Antibin Kid 100 mg/50 mg Tablet: Complete Information
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of eyes or skin (jaundice)
- Dark urine or pale stools
- Severe abdominal pain
- Persistent vomiting
- Unusual bleeding or bruising
- Severe headache with confusion
- Shortness of breath or difficulty breathing
- Swelling of face, lips, or throat
- Decreased urine output
- Seizures
If experiencing severe symptoms, call emergency services immediately.
What is isorif p 100mg/50mg tablet used for?
This medicine is a combination of rifampicin and isoniazid used to treat tuberculosis in children. It works by killing the bacteria that cause tuberculosis. It must be taken exactly as prescribed, usually once daily, for several months.
- Generic Name: Rifampicin (100mg) + Isoniazid (50mg)
- Manufacturer: Dynamic Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 isorif p 100mg/50mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा बच्चों में तपेदिक (टीबी) के इलाज के लिए इस्तेमाल की जाती है। इसमें रिफैम्पिसिन और आइसोनियाजिड दो दवाएं शामिल हैं जो टीबी के बैक्टीरिया को मारती हैं। यह दवा अकेले नहीं दी जाती, बल्कि डॉक्टर द्वारा बताए गए अन्य टीबी की दवाओं के साथ दी जाती है। इसे रोजाना एक बार लेना होता है और इलाज का पूरा कोर्स करना बहुत जरूरी है।
साइड इफेक्ट्स: आम दुष्प्रभावों में जी मिचलाना, उल्टी, पेट दर्द, भूख न लगना और पेशाब, पसीना, आंसू का नारंगी-लाल रंग होना शामिल है। यह रंग बदलना हानिकारक नहीं है और दवा बंद करने पर ठीक हो जाता है। गंभीर दुष्प्रभावों में लिवर की सूजन, एलर्जी, खून की बीमारी और किडनी की समस्या हो सकती है। अगर आंख या त्वचा पीली पड़े, गहरे रंग का पेशाब आए, या बहुत थकान लगे तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: यह दवा सिर्फ डॉक्टर की देखरेख में ही लें। इलाज से पहले और दौरान लिवर की जांच कराना जरूरी है। शराब बिल्कुल न लें। बच्चे को कोई और दवा देने से पहले डॉक्टर को बताएं। दवा की खुराक न छोड़ें और इलाज बीच में न रोकें, वरना टीबी दोबारा हो सकती है और दवा काम नहीं करेगी। दवा को ठंडी, सूखी जगह पर रखें और बच्चों की पहुंच से दूर रखें।
💊 isorif p 100mg/50mg tablet Uses & Benefits
[{"condition":"Active tuberculosis in children","description":"Used as part of a combination regimen to treat active tuberculosis caused by Mycobacterium tuberculosis.","evidence":"Well-established"},{"condition":"Prevention of tuberculosis in children exposed to infected individuals","description":"Sometimes used as preventive therapy in children who have been in close contact with a person with active tuberculosis.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Atypical mycobacterial infections","description":"Rarely used in combination with other drugs for certain atypical mycobacterial infections in children, but not a standard first-line option.","evidence":"Limited"}]
Primary treatment for: Tuberculosis
Also treats: Latent tuberculosis infection, Mycobacterial infections
📋 Drug Information
| Generic Name(s) | Rifampicin (100mg) + Isoniazid (50mg) |
| Brand Name | isorif p 100mg/50mg tablet |
| Manufacturer | Dynamic Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store below 30°C in a dry place, protected from light. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization recommends rifampicin and isoniazid as part of standard antitubercular therapy for children, with doses based on weight. This fixed-dose combination is included in WHO essential medicines list for children. |
| ICMR Guideline | The Indian Council of Medical Research recommends weight-based dosing of rifampicin and isoniazid for pediatric tuberculosis, with regular monitoring for adverse effects. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antitubercular drugs with distinct mechanisms. Rifampicin inhibits bacterial DNA-dependent RNA polymerase, preventing RNA synthesis and thus protein production. Isoniazid is a prodrug activated by bacterial catalase-peroxidase; it inhibits mycolic acid synthesis, disrupting the bacterial cell wall. Together, they are bactericidal against Mycobacterium tuberculosis.
Mechanism Steps
💡 How to Take isorif p 100mg/50mg tablet
Strength: Tablet containing rifampicin 100 mg and isoniazid 50 mg.
Dosage Information
| Adult Dosage | This pediatric formulation is not intended for adults. Adult dosing of rifampicin and isoniazid is different and must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Typically, adults receive higher strengths. |
| Pediatric Dosage | The dosage is based on body weight and must be prescribed by a pediatrician or tuberculosis specialist. This fixed-dose combination is designed for children and is usually given once daily. The exact dose depends on the child's weight and the treatment phase. Do not adjust the dose without medical advice. |
| Elderly Dosage | This pediatric formulation is not intended for elderly patients. Elderly patients should receive adult formulations with doses adjusted based on renal and hepatic function. |
| Renal Impairment | Dose adjustment may be needed in severe renal impairment. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Use with extreme caution in patients with liver disease. Dose reduction or alternative regimens may be necessary. Regular monitoring of liver function is mandatory. |
| Maximum Daily Dose | The maximum daily dose is determined by the prescribing doctor based on the child's weight and clinical response. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of isorif p 100mg/50mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Protease inhibitors | Major | |
| Oral contraceptives | Major | |
| Phenytoin | Moderate | |
| Ketoconazole | Major | |
| Carbamazepine | Moderate | |
| Fluconazole | Moderate | |
| Antacids | Minor | |
| Paracetamol | Minor | |
| Isoniazid | Moderate |
🚨 Major Interactions
- Protease inhibitors (e.g., ritonavir, lopinavir)
- Warfarin
- Oral contraceptives
- Ketoconazole
⚡ Moderate Interactions
- Phenytoin
- Carbamazepine
- Fluconazole
🍷 Alcohol Interaction
Alcohol should be strictly avoided while taking this medicine because both rifampicin and isoniazid can cause liver damage, and alcohol increases this risk significantly. Alcohol may also reduce the effectiveness of the treatment and worsen side effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to rifampicin or isoniazid","Severe liver disease (e.g., cirrhosis with decompensation)","Acute hepatitis","Concurrent use with certain protease inhibitors (e.g., saquinavir/ritonavir)","History of drug-induced hepatitis"]
⚠️ Warnings & Precautions
["Monitor liver function closely; discontinue if signs of hepatitis occur.","Warn patients about orange-red discoloration of body fluids.","Use with caution in patients with pre-existing liver disease or alcohol use.","May reduce effectiveness of oral contraceptives; advise alternative contraception.","Isoniazid may cause peripheral neuropathy; consider pyridoxine supplementation.","Rifampicin may cause flu-like syndrome with intermittent dosing.","Avoid in patients with porphyria."]
🤱 Lactation Safety
Rifampicin and isoniazid are excreted in breast milk. Breastfeeding is generally considered safe while on this medicine, but consult a doctor to monitor the infant for potential side effects.
💊 Overdose Management
Overdose can cause nausea, vomiting, abdominal pain, liver damage, and in severe cases, seizures and coma. Seek immediate medical attention. Treatment is supportive and symptomatic. Activated charcoal may be given if within 1-2 hours of ingestion. Monitor liver and kidney function closely.
⏰ Missed Dose
If a dose is missed, take it as soon as remembered if less than half the dosing interval has passed. If more than half the interval has passed, skip the missed dose and continue with the regular schedule. Do not double dose.
Additional Safety Advice
This medicine must only be taken under the supervision of a doctor experienced in treating tuberculosis. Regular blood tests to check liver function are essential before and during treatment. Avoid alcohol completely, as it increases the risk of liver damage. Inform your doctor if the child has any liver or kidney problems, or if they are taking any other medicines, especially anticonvulsants or blood thinners. Do not skip doses or stop treatment early, even if the child feels better, as this can lead to treatment failure and drug resistance. Keep all appointments for monitoring. If a dose is missed, follow the missed dose instructions provided by your doctor. Store the tablets in a cool, dry place away from direct sunlight and out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
This pediatric formulation is not intended for elderly patients. Elderly patients should receive adult formulations with doses adjusted based on renal and hepatic function.
🤰 Pregnancy Planning (TTC)
This medicine is for pediatric use. For women planning pregnancy, consult a doctor for appropriate tuberculosis management.
🏥 Post-Surgery Considerations
If surgery is planned, inform the surgical team about this medicine. It may interact with anesthetics and other medications used during surgery.
🦷 Dental Procedures
Inform the dentist about this medicine before any dental procedure. It may interact with certain antibiotics and anesthetics.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Children on this medicine can engage in normal physical activities as tolerated. However, if they experience fatigue or dizziness, they should avoid strenuous exercise. Consult a doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue in some children, which can affect school performance. Parents should inform teachers about the child's condition and treatment. The child can usually attend school once they are no longer contagious, which is typically after a few weeks of treatment.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting the doctor. Stopping early can lead to treatment failure and drug resistance. The doctor will determine when to stop based on clinical response and test results.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe when monitored appropriately. However, prolonged use can increase the risk of liver toxicity, peripheral neuropathy, and drug interactions. Regular monitoring of liver function and clinical assessment are necessary. The duration of treatment is determined by the doctor based on the type and severity of tuberculosis.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A healthy diet can help support the immune system during tuberculosis treatment.
Evidence: Well-establishedSupervision of medication intake by a healthcare worker improves adherence and outcomes.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during tuberculosis treatment as the immune response may be altered. Inactivated vaccines are generally safe. Consult a doctor for vaccination scheduling.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of the prescription. Keep it in hand luggage to avoid loss. Store at room temperature and protect from extreme heat. If crossing time zones, adjust dosing times gradually under medical advice. Check customs regulations for carrying prescription medicines. Always carry enough supply for the entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Improvement in symptoms may be seen within a few weeks, but the full course must be completed to cure the infection.
A: It can interact with many medicines. Always inform the doctor about all medicines your child is taking.
A: If vomiting occurs within 30 minutes of taking the dose, consult the doctor for advice on whether to repeat the dose.
🤔 Common Patient Concerns
🔄 Substitutes for isorif p 100mg/50mg tablet
View AllAlternative brands with exact same active ingredient:
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antibin kid 100 mg/50 mg tabletMedispan Ltd ₹11.34 42.4% CHEAPER
-
rimactazid 100 mg/50 mg tablet dtNovartis India Ltd ₹12.16 38.2% CHEAPER
-
Rifaden Kid 100mg/50mg TabletEden Healthcare Pvt Ltd ₹12.19 38.1% CHEAPER
-
binex 100mg/50mg tablet dtBiological E Ltd ₹12.43 36.9% CHEAPER
-
bicox kid 100mg/50mg tabletOverseas Healthcare Pvt Ltd ₹12.59 36.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Tuberculosis treatment can be stopped once symptoms improve.
Fact: Treatment must be completed for the full duration to prevent relapse and drug resistance. - Myth: This medicine causes permanent orange discoloration of body fluids.
Fact: The discoloration is temporary and harmless; it resolves after stopping the medicine. - Myth: Children with tuberculosis should be isolated from others.
Fact: With proper treatment, children are usually not contagious after a few weeks and can attend school.
🔄 Alternative Options
Generic Alternatives
- Rifampicin and isoniazid fixed-dose combination tablets are available from various generic manufacturers.
Brand Alternatives
- Not applicable as this is a generic product.