klarim 500 tablet - Clarithromycin (500mg) medicine

Aliclair 500mg Tablet: Complete Medicine Guide

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🏭 Morepen Laboratories Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 26, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Evidence: Well-established for approved indications.
Reviewed by
SaathiMed Expert Panel | Sep 26, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Severe or bloody diarrhea
  • Yellowing of skin or eyes
  • Palpitations or fainting
  • Swelling of face, lips, or throat
  • Difficulty breathing
  • Severe abdominal pain
  • Dark urine

If experiencing severe symptoms, call emergency services immediately.

What is klarim 500 tablet used for?

This medicine is a macrolide antibiotic containing clarithromycin 500 mg. It treats bacterial infections of the respiratory tract, skin, and stomach by stopping bacterial protein synthesis. It is not effective against viral infections.

  • Generic Name: Clarithromycin (500mg)
  • Manufacturer: Morepen Laboratories Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 klarim 500 tablet के बारे में (Hindi Summary)

उपयोग: यह दवा क्लैरिथ्रोमाइसिन 500 मिलीग्राम टैबलेट है, जो एक मैक्रोलाइड एंटीबायोटिक है। इसका उपयोग बैक्टीरियल संक्रमण जैसे श्वसन तंत्र के संक्रमण, त्वचा के संक्रमण, और पेट के अल्सर का कारण बनने वाले हेलिकोबैक्टर पाइलोरी के इलाज में किया जाता है। यह वायरल संक्रमण जैसे सर्दी-जुकाम के लिए प्रभावी नहीं है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, दस्त, पेट दर्द, स्वाद में बदलाव और सिरदर्द शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें तेज बुखार, पीलिया, दिल की धड़कन में अनियमितता, और गंभीर एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि आपको गंभीर या लगातार दस्त, पीलिया, या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। पूरा कोर्स पूरा करें, भले ही आप बेहतर महसूस करें। इस दवा के साथ शराब का सेवन न करें। अपने डॉक्टर को अपनी सभी दवाओं के बारे में बताएं, क्योंकि यह कई दवाओं के साथ प्रतिक्रिया कर सकती है। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 klarim 500 tablet Uses & Benefits

  • [{"condition":"Community-acquired respiratory tract infections","description":"Used to treat bacterial bronchitis, pneumonia, and sinusitis caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Effective against many gram-positive bacteria causing cellulitis, impetigo, and wound infections.","evidence":"Well-established"},{"condition":"Helicobacter pylori eradication","description":"Used in combination with other antibiotics and acid suppressants to treat H.
  • pylori-associated peptic ulcer disease.","evidence":"Well-established"},{"condition":"Mycobacterium avium complex (MAC) infection","description":"Part of combination therapy for prevention and treatment of disseminated MAC in patients with advanced HIV.","evidence":"Well-established"},{"condition":"Sexually transmitted infections","description":"Used for certain infections such as chlamydia when other options are not suitable.","evidence":"Established"}]

Off-label uses: [{"condition":"Chronic rhinosinusitis","description":"Sometimes prescribed off-label for persistent sinus inflammation when bacterial infection is suspected.","evidence":"Limited"},{"condition":"Lyme disease","description":"Occasionally used off-label for early Lyme disease in patients who cannot take doxycycline.","evidence":"Limited"}]

Primary treatment for: Bacterial infections

Also treats: Respiratory tract infections, Skin infections, Helicobacter pylori infection, Mycobacterium avium complex infection

📋 Drug Information

Generic Name(s)Clarithromycin (500mg)
Brand Nameklarim 500 tablet
ManufacturerMorepen Laboratories Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassMacrolides
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F) in a dry place, away from direct sunlight and moisture.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Complete the full prescribed course even if you feel better.
3
Avoid alcohol while taking this medicine.
4
Inform your doctor about all other medicines you take, especially blood thinners and statins.
5
Do not share this medicine with others.
6
Report any severe diarrhea, yellowing of eyes, or palpitations immediately.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Bacterial respiratory infection
This medicine is commonly prescribed for this.
Likely Use
❌
Viral cold
This medicine is not effective against viruses.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is rapidly absorbed from the gastrointestinal tract after oral administration. The absolute bioavailability is approximately 50-55% due to first-pass metabolism. Food may slightly delay absorption but does not significantly affect the overall extent of absorption.
DistributionThis medicine distributes widely into body tissues and fluids, including lung tissue, nasal mucosa, skin, and middle ear fluid. It achieves intracellular concentrations higher than plasma levels, which is useful for treating intracellular pathogens. It also crosses the placenta and is excreted in breast milk.
Protein BindingThis medicine is approximately 70% bound to plasma proteins, primarily to alpha-1-acid glycoprotein and albumin.
MetabolismThis medicine undergoes extensive hepatic metabolism, primarily by the cytochrome P450 3A4 enzyme, to form an active metabolite, 14-hydroxyclarithromycin, which also has antibacterial activity.
Half-LifeThe elimination half-life of this medicine is approximately 3 to 4 hours in healthy adults with normal renal function. It may be prolonged in patients with renal impairment.
ExcretionThis medicine is excreted primarily in the urine (about 20-40% as unchanged drug) and in the feces via biliary elimination. Renal impairment can significantly affect elimination.
BioavailabilityThe oral bioavailability of this medicine is approximately 50-55%.
Onset of ActionThe onset of antibacterial action begins within a few hours after oral administration, but clinical improvement of symptoms may take 1 to 3 days.
Peak Plasma TimePeak plasma concentrations of this medicine are reached approximately 2 to 3 hours after oral administration.
Duration of ActionThe antibacterial effect of this medicine persists for approximately 12 to 24 hours after a single dose, depending on the susceptibility of the organism.

How It Works

This medicine works by binding to the 50S subunit of the bacterial ribosome, specifically interacting with the peptidyl transferase center and blocking the translocation step of protein synthesis. This prevents bacteria from building essential proteins, which stops their growth and multiplication. Because human cells have different ribosomes, the medicine selectively targets bacteria without affecting human protein production.

Mechanism Steps

1
Entry into bacterial cell: This medicine penetrates the bacterial cell wall and enters the cytoplasm of susceptible bacteria.
2
Binding to 50S ribosome: It binds reversibly to the 50S ribosomal subunit near the peptidyl transferase center.
3
Blocking protein synthesis: This binding prevents the translocation of tRNA and inhibits the elongation of the growing peptide chain.
4
Inhibition of bacterial growth: Without essential proteins, bacteria cannot multiply, and the immune system can clear the infection.

💡 How to Take klarim 500 tablet

Strength: 500 mg immediate-release tablet

1Take this medicine by mouth with a full glass of water.
2You may take it with or without food, but taking it with food may reduce stomach upset.
3Swallow the tablet whole; do not crush or chew.
4Take at evenly spaced intervals as prescribed by your doctor.
5Complete the full course of treatment even if you feel better.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 250 mg to 500 mg taken every 12 hours, depending on the type and severity of infection. For some infections, a dose of 500 mg every 12 hours for 7 to 14 days is common. For H. pylori eradication, it is used in combination with other medicines. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may have reduced renal function and are more susceptible to side effects. Dose adjustment may be necessary based on renal function. Consult a doctor for individualized dosing.
Renal ImpairmentIn patients with severe renal impairment (creatinine clearance <30 mL/min), the dose of this medicine should be reduced by half or the dosing interval extended. Consult a doctor for specific adjustments.
Hepatic ImpairmentIn patients with severe hepatic impairment, caution is advised and dose reduction may be necessary. Monitor liver function closely.
Maximum Daily DoseThe maximum recommended daily dose of this medicine is 1000 mg (1 gram) per day in divided doses for most indications.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase drug levels.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of klarim 500 tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food and stay hydrated. Consult doctor if persistent.
Diarrhea (Common (5-10%))
Drink plenty of fluids. If diarrhea is severe or bloody, seek medical attention.
Abdominal pain (Common (3-5%))
Take with meals. Report if pain is severe or persistent.
Altered taste (Common (3-5%))
Usually temporary. Avoid strong-flavored foods if bothersome.
Headache (Common (2-5%))
Rest and stay hydrated. Consult doctor if headache is severe.

🚨 Serious Side Effects

Clostridioides difficile-associated diarrhea (Rare (<1%))
Seek immediate medical attention if you develop severe, persistent, or bloody diarrhea.
Severe allergic reactions (anaphylaxis) (Rare (<0.1%))
Call emergency services if you experience swelling of face, lips, throat, difficulty breathing, or widespread rash.
Liver toxicity (Rare (<0.1%))
Report yellowing of skin or eyes, dark urine, or severe abdominal pain immediately.
QT prolongation and arrhythmias (Rare (<0.1%))
Seek medical help if you experience palpitations, fainting, or dizziness.

⚠️ Rare Side Effects

Pancreatitis
Seek immediate care for severe upper abdominal pain radiating to the back.
Seizures
Call emergency services if seizures occur.
Hearing loss
Report any hearing changes to your doctor promptly.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Simvastatin Major
Amiodarone Major
Carbamazepine Moderate
Theophylline Moderate
Oral hypoglycemics Moderate
Antacids Minor
Rifampicin Minor
Digoxin Moderate
Colchicine Major

🚨 Major Interactions

  • Warfarin
  • Statins (simvastatin, atorvastatin)
  • Ergot alkaloids
  • QT-prolonging drugs (e.g., amiodarone, sotalol)

⚡ Moderate Interactions

  • Carbamazepine
  • Theophylline
  • Oral hypoglycemics

🍷 Alcohol Interaction

Alcohol may worsen stomach upset and liver stress while taking this medicine. It is advisable to avoid alcohol during treatment.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to clarithromycin or other macrolide antibiotics","Concurrent use with ergot alkaloids","Concurrent use with cisapride, pimozide, or terfenadine","History of QT prolongation or ventricular arrhythmias","Severe hepatic impairment","Concurrent use with lovastatin or simvastatin"]

⚠️ Warnings & Precautions

["Use with caution in patients with liver disease; monitor liver function.","Use with caution in patients with kidney disease; dose adjustment may be needed.","May prolong QT interval; avoid in patients with risk factors.","Can cause Clostridioides difficile-associated diarrhea; report severe diarrhea.","May interact with many drugs; review all medications before starting.","Avoid alcohol during treatment.","Do not use for viral infections; it is ineffective against viruses."]

🤱 Lactation Safety

This medicine is excreted in human breast milk. Caution is advised when used during breastfeeding. Consult your doctor to weigh benefits and risks.

💊 Overdose Management

Overdose of this medicine may cause severe gastrointestinal symptoms, liver toxicity, and cardiac arrhythmias. Treatment is supportive and symptomatic. Gastric lavage may be considered if ingestion is recent. Contact a poison control center or emergency department immediately.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor, usually with or without food, at evenly spaced intervals. Do not skip doses or stop early, even if you feel better, because incomplete treatment can allow bacteria to become resistant. Avoid alcohol while taking this medicine because it may worsen stomach upset and liver stress. Tell your doctor about all other medicines you take, especially blood thinners, statins, diabetes medicines, and heart rhythm medicines, as this medicine can interact with them. Do not share this medicine with others, and keep it out of reach of children. If you are pregnant, planning pregnancy, or breastfeeding, speak to your doctor before using this medicine. Store it at room temperature away from moisture and direct sunlight.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may have reduced renal function and are more prone to side effects. Dose adjustment may be needed. Monitor for dizziness and heart rhythm changes.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before taking this medicine. It should be used during pregnancy only if clearly needed.

🏥 Post-Surgery Considerations

This medicine may be prescribed after surgery to prevent or treat bacterial infections. Follow your surgeon's instructions carefully.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may interact with certain dental medications and can affect bleeding risk.

💚 Lifestyle Tips for Better Results

🏃
Stay well hydrated.
🥗
Get plenty of rest to help your body fight infection.
😴
Eat a balanced diet rich in fruits and vegetables.
💧
Avoid alcohol during treatment.
🧘
Practice good hand hygiene to prevent spread of infection.

🏋️ Exercise Considerations

Mild exercise is generally safe, but if you feel dizzy or weak, avoid strenuous activity. Consult your doctor before resuming intense exercise.

🥗 Diet Recommendations

Include probiotics like yogurt to prevent diarrhea.
Stay well hydrated.
Avoid grapefruit juice.
Eat light, easily digestible meals if you have stomach upset.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or stomach upset in some people. Avoid driving or operating heavy machinery if you feel unwell. Most people can continue their daily activities.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor, even if you feel better. Complete the full prescribed course. If you experience severe side effects, contact your doctor immediately.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to bacterial resistance and rare liver or heart effects. It is usually prescribed for short courses. Prolonged use should be monitored by a doctor with regular liver and renal function tests.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Azithromycin

Another macrolide antibiotic with a longer half-life and fewer drug interactions.

Evidence: Well-established
Doxycycline

Alternative antibiotic for certain respiratory and skin infections.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

This medicine does not interact with most vaccines. However, live bacterial vaccines should be avoided during antibiotic therapy. Consult your doctor for specific advice.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing intervals as advised by your doctor. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man with bacterial bronchitis
He was prescribed this medicine for 7 days. He took it with food and completed the course. His cough and fever improved within 3 days, and he recovered fully.
💡 Lesson: Taking the full course and with food improves outcomes and reduces stomach upset.
👤 A 50-year-old woman with H. pylori infection
She was given this medicine along with two other antibiotics and an acid reducer for 14 days. She experienced mild nausea but completed the treatment. Follow-up testing showed the infection was cured.
💡 Lesson: Combination therapy and adherence are key to eradicating H. pylori.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: You may start feeling better within 1 to 3 days, but you must complete the full prescribed course.

Q: Can I take this medicine with food?

A: Yes, you can take it with or without food. Taking it with food may reduce stomach upset.

Q: Is this medicine safe during pregnancy?

A: Consult your doctor. It should be used during pregnancy only if clearly needed.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for klarim 500 tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure the common cold.
    Fact: This medicine is an antibiotic and is ineffective against viruses, including those causing the common cold.
  • Myth: You can stop taking this medicine once you feel better.
    Fact: You must complete the full prescribed course to prevent bacterial resistance and relapse.
  • Myth: This medicine is safe to take with any other medication.
    Fact: This medicine interacts with many drugs, so always inform your doctor about all medicines you take.

🔄 Alternative Options

Generic Alternatives

  • Clarithromycin 500 mg tablet

Brand Alternatives

  • Aliclair 500mg Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Clarithromycin","class":"Macrolide","half_life":"3-4 hours","common_use":"Respiratory, skin, H. pylori"},{"medicine":"Azithromycin","class":"Macrolide","half_life":"68 hours","common_use":"Respiratory, STIs"},{"medicine":"Erythromycin","class":"Macrolide","half_life":"1.5-2 hours","common_use":"Respiratory, skin"}]

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