Jectophen 1gm Injection (Chloramphenicol): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Unusual tiredness, weakness, or pale skin
- Easy bruising or bleeding
- Sore throat, fever, or signs of infection
- Yellowing of skin or eyes (jaundice)
- Severe abdominal pain or persistent vomiting
- Numbness, tingling, or burning in hands or feet
- Vision changes or eye pain
- Swelling of face, lips, or throat, or difficulty breathing
If experiencing severe symptoms, call emergency services immediately.
What is kemicetine 1gm injection used for?
This medicine is a chloramphenicol injection used to treat serious bacterial infections like meningitis and typhoid fever when other antibiotics are not suitable. It works by stopping bacteria from making proteins. It is given by a healthcare professional and requires regular blood tests due to the risk of serious blood disorders.
- Generic Name: Chloramphenicol (1gm)
- Manufacturer: Mac Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 kemicetine 1gm injection के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोरैम्फेनिकॉल 1 ग्राम इंजेक्शन है, जिसका उपयोग गंभीर बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। यह मेनिनजाइटिस, टाइफाइड बुखार, निमोनिया और रक्त संक्रमण जैसी बीमारियों में प्रभावी है। यह दवा बैक्टीरिया के प्रोटीन बनाने की प्रक्रिया को रोककर उन्हें मारती है। यह केवल अस्पताल में डॉक्टर या नर्स द्वारा इंजेक्शन के रूप में दी जाती है। इस दवा का उपयोग सामान्य संक्रमणों के लिए नहीं किया जाना चाहिए क्योंकि इसके गंभीर दुष्प्रभाव हो सकते हैं।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट में परेशानी और इंजेक्शन की जगह पर दर्द शामिल हैं। गंभीर दुष्प्रभावों में अस्थि मज्जा का दबना, जिससे खून की कमी, संक्रमण का खतरा और रक्तस्राव की समस्या हो सकती है। एक दुर्लभ लेकिन बहुत गंभीर प्रतिक्रिया एप्लास्टिक एनीमिया है, जो जानलेवा हो सकती है। अगर आपको असामान्य थकान, पीलापन, आसानी से चोट लगना या खून बहना, गले में खराश, बुखार या संक्रमण के लक्षण दिखें, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्य पेशेवर द्वारा अस्पताल या क्लिनिक में ही दी जानी चाहिए। इस इंजेक्शन को स्वयं लगाने की कोशिश न करें। इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों, विशेष रूप से रक्त विकार, लीवर या किडनी की समस्याओं, या एलर्जी के बारे में बताएं। अपने डॉक्टर को अपनी सभी अन्य दवाओं के बारे में भी बताएं। इलाज के दौरान नियमित रक्त परीक्षण की आवश्यकता होती है। इस दवा को लेते समय शराब से बचें। यदि आप गर्भवती हैं, गर्भवती होने की योजना बना रही हैं, या स्तनपान करा रही हैं, तो अपने डॉक्टर से जोखिम और लाभ पर चर्चा करें। बेहतर महसूस होने पर भी डॉक्टर की सलाह के बिना इलाज बंद न करें।
💊 kemicetine 1gm injection Uses & Benefits
[{"condition":"Bacterial meningitis","description":"Used to treat meningitis caused by susceptible bacteria such as Haemophilus influenzae, Neisseria meningitidis, and Streptococcus pneumoniae when other antibiotics are not suitable.","evidence":"Well-established"},{"condition":"Typhoid fever","description":"Effective against Salmonella typhi, the bacteria that causes typhoid fever, especially in areas where resistance to other antibiotics is common.","evidence":"Well-established"},{"condition":"Severe respiratory tract infections","description":"Used for serious lung infections like pneumonia caused by susceptible bacteria when other options are limited.","evidence":"Established"},{"condition":"Bloodstream infections (septicemia)","description":"Treats life-threatening blood infections caused by susceptible organisms.","evidence":"Established"},{"condition":"Brain abscess","description":"Used as part of combination therapy for brain abscesses caused by susceptible bacteria.","evidence":"Limited"},{"condition":"Rickettsial infections","description":"Alternative treatment for infections like Rocky Mountain spotted fever when other antibiotics cannot be used.","evidence":"Limited"}]
Off-label uses: [{"condition":"Melioidosis","description":"Sometimes used as part of combination therapy for melioidosis, a bacterial infection caused by Burkholderia pseudomallei, in resource-limited settings.","evidence":"Limited"},{"condition":"Plague","description":"May be used as an alternative treatment for plague caused by Yersinia pestis when standard antibiotics are unavailable or ineffective.","evidence":"Limited"}]
Primary treatment for: Serious bacterial infections
Also treats: Meningitis, Typhoid fever, Pneumonia, Septicemia, Brain abscess, Rickettsial infections
📋 Drug Information
| Generic Name(s) | Chloramphenicol (1gm) |
| Brand Name | kemicetine 1gm injection |
| Manufacturer | Mac Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | OTOLOGICALS |
| Action Class | Chloramphenicol |
| Route of Administration | Parenteral (intravenous or intramuscular injection) |
| Storage | Store below 25°C, protected from light and moisture. Do not freeze. Keep out of reach of children. Once reconstituted, use immediately or store as directed by the manufacturer. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise specified on the packaging. |
| WHO Guideline | Chloramphenicol is included in the WHO Model List of Essential Medicines for the treatment of bacterial meningitis and other serious infections. However, it is not recommended as a first-line agent in many settings due to resistance and toxicity. Consult current WHO guidelines for specific recommendations. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) has published guidelines on the use of antibiotics. Chloramphenicol is reserved for specific indications due to its toxicity profile. Consult the latest ICMR guidelines for detailed recommendations. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by binding to the 50S subunit of the bacterial ribosome, which is the cell structure responsible for making proteins. By binding to this subunit, it blocks the action of an enzyme called peptidyl transferase, which is needed to form peptide bonds between amino acids. Without these bonds, the bacteria cannot build the proteins they need to grow and multiply. This stops bacterial growth and gives the body's immune system a chance to clear the infection. This medicine is usually bacteriostatic, meaning it stops bacteria from growing rather than killing them directly, but it can be bactericidal against certain highly susceptible organisms like Haemophilus influenzae.
Mechanism Steps
💡 How to Take kemicetine 1gm injection
Strength: Each vial contains chloramphenicol 1 gram as a sterile powder for reconstitution. After reconstitution, the concentration depends on the diluent volume used.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 50 mg/kg per day divided into 4 doses (every 6 hours) for intravenous administration. For intramuscular administration, the same total daily dose is given in 2 to 4 divided doses. The dose may be increased to 100 mg/kg per day for severe infections such as meningitis. The maximum recommended daily dose is 4 grams. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. In general, chloramphenicol is used with extreme caution in children, especially newborns, due to the risk of gray baby syndrome. Dosing in children is weight-based and must be determined by a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced liver and kidney function, which can increase the risk of side effects. Dose adjustment may be necessary based on renal and hepatic function. Close monitoring is recommended. |
| Renal Impairment | In patients with kidney impairment, dose adjustment may be needed. The dose may need to be reduced or the dosing interval increased. Monitor serum levels if available. Consult a nephrologist or clinical pharmacist for guidance. |
| Hepatic Impairment | In patients with liver disease, the dose of this medicine should be reduced because it is metabolized in the liver. Close monitoring of liver function and blood counts is required. Consult a hepatologist for guidance. |
| Maximum Daily Dose | The maximum recommended daily dose is 4 grams for adults, but this may be lower depending on the indication and patient factors. Dose must be individualized by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of kemicetine 1gm injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Phenytoin | Major | |
| Rifampicin | Major | |
| Paracetamol | Moderate | |
| Oral hypoglycemics | Moderate | |
| Cyclosporine | Moderate | |
| Vitamin B12 | Minor | |
| Iron supplements | Minor | |
| Chemotherapy drugs | Major | |
| Alcohol | Moderate |
🚨 Major Interactions
- Warfarin
- Phenytoin
- Rifampicin
- Bone marrow suppressants (e.g., chemotherapy drugs)
⚡ Moderate Interactions
- Paracetamol (acetaminophen)
- Oral hypoglycemics (e.g., tolbutamide)
- Cyclosporine
🍷 Alcohol Interaction
Avoid alcohol while receiving this medicine. Alcohol can increase the risk of liver damage and bone marrow suppression, and it may worsen side effects like nausea and dizziness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to chloramphenicol or any component of the formulation","History of bone marrow suppression or blood dyscrasias","Use in newborns and premature infants due to risk of gray baby syndrome","Pregnancy, especially near term, unless absolutely necessary","Breastfeeding, unless benefits outweigh risks","Concurrent use with bone marrow suppressants or live vaccines"]
⚠️ Warnings & Precautions
["This medicine can cause serious and potentially fatal blood disorders, including aplastic anemia and bone marrow suppression. Use only when other antibiotics are ineffective or contraindicated.","Blood tests are required before, during, and after treatment to monitor for blood disorders.","Avoid use in newborns and premature infants due to the risk of gray baby syndrome.","Use with caution in patients with liver or kidney disease; dose adjustment may be needed.","This medicine may cause peripheral neuropathy and optic neuritis, especially with long-term use.","Do not use for minor infections or viral illnesses.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Avoid alcohol during treatment.","This medicine may interact with many other drugs; provide a complete list of medications to your doctor."]
🤱 Lactation Safety
This medicine passes into breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Consult your doctor.
💊 Overdose Management
Overdose of this medicine can cause severe bone marrow suppression, liver toxicity, and gray baby syndrome in infants. There is no specific antidote. Treatment is supportive and symptomatic. In case of overdose, seek immediate medical attention. Hemodialysis may be considered in severe cases but is not very effective because the drug is not efficiently removed by dialysis.
⏰ Missed Dose
This medicine is given by a healthcare professional, so missed doses are unlikely. If you miss a scheduled dose, contact your doctor or nurse as soon as possible. Do not attempt to self-administer a double dose.
Additional Safety Advice
This medicine must only be given by a qualified healthcare professional in a hospital or clinic setting. Do not attempt to self-administer this injection. Before receiving this medicine, tell your doctor about all your medical conditions, especially any blood disorders, liver or kidney problems, or allergies. Inform your doctor about all other medicines you are taking, including over-the-counter drugs and herbal supplements, as many interactions are possible. Regular blood tests are usually needed before, during, and after treatment to check your blood cell counts. Avoid alcohol while receiving this medicine, as it can increase the risk of side effects. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits with your doctor. Do not stop treatment early without your doctor's advice, even if you feel better, to prevent the infection from returning. Report any unusual symptoms such as fever, sore throat, fatigue, easy bruising, or bleeding immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially bone marrow suppression and liver toxicity. Dose adjustment may be needed based on liver and kidney function. Close monitoring is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting this medicine. It should be used during pregnancy only if clearly needed. Effective contraception is recommended during treatment.
🏥 Post-Surgery Considerations
If you have recently had surgery, inform your surgeon and anesthesiologist that you are receiving this medicine. It may interact with other medications used during surgery and can increase the risk of bleeding.
🦷 Dental Procedures
Inform your dentist that you are receiving this medicine before any dental procedure. It may increase the risk of bleeding and interact with other medications.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While receiving this medicine, you may feel tired or weak. Avoid strenuous exercise until you have recovered. Light activity like walking may be beneficial, but consult your doctor before starting any exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital setting, so you will likely need to take time off work during treatment. You may experience fatigue, dizziness, or other side effects that can affect your ability to drive or operate machinery. Avoid driving until you know how this medicine affects you.
🛑 When to Stop This Medicine
Do not stop this medicine without your doctor's advice. Stopping early can allow the infection to return and may lead to antibiotic resistance. Your doctor will determine the appropriate duration of treatment based on your condition and response.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to serious blood disorders, including aplastic anemia and bone marrow suppression, which may be irreversible. It can also cause peripheral neuropathy and optic neuritis. Regular monitoring of blood counts, liver function, and kidney function is essential. The risk of these effects increases with prolonged use, so the medicine should be used for the shortest duration necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the infection, other antibiotics like ceftriaxone or meropenem may be used instead of this medicine.
Evidence: Well-establishedRest, hydration, and fever control can help manage symptoms while the infection is treated.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should not be given during treatment with this medicine because it may reduce the immune response. Consult your doctor about vaccination timing.
📦 Storage Guide
✅ DO
Store below 25°C, protected from light and moisture.
❌ DON'T
Do not freeze.
✅ DO
Keep in original container.
❌ DON'T
Do not transfer to unmarked containers.
✅ DO
Keep away from direct sunlight.
❌ DON'T
Do not store in bathroom cabinet.
✅ DO
Use immediately after reconstitution.
❌ DON'T
Do not use if the solution is discolored or contains particles.
✈️ Traveling with This Medicine
This medicine is given in a hospital setting, so travel advice is limited. If you are prescribed this medicine and need to travel, carry it in its original packaging with the prescription. Keep it in a cool, dry place, away from direct sunlight. Inform your doctor before travel to ensure you have enough doses and to arrange for administration at your destination. Check customs regulations for carrying injectable medicines across borders.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 30 minutes to 1 hour after injection, but you may not feel better immediately. It may take 24 to 48 hours to see improvement in symptoms like fever.
A: This medicine is given by a healthcare professional as an intravenous or intramuscular injection, usually in a hospital or clinic.
A: Serious side effects include bone marrow suppression, aplastic anemia, severe allergic reactions, nerve damage, and eye problems. Regular blood tests are needed to monitor for these.
A: This medicine should be used during pregnancy only if the benefits clearly outweigh the risks. It can cause serious side effects in the newborn. Consult your doctor.
A: No, you should avoid alcohol while receiving this medicine as it can increase the risk of liver toxicity and bone marrow suppression.
🤔 Common Patient Concerns
🔄 Substitutes for kemicetine 1gm injection
View AllAlternative brands with exact same active ingredient:
-
fencol 1gm injectionInd Swift Laboratories Ltd ₹6.35 86.3% CHEAPER
-
Tromycetin 1gm InjectionTroikaa Pharmaceuticals Ltd ₹19.92 57.2% CHEAPER
-
labchlor 1gm injectionLaborate Pharmaceuticals India Ltd ₹22.25 52.2% CHEAPER
-
jectophen 1gm injectionFusion Healthcare Pvt Ltd ₹28.13 39.5% CHEAPER
-
tyde s 1gm injectionNeon Laboratories Ltd ₹29.06 37.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be used for any infection.
Fact: This medicine is reserved for serious bacterial infections only, due to its risk of severe side effects. - Myth: This medicine is safe for everyone.
Fact: This medicine is not safe for newborns, pregnant women near term, and people with blood disorders. - Myth: You can stop this medicine once you feel better.
Fact: You must complete the full course as prescribed by your doctor to prevent the infection from returning. - Myth: This medicine is a first-choice antibiotic.
Fact: This medicine is usually not a first-choice antibiotic because of its toxicity. It is used when other options are not suitable.
🔄 Alternative Options
Generic Alternatives
- Chloramphenicol 1g injection
Brand Alternatives
- Jectophen 1gm injection