isonit 30mg tablet sr - Isosorbide Mononitrate (30mg) medicine

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🏭 Johnlee Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for angina prevention.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Severe chest pain that is different from your usual angina
  • Fainting or severe dizziness
  • Bluish discoloration of lips, nails, or skin
  • Shortness of breath or difficulty breathing
  • Severe headache that does not go away
  • Sudden swelling of face, lips, or throat
  • Irregular heartbeat or palpitations

If experiencing severe symptoms, call emergency services immediately.

What is isonit 30mg tablet sr used for?

This medicine is a nitrate used to prevent chest pain (angina) in people with heart conditions. It works by relaxing blood vessels to improve blood flow to the heart. It is taken orally once daily as prescribed by a doctor.

  • Generic Name: Isosorbide Mononitrate (30mg)
  • Manufacturer: Johnlee Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 isonit 30mg tablet sr के बारे में (Hindi Summary)

उपयोग: यह दवा एंजाइना (सीने में दर्द) को रोकने के लिए इस्तेमाल की जाती है। यह रक्त वाहिकाओं को फैलाकर हृदय तक रक्त का प्रवाह बढ़ाती है और हृदय पर दबाव कम करती है। यह दवा एंजाइना के दौरे को रोकने के लिए नियमित रूप से ली जाती है, तीव्र दौरे के इलाज के लिए नहीं।

साइड इफेक्ट्स: आम दुष्प्रभावों में सिरदर्द, चक्कर आना, हल्का सिर घूमना और चेहरे पर लालिमा शामिल हैं। ये आमतौर पर अस्थायी होते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें गंभीर निम्न रक्तचाप, बेहोशी और मेथेमोग्लोबिनेमिया शामिल हो सकते हैं। यदि आपको गंभीर चक्कर या बेहोशी महसूस हो तो तुरंत चिकित्सा सहायता लें।

सुरक्षा सलाह: इस दवा को अपने डॉक्टर के निर्देशानुसार ही लें। इसे अचानक बंद न करें क्योंकि इससे एंजाइना बिगड़ सकता है। इस दवा के साथ शराब का सेवन न करें क्योंकि इससे निम्न रक्तचाप का खतरा बढ़ सकता है। बैठने या लेटने की स्थिति से धीरे-धीरे उठें ताकि चक्कर न आएं। यदि आप गर्भवती हैं, गर्भवती होने की योजना बना रही हैं, या स्तनपान करा रही हैं तो अपने डॉक्टर को बताएं। सिल्डेनाफिल, टैडालाफिल या वर्डेनाफिल जैसी दवाओं के साथ इस दवा का सेवन न करें क्योंकि इससे खतरनाक रूप से रक्तचाप गिर सकता है।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 isonit 30mg tablet sr Uses & Benefits

[{"condition":"Prevention of angina pectoris","description":"This medicine is used to prevent chest pain episodes in patients with coronary artery disease.","evidence":"Well-established"},{"condition":"Chronic stable angina","description":"It helps reduce the frequency and severity of angina attacks when used regularly.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Heart failure","description":"Sometimes used in combination with other medicines to manage heart failure symptoms.","evidence":"Limited"},{"condition":"Esophageal spasm","description":"May be used to relieve chest pain caused by esophageal spasms.","evidence":"Limited"}]

Primary treatment for: Angina pectoris

Also treats: Coronary artery disease, Heart failure

📋 Drug Information

Generic Name(s)Isosorbide Mononitrate (30mg)
Brand Nameisonit 30mg tablet sr
ManufacturerJohnlee Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassNO Donors
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F and 86°F). Protect from light and moisture.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at the same time each day to maintain consistent levels and prevent tolerance.
2
Do not stop this medicine suddenly without consulting your doctor, as it can worsen angina.
3
Avoid alcohol while taking this medicine to prevent severe low blood pressure.
4
Rise slowly from sitting or lying positions to avoid dizziness.
5
Inform your doctor if you experience persistent headaches, as dose adjustment may be needed.
6
Do not take erectile dysfunction medicines while on this therapy due to the risk of dangerous hypotension.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chest pain (angina)
This medicine is commonly prescribed to prevent angina.
Likely Use
❌
High blood pressure
This medicine is not a primary treatment for high blood pressure.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionIsosorbide Mononitrate is rapidly and completely absorbed from the gastrointestinal tract after oral administration. The bioavailability is approximately 100% because it does not undergo first-pass metabolism.
DistributionIsosorbide Mononitrate is widely distributed in the body. It has a volume of distribution of approximately 0.6 L/kg.
Protein BindingLess than 5% of Isosorbide Mononitrate is bound to plasma proteins.
MetabolismIsosorbide Mononitrate is metabolized in the liver by denitration to isosorbide and other metabolites. It does not undergo significant first-pass metabolism.
Half-LifeThe elimination half-life of Isosorbide Mononitrate is approximately 5 hours.
ExcretionIsosorbide Mononitrate is excreted primarily in the urine as metabolites. About 2% is excreted unchanged.
BioavailabilityThe oral bioavailability of Isosorbide Mononitrate is approximately 100%.
Onset of ActionThe onset of action for angina prevention is within 30 to 60 minutes after oral administration.
Peak Plasma TimePeak plasma concentrations are reached approximately 1 to 2 hours after oral administration.
Duration of ActionThe duration of action is approximately 12 to 24 hours, depending on the dose and individual response.

How It Works

Isosorbide Mononitrate works by releasing nitric oxide, which activates guanylate cyclase and increases cyclic GMP levels in vascular smooth muscle cells. This leads to relaxation of smooth muscle and dilation of blood vessels, particularly veins. The dilation of veins reduces preload, while dilation of arteries reduces afterload, decreasing myocardial oxygen demand and improving blood flow to the heart.

Mechanism Steps

1
Release of nitric oxide: Isosorbide Mononitrate is metabolized to release nitric oxide in the body.
2
Activation of guanylate cyclase: Nitric oxide activates the enzyme guanylate cyclase in vascular smooth muscle cells.
3
Increase in cyclic GMP: Activation of guanylate cyclase leads to increased production of cyclic GMP.
4
Smooth muscle relaxation: Increased cyclic GMP causes relaxation of vascular smooth muscle.
5
Vasodilation: Relaxation of smooth muscle leads to dilation of veins and arteries.
6
Reduced cardiac workload: Vasodilation reduces preload and afterload, decreasing myocardial oxygen demand.

💡 How to Take isonit 30mg tablet sr

Strength: Isosorbide Mononitrate 30 mg immediate-release tablet.

1Take this medicine orally with a glass of water.
2Swallow the tablet whole; do not crush or chew.
3Take it at the same time each day to maintain consistent levels.
4Follow the prescribed dosing schedule to prevent tolerance.
5Do not stop taking this medicine suddenly without consulting your doctor.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 30 mg to 60 mg taken once daily. The dose may be increased to 120 mg once daily if needed. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. It is important to follow the prescribed dosing schedule to prevent tolerance.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine, especially dizziness and hypotension. Start with a lower dose and monitor closely.
Renal ImpairmentNo dose adjustment is required for mild to moderate renal impairment. Use with caution in severe renal impairment.
Hepatic ImpairmentNo dose adjustment is required for mild to moderate hepatic impairment. Use with caution in severe hepatic impairment.
Maximum Daily DoseThe maximum recommended daily dose is 120 mg.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With or without food
Can be taken with or without food
Food does not significantly affect absorption.
Grapefruit juice
Avoid
May increase drug levels and risk of side effects.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of isonit 30mg tablet sr

✅ Common Side Effects

Headache (Common (10-30%))
Usually resolves within a few days. If persistent or severe, consult your doctor.
Dizziness (Common (5-10%))
Rise slowly from sitting or lying positions. Avoid driving if affected.
Flushing (Common (5-10%))
Usually temporary. Consult doctor if bothersome.
Lightheadedness (Common (5-10%))
Avoid sudden changes in posture. Stay hydrated.

🚨 Serious Side Effects

Severe hypotension (Rare (<0.1%))
Seek immediate medical attention if you experience fainting, severe dizziness, or blurred vision.
Methemoglobinemia (Very rare (<0.01%))
Seek immediate medical attention if you experience bluish discoloration of lips, nails, or skin, shortness of breath, or confusion.
Syncope (Rare (<0.1%))
Lie down and elevate legs if feeling faint. Seek medical attention if it occurs.

⚠️ Rare Side Effects

Allergic reactions
Seek immediate medical attention if you experience rash, itching, swelling, or difficulty breathing.
Exfoliative dermatitis
Seek immediate medical attention if you experience peeling or blistering of the skin.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Sildenafil Major
Tadalafil Major
Vardenafil Major
Riociguat Major
Alcohol Moderate
Beta-blockers Moderate
Calcium channel blockers Moderate
Diuretics Moderate
NSAIDs Minor
Grapefruit juice Minor

🚨 Major Interactions

  • Phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)
  • Riociguat

⚡ Moderate Interactions

  • Alcohol
  • Antihypertensives (e.g., beta-blockers, calcium channel blockers)
  • Diuretics

🍷 Alcohol Interaction

Alcohol may enhance the blood pressure-lowering effect of this medicine, leading to dizziness, fainting, or severe hypotension. It is advisable to avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to Isosorbide Mononitrate or other nitrates","Severe hypotension","Concomitant use with phosphodiesterase-5 inhibitors","Concomitant use with riociguat","Increased intracranial pressure"]

⚠️ Warnings & Precautions

["Avoid abrupt discontinuation as it may precipitate angina.","Use with caution in patients with low blood pressure or heart failure.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Alcohol may enhance hypotensive effects.","Use with caution in patients with severe liver or kidney disease."]

🤱 Lactation Safety

Not established from the available information. Consult your doctor before breastfeeding.

💊 Overdose Management

Overdose may cause severe hypotension, headache, dizziness, and methemoglobinemia. Seek immediate medical attention. Treatment is supportive and symptomatic. If methemoglobinemia occurs, methylene blue may be used as an antidote.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not stop taking it suddenly, as this can worsen angina. Avoid alcohol while taking this medicine because it can increase the risk of low blood pressure. Rise slowly from sitting or lying positions to prevent dizziness. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not use this medicine if you are taking medicines for erectile dysfunction such as sildenafil, tadalafil, or vardenafil, as this can cause a dangerous drop in blood pressure. Keep this medicine out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Start with a lower dose and monitor blood pressure regularly. Use caution to prevent falls due to dizziness.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor. The safety of this medicine during pregnancy is not well established, and your doctor may consider alternative treatments.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and affect blood pressure during surgery. Your doctor may advise temporary discontinuation.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine. It may cause dizziness or low blood pressure during dental procedures. Your dentist may take precautions.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce the workload on your heart.
🥗
Engage in regular low-impact exercise as advised by your doctor.
😴
Avoid smoking and limit alcohol consumption.
💧
Eat a heart-healthy diet rich in fruits, vegetables, and whole grains.
🧘
Manage stress through relaxation techniques like deep breathing or meditation.
🌞
Get adequate sleep to support heart health.

🏋️ Exercise Considerations

Exercise is beneficial for heart health, but avoid strenuous activities that trigger angina. Consult your doctor before starting any new exercise program. If you experience chest pain during exercise, stop immediately and rest.

🥗 Diet Recommendations

Include omega-3 rich foods like fish and flaxseeds.
Reduce intake of processed and high-fat foods.
Limit salt to control blood pressure.
Stay well hydrated.
Avoid excessive caffeine.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or lightheadedness, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal activities with caution.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience severe side effects or your condition changes, your doctor may adjust or stop the medicine. Abrupt discontinuation can worsen angina.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to tolerance, where the medicine becomes less effective. To prevent this, doctors often prescribe a nitrate-free interval. Regular monitoring of blood pressure and angina symptoms is recommended. Long-term use is generally safe when taken as prescribed.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Diet, exercise, and stress management can complement medicine for heart health.

Evidence: Well-established
Other antianginal medicines

Beta-blockers or calcium channel blockers may be used as alternatives or in combination.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are known. However, consult your doctor before receiving any vaccine while on this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from light and moisture. If crossing time zones, consult your doctor about adjusting the dosing schedule. Keep enough supply for the entire trip and carry it in your hand luggage. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 58-year-old man with a history of coronary artery disease
He was prescribed this medicine to prevent angina attacks. Initially, he experienced mild headaches, but they subsided after a week. He found that taking the medicine at the same time every morning helped him remember and reduced the frequency of his chest pain.
💡 Lesson: Consistent daily dosing and patience with initial side effects can lead to better outcomes.
👤 A 65-year-old woman with chronic stable angina
She was hesitant to take a daily medicine but started after her doctor explained it could prevent chest pain. She learned to avoid alcohol and to stand up slowly to prevent dizziness. She has had fewer angina episodes since starting the medicine.
💡 Lesson: Understanding the purpose of preventive medicine and following safety advice improves adherence and quality of life.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine starts working within 30 to 60 minutes after taking a dose, but its full preventive effect develops with regular use.

Q: Can I take this medicine if I have diabetes?

A: Yes, but inform your doctor about all your medicines. Your doctor will monitor your condition.

Q: Is it safe to take this medicine during pregnancy?

A: Consult your doctor. The safety of this medicine during pregnancy is not well established, so it should be used only if clearly needed.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for isonit 30mg tablet sr

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken to relieve an acute angina attack.
    Fact: This medicine is for prevention, not for immediate relief of an ongoing angina attack.
  • Myth: You can stop this medicine suddenly if you feel better.
    Fact: Abrupt discontinuation can worsen angina. Always consult your doctor before stopping.
  • Myth: It is safe to take this medicine with erectile dysfunction drugs.
    Fact: Combining with erectile dysfunction drugs can cause a dangerous drop in blood pressure and is contraindicated.

🔄 Alternative Options

Generic Alternatives

  • Isosorbide Mononitrate 30 mg tablet

Brand Alternatives

  • Imdur 30mg tablet PR

📊 Comparison with Similar Medicines

[{"medicine":"Isosorbide Mononitrate","class":"Nitrate","half_life":"5 hours","bioavailability":"100%"},{"medicine":"Isosorbide Dinitrate","class":"Nitrate","half_life":"1 hour","bioavailability":"20-25%"}]

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