What is itixo sb 130mg capsule used for?

This medicine is an antifungal capsule containing itraconazole 130 mg. It treats fungal infections of the skin, nails, mouth, and internal organs by disrupting the fungal cell membrane. It should be taken with food and avoided in people with heart failure or liver disease.

Generic Name: Itraconazole (130mg)
Manufacturer: Aleixo Pharma
Form: Allopathy
Pregnancy Category: Consult doctor
Prescription Required: Yes

🇮🇳 itixo sb 130mg capsule के बारे में (Hindi Summary)

उपयोग: यह दवा एक एंटीफंगल कैप्सूल है जिसमें इट्राकोनाज़ोल 130 मिलीग्राम सक्रिय घटक के रूप में होता है। इसका उपयोग त्वचा, नाखून, मुंह और शरीर के आंतरिक अंगों के फंगल संक्रमण के इलाज के लिए किया जाता है। यह फंगस की कोशिका झिल्ली को नष्ट करके काम करती है। इसे भोजन के साथ लेना चाहिए और हृदय विफलता या गंभीर यकृत रोग वाले लोगों को इससे बचना चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट दर्द, सिरदर्द और चक्कर आना शामिल हैं। कुछ लोगों को दाने, खुजली या स्वाद में बदलाव हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें यकृत की क्षति, हृदय विफलता और तंत्रिका क्षति शामिल हो सकती है। यदि आपको पीलिया, गहरे रंग का मूत्र, अत्यधिक थकान, टखनों में सूजन या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को अपने डॉक्टर के निर्देशानुसार ही लें। कैप्सूल को पूरा निगलें, इसे चबाएं या तोड़ें नहीं। इसे भोजन के साथ लें ताकि अवशोषण बेहतर हो और पेट की परेशानी कम हो। एंटासिड या एसिड कम करने वाली दवाओं के साथ इसे लेने से बचें, क्योंकि इससे इसका असर कम हो सकता है। इस दवा को लेते समय शराब न पिएं। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं। बेहतर महसूस होने पर भी दवा लेना बंद न करें।

💊 itixo sb 130mg capsule Uses & Benefits

[{"condition":"Onychomycosis (fungal nail infection)","description":"This medicine is used to treat fungal infections of the fingernails and toenails caused by dermatophytes and yeasts.","evidence":"Well-established"},{"condition":"Tinea corporis, tinea cruris, and tinea pedis","description":"It is prescribed for persistent or extensive ringworm infections of the body, groin, and feet when topical treatments are not effective.","evidence":"Well-established"},{"condition":"Oral and esophageal candidiasis","description":"This medicine treats yeast infections of the mouth and throat, especially in patients with weakened immune systems.","evidence":"Well-established"},{"condition":"Systemic fungal infections","description":"It is used for invasive fungal infections such as histoplasmosis, blastomycosis, and aspergillosis in appropriate patients.","evidence":"Well-established"},{"condition":"Pityriasis versicolor","description":"This medicine is effective against the yeast that causes this common skin condition, particularly when it is widespread or recurrent.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Seborrheic dermatitis","description":"Sometimes prescribed off-label when standard treatments fail, based on the role of Malassezia yeast.","evidence":"Limited"},{"condition":"Allergic bronchopulmonary aspergillosis","description":"Occasionally used as part of a treatment regimen in specialist care.","evidence":"Limited"}]

Primary treatment for: Fungal infections

Also treats: Onychomycosis, Tinea infections, Candidiasis, Histoplasmosis, Blastomycosis, Aspergillosis, Pityriasis versicolor

📋 Drug Information

Generic Name(s)	Itraconazole (130mg)
Brand Name	itixo sb 130mg capsule
Manufacturer	Aleixo Pharma
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	OPHTHAL
Action Class	Fungal ergosterol synthesis inhibitor
Route of Administration	Oral
Storage	Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture and direct sunlight. Keep out of reach of children.
Shelf Life	24 months from the date of manufacture.
WHO Guideline	Not established from the available information.
ICMR Guideline	Not established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1

Always take this medicine with a full meal to enhance absorption and minimize stomach upset.

2

Avoid taking antacids, H2 blockers, or proton pump inhibitors within 2 hours of this medicine, as they reduce its effectiveness.

3

Monitor for signs of liver injury such as yellowing of eyes or skin, dark urine, or unexplained fatigue, and report them immediately.

4

Do not start any new medication, including over-the-counter products and herbal supplements, without consulting your doctor due to significant interaction risks.

5

Complete the full prescribed course even if symptoms improve early, to prevent recurrence of the fungal infection.

6

Inform your dentist or surgeon about this medicine before any procedure, as it can interact with anesthetics and other drugs.

7

Use effective contraception during treatment and for one menstrual cycle after stopping if you are of childbearing age.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅

Fungal nail infection

This medicine is commonly prescribed for this.

Likely Use

✅

Ringworm skin infection

This medicine is used for extensive or resistant cases.

Likely Use

✅

Oral thrush

This medicine treats oral candidiasis.

Likely Use

❌

Bacterial skin infection

This medicine is not effective against bacteria.

Not Primary

❌

Viral infection

This medicine does not treat viruses.

Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is absorbed from the gastrointestinal tract, and absorption is enhanced when taken with food. The capsule formulation provides consistent absorption.

DistributionThis medicine is widely distributed in body tissues, with high concentrations in fatty tissues, skin, and nails. It is highly protein-bound.

Protein BindingApproximately 99.8% bound to plasma proteins, primarily albumin.

MetabolismThis medicine is extensively metabolized in the liver by cytochrome P450 enzymes, particularly CYP3A4, into numerous metabolites. One major metabolite, hydroxyitraconazole, has antifungal activity.

Half-LifeThe elimination half-life is approximately 21 hours after a single dose, but it increases to 30-40 hours with repeated dosing.

ExcretionThis medicine is excreted mainly as inactive metabolites in the urine and feces. About 35% of a dose is excreted in urine and 54% in feces.

BioavailabilityThe oral bioavailability is approximately 55% when taken with food. It is lower when taken on an empty stomach.

Onset of ActionAntifungal effects begin within a few days, but clinical improvement may take several weeks depending on the infection.

Peak Plasma TimePeak plasma concentrations are reached about 4 to 5 hours after oral administration.

Duration of ActionThe antifungal effect persists for several days after the last dose due to the long half-life and tissue accumulation.

How It Works

This medicine works by inhibiting the fungal enzyme cytochrome P450 14-alpha-demethylase, which is responsible for converting lanosterol to ergosterol. Ergosterol is an essential component of the fungal cell membrane. When ergosterol production is blocked, the fungal cell membrane becomes weak and leaky, leading to cell death. This medicine is selective for the fungal enzyme over the human equivalent, which contributes to its safety profile.

Mechanism Steps

1

Binding to fungal CYP51: This medicine binds to the heme iron of fungal cytochrome P450 14-alpha-demethylase, blocking its activity.

2

Inhibition of ergosterol synthesis: Without this enzyme, the fungus cannot convert lanosterol to ergosterol, leading to a shortage of ergosterol in the cell membrane.

3

Membrane disruption: The lack of ergosterol weakens the fungal cell membrane, causing leakage of cellular contents.

4

Fungal cell death: The damaged membrane leads to cell lysis and death of the fungus, helping to clear the infection.

💡 How to Take itixo sb 130mg capsule

Strength: Itraconazole 130 mg immediate-release capsule

1Take this medicine with a full meal to improve absorption and reduce stomach upset.

2Swallow the capsule whole with a glass of water. Do not crush, chew, or open it.

3If you also take antacids, acid reducers, or proton pump inhibitors, take this medicine at least 2 hours before or 6 hours after them.

4Take it at the same time each day to maintain consistent levels in your body.

5Do not take this medicine with grapefruit juice or alcohol.

6If you miss a dose, follow the missed dose instructions provided by your doctor.

Dosage Information

Adult Dosage	The usual adult dose of this medicine is 100 mg to 200 mg once daily, but the exact dose and duration depend on the type and severity of the fungal infection. For example, nail infections may require 200 mg once daily for 12 weeks, while skin infections may need 100 mg to 200 mg daily for 1 to 4 weeks. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric Dosage	Pediatric dosing is not established from available information. Consult a pediatrician.
Elderly Dosage	Elderly patients may be more sensitive to the side effects of this medicine. Dose selection should be cautious, and liver and kidney function should be monitored. Consult a doctor for individualized dosing.
Renal Impairment	No specific dose adjustment is provided for renal impairment in the available information. Use with caution and monitor renal function. Consult a doctor for individualized dosing.
Hepatic Impairment	This medicine is extensively metabolized in the liver. It should be used with caution in patients with hepatic impairment. Dose reduction may be necessary, and liver function should be monitored. Consult a doctor for individualized dosing.
Maximum Daily Dose	The maximum recommended daily dose is 200 mg for most indications, but in some serious systemic infections, doses up to 400 mg per day may be used under specialist supervision. Do not exceed the dose prescribed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food

Take with meals

Improves absorption and reduces stomach upset.

Grapefruit

Avoid

May increase drug levels and risk of side effects.

Alcohol

Avoid

Increases risk of liver damage and side effects.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed

→ Take the missed dose as soon as you remember.

💡 Continue with the regular schedule.

📌 More than half the dosing interval has passed

→ Skip the missed dose.

💡 Do not double dose to catch up.

⚠️ Side Effects of itixo sb 130mg capsule

✅ Common Side Effects

Nausea (Common (5-10%))

Take with food to reduce nausea. If it persists, consult your doctor.

Headache (Common (5-10%))

Rest and stay hydrated. Consult your doctor if headaches are severe or persistent.

Diarrhea (Common (5-10%))

Drink plenty of fluids. If diarrhea is severe or contains blood, seek medical attention.

Abdominal pain (Common (5-10%))

Take with food. If pain is severe or persistent, contact your doctor.

Rash (Uncommon (1-5%))

Stop the medicine and consult your doctor if rash develops.

🚨 Serious Side Effects

Liver injury (Rare (<0.1%))

Seek immediate medical attention if you notice yellowing of skin or eyes, dark urine, or severe fatigue.

Heart failure (Rare (<0.1%))

Report swelling of ankles, shortness of breath, or sudden weight gain to your doctor immediately.

Peripheral neuropathy (Rare (<0.1%))

Inform your doctor if you experience numbness, tingling, or burning in hands or feet.

Severe allergic reaction (Rare (<0.1%))

Seek emergency care if you have swelling of face, lips, tongue, or difficulty breathing.

⚠️ Rare Side Effects

Hearing loss

Report any hearing changes to your doctor promptly.

Stevens-Johnson syndrome

Seek emergency care if you develop painful rash, blisters, or peeling skin.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug	Severity	Effect
Cisapride	Major
Warfarin	Major
Simvastatin	Major
Midazolam	Major
Rifampicin	Major
Omeprazole	Moderate
Antacids	Moderate
Amlodipine	Moderate
Sulfonylureas	Minor
Dexamethasone	Minor

🚨 Major Interactions

Cisapride, pimozide, quinidine, dofetilide
Midazolam, triazolam
Statins (simvastatin, lovastatin)
Warfarin
Rifampicin, rifabutin, phenytoin, carbamazepine

⚡ Moderate Interactions

Proton pump inhibitors (omeprazole, esomeprazole)
H2 blockers (ranitidine, famotidine)
Antacids (aluminum, magnesium hydroxide)
Calcium channel blockers (nifedipine, amlodipine)

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine because it can increase the risk of liver damage and may worsen side effects such as nausea and dizziness.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to itraconazole or other azole antifungals","History of heart failure or ventricular dysfunction","Concurrent use with cisapride, pimozide, quinidine, dofetilide, or levomethadyl","Concurrent use with certain statins (simvastatin, lovastatin)","Concurrent use with midazolam or triazolam for oral sedation","Pregnancy, especially in the first trimester, unless clearly needed","Severe liver disease"]

⚠️ Warnings & Precautions

["This medicine can cause serious liver injury. Report symptoms like jaundice, dark urine, or fatigue immediately.","It may worsen heart failure. Inform your doctor if you have a history of heart problems.","Avoid grapefruit juice and alcohol during treatment.","Tell your doctor about all other medications, especially those for heart rhythm, cholesterol, or anxiety.","Do not take antacids or acid reducers within 2 hours of this medicine.","Use with caution in elderly patients and those with kidney or liver impairment.","This medicine may cause dizziness; avoid driving or operating machinery until you know how it affects you."]

🤱 Lactation Safety

This medicine is excreted in breast milk in small amounts. It is not recommended during breastfeeding unless the benefit outweighs the risk. Consult your doctor before use.

💊 Overdose Management

There is no specific antidote for an overdose of this medicine. In case of overdose, seek immediate medical attention. Treatment should be symptomatic and supportive, including monitoring of vital signs and liver function. Activated charcoal may be considered if the overdose is recent and the patient is stable.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Swallow the capsule whole with a full glass of water, preferably with a meal, to improve absorption and reduce stomach upset. Do not crush, chew, or open the capsule. Avoid taking antacids, acid reducers, or proton pump inhibitors within two hours of this medicine, as they can reduce its effectiveness. Do not drink alcohol while taking this medicine because it can increase the risk of liver problems. Inform your doctor about all other medicines, supplements, and herbal products you are taking, especially those for heart rhythm, cholesterol, or anxiety. Do not stop taking this medicine early, even if you feel better, because the infection may return. Keep all follow-up appointments and blood tests as advised by your doctor.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more susceptible to side effects, especially heart failure and liver toxicity. Dose adjustment may be necessary, and close monitoring is recommended.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, discuss with your doctor before taking this medicine. It is not recommended during pregnancy unless clearly needed. Use effective contraception during treatment and for one menstrual cycle after stopping.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine, as it can interact with anesthetic agents and other medications used during surgery. It may need to be stopped temporarily before surgery.

🦷 Dental Procedures

Tell your dentist that you are taking this medicine, as it can interact with certain antibiotics and anesthetics used in dental procedures. Your dentist may need to adjust your treatment plan.

💚 Lifestyle Tips for Better Results

🏃

Maintain good hygiene to prevent reinfection.

🥗

Keep your skin and nails clean and dry.

😴

Avoid sharing personal items like towels and nail clippers.

💧

Wear breathable footwear to reduce moisture.

🧘

Follow a healthy diet to support your immune system.

🌞

Avoid excessive alcohol consumption to protect your liver.

🏋️ Exercise Considerations

This medicine may cause dizziness or fatigue. Avoid strenuous exercise or activities requiring alertness until you know how it affects you. Stay hydrated during exercise.

🥗 Diet Recommendations

Take this medicine with a meal containing some fat to enhance absorption.

Avoid grapefruit and grapefruit juice.

Limit alcohol intake.

Stay well hydrated.

Include probiotic-rich foods to support gut health if approved by your doctor.

💼 Impact on Daily Work & Life

This medicine may cause dizziness, fatigue, or headache, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is generally safe to continue most work activities, but inform your employer if you have safety-sensitive duties.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as liver problems, heart failure symptoms, or severe allergic reactions, seek immediate medical attention and follow your doctor's advice on whether to stop.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of liver toxicity, heart failure, and peripheral neuropathy. Regular monitoring of liver function and heart health is recommended. Prolonged use can also lead to fungal resistance. Your doctor will determine the appropriate duration based on your condition.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Topical antifungals

For mild skin infections, topical creams may be sufficient.

Evidence: Well-established

Terbinafine

An alternative oral antifungal for nail and skin infections.

Evidence: Well-established

Fluconazole

Another oral antifungal for certain yeast infections.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

This medicine does not interact with vaccines. However, if you are immunocompromised, discuss vaccination timing with your doctor.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid temperature extremes in checked baggage. If crossing time zones, adjust your dosing schedule gradually, but do not double up on doses. Store at room temperature and protect from moisture. Check local customs regulations for carrying prescription medications.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 52-year-old man with toenail fungus

He was prescribed this medicine for 12 weeks. He took it with breakfast every day and avoided alcohol. His nails gradually cleared, and he did not experience any serious side effects. He emphasized the importance of patience and consistency.

💡 Lesson: Nail fungus treatment takes months; completing the full course is essential for a cure.

👤 A 34-year-old woman with recurrent vaginal yeast infections

After multiple topical treatments failed, her doctor prescribed this medicine. She was monitored for liver function and advised to avoid grapefruit juice. Her symptoms resolved within two weeks, and she remained infection-free for six months.

💡 Lesson: Systemic antifungals can be effective for resistant yeast infections, but require monitoring and lifestyle adjustments.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Improvement in skin infections may be seen within 1-2 weeks, but nail infections may take several months to clear completely. Complete the full course as prescribed.

Q: Can I take this medicine with food?

A: Yes, take it with a full meal to improve absorption and reduce stomach upset.

Q: What should I avoid while taking this medicine?

A: Avoid alcohol, grapefruit juice, and antacids within 2 hours of dosing. Also avoid interacting medications.

Q: Is this medicine safe during pregnancy?

A: It is not recommended during pregnancy unless clearly needed. Consult your doctor.

Q: Can I stop taking this medicine when I feel better?

A: No, complete the full course to prevent recurrence, even if symptoms improve.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

Can I take this medicine long-term?
Will it affect my liver function?
Can I drive after taking this medicine?
Does it interact with my blood pressure medicine?
What if I miss a dose?
Can I drink alcohol while taking this?
Is it safe during pregnancy?
How long does it take to work?

🔄 Substitutes for itixo sb 130mg capsule

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

Myth: This medicine can cure any skin infection.
Fact: This medicine only treats fungal infections. It is not effective against bacterial or viral skin infections.
Myth: You can stop taking this medicine once symptoms improve.
Fact: You must complete the full course as prescribed, even if symptoms improve, to prevent the infection from returning.
Myth: This medicine is safe for everyone.
Fact: This medicine is not safe for people with heart failure, certain liver problems, or those taking interacting medications.

🔄 Alternative Options

Generic Alternatives

Itraconazole 130 mg capsule

Brand Alternatives

Funzi IT SB 130 Capsule

📊 Comparison with Similar Medicines

[{"medicine":"Itraconazole","class":"Triazole","common_uses":"Nail, skin, systemic fungal infections","half_life":"21-40 hours","notes":"Requires acidic stomach for absorption; many interactions."},{"medicine":"Fluconazole","class":"Triazole","common_uses":"Candidiasis, cryptococcosis","half_life":"30 hours","notes":"Better absorbed; fewer interactions."},{"medicine":"Terbinafine","class":"Allylamine","common_uses":"Nail and skin fungal infections","half_life":"36 hours","notes":"Effective for dermatophytes; fewer drug interactions."}]

Itraconazole 130mg Capsule: Complete Medicine Guide

When to Call Your Doctor IMMEDIATELY

What is itixo sb 130mg capsule used for?

🇮🇳 itixo sb 130mg capsule के बारे में (Hindi Summary)

💊 itixo sb 130mg capsule Uses & Benefits

📋 Drug Information

👨‍⚕️ Doctor's Practical Tips

🔍 Is This Medicine Right for Your Symptom?

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

How It Works

Mechanism Steps

💡 How to Take itixo sb 130mg capsule

Dosage Information

Dosage Timeline

🍽️ Food Timing Guide

⏰ What to Do If You Miss a Dose

⚠️ Side Effects of itixo sb 130mg capsule

✅ Common Side Effects

🚨 Serious Side Effects

⚠️ Rare Side Effects

🔬 Drug Interactions

🚨 Major Interactions

⚡ Moderate Interactions

🍷 Alcohol Interaction

🔎 Check Your Other Medicines

🛡️ Safety & Warnings

🚫 Contraindications

⚠️ Warnings & Precautions

🤱 Lactation Safety

💊 Overdose Management

⏰ Missed Dose

Additional Safety Advice

👴 Special Considerations for Elderly

💡 For Patients Above 65

🤰 Pregnancy Planning (TTC)

🏥 Post-Surgery Considerations

🦷 Dental Procedures

💚 Lifestyle Tips for Better Results

🏋️ Exercise Considerations

🥗 Diet Recommendations

💼 Impact on Daily Work & Life

🛑 When to Stop This Medicine

📅 Long-Term Use Effects

🌿 Non-Medicine Approaches

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

📦 Storage Guide

✅ DO

❌ DON'T

✅ DO

❌ DON'T

✅ DO

❌ DON'T

✈️ Traveling with This Medicine

💰 Cost Analysis & Savings

👥 Real Patient Stories

💬 Questions Patients Often Ask

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

🔄 Substitutes for itixo sb 130mg capsule

🛑 Myths vs. Facts

🔄 Alternative Options

Generic Alternatives

Brand Alternatives

📊 Comparison with Similar Medicines

😊 Was this information helpful?

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