can provide symptomatic relief for dry eyes, but do not treat infection.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No known interactions with vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling with this medicine, keep it in its original packaging with the prescription label. Carry a copy of your prescription in case of customs checks. Store at room temperature and protect from extreme heat or cold. If traveling across time zones, continue your regular dosing schedule as close as possible. Do not leave the bottle in a hot car or checked luggage. If you need to use the drops during a flight, you can do so, but be aware of temporary blurred vision.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with bacterial conjunctivitis
Ravi noticed his eye was red, itchy, and had a sticky discharge. His doctor prescribed this medicine. After using it for 2 days, the redness and discharge reduced significantly. He completed the 7-day course as directed and the infection cleared completely.
💡 Lesson: Completing the full course of antibiotics is essential to prevent recurrence and resistance.
👤 A 60-year-old woman after cataract surgery
Mrs. Sharma was prescribed this medicine after her cataract surgery to prevent infection and reduce inflammation. She used it four times a day for two weeks. She experienced mild stinging initially, but it subsided. Her recovery was smooth with no complications.
💡 Lesson: Using the drops as prescribed after surgery helps prevent infection and promotes healing.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: You may start feeling relief from pain and inflammation within 30 minutes, but the antibacterial effect takes 24-48 hours to show improvement in infection symptoms.

Q: Can I wear contact lenses while using this medicine?

A: No, you should remove contact lenses before applying the drops and wait at least 15 minutes before reinserting them.

Q: Is this medicine safe during pregnancy?

A: It is classified as FDA pregnancy category C. Use only if the potential benefit justifies the potential risk to the fetus. Consult your doctor.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I use this medicine for dry eyes?
  • Is it safe to use this medicine with other eye drops?
  • How long does it take to work?
  • Can I drive after using this medicine?
  • What if I accidentally swallow the drops?

🔄 Substitutes for ktl-plus eye drops

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be used for any eye infection.
    Fact: This medicine is only effective against bacterial infections and should not be used for viral or fungal eye infections.
  • Myth: You can stop using this medicine as soon as symptoms improve.
    Fact: You must complete the full course as prescribed to prevent recurrence and antibiotic resistance.
  • Myth: This medicine is safe to use with contact lenses.
    Fact: Contact lenses should be removed before use and not reinserted for at least 15 minutes.

🔄 Alternative Options

Generic Alternatives

  • Ofloxacin 0.3% + Ketorolac 0.5% ophthalmic solution (generic)

Brand Alternatives

  • Aflox K Eye Drop

📊 Comparison with Similar Medicines

[{"medicine":"Ofloxacin alone","difference":"Lacks anti-inflammatory component; only treats infection."},{"medicine":"Ketorolac alone","difference":"Lacks antibiotic component; only reduces inflammation and pain."},{"medicine":"Moxifloxacin eye drops","difference":"Another fluoroquinolone antibiotic; no anti-inflammatory component."}]

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