Grapezone-S 2000mg/1000mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Severe skin rash with blisters or peeling
- Severe or bloody diarrhea
- Signs of a severe allergic reaction such as a sudden drop in blood pressure
- Yellowing of the skin or eyes
- Decreased urine output or swelling in the legs
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is kefotax sb injection used for?
This medicine is a combination antibiotic injection containing ceftriaxone and sulbactam. It is used to treat serious bacterial infections. It works by killing bacteria and preventing their growth. It is given by a healthcare professional and must be prescribed by a doctor.
- Generic Name: Ceftriaxone (2000mg) + Sulbactam (1000mg)
- Manufacturer: Strides shasun Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 kefotax sb injection के बारे में (Hindi Summary)
उपयोग: यह दवा सेफ्ट्रिएक्सोन और सल्बैक्टम का संयोजन है, जिसे इंजेक्शन के रूप में दिया जाता है। यह गंभीर बैक्टीरियल संक्रमणों जैसे निमोनिया, मूत्र मार्ग संक्रमण, पेट के संक्रमण, त्वचा संक्रमण और मेनिनजाइटिस के इलाज के लिए उपयोग की जाती है। यह दवा बैक्टीरिया को मारती है और उनके विकास को रोकती है। यह केवल डॉक्टर के निर्देश पर अस्पताल या क्लिनिक में ही दी जानी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन स्थल पर दर्द, लालिमा या सूजन, दस्त, जी मिचलाना, उल्टी, दाने और सिरदर्द शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें एलर्जी, त्वचा पर गंभीर प्रतिक्रिया, गंभीर दस्त, गुर्दे की समस्या और रक्त विकार हो सकते हैं। किसी भी गंभीर लक्षण पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्य पेशेवर द्वारा ही दी जानी चाहिए। इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी एलर्जी, विशेषकर पेनिसिलिन या सेफलोस्पोरिन से एलर्जी, और गुर्दे या यकृत की बीमारी के बारे में बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। शराब का सेवन न करें। दवा का पूरा कोर्स पूरा करें।
💊 kefotax sb injection Uses & Benefits
[{"condition":"Community-acquired pneumonia","description":"Used to treat moderate to severe bacterial pneumonia caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Complicated urinary tract infections","description":"Effective against many bacteria causing kidney and bladder infections.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Used in combination with other antibiotics for infections such as peritonitis and abscesses.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats serious bacterial skin infections including cellulitis and abscesses.","evidence":"Well-established"},{"condition":"Bacterial meningitis","description":"Used as part of initial therapy for suspected bacterial meningitis.","evidence":"Well-established"},{"condition":"Gonorrhea","description":"Effective against Neisseria gonorrhoeae, though resistance patterns vary.","evidence":"Well-established"},{"condition":"Septicemia","description":"Used in hospitalized patients with bloodstream infections caused by susceptible bacteria.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Lyme disease with neurological involvement","description":"Sometimes used as an alternative to other antibiotics for certain manifestations.","evidence":"Limited"},{"condition":"Prophylaxis in certain surgical procedures","description":"Occasionally used for prevention of surgical site infections when standard agents are not suitable.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Pneumonia, Urinary tract infections, Intra-abdominal infections, Skin infections, Meningitis, Septicemia
📋 Drug Information
| Generic Name(s) | Ceftriaxone (2000mg) + Sulbactam (1000mg) |
| Brand Name | kefotax sb injection |
| Manufacturer | Strides shasun Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Parenteral (intravenous or intramuscular injection) |
| Storage | Store the unopened vial at room temperature between 20°C and 25°C (68°F to 77°F). Protect from light and moisture. Once reconstituted, the solution should be used immediately or stored as directed by the manufacturer. Do not freeze. |
| Shelf Life | The shelf life of the unopened vial is typically 24 months from the date of manufacture. Check the expiry date on the packaging. Once reconstituted, use within the time specified by the manufacturer, usually within a few hours if kept at room temperature. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Ceftriaxone, the primary active component, is a third-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to weakened cell walls and bacterial death. Sulbactam is a beta-lactamase inhibitor that irreversibly binds to certain beta-lactamase enzymes produced by bacteria, preventing them from destroying ceftriaxone. This combination extends the spectrum of ceftriaxone against bacteria that produce these enzymes, making the product effective against a broader range of pathogens.
Mechanism Steps
💡 How to Take kefotax sb injection
Strength: Injection: Ceftriaxone 2000 mg + Sulbactam 1000 mg per vial.
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on the type and severity of infection, the patient's age, weight, kidney and liver function, and the susceptibility of the infecting organism. For many serious infections, a common adult dose is 1-2 grams of ceftriaxone with sulbactam every 12-24 hours, but this can vary. It is given by intravenous or intramuscular injection. Do not self-administer. Always follow your doctor's prescription. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have reduced kidney function, which can affect the elimination of this medicine. Dose adjustment may be necessary based on kidney function. Your doctor will determine the appropriate dose. Monitor for side effects closely. |
| Renal Impairment | In patients with kidney impairment, dose adjustment may be required. Ceftriaxone is not significantly removed by dialysis, but sulbactam may accumulate. Consult your doctor for specific dosing recommendations based on creatinine clearance. |
| Hepatic Impairment | In patients with liver impairment, dose adjustment may be needed, especially if there is also kidney impairment. Monitor liver function tests. Consult your doctor for specific dosing recommendations. |
| Maximum Daily Dose | The maximum daily dose should not exceed 4 grams of ceftriaxone and 2 grams of sulbactam, but this must be determined by a qualified clinician based on the individual patient's condition. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of kefotax sb injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Calcium-containing IV solutions | Major | |
| Aminoglycosides | Moderate | |
| Loop diuretics | Moderate | |
| Probenecid | Moderate | |
| Oral contraceptives | Minor | |
| Live bacterial vaccines | Minor |
🚨 Major Interactions
- Warfarin
- Calcium-containing intravenous solutions (e.g., Ringer's lactate)
⚡ Moderate Interactions
- Aminoglycosides (e.g., gentamicin)
- Loop diuretics (e.g., furosemide)
- Probenecid
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine. Alcohol can increase the risk of liver problems and may worsen side effects such as nausea, dizziness, and drowsiness. It is best to abstain from alcohol during treatment and for a few days after the last dose.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe allergy to ceftriaxone, sulbactam, or other cephalosporins","Known severe allergy to penicillins (cross-reactivity possible)","History of severe allergic reaction to beta-lactam antibiotics","Use in neonates with hyperbilirubinemia","Concurrent use with calcium-containing intravenous solutions in neonates","Not for intrathecal administration"]
⚠️ Warnings & Precautions
["Serious allergic reactions, including anaphylaxis, can occur. Discontinue immediately if suspected.","Clostridioides difficile-associated diarrhea can occur during or after treatment. Report severe diarrhea.","Use with caution in patients with kidney or liver impairment. Dose adjustment may be needed.","May cause gallbladder sludge or stones, especially in children. Monitor if symptoms occur.","Prolonged use may lead to superinfections with non-susceptible organisms.","Do not mix with calcium-containing solutions. Fatal precipitates can form.","May interfere with certain lab tests, such as urine glucose tests.","Use with caution in patients with a history of seizures."]
🤱 Lactation Safety
Ceftriaxone and sulbactam are excreted in small amounts in breast milk. This medicine is generally considered compatible with breastfeeding, but it may cause diarrhea or thrush in the nursing infant. Consult your doctor before use while breastfeeding.
💊 Overdose Management
Overdose with this medicine is unlikely due to its administration by healthcare professionals. If overdose is suspected, treatment should be symptomatic and supportive. Ceftriaxone and sulbactam are not removed significantly by hemodialysis. Monitor vital signs and provide supportive care. Contact a poison control center for guidance.
⏰ Missed Dose
This medicine is given by a healthcare professional, so missed doses are unlikely. If you miss a scheduled dose, contact your doctor or nurse as soon as possible. Do not attempt to self-administer an extra dose. Your healthcare provider will determine the best course of action.
Additional Safety Advice
This medicine must only be administered by a qualified healthcare professional. Before receiving this medicine, inform your doctor about all your allergies, especially to penicillins or cephalosporins, and about any kidney or liver disease. Do not use this medicine if you have previously had a severe allergic reaction to similar antibiotics. Tell your doctor about all other medicines you are taking, particularly blood thinners such as warfarin, because this medicine can increase the risk of bleeding. Avoid alcohol during treatment as it may worsen side effects and stress the liver. If you are pregnant, planning pregnancy, or breastfeeding, discuss the risks and benefits with your doctor. Do not attempt to self-administer this injection. Complete the full course as prescribed by your doctor, even if you feel better, to prevent the infection from returning and to reduce the risk of antibiotic resistance.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function, which can affect the elimination of this medicine. Dose adjustment may be necessary. Monitor for side effects such as confusion, diarrhea, and allergic reactions. Ensure adequate hydration.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting this medicine. It is generally considered safe in pregnancy when clearly needed, but the benefits and risks should be weighed. Use effective contraception if appropriate.
🏥 Post-Surgery Considerations
This medicine may be used to treat or prevent surgical site infections. If you have recently had surgery, inform your surgeon and anesthesiologist about all medicines you are taking. Monitor for signs of infection at the surgical site.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. It may interact with certain dental treatments or medications. Maintain good oral hygiene to prevent infections.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While receiving this medicine, you may feel tired or dizzy. Avoid strenuous exercise until you feel fully recovered. Light activity such as walking is generally safe, but listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital or clinic, so you may need to take time off work or arrange for transportation. You may experience fatigue, dizziness, or diarrhea, which can affect your ability to drive or operate machinery. Avoid driving until you know how this medicine affects you.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping early can lead to incomplete treatment and antibiotic resistance. Your doctor will determine when to stop based on your clinical response and the type of infection.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance, superinfections, and rarely, blood disorders or liver and kidney problems. It is important to use this medicine only as prescribed and for the recommended duration. Regular monitoring of blood counts, liver, and kidney function may be required during prolonged therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For milder infections, oral antibiotics may be used instead of injections.
Evidence: Well-establishedDepending on the bacteria and resistance patterns, other antibiotics may be more appropriate.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the effectiveness of live bacterial vaccines. Avoid receiving live bacterial vaccines during treatment. Inactivated vaccines are generally safe to administer. Consult your doctor for specific advice.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light and moisture
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
This medicine is administered by a healthcare professional, so travel is not typically applicable. If you are traveling and need to continue treatment, ensure you carry a copy of your prescription and the medicine in its original packaging. Check with your doctor about storage conditions during travel. For international travel, verify that the medicine is legal in your destination country and carry appropriate documentation.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24-48 hours, but it may take a few days for full effect. Complete the full course as prescribed.
A: No, this medicine must be given by a healthcare professional in a hospital or clinic setting.
A: Inform your doctor immediately. This medicine may not be suitable for you if you have a severe penicillin allergy.
A: It is generally considered safe when prescribed by a doctor, but always consult your obstetrician.
🤔 Common Patient Concerns
🔄 Substitutes for kefotax sb injection
View AllAlternative brands with exact same active ingredient:
-
yuvicef 3gm injectionVindcare Lifesciences ₹123.75 11.4% CHEAPER
-
grapezone-s 2000mg/1000mg injectionH & I Critical Care ₹210.61 50.8% COSTLIER
-
xtum 2000mg/1000mg injectionShreya Life Sciences Pvt Ltd ₹210.94 51% COSTLIER
-
Sulbactomax 2000 mg/1000 mg InjectionVenus Remedies Ltd ₹283.81 103.2% COSTLIER
-
ceftiforce sb 2000mg/1000mg injectionMankind Pharma Ltd ₹294.38 110.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the common cold.
Fact: This medicine is an antibiotic and only works against bacterial infections. It is not effective against viruses. - Myth: You can stop taking this medicine as soon as you feel better.
Fact: You must complete the full course as prescribed to prevent the infection from returning and to reduce antibiotic resistance. - Myth: This medicine is safe to self-administer at home.
Fact: This medicine must only be given by a qualified healthcare professional in a medical setting.
🔄 Alternative Options
Generic Alternatives
- Ceftriaxone + Sulbactam injection (generic)
Brand Alternatives
- Grapezone-S 2000mg/1000mg injection