Itraconazole 1% w/w Cream: Complete Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction with swelling of face, lips, or throat.
- Difficulty breathing or swallowing.
- Severe blistering or peeling of the skin.
- Signs of secondary infection such as pus or increased pain.
- No improvement after completing the prescribed course.
If experiencing severe symptoms, call emergency services immediately.
What is itrazil 1% dusting powder used for?
This medicine is a topical antifungal cream containing itraconazole 1% w/w. It is used to treat fungal skin infections such as ringworm, jock itch, and athlete's foot. Apply a thin layer to the affected area as directed by your doctor.
- Generic Name: Itraconazole (1% w/w)
- Manufacturer: Nilrise Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 itrazil 1% dusting powder के बारे में (Hindi Summary)
उपयोग: यह दवा एक टॉपिकल एंटीफंगल क्रीम है जिसमें आइट्राकोनाज़ोल 1% w/w होता है। इसका उपयोग त्वचा के फंगल संक्रमण जैसे दाद, खुजली, और एथलीट फुट के इलाज के लिए किया जाता है। यह कवक की कोशिका झिल्ली को नष्ट करके काम करती है। इसे प्रभावित क्षेत्र पर पतली परत में लगाएं।
साइड इफेक्ट्स: आम दुष्प्रभावों में लगाने की जगह पर हल्की जलन, खुजली, लालिमा या जलन शामिल है। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी प्रतिक्रिया हो सकती है। यदि सांस लेने में कठिनाई, चेहरे या गले में सूजन हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: केवल बाहरी उपयोग के लिए। आंखों, मुंह और अन्य श्लेष्म झिल्ली के संपर्क से बचें। बड़े क्षेत्रों पर लंबे समय तक उपयोग न करें। उपयोग से पहले और बाद में हाथ धोएं। बच्चों की पहुंच से दूर रखें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।
💊 itrazil 1% dusting powder Uses & Benefits
[{"condition":"Tinea corporis (ringworm of the body)","description":"This medicine is effective in treating fungal infections of the body caused by dermatophytes.","evidence":"Well-established"},{"condition":"Tinea cruris (jock itch)","description":"It helps clear fungal infections in the groin area.","evidence":"Well-established"},{"condition":"Tinea pedis (athlete's foot)","description":"This medicine is used to treat fungal infections of the feet.","evidence":"Well-established"},{"condition":"Cutaneous candidiasis","description":"It is effective against skin infections caused by Candida species.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Seborrheic dermatitis","description":"Sometimes used off-label for its antifungal and anti-inflammatory effects.","evidence":"Limited"}]
Primary treatment for: Fungal skin infections
Also treats: Tinea corporis, Tinea cruris, Tinea pedis, Cutaneous candidiasis
📋 Drug Information
| Generic Name(s) | Itraconazole (1% w/w) |
| Brand Name | itrazil 1% dusting powder |
| Manufacturer | Nilrise Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | OPHTHAL |
| Action Class | Fungal ergosterol synthesis inhibitor |
| Route of Administration | Topical |
| Storage | Store at room temperature (15-30°C). Protect from light and moisture. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting the enzyme lanosterol 14-alpha-demethylase, which is a cytochrome P450-dependent enzyme. This inhibition blocks the conversion of lanosterol to ergosterol, a vital component of the fungal cell membrane. The resulting depletion of ergosterol and accumulation of abnormal sterols lead to increased membrane permeability and ultimately fungal cell death.
Mechanism Steps
💡 How to Take itrazil 1% dusting powder
Strength: Cream containing itraconazole 1% w/w.
Dosage Information
| Adult Dosage | Apply a thin layer to the affected area and surrounding skin once or twice daily, or as directed by your doctor. The duration of treatment depends on the type and severity of the infection. Typically, treatment may last for 2 to 4 weeks. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dosage adjustments are required for elderly patients. However, consult a doctor for proper evaluation. |
| Renal Impairment | No dosage adjustment is required for renal impairment when used topically. |
| Hepatic Impairment | No dosage adjustment is required for hepatic impairment when used topically. |
| Maximum Daily Dose | Not established from the available information. Use as prescribed by your doctor. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of itrazil 1% dusting powder
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ritonavir | Major | |
| Clarithromycin | Major | |
| Topical corticosteroids | Moderate | |
| Topical antibiotics | Minor |
🚨 Major Interactions
- Oral anticoagulants (e.g., warfarin)
- CYP3A4 inhibitors (e.g., ritonavir, clarithromycin)
⚡ Moderate Interactions
- Other topical corticosteroids
🍷 Alcohol Interaction
No known interaction with alcohol when used topically. However, avoid excessive alcohol consumption as it may affect overall health.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to itraconazole or any component of the cream.","Not for ophthalmic, oral, or intravaginal use."]
⚠️ Warnings & Precautions
["For external use only.","Avoid contact with eyes and mucous membranes.","Do not use on large areas or for prolonged periods without medical advice.","Discontinue if irritation or hypersensitivity occurs.","Keep out of reach of children."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in breast milk. Consult your doctor before use.
💊 Overdose Management
Overdose with topical application is unlikely. If accidental ingestion occurs, seek medical attention immediately. Symptoms of overdose may include nausea, vomiting, and abdominal pain.
⏰ Missed Dose
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.
Additional Safety Advice
For external use only. Avoid contact with eyes, mouth, and other mucous membranes. If accidental contact occurs, rinse thoroughly with water. Do not apply to large areas of the skin or for prolonged periods without medical advice. Do not cover the treated area with airtight dressings unless instructed. Wash hands before and after application. Do not share this medicine with others. Keep out of reach of children. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before use. Inform your doctor if you have any other skin conditions or are using other topical products.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients can use this medicine safely. However, consult a doctor if you have other health conditions or are taking multiple medications.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before using this medicine. Topical itraconazole is generally considered low risk, but medical advice is recommended.
🏥 Post-Surgery Considerations
Consult your doctor before using this medicine on surgical wounds or nearby areas.
🦷 Dental Procedures
No specific considerations for dental procedures. Inform your dentist about all medications you are using.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
No specific exercise restrictions are required while using this medicine. However, if the infection is on the feet, avoid activities that cause excessive sweating until it heals.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine does not affect your ability to drive or operate machinery. You can continue your daily activities as usual.
🛑 When to Stop This Medicine
Stop using this medicine if you experience severe irritation or allergic reaction. Otherwise, complete the full course as prescribed. Do not stop early even if symptoms improve, as the infection may return.
📅 Long-Term Use Effects
Long-term use of this medicine is generally not recommended without medical supervision. Prolonged use may lead to skin thinning or secondary infections. If you need to use it for more than 4 weeks, consult your doctor for evaluation.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps prevent fungal growth and supports healing.
Evidence: Well-establishedCan be used as adjunctive therapy for moist areas.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interactions with vaccines. Continue routine vaccinations as scheduled.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from extreme heat or cold. When traveling across time zones, continue your regular application schedule. If you are flying, keep it in your carry-on luggage to avoid temperature extremes in checked baggage. Check customs regulations for carrying prescription medications.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start noticing improvement within a few days to a week. However, it is important to complete the full course as prescribed.
A: No, you should complete the full course to prevent the infection from returning.
A: Consult a pediatrician before using this medicine on children.
🤔 Common Patient Concerns
🔄 Substitutes for itrazil 1% dusting powder
View AllAlternative brands with exact same active ingredient:
-
davaindia itraconazole 1% dusting powderDavaindia Generic Pharmacy ₹42.00 72% CHEAPER
-
itom 1% dusting powderKnoll Pharmaceuticals Ltd ₹56.72 62.2% CHEAPER
-
itraxil 1% creamWerke Healthcare ₹74.91 50.1% CHEAPER
-
itromed gelLeeford Healthcare Ltd ₹79.69 46.9% CHEAPER
-
etaviv 1% gelBiochemix Health Care Pvt. Ltd. ₹83.44 44.4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This cream can cure any skin infection.
Fact: This medicine is specifically for fungal infections and may not work for bacterial or viral infections. - Myth: You can stop using it once symptoms improve.
Fact: Complete the full course to prevent recurrence.
🔄 Alternative Options
Generic Alternatives
- Itraconazole 1% w/w cream