Aliclair 250mg Tablet (Clarithromycin): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain or cramping
- Yellowing of skin or eyes (jaundice)
- Dark urine or pale stools
- Palpitations, fainting, or irregular heartbeat
- Swelling of face, lips, or throat, or difficulty breathing
- Severe skin rash with blistering or peeling
- Decreased urine output or swelling in legs
If experiencing severe symptoms, call emergency services immediately.
What is klarim 250mg tablet used for?
This medicine is a clarithromycin 250 mg tablet, a macrolide antibiotic used to treat bacterial infections such as pneumonia, bronchitis, sinusitis, and skin infections. It works by stopping bacterial protein synthesis. Take it exactly as prescribed, usually every 12 hours, and complete the full course.
- Generic Name: Clarithromycin (250mg)
- Manufacturer: Morepen Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 klarim 250mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा क्लैरिथ्रोमाइसिन 250 मिलीग्राम की गोली है, जो एक मैक्रोलाइड एंटीबायोटिक है। इसका उपयोग बैक्टीरियल संक्रमणों जैसे निमोनिया, ब्रोंकाइटिस, साइनसाइटिस, गले में संक्रमण, त्वचा के संक्रमण और पेट के अल्सर में हेलिकोबैक्टर पाइलोरी के इलाज के लिए किया जाता है। यह बैक्टीरिया के प्रोटीन संश्लेषण को रोककर उन्हें मार देती है। इसे डॉक्टर के निर्देशानुसार ही लें और कोर्स पूरा करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, दस्त, पेट दर्द, उल्टी, सिरदर्द और स्वाद में बदलाव शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ दिनों में ठीक हो जाते हैं। कभी-कभी गंभीर दस्त, लिवर की समस्या, दिल की धड़कन में गड़बड़ी या त्वचा पर गंभीर रैश हो सकते हैं। अगर आपको खूनी दस्त, पीलिया, दिल की धड़कन तेज या बेहोशी महसूस हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, खुराक न छोड़ें और कोर्स पूरा करें। इसे पानी के साथ निगलें, चबाएं नहीं। इसे भोजन के साथ या बिना भोजन के लिया जा सकता है, लेकिन भोजन के साथ लेने से पेट की जलन कम होती है। इस दवा के साथ शराब न लें। एंटासिड के साथ 2 घंटे का अंतराल रखें। अगर आपको दिल, लिवर या किडनी की बीमारी है, या आप अन्य दवाएं ले रहे हैं, तो डॉक्टर को बताएं। इसे दूसरों के साथ साझा न करें।
💊 klarim 250mg tablet Uses & Benefits
- [{"condition":"Community-acquired pneumonia","description":"Used to treat pneumonia caused by susceptible bacteria such as Streptococcus pneumoniae, Haemophilus influenzae, and atypical pathogens like Mycoplasma pneumoniae and Chlamydophila pneumoniae.","evidence":"Well-established"},{"condition":"Acute bacterial exacerbation of chronic bronchitis","description":"Prescribed to reduce symptoms and clear infection in patients with chronic obstructive pulmonary disease experiencing acute worsening due to bacterial infection.","evidence":"Well-established"},{"condition":"Acute bacterial sinusitis","description":"Used as an alternative for patients allergic to penicillin or when first-line antibiotics are not suitable, targeting common respiratory pathogens.","evidence":"Well-established"},{"condition":"Pharyngitis and tonsillitis","description":"Effective against Streptococcus pyogenes when penicillin cannot be used, helping to prevent rheumatic fever complications.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats infections such as cellulitis, impetigo, and erysipelas caused by susceptible staphylococci and streptococci.","evidence":"Well-established"},{"condition":"Helicobacter pylori eradication","description":"Used in combination with other antibiotics and a proton pump inhibitor to eradicate H.
- pylori in patients with peptic ulcer disease.","evidence":"Well-established"},{"condition":"Mycobacterium avium complex (MAC) infection","description":"Part of combination therapy for disseminated MAC in patients with advanced HIV infection and for prophylaxis in certain high-risk individuals.","evidence":"Well-established"},{"condition":"Lyme disease","description":"An alternative treatment for early localized Lyme disease in patients who cannot take doxycycline or amoxicillin.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Cat scratch disease","description":"Sometimes used to treat Bartonella henselae infection, especially in immunocompromised patients, though evidence is limited.","evidence":"Limited"},{"condition":"Community-acquired pneumonia in children","description":"Occasionally used off-label in children for atypical pneumonia, but pediatric dosing must be determined by a specialist.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Community-acquired pneumonia, Acute bacterial exacerbation of chronic bronchitis, Acute bacterial sinusitis, Pharyngitis, Tonsillitis, Skin and soft tissue infections, Helicobacter pylori infection, Mycobacterium avium complex infection
📋 Drug Information
| Generic Name(s) | Clarithromycin (250mg) |
| Brand Name | klarim 250mg tablet |
| Manufacturer | Morepen Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Macrolides |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature between 15°C and 30°C (59°F to 86°F) in a dry place. Protect it from light and moisture. Keep the tablets in their original container with the lid tightly closed. Do not store in the bathroom. Keep out of reach of children and pets. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture. Check the expiry date on the packaging before use. Do not use if the expiry date has passed. |
| WHO Guideline | The World Health Organization (WHO) includes clarithromycin in its Model List of Essential Medicines for the treatment of certain bacterial infections, including community-acquired pneumonia and Helicobacter pylori eradication. However, specific recommendations depend on local resistance patterns and guidelines. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) guidelines recommend clarithromycin as an alternative for patients allergic to penicillin in respiratory tract infections and as part of combination therapy for H. pylori eradication. It should be used judiciously due to increasing macrolide resistance. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by binding to the 50S ribosomal subunit of susceptible bacteria, specifically to the 23S ribosomal RNA component. This binding blocks the translocation step of protein synthesis, preventing the bacteria from forming essential proteins needed for growth and multiplication. As a result, bacterial protein production stops, and the bacteria cannot survive or replicate. This medicine is bacteriostatic at usual concentrations but can be bactericidal against certain highly susceptible organisms. It is effective against a broad range of gram-positive and atypical bacteria, including Streptococcus species, Staphylococcus species, Haemophilus influenzae, Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila. It also has activity against Mycobacterium avium complex and Helicobacter pylori.
Mechanism Steps
💡 How to Take klarim 250mg tablet
Strength: This medicine is available as a 250 mg immediate-release tablet for oral administration.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 250 mg taken orally every 12 hours for 7 to 14 days, depending on the type and severity of the infection. For more severe infections, the dose may be increased to 500 mg every 12 hours. For Helicobacter pylori eradication, it is used in combination with other drugs, typically 500 mg twice daily. The dose must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and other medications being taken. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information for this specific 250 mg immediate-release tablet. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially cardiac arrhythmias and liver toxicity. Dose adjustment is not usually necessary based on age alone, but renal function should be assessed, and the dose should be adjusted if renal impairment is present. Elderly patients should be monitored closely for adverse effects. |
| Renal Impairment | In patients with severe renal impairment (creatinine clearance less than 30 mL/min), the dose of this medicine should be reduced by half. For example, if the usual dose is 250 mg twice daily, it should be reduced to 250 mg once daily. In patients with end-stage renal disease on dialysis, the dose should be adjusted, and the medicine should be taken after dialysis. Consult a nephrologist or clinical pharmacist for precise dosing. |
| Hepatic Impairment | This medicine is extensively metabolized in the liver. In patients with moderate to severe hepatic impairment, the dose should be used with caution, and liver function should be monitored. No specific dose adjustment guidelines are established, but a reduced dose may be considered. Consult a hepatologist or clinical pharmacist for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose of this medicine for adults is 1000 mg (500 mg twice daily) for most indications. For Helicobacter pylori eradication, the maximum daily dose is also 1000 mg. Do not exceed the prescribed dose without consulting your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of klarim 250mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Cisapride | Major | |
| Pimozide | Major | |
| Ergotamine | Major | |
| Lovastatin | Major | |
| Simvastatin | Major | |
| Warfarin | Major | |
| Colchicine | Major | |
| Carbamazepine | Major | |
| Rifampicin | Major | |
| Atorvastatin | Moderate |
🚨 Major Interactions
- Cisapride
- Pimozide
- Ergotamine and dihydroergotamine
- Lovastatin and simvastatin
- Warfarin
- Colchicine
- Carbamazepine
- Rifampicin
⚡ Moderate Interactions
- Atorvastatin
- Digoxin
- Verapamil
- Fluconazole
- Midazolam
- Omeprazole
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Combining alcohol with clarithromycin can increase the risk of liver-related side effects and may worsen cardiac arrhythmias. It can also increase stomach irritation and nausea. It is best to abstain from alcohol until you have completed the course and your doctor confirms it is safe.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to clarithromycin or other macrolide antibiotics","Concomitant use with cisapride, pimozide, ergotamine, or dihydroergotamine","Concomitant use with lovastatin or simvastatin","History of QT prolongation or ventricular arrhythmias, including torsades de pointes","Severe hepatic impairment","Concomitant use with colchicine in patients with renal or hepatic impairment","Use in patients with known history of cholestatic jaundice or hepatic dysfunction associated with prior clarithromycin use"]
⚠️ Warnings & Precautions
["This medicine should be used with caution in patients with coronary artery disease, severe heart failure, bradycardia, or electrolyte abnormalities.","Avoid concurrent use with other drugs that prolong the QT interval.","Clostridioides difficile-associated diarrhea can occur during or after treatment; if suspected, discontinue use and manage appropriately.","This medicine may exacerbate myasthenia gravis symptoms.","Use with caution in patients with hepatic impairment; monitor liver function.","Dose adjustment is required in patients with severe renal impairment.","This medicine may interact with many drugs; review all concomitant medications before starting therapy.","Do not use this medicine for viral infections as it is ineffective and may promote resistance."]
🤱 Lactation Safety
This medicine is excreted in human breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose of this medicine may cause severe gastrointestinal symptoms such as nausea, vomiting, and diarrhea. In severe cases, it can lead to electrolyte imbalances and cardiac arrhythmias. There is no specific antidote. Treatment should be symptomatic and supportive, including gastric lavage if ingestion is recent, monitoring of vital signs, electrolytes, and ECG. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, and do not skip doses or stop early even if you feel better. Complete the full course to prevent the infection from returning and to reduce the risk of antibiotic resistance. Swallow the tablet whole with a glass of water; do not crush or chew it. You may take this medicine with or without food, but taking it with food can help reduce stomach upset. Avoid alcohol while taking this medicine because it can worsen liver-related side effects and increase the risk of irregular heart rhythms. Do not take antacids containing aluminum or magnesium within two hours of this medicine, as they can reduce its absorption. Inform your doctor if you have heart, liver, or kidney problems, or if you are taking blood thinners, statins, or diabetes medicines. Do not share this medicine with others, even if they have similar symptoms. Store it at room temperature away from moisture and heat, and keep it out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients (above 65 years) may be more susceptible to the side effects of this medicine, particularly cardiac arrhythmias, liver toxicity, and hearing loss. Renal function should be assessed before starting therapy, and dose adjustment may be needed if renal impairment is present. Elderly patients should be monitored closely for any signs of adverse effects.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It is classified as Pregnancy Category C, meaning risk cannot be ruled out. Your doctor will weigh the benefits and risks and may prescribe an alternative antibiotic if appropriate. Use effective contraception while taking this medicine if you are of childbearing age and not planning pregnancy.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon that you are taking this medicine. It may interact with anesthetics and other medications used during surgery. Your doctor may advise you to stop the medicine before surgery or adjust the dose. Do not stop the medicine without consulting your doctor.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may interact with certain antibiotics or anesthetics used in dentistry. Your dentist may need to adjust your treatment plan. Do not stop the medicine without consulting your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may feel tired or dizzy. Avoid strenuous exercise if you are not feeling well. Light activities like walking are generally safe, but listen to your body and rest when needed. If you experience palpitations, chest pain, or shortness of breath during exercise, stop immediately and seek medical attention.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, confusion, or altered taste, which can affect your ability to drive or operate machinery. Avoid driving or operating heavy machinery until you know how this medicine affects you. It is generally safe to continue desk work, but take breaks if you feel tired. Inform your employer if you need to take time off due to illness.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor, even if you feel better. Stopping early can lead to recurrence of infection and antibiotic resistance. If you experience severe side effects such as severe diarrhea, jaundice, palpitations, or allergic reactions, stop the medicine and seek immediate medical attention. Your doctor will advise you on whether to stop or switch to another antibiotic.
📅 Long-Term Use Effects
Long-term use of this medicine is not usually recommended unless for specific chronic infections like Mycobacterium avium complex. Prolonged use can lead to antibiotic resistance, superinfections (such as oral thrush or C. difficile colitis), and rarely liver or heart complications. Regular monitoring of liver and renal function may be required during prolonged therapy. Always consult your doctor before extending the duration of treatment.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another macrolide antibiotic with a longer half-life and once-daily dosing, used for similar indications.
Evidence: Well-establishedA penicillin antibiotic often used as first-line therapy for respiratory and skin infections.
Evidence: Well-establishedA tetracycline antibiotic used for atypical pneumonia, Lyme disease, and skin infections.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you are scheduled to receive a live vaccine, inform your doctor, as antibiotics generally do not affect vaccine efficacy but the underlying infection may. There is no need to delay vaccination unless advised by your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label clearly visible. Bring a copy of your prescription or a letter from your doctor, especially for international travel, as some countries have strict rules about antibiotics. Store it in your carry-on luggage to avoid temperature extremes in checked baggage. Keep it away from direct sunlight and moisture. If crossing time zones, maintain the dosing schedule as close to every 12 hours as possible; consult your doctor or pharmacist for specific advice. Do not pack it in checked luggage in case of loss.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours, but it may take a few days for full effect. Complete the full course as prescribed.
A: Yes, you can take it with or without food. Taking it with food may help reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: This medicine is classified as Pregnancy Category C. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor.
A: It is best to avoid alcohol while taking this medicine, as it can increase the risk of liver toxicity and cardiac arrhythmias.
A: Store at room temperature between 15°C and 30°C in a dry place, away from light and moisture. Keep in the original container.
🤔 Common Patient Concerns
🔄 Substitutes for klarim 250mg tablet
View AllAlternative brands with exact same active ingredient:
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klarcid 250mg oral gelKlar Sehen Pvt Ltd ₹39.26 84.3% CHEAPER
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biomycin syrupBiochem Pharmaceutical Industries ₹40.00 84.1% CHEAPER
-
vasu clear 250mg capsuleVASU Healthcare Pvt Ltd ₹47.58 81% CHEAPER
-
clavid 250mg tabletVivid Labs Pvt Ltd ₹65.63 73.8% CHEAPER
-
clar 250mg tabletHetero Drugs Ltd ₹70.25 72% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure the common cold.
Fact: This medicine is an antibiotic and is ineffective against viruses, including those that cause the common cold. It should only be used for bacterial infections. - Myth: You can stop taking this medicine as soon as you feel better.
Fact: You must complete the full course as prescribed, even if symptoms improve, to prevent the infection from returning and to reduce antibiotic resistance. - Myth: This medicine is safe to take with any other medication.
Fact: This medicine interacts with many drugs, some seriously. Always inform your doctor about all medicines you are taking. - Myth: This medicine can be shared with family members who have similar symptoms.
Fact: Antibiotics are prescribed for specific infections and should never be shared. Sharing can lead to incorrect treatment and resistance.
🔄 Alternative Options
Generic Alternatives
- Clarithromycin 250 mg tablet
Brand Alternatives
- Aliclair 250mg tablet