Acwis 5mg Tablet (isotretinoin 5mg): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe headache with vision changes or nausea
- Yellowing of skin or eyes, dark urine, or severe abdominal pain
- Blurred vision or decreased night vision
- Hearing loss or ringing in the ears
- Mood changes, depression, or suicidal thoughts
- Severe skin rash, blisters, or peeling skin
- Difficulty breathing or swelling of face, lips, or throat
- Severe abdominal pain with nausea and vomiting
If experiencing severe symptoms, call emergency services immediately.
What is isotane 5mg capsule used for?
This medicine contains Isotretinoin 5mg, a retinoid used to treat severe nodulocystic acne that has not responded to other treatments. It works by reducing sebum production and preventing comedone formation. It is a prescription-only medicine and must be used under strict medical supervision, especially in women of childbearing age due to the risk of birth defects.
- Generic Name: Isotretinoin (5mg)
- Manufacturer: Micro Labs Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 isotane 5mg capsule के बारे में (Hindi Summary)
उपयोग: यह दवा आइसोट्रेटिनोइन 5mg युक्त एक रेटिनॉइड है, जिसका उपयोग गंभीर मुँहासे (नोड्यूलोसिस्टिक एक्ने) के इलाज के लिए किया जाता है, जो अन्य उपचारों से ठीक नहीं हुए हों। यह त्वचा में तेल ग्रंथियों का आकार कम करती है, तेल उत्पादन घटाती है, और मुँहासे पैदा करने वाले बैक्टीरिया को कम करती है। यह केवल डॉक्टर के पर्चे पर ही मिलती है और गर्भवती महिलाओं के लिए पूरी तरह वर्जित है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में त्वचा का सूखापन, होंठ फटना, आँखों का सूखापन, नाक से खून आना, और धूप के प्रति संवेदनशीलता बढ़ना शामिल हैं। कुछ रोगियों को मांसपेशियों या जोड़ों में दर्द, सिरदर्द, और बालों का पतला होना भी हो सकता है। गंभीर दुष्प्रभावों में यकृत की क्षति, दृष्टि में बदलाव, और मनोदशा में बदलाव शामिल हैं। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को केवल डॉक्टर के पर्चे और देखरेख में ही लें। गर्भवती महिलाएं या जो गर्भवती हो सकती हैं, इस दवा का सेवन बिल्कुल न करें। उपचार के दौरान और बाद में भी गर्भधारण से बचने के लिए दो विश्वसनीय गर्भनिरोधक तरीके अपनाएं। इलाज के दौरान रक्तदान न करें। शराब का सेवन न करें। धूप से बचाव करें और सनस्क्रीन का उपयोग करें। नियमित रक्त परीक्षण करवाएं।
💊 isotane 5mg capsule Uses & Benefits
[{"condition":"Severe nodulocystic acne","description":"This medicine is indicated for the treatment of severe recalcitrant nodular acne that has not responded to conventional therapies including oral antibiotics and topical treatments.","evidence":"Well-established"},{"condition":"Acne conglobata","description":"A severe form of acne with deep nodules and cysts, often treated with this medicine when other treatments fail.","evidence":"Well-established"},{"condition":"Acne fulminans","description":"A rare and severe form of acne with systemic symptoms, where this medicine may be used as part of management.","evidence":"Limited"},{"condition":"Gram-negative folliculitis","description":"A type of bacterial infection of hair follicles that can occur after long-term antibiotic use for acne; this medicine may be helpful in selected cases.","evidence":"Limited"}]
Off-label uses: [{"condition":"Rosacea","description":"Sometimes prescribed off-label for severe rosacea that has not responded to other treatments.","evidence":"Limited"},{"condition":"Hidradenitis suppurativa","description":"May be used off-label in some patients with this chronic skin condition, though evidence is limited.","evidence":"Limited"},{"condition":"Keratosis pilaris","description":"Rarely used off-label for severe keratosis pilaris, but not a standard treatment.","evidence":"Limited"},{"condition":"Cutaneous lupus erythematosus","description":"Occasionally used off-label for certain skin manifestations of lupus, but evidence is not strong.","evidence":"Limited"}]
Primary treatment for: Severe nodulocystic acne
Also treats: Acne conglobata, Acne fulminans, Gram-negative folliculitis
📋 Drug Information
| Generic Name(s) | Isotretinoin (5mg) |
| Brand Name | isotane 5mg capsule |
| Manufacturer | Micro Labs Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | DERMA |
| Action Class | Retinoids- First generation |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | Typically 24 months from the date of manufacture, but check the packaging for the exact expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Isotretinoin works by binding to retinoic acid receptors in the skin, leading to reduced sebaceous gland size and decreased sebum production. It also promotes normal differentiation of follicular epithelial cells, preventing comedone formation, and reduces the population of Cutibacterium acnes bacteria in the follicles. Additionally, it has anti-inflammatory effects that help reduce redness and swelling associated with acne.
Mechanism Steps
💡 How to Take isotane 5mg capsule
Strength: Isotretinoin 5mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is individualized by a qualified clinician based on the severity of acne, patient weight, and response to treatment. It is typically taken once or twice daily with food. The dose may be adjusted during treatment. Do not self-adjust the dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Safety and efficacy in elderly patients have not been established. Use with caution and under medical supervision. |
| Renal Impairment | Dose adjustment may be necessary in patients with renal impairment. Consult a clinician for individualized dosing. |
| Hepatic Impairment | Isotretinoin is contraindicated in patients with severe hepatic impairment. In mild to moderate impairment, dose reduction may be required. Consult a clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is 2 mg/kg per day, but the exact dose must be determined by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of isotane 5mg capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Tetracycline antibiotics | Major | |
| Vitamin A supplements | Major | |
| Phenytoin | Moderate | |
| Corticosteroids | Moderate | |
| Alcohol | Moderate | |
| St. John's wort | Moderate | |
| Carbamazepine | Moderate | |
| Progestin-only contraceptives | Moderate | |
| Topical retinoids | Minor | |
| Topical acne treatments | Minor |
🚨 Major Interactions
- Tetracycline antibiotics (e.g., doxycycline, minocycline)
- Vitamin A supplements
- Hormonal contraceptives (combined oral contraceptives)
- Phenytoin
- Corticosteroids (oral)
⚡ Moderate Interactions
- Alcohol
- St. John's wort
- Carbamazepine
- Progestin-only contraceptives
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can increase the risk of liver toxicity and elevate triglyceride levels. It may also worsen side effects such as drowsiness and dizziness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Pregnancy or women who may become pregnant during treatment","Breastfeeding","Known hypersensitivity to isotretinoin or any component of the formulation","Concurrent use of tetracycline antibiotics","Severe liver disease","Very high blood triglyceride levels","Vitamin A toxicity"]
⚠️ Warnings & Precautions
["This medicine can cause severe birth defects. Women must use two forms of contraception and undergo regular pregnancy testing.","Do not donate blood during treatment and for at least one month after stopping.","Avoid alcohol during treatment.","Use sunscreen and protective clothing due to increased sun sensitivity.","Report any mood changes, depression, or suicidal thoughts immediately.","Regular blood tests are required to monitor liver function and lipid levels.","Avoid driving at night if you experience decreased night vision.","Do not take vitamin A supplements.","Inform your doctor if you have a history of liver disease, diabetes, or high cholesterol.","This medicine may cause dry eyes; contact lens wearers may need to use glasses."]
🤱 Lactation Safety
Isotretinoin is excreted in breast milk and may harm a nursing infant. Breastfeeding is not recommended while taking this medicine.
💊 Overdose Management
Overdose of isotretinoin may cause severe headache, nausea, vomiting, and signs of vitamin A toxicity. If overdose is suspected, seek immediate medical attention. Treatment is supportive and symptomatic. Contact a poison control center if available.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
This medicine must only be taken with a valid prescription and under the care of a dermatologist or qualified physician. Women of childbearing potential must use two reliable forms of contraception before, during, and for at least one month after stopping this medicine. Pregnancy testing is required before starting and periodically during treatment. Do not donate blood while taking this medicine and for at least one month after the last dose, because it can harm a pregnant recipient. Avoid alcohol during treatment as it can increase triglyceride levels and liver stress. Use sunscreen and protective clothing because this medicine increases sun sensitivity. Do not share this medicine with anyone else. Keep all follow-up appointments for blood tests and clinical monitoring.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Safety and efficacy of this medicine in elderly patients have not been established. Use with caution and under close medical supervision.
🤰 Pregnancy Planning (TTC)
This medicine is highly teratogenic. Women planning pregnancy must stop this medicine at least one month before attempting conception. Use effective contraception during treatment and for at least one month after the last dose. Consult your doctor for guidance.
🏥 Post-Surgery Considerations
This medicine may affect wound healing and increase sun sensitivity. Inform your surgeon if you are taking this medicine before any surgery. It may need to be stopped temporarily.
🦷 Dental Procedures
This medicine can cause dry mouth and increase the risk of dental caries. Maintain good oral hygiene and inform your dentist if you are taking this medicine. It may also affect healing after dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause muscle and joint pain. Avoid strenuous exercise if you experience these symptoms. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause vision changes, especially decreased night vision, which can affect driving and operating machinery. Avoid driving at night if you experience vision problems. Dry eyes may make contact lens wear uncomfortable; consider wearing glasses. Mood changes may affect work performance; report any such changes to your doctor.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects such as vision changes, severe headache, mood changes, or signs of liver injury, contact your doctor immediately. Your doctor will decide whether to adjust the dose or stop treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may be associated with persistent dry skin, increased sun sensitivity, and rare effects on liver and lipid levels. Regular monitoring is required. Some patients may experience continued improvement after stopping. Long-term use should be under medical supervision with periodic assessments.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Tetracyclines or macrolides may be used for moderate to severe acne, but they are not as effective as isotretinoin for severe nodulocystic acne.
Evidence: Well-establishedTopical tretinoin, adapalene, or tazarotene can be used for mild to moderate acne.
Evidence: Well-establishedOral contraceptives or anti-androgens may be helpful in women with hormonal acne.
Evidence: Well-establishedLasers can be used for acne scars and sometimes for active acne, but they are not a replacement for systemic treatment in severe cases.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, continue taking your doses at the same intervals as prescribed; consult your doctor for specific advice. Be aware of customs regulations regarding prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Improvement may be seen within 2 to 4 weeks, but significant improvement typically takes 1 to 2 months. Full therapeutic effect may require 15 to 20 weeks.
A: Yes, take this medicine with food to improve absorption and reduce stomach upset.
A: Avoid alcohol, vitamin A supplements, and prolonged sun exposure. Do not donate blood during treatment and for at least one month after stopping.
A: No, this medicine is contraindicated in pregnancy as it can cause severe birth defects. Women of childbearing age must use effective contraception.
A: No, you must complete the full course as prescribed by your doctor to prevent recurrence.
🤔 Common Patient Concerns
🔄 Substitutes for isotane 5mg capsule
View AllAlternative brands with exact same active ingredient:
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nutret 5mg capsuleNuper therapeutics ₹51.56 31.3% CHEAPER
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Tretiroz 5mg Soft Gelatin CapsuleDazroz Pharmaceuticals Pvt Ltd ₹74.06 1.3% CHEAPER
-
actame 5mg tabletSol Derma Pharmaceuiticals Pvt Ltd ₹75.00 SAME PRICE
-
isopil 5 tabletGlowderma Labs Pvt Ltd ₹75.00 SAME PRICE
-
isokon 5mg capsuleEskon Pharma ₹75.00 SAME PRICE
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be used for mild acne.
Fact: This medicine is only for severe nodulocystic acne that has not responded to other treatments. It is not for mild acne. - Myth: You can stop this medicine as soon as your acne clears.
Fact: You must complete the full course as prescribed by your doctor to prevent recurrence and ensure optimal results. - Myth: This medicine is safe during pregnancy.
Fact: This medicine is highly teratogenic and can cause severe birth defects. It is absolutely contraindicated in pregnancy. - Myth: You can drink alcohol while taking this medicine.
Fact: Alcohol should be avoided as it increases the risk of liver toxicity and high triglycerides.
🔄 Alternative Options
Generic Alternatives
- Isotretinoin 5mg generic tablets (various manufacturers)
Brand Alternatives
- Not applicable as this is a generic product.