Ismo 10 Tablet: Complete Guide to Uses, Dosage, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe chest pain that does not go away with rest or usual medication
- Fainting or loss of consciousness
- Severe dizziness or lightheadedness
- Bluish discoloration of lips, nails, or skin
- Difficulty breathing or shortness of breath
- Swelling of face, lips, tongue, or throat
- Irregular or very fast heartbeat
If experiencing severe symptoms, call emergency services immediately.
What is isonit 10mg tablet used for?
This medicine is a nitrate used to prevent chest pain (angina) in people with heart conditions. It works by relaxing blood vessels to improve blood flow to the heart. It is not for immediate relief of an ongoing angina attack.
- Generic Name: Isosorbide Mononitrate (10mg)
- Manufacturer: Johnlee Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 isonit 10mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एंजाइना (सीने में दर्द) को रोकने के लिए इस्तेमाल की जाती है। यह रक्त वाहिकाओं को फैलाकर हृदय तक रक्त का प्रवाह बढ़ाती है और हृदय पर दबाव कम करती है। यह दवा तीव्र एंजाइना के दौरे के इलाज के लिए नहीं है, बल्कि इससे बचाव के लिए है। इसे डॉक्टर के निर्देशानुसार नियमित रूप से लें।
साइड इफेक्ट्स: इस दवा के सबसे आम दुष्प्रभावों में सिरदर्द, चक्कर आना, चेहरे पर लालिमा और धड़कन तेज होना शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर आपको बेहोशी, गंभीर सिरदर्द, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे अचानक बंद न करें। शराब का सेवन न करें क्योंकि इससे रक्तचाप कम हो सकता है और चक्कर आ सकते हैं। अगर आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर को बताएं। इरेक्टाइल डिसफंक्शन की दवाओं के साथ इसका सेवन न करें। इसे बच्चों की पहुंच से दूर रखें।
💊 isonit 10mg tablet Uses & Benefits
- [{"condition":"Prevention of angina pectoris","description":"This medicine is used to prevent chest pain (angina) in patients with coronary artery disease.
- It helps reduce the frequency and severity of angina attacks.","evidence":"Well-established"},{"condition":"Heart failure","description":"This medicine may be used as part of combination therapy in patients with heart failure to reduce symptoms and improve exercise tolerance.","evidence":"Established"},{"condition":"Post-myocardial infarction","description":"This medicine may be prescribed after a heart attack to help prevent future angina episodes and improve blood flow to the heart.","evidence":"Established"}]
Off-label uses: [{"condition":"Esophageal spasm","description":"Sometimes used off-label to relieve chest pain caused by esophageal spasm.","evidence":"Limited"},{"condition":"Raynaud's phenomenon","description":"May be used off-label to improve blood flow in fingers and toes in Raynaud's phenomenon.","evidence":"Limited"}]
Primary treatment for: Angina pectoris
Also treats: Heart failure, Coronary artery disease, Post-myocardial infarction
📋 Drug Information
| Generic Name(s) | Isosorbide Mononitrate (10mg) |
| Brand Name | isonit 10mg tablet |
| Manufacturer | Johnlee Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | NO Donors |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by releasing nitric oxide in the smooth muscle cells of blood vessels. Nitric oxide activates an enzyme called guanylate cyclase, which increases the production of cyclic guanosine monophosphate (cGMP). This leads to relaxation of vascular smooth muscle, causing blood vessels to widen (vasodilation). As a result, blood flow to the heart improves, and the workload on the heart decreases, which helps prevent angina.
Mechanism Steps
💡 How to Take isonit 10mg tablet
Strength: Isosorbide Mononitrate 10 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 10 mg to 20 mg taken orally twice daily, or as directed by your doctor. The dose may be increased gradually based on your response and tolerance. To prevent tolerance, a nitrate-free interval of 10 to 12 hours is often recommended, which may mean taking the first dose in the morning and the second dose in the early afternoon. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially hypotension and dizziness. Start with a lower dose and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No specific dose adjustment is recommended for patients with renal impairment. However, use with caution in severe renal impairment. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | No specific dose adjustment is recommended for patients with hepatic impairment. However, use with caution in severe hepatic impairment. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is 40 mg, but this may vary based on clinical judgment. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of isonit 10mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Sildenafil | Major | |
| Tadalafil | Major | |
| Riociguat | Major | |
| Alcohol | Moderate | |
| Beta-blockers | Moderate | |
| Calcium channel blockers | Moderate | |
| Ergotamine | Moderate | |
| NSAIDs | Minor |
🚨 Major Interactions
- Phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)
- Riociguat
⚡ Moderate Interactions
- Alcohol
- Antihypertensive drugs (e.g., beta-blockers, calcium channel blockers, ACE inhibitors)
- Ergot alkaloids (e.g., ergotamine)
🍷 Alcohol Interaction
Alcohol may increase the blood pressure-lowering effect of this medicine, leading to dizziness, lightheadedness, and fainting. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to isosorbide mononitrate or other nitrates","Severe hypotension (systolic blood pressure
⚠️ Warnings & Precautions
["This medicine may cause severe hypotension, especially when standing up quickly. Rise slowly.","Avoid alcohol while taking this medicine as it can increase the risk of low blood pressure.","Do not use this medicine to treat an acute attack of angina. It is for prevention only.","Tolerance to the effects of this medicine can develop with continuous use. A nitrate-free interval of 10-12 hours is often recommended.","Use with caution in patients with glaucoma or increased intraocular pressure.","Use with caution in patients with severe liver or kidney disease.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe hypotension, headache, dizziness, palpitations, and fainting. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic. If hypotension occurs, place the patient in a supine position with legs elevated. Intravenous fluids and vasopressors may be needed in severe cases.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without consulting your doctor. This medicine can cause dizziness or lightheadedness, especially when you stand up quickly. Rise slowly from a sitting or lying position. Avoid alcohol while taking this medicine, as it can increase the risk of low blood pressure and dizziness. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not take this medicine if you are using medicines for erectile dysfunction such as sildenafil, tadalafil, or vardenafil, as this can cause a dangerous drop in blood pressure. Keep this medicine out of reach of children. Store it at room temperature, away from moisture and direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Start with a lower dose and monitor blood pressure closely. Rise slowly to avoid falls due to dizziness.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this medicine during pregnancy is not well established. Your doctor will weigh the benefits and risks.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may interact with anesthetic agents and affect blood pressure during surgery. Your doctor may advise you to stop it temporarily.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may cause dizziness or low blood pressure during the procedure. Your dentist may take precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause dizziness or lightheadedness, especially when you start treatment or change doses. Avoid strenuous exercise or heavy lifting until you know how this medicine affects you. Consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or lightheadedness, which can affect your ability to drive or operate machinery. Avoid driving or operating heavy machinery until you know how this medicine affects you. It is generally safe to continue your daily activities, but take precautions when standing up quickly.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your condition changes, your doctor may adjust or stop the medicine. Always seek medical advice before discontinuation.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to tolerance, where the medicine becomes less effective. To prevent this, a nitrate-free interval of 10-12 hours is recommended. Regular monitoring of blood pressure and heart rate is advised. Long-term use is generally safe when taken as prescribed, but periodic evaluation by your doctor is necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Heart-healthy diet, regular exercise, smoking cessation, and stress management can complement medicine for angina.
Evidence: Well-establishedAnother class of medicines used to prevent angina by reducing heart rate and workload.
Evidence: Well-establishedUsed to prevent angina by relaxing blood vessels and reducing heart workload.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from moisture. If crossing time zones, consult your doctor about adjusting the dosing schedule. Carry enough supply for the entire trip. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 30 to 60 minutes after taking a dose. However, its full benefits in preventing angina may take a few days to become noticeable.
A: This medicine can lower blood pressure further. It is contraindicated in severe hypotension. Consult your doctor if you have low blood pressure.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: No, do not stop taking this medicine without consulting your doctor. Sudden discontinuation may worsen angina or cause withdrawal symptoms.
🤔 Common Patient Concerns
🔄 Substitutes for isonit 10mg tablet
View AllAlternative brands with exact same active ingredient:
-
angitrate 10mg tabletTOSC International Pvt Ltd ₹9.75 48% CHEAPER
-
vasotrate 10mg tabletTorrent Pharmaceuticals Ltd ₹9.86 47.4% CHEAPER
-
monopark 10mg tabletPfizer Ltd ₹10.70 42.9% CHEAPER
-
angitab 10mg tabletAbbott ₹11.70 37.6% CHEAPER
-
isbid 10mg tabletParenteral Drugs India Ltd ₹11.70 37.6% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken to relieve an acute angina attack.
Fact: This medicine is for prevention of angina, not for immediate relief of an ongoing attack. For acute attacks, fast-acting nitrates like sublingual nitroglycerin are used. - Myth: This medicine can be taken with erectile dysfunction drugs.
Fact: Combining this medicine with erectile dysfunction drugs like sildenafil can cause a dangerous drop in blood pressure and is contraindicated. - Myth: Once you feel better, you can stop taking this medicine.
Fact: Do not stop taking this medicine without consulting your doctor. Sudden discontinuation may worsen angina.
🔄 Alternative Options
Generic Alternatives
- Isosorbide Mononitrate 10 mg tablet (various manufacturers)
Brand Alternatives
- Ismo 10 Tablet