Lamivir HBV Tablet (Lamivudine 100 mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe abdominal pain radiating to the back, with nausea and vomiting
- Rapid breathing, muscle weakness, or extreme fatigue
- Yellowing of the skin or eyes, or dark urine
- Swelling of the face, lips, tongue, or throat
- Unusual bleeding or bruising
- Signs of a hepatitis B flare-up after stopping the medicine, such as worsening fatigue, nausea, or jaundice
- Decreased urine output or swelling in the legs
If experiencing severe symptoms, call emergency services immediately.
What is jonvir 100 tablet used for?
This medicine contains lamivudine 100 mg, an antiviral tablet used to treat chronic hepatitis B infection. It works by blocking the virus from multiplying, helping to protect the liver. It is taken once daily as prescribed and should not be stopped suddenly.
- Generic Name: Lamivudine (100mg)
- Manufacturer: Johnlee Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 jonvir 100 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा लैमिवुडीन 100 मिलीग्राम की एक एंटीवायरल गोली है, जिसका उपयोग पुरानी हेपेटाइटिस बी संक्रमण के इलाज के लिए किया जाता है। यह वायरस को शरीर में बढ़ने से रोकती है और लिवर को नुकसान से बचाने में मदद करती है। यह दवा हेपेटाइटिस बी को पूरी तरह से ठीक नहीं करती, लेकिन वायरस को नियंत्रण में रखती है। इसे रोजाना एक बार डॉक्टर के बताए अनुसार लेना चाहिए। इसे अचानक बंद करने से हेपेटाइटिस बी फिर से भड़क सकता है, इसलिए डॉक्टर की सलाह के बिना कभी न रोकें। यह दवा एचआईवी के इलाज में भी अन्य दवाओं के साथ मिलाकर दी जाती है।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में सिरदर्द, जी मिचलाना, दस्त, थकान और नींद न आना शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। कभी-कभी दाने, खुजली या बाल झड़ना भी हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें लैक्टिक एसिडोसिस, अग्न्याशय की सूजन, या गंभीर लिवर समस्याएं शामिल हो सकती हैं। अगर आपको पेट में तेज दर्द, सांस लेने में तकलीफ, आंखों या त्वचा का पीलापन, या गहरे रंग का पेशाब दिखे, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, हर दिन एक ही समय पर। इसे अचानक बंद न करें, क्योंकि इससे हेपेटाइटिस बी फिर से भड़क सकता है। नियमित रूप से लिवर और किडनी की जांच कराते रहें। शराब का सेवन बिल्कुल न करें, क्योंकि इससे लिवर को और नुकसान हो सकता है। गर्भवती होने या स्तनपान कराने से पहले डॉक्टर से सलाह लें। इस दवा को ठंडी और सूखी जगह पर, धूप से दूर, मूल डिब्बे में ही रखें। इसे किसी और के साथ साझा न करें।
💊 jonvir 100 tablet Uses & Benefits
[{"condition":"Chronic hepatitis B infection","description":"This medicine is used to suppress hepatitis B virus replication in adults with chronic infection, helping to reduce liver inflammation and the risk of long-term liver damage.","evidence":"Well-established"},{"condition":"HIV infection (as part of combination therapy)","description":"Lamivudine is also used in combination with other antiretroviral medicines for the treatment of HIV infection, although this 100 mg strength is primarily intended for hepatitis B.","evidence":"Well-established"},{"condition":"Prevention of mother-to-child transmission of hepatitis B","description":"In certain situations, this medicine may be used in pregnant women with high hepatitis B viral loads to reduce the risk of passing the virus to the baby, as part of a comprehensive prevention plan.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Hepatitis B in children","description":"Sometimes used in children with chronic hepatitis B under specialist supervision, but dosing and safety are not fully established for all age groups.","evidence":"Limited"},{"condition":"Prevention of hepatitis B reactivation during chemotherapy","description":"May be prescribed to prevent hepatitis B flare-ups in patients receiving chemotherapy or immunosuppressive treatment, based on specialist assessment.","evidence":"Moderate"}]
Primary treatment for: Chronic hepatitis B infection
Also treats: HIV infection (as part of combination therapy), Prevention of hepatitis B reactivation in immunosuppressed patients
📋 Drug Information
| Generic Name(s) | Lamivudine (100mg) |
| Brand Name | jonvir 100 tablet |
| Manufacturer | Johnlee Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature between 15°C and 30°C (59°F to 86°F) in a dry place. Keep it in the original container, tightly closed, away from direct sunlight and moisture. Do not refrigerate unless specifically instructed. Keep out of reach of children. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture. Always check the expiry date on the pack before use. Do not use if the expiry date has passed. |
| WHO Guideline | The World Health Organization recommends tenofovir or entecavir as first-line treatments for chronic hepatitis B. Lamivudine is not recommended as a first-line agent due to high rates of drug resistance, but it may be used in certain situations where other options are not available or not tolerated. |
| ICMR Guideline | The Indian Council of Medical Research guidelines for hepatitis B management also prefer tenofovir or entecavir as first-line therapy. Lamivudine is considered an alternative in specific circumstances, with careful monitoring for resistance. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by entering liver cells and being converted into an active form called lamivudine triphosphate. This active form competes with the natural building blocks that the hepatitis B virus uses to copy its genetic material. By blocking the viral enzyme reverse transcriptase, this medicine stops the virus from multiplying. It also gets incorporated into the viral DNA chain and causes it to terminate, which further prevents the virus from replicating. This reduces the amount of virus in the blood and lessens damage to the liver over time.
Mechanism Steps
💡 How to Take jonvir 100 tablet
Strength: This medicine is available as an immediate-release film-coated tablet containing 100 mg of lamivudine.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine for chronic hepatitis B is 100 mg taken orally once daily. For patients with HIV infection, the dose is usually higher (150 mg twice daily or 300 mg once daily) in combination with other antiretroviral medicines, but this 100 mg strength is specifically intended for hepatitis B. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Patients with kidney impairment may need a reduced dose or less frequent dosing. Always follow your doctor's prescription exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information for this specific 100 mg tablet. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have reduced kidney function, which can affect the elimination of this medicine. Dose adjustment may be necessary based on kidney function tests. Your doctor will determine the appropriate dose for you. |
| Renal Impairment | In patients with impaired kidney function, the dose of this medicine must be adjusted. For creatinine clearance between 30 and 49 mL/min, a reduced dose is usually recommended. For creatinine clearance between 15 and 29 mL/min, a further reduced dose is needed. For creatinine clearance less than 15 mL/min, a very low dose or less frequent dosing is required. Patients on dialysis should take the medicine after dialysis. Always consult your doctor for precise dosing based on your kidney function. |
| Hepatic Impairment | No specific dose adjustment is required for patients with mild to moderate liver impairment. However, patients with severe liver disease should be monitored closely, as the medicine may accumulate. Your doctor will decide if any dose changes are needed. |
| Maximum Daily Dose | The maximum recommended daily dose for chronic hepatitis B is 100 mg once daily. For HIV treatment, the maximum daily dose is 300 mg, but this 100 mg tablet is not intended for HIV monotherapy. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of jonvir 100 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Zalcitabine | Major | |
| Trimethoprim-sulfamethoxazole | Major | |
| Emtricitabine | Moderate | |
| Ribavirin | Moderate | |
| Paracetamol | Minor | |
| Antacids | Minor |
🚨 Major Interactions
- Zalcitabine
- Trimethoprim-sulfamethoxazole
⚡ Moderate Interactions
- Emtricitabine
- Ribavirin
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can worsen liver inflammation and increase the risk of liver damage. If you have hepatitis B, protecting your liver is especially important, so it is best to abstain from alcohol completely during treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to lamivudine or any component of the tablet","Use as monotherapy for HIV infection (due to rapid development of resistance)","Severe kidney impairment without appropriate dose adjustment","Not recommended for children under 2 years of age unless directed by a specialist"]
⚠️ Warnings & Precautions
["Do not stop this medicine suddenly, as it can cause a severe flare-up of hepatitis B.","Lactic acidosis and severe liver enlargement with fatty liver have been reported with nucleoside analogues, sometimes fatally. Report symptoms like rapid breathing, muscle weakness, or abdominal pain immediately.","This medicine may cause pancreatitis. Report severe abdominal pain promptly.","Patients with both HIV and hepatitis B should be managed by a specialist, as stopping lamivudine can cause HIV resistance.","Regular monitoring of liver and kidney function is essential during treatment.","This medicine does not prevent the transmission of hepatitis B to others. Practice safe sex and do not share needles.","Use with caution in elderly patients and those with kidney disease; dose adjustment may be needed."]
🤱 Lactation Safety
This medicine is excreted in human breast milk. The amount is small, but because of the potential for serious side effects in the nursing infant, mothers should consult their doctor before breastfeeding while taking this medicine. In many cases, formula feeding may be recommended to prevent transmission of hepatitis B, but this decision should be made with a healthcare provider.
💊 Overdose Management
There is no specific antidote for an overdose of this medicine. If you suspect an overdose, seek immediate medical attention. Treatment should be supportive and symptomatic, with close monitoring of vital signs and kidney function. Haemodialysis may be considered in severe cases, as it can remove lamivudine from the blood.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, contact your doctor or pharmacist for advice.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, at the same time each day, with or without food. Do not skip doses or stop taking it on your own, because stopping suddenly can cause a serious flare-up of hepatitis B. Keep all scheduled blood tests, including liver function tests and viral load checks, because these help your doctor monitor how well the medicine is working and detect any problems early. Tell your doctor about all other medicines, supplements, and herbal products you take, especially medicines for HIV, because some combinations can reduce effectiveness or increase side effects. Avoid alcohol while taking this medicine to protect your liver. If you are pregnant, planning pregnancy, or breastfeeding, discuss this with your doctor before continuing. Store the tablets in their original container at room temperature, away from moisture and direct sunlight. Do not share this medicine with anyone else, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced kidney function, which can affect the elimination of this medicine. Dose adjustment may be necessary based on kidney function tests. Elderly patients should be monitored closely for side effects, and regular blood tests are recommended.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before conception. This medicine is classified as Pregnancy Category B and may be continued during pregnancy if needed to control hepatitis B. Your doctor will weigh the benefits and risks. It is important to control hepatitis B during pregnancy to reduce the risk of transmission to the baby.
🏥 Post-Surgery Considerations
After surgery, continue taking this medicine as prescribed unless your doctor advises otherwise. Inform your surgeon and anesthesiologist about this medicine. If you are unable to take oral medicines after surgery, your doctor may prescribe an alternative form or adjust the timing.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. There are no specific contraindications for dental procedures, but maintaining good oral hygiene is important. If you have bleeding problems, your dentist should be aware. No dose adjustment is typically needed for dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe and beneficial while taking this medicine. However, if you experience fatigue, muscle weakness, or any signs of lactic acidosis, avoid strenuous exercise and consult your doctor. Patients with advanced liver disease should discuss an appropriate exercise plan with their doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is unlikely to affect your ability to drive or operate machinery. However, if you experience fatigue, dizziness, or difficulty concentrating, avoid driving or operating heavy machinery until you know how the medicine affects you. Most people can continue their normal work and daily activities while on treatment.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Stopping suddenly can cause a severe flare-up of hepatitis B. Your doctor may decide to stop treatment if the virus is well-controlled for a long period, but this decision must be made carefully with close monitoring. If you experience serious side effects, contact your doctor immediately; they will advise whether to stop or adjust the dose.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe, but it requires regular monitoring of liver and kidney function. The main concern with long-term use is the development of viral resistance, which can make the medicine less effective over time. Your doctor will monitor your viral load to detect resistance early. If resistance develops, your treatment may need to be changed. Long-term use may also rarely cause bone marrow suppression or peripheral neuropathy. Regular follow-up is essential to ensure the medicine continues to work and to manage any side effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
These are first-line antivirals for chronic hepatitis B with lower resistance rates and are often preferred over lamivudine.
Evidence: Well-establishedAn injectable treatment that can be used for chronic hepatitis B in selected patients, with the goal of achieving a sustained response.
Evidence: ModerateAvoiding alcohol, maintaining a healthy weight, and regular monitoring can help protect the liver alongside antiviral therapy.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Patients with chronic hepatitis B should be vaccinated against hepatitis A if not already immune, as co-infection can be severe. Hepatitis B vaccination is recommended for close contacts. Live vaccines should be avoided if you are immunocompromised, but this medicine itself does not typically require avoidance of vaccines. Discuss with your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep enough supply for your entire trip, as it may not be readily available everywhere. Store it in a cool, dry place away from direct sunlight. If crossing time zones, continue taking your dose at the same interval as prescribed; you may need to adjust the timing gradually. Check customs regulations for carrying prescription medicines into your destination country. Always keep the medicine in your hand luggage in case your checked baggage is lost.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working soon after you begin treatment, but it may take several weeks to months to see a significant reduction in viral load. Your doctor will monitor your response with blood tests.
A: No, this medicine controls the virus but does not cure hepatitis B. Treatment is usually long-term to keep the virus suppressed and protect the liver.
A: Stopping suddenly can cause a severe flare-up of hepatitis B, which can be dangerous. Always consult your doctor before stopping.
A: It is classified as Pregnancy Category B. It should be used during pregnancy only if clearly needed and under medical supervision. Discuss with your doctor.
A: Some medicines can interact with this medicine. Always inform your doctor about all medicines, supplements, and herbal products you take.
🤔 Common Patient Concerns
🔄 Substitutes for jonvir 100 tablet
View AllAlternative brands with exact same active ingredient:
-
heptavir 100mg tabletHetero Drugs Ltd ₹75.00 77.1% CHEAPER
-
Tapivir 100mg TabletTaj Pharma India Ltd ₹75.94 76.9% CHEAPER
-
virolam 100mg tabletSun Pharmaceutical Industries Ltd ₹76.00 76.8% CHEAPER
-
hivir 100mg tabletSain Medicaments Pvt Ltd ₹96.56 70.6% CHEAPER
-
Shanvudin 100mg TabletShantha Biotech ₹99.00 69.8% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure hepatitis B completely.
Fact: This medicine controls the virus but does not cure hepatitis B. Treatment is usually long-term. - Myth: I can stop taking this medicine once I feel better.
Fact: Stopping suddenly can cause a dangerous flare-up of hepatitis B. Always consult your doctor before stopping. - Myth: This medicine can be taken for any type of hepatitis.
Fact: This medicine is specifically for hepatitis B and HIV. It is not effective against hepatitis A, C, or E. - Myth: This medicine is safe to take during pregnancy without any risk.
Fact: It is classified as Pregnancy Category B. Use during pregnancy should be discussed with your doctor.
🔄 Alternative Options
Generic Alternatives
- Lamivudine 100 mg tablet
Brand Alternatives
- Lamivir HBV Tablet