Appavisc Injection: Comprehensive Medicine Profile
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe eye pain that does not improve with prescribed pain relief.
- Sudden loss of vision or a significant decrease in vision.
- Increasing redness, swelling, or discharge from the eye.
- Flashes of light, floaters, or a curtain-like shadow in the vision.
- Nausea or vomiting accompanied by eye pain.
- Signs of an allergic reaction such as rash, itching, or difficulty breathing.
If experiencing severe symptoms, call emergency services immediately.
What is intavisc injection used for?
This medicine is a sterile ophthalmic viscosurgical device containing 2% w/v hydroxypropylmethylcellulose. It is used during eye surgery to maintain the anterior chamber, protect delicate tissues, and facilitate surgical maneuvers. It is administered only by an ophthalmic surgeon.
- Generic Name: Hydroxypropylmethylcellulose (2% w/v)
- Manufacturer: Intas Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 intavisc injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक विशेष नेत्र शल्य चिकित्सा सहायक है जिसका उपयोग आंखों की सर्जरी के दौरान किया जाता है। इसमें हाइड्रॉक्सीप्रोपाइलमिथाइलसेलुलोज़ (2% w/v) होता है। यह आंख के अंदर की जगह को बनाए रखने, नाजुक ऊतकों की रक्षा करने और सर्जन को सर्जरी करने में मदद करता है। यह केवल नेत्र सर्जन द्वारा ही दिया जाता है, मरीज इसे खुद नहीं लगा सकते।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में आंखों में दबाव बढ़ना, हल्की सूजन और लालिमा शामिल हो सकते हैं, जो आमतौर पर कुछ दिनों में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें आंखों में गंभीर संक्रमण, रेटिना डिटैचमेंट या एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि सर्जरी के बाद तेज दर्द, दृष्टि में कमी या असामान्य लालिमा हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल अस्पताल में योग्य नेत्र सर्जन द्वारा ही दी जाती है। मरीज को सर्जरी से पहले अपनी सभी एलर्जी और दवाओं के बारे में डॉक्टर को बताना चाहिए। सर्जरी के बाद डॉक्टर के बताए अनुसार आई ड्रॉप्स का उपयोग करें और फॉलो-अप अपॉइंटमेंट पर जरूर जाएं। आंखों को रगड़ें नहीं और पानी से बचाएं। यदि कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से मिलें।
💊 intavisc injection Uses & Benefits
[{"condition":"Cataract surgery","description":"Used to maintain the anterior chamber and protect the corneal endothelium during phacoemulsification and intraocular lens implantation.","evidence":"Well-established"},{"condition":"Corneal transplantation","description":"Helps maintain the anterior chamber and protect delicate tissues during penetrating keratoplasty.","evidence":"Well-established"},{"condition":"Glaucoma surgery","description":"Used as a viscoelastic agent to maintain space and control intraocular pressure during trabeculectomy and other glaucoma procedures.","evidence":"Well-established"},{"condition":"Intraocular foreign body removal","description":"Assists in maintaining a clear surgical field and protecting intraocular structures during removal of foreign bodies.","evidence":"Limited"}]
Off-label uses: [{"condition":"Vitreoretinal surgery","description":"Sometimes used off-label as a tamponade agent or to assist in membrane peeling, though its role is not fully established.","evidence":"Limited"}]
Primary treatment for: Not applicable. This medicine is a surgical aid, not a treatment for a specific disease.
📋 Drug Information
| Generic Name(s) | Hydroxypropylmethylcellulose (2% w/v) |
| Brand Name | intavisc injection |
| Manufacturer | Intas Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | OPHTHAL |
| Action Class | Tear substitues |
| Route of Administration | Parenteral (intraocular injection) |
| Storage | Store at room temperature (15-30°C). Protect from light. Do not freeze. Keep in the original packaging until use. |
| Shelf Life | Refer to the product label for the expiration date. Typically 2-3 years from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by physically occupying space and coating intraocular tissues. Hydroxypropylmethylcellulose is a high molecular weight polymer that forms a viscous, transparent solution. When injected into the eye, it creates a cohesive gel that maintains the anterior chamber depth, separates tissues, and provides a protective layer over the corneal endothelium. Its viscoelastic properties allow it to absorb mechanical energy during surgical manipulation, reducing trauma to delicate structures. The polymer is not metabolized and is eventually cleared from the eye through the trabecular meshwork and other outflow pathways.
Mechanism Steps
💡 How to Take intavisc injection
Strength: 2% w/v sterile ophthalmic injection
Dosage Information
| Adult Dosage | The dose of this medicine is determined by the ophthalmic surgeon based on the specific surgical procedure and the amount needed to maintain the anterior chamber. It is injected as needed during surgery. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric ophthalmologist. |
| Elderly Dosage | No specific dose adjustments are required for elderly patients. The dose is determined by the surgeon based on the surgical needs. |
| Renal Impairment | No dose adjustment is required as this medicine is not systemically absorbed. |
| Hepatic Impairment | No dose adjustment is required as this medicine is not systemically absorbed. |
| Maximum Daily Dose | Not applicable. This medicine is used as a single administration during surgery. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of intavisc injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to hydroxypropylmethylcellulose or any component of the formulation.","Active intraocular infection or inflammation.","Any condition where the use of viscoelastic agents is not advisable, as determined by the surgeon."]
⚠️ Warnings & Precautions
["For single use only. Discard any unused portion.","Do not use if the solution is cloudy or contains particles.","Use with caution in patients with a history of allergic reactions to cellulose derivatives.","The product should be administered only by a qualified ophthalmic surgeon.","Postoperative monitoring for intraocular pressure is recommended.","The safety and effectiveness in pediatric patients have not been fully established."]
🤱 Lactation Safety
Not established from the available information. It is unknown whether hydroxypropylmethylcellulose is excreted in breast milk. Since it is administered locally during surgery, systemic exposure is minimal. Consult your surgeon if you are breastfeeding.
💊 Overdose Management
Overdose is unlikely as this medicine is administered by a surgeon in a controlled dose. If excessive amounts are used, the surgeon will remove the excess during the procedure. Any remaining material is gradually cleared. No specific antidote is required.
⏰ Missed Dose
Not applicable. This medicine is administered as a single dose during surgery by a healthcare professional.
Additional Safety Advice
This medicine is for professional use only and must be administered by a qualified ophthalmic surgeon in a sterile surgical setting. Patients should inform their surgeon of any allergies, especially to cellulose derivatives, before the procedure. After surgery, patients should follow all postoperative instructions carefully, including using any prescribed eye drops and attending follow-up appointments. Patients should not rub their eyes or touch the surgical area. If they experience severe pain, vision loss, or unusual redness after surgery, they should contact their surgeon immediately. This medicine should not be used if the packaging is damaged or if the solution appears cloudy or contains particles. It is for single use only; any unused portion should be discarded. The product should be stored as directed on the label, typically at room temperature, and protected from light. Pregnant or breastfeeding women should discuss the risks and benefits with their surgeon before undergoing surgery that involves this product. The safety and effectiveness of this medicine in children have not been fully established, but it may be used in pediatric ophthalmic surgery at the surgeon's discretion.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more prone to postoperative increases in intraocular pressure. Close monitoring is recommended. The dose is not adjusted based on age, but the surgeon will consider overall health status.
🤰 Pregnancy Planning (TTC)
If you are pregnant or planning to become pregnant, inform your surgeon before surgery. The safety of this medicine during pregnancy has not been fully established. The surgeon will weigh the benefits and risks.
🏥 Post-Surgery Considerations
After surgery, follow all postoperative instructions carefully. Use prescribed eye drops, avoid rubbing your eyes, and attend follow-up appointments. Report any unusual symptoms such as severe pain, vision loss, or increased redness immediately.
🦷 Dental Procedures
Inform your dentist if you have recently had eye surgery. There is no direct interaction, but your dentist may need to know about your overall health status. Avoid dental procedures that could increase pressure in the eye until your surgeon approves.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise, bending, or heavy lifting for at least one week after eye surgery. Your surgeon will advise you on when you can resume normal activities. Gentle walking is usually allowed, but avoid activities that increase intraocular pressure.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
After eye surgery with this medicine, you may need to take a few days off work to recover. Your vision may be blurry initially, and you should not drive until your surgeon says it is safe. Avoid operating heavy machinery or performing tasks that require clear vision until your eye has healed. Most people can return to desk work within a few days, but physical jobs may require longer recovery.
🛑 When to Stop This Medicine
This medicine is given as a single dose during surgery, so there is no ongoing use to stop. If you experience any severe side effects after surgery, contact your surgeon immediately. Do not stop any prescribed postoperative medications without consulting your doctor.
📅 Long-Term Use Effects
Long-term effects of this medicine are generally minimal because it is cleared from the eye after surgery. However, in rare cases, residual material may cause prolonged inflammation or increased intraocular pressure. Long-term monitoring of intraocular pressure and corneal health is recommended after any eye surgery. There is no evidence of systemic long-term effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another type of ophthalmic viscosurgical device that can be used for similar purposes.
Evidence: Well-establishedA combination viscoelastic agent used in some eye surgeries.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interactions with vaccines. However, if you are scheduled for surgery, inform your surgeon about any recent vaccinations. There is no need to delay vaccination due to this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not freeze
✅ DO
Keep in the original packaging until use
❌ DON'T
Do not use if the packaging is damaged
✅ DO
Protect from light
❌ DON'T
Do not store in direct sunlight
✈️ Traveling with This Medicine
This medicine is administered by a healthcare professional during surgery, so travel advice is not applicable for patients. If you are traveling after eye surgery, carry a copy of your surgical report and prescription. Protect your eye from injury and follow your surgeon's instructions regarding activity restrictions. Avoid air travel if advised by your surgeon, especially if you have had certain types of eye surgery. Keep all postoperative eye drops in your carry-on luggage and bring enough for your trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine works immediately upon injection during surgery to maintain the eye's internal space and protect tissues.
A: The injection is given during surgery, so you will not feel it. Your eye will be numbed with anesthesia.
A: No, this medicine is for professional use only and must be administered by an ophthalmic surgeon.
A: Watch for severe eye pain, vision loss, increasing redness, or discharge. Contact your surgeon immediately if these occur.
🤔 Common Patient Concerns
🔄 Substitutes for intavisc injection
View AllAlternative brands with exact same active ingredient:
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appavisc injectionAppasamy Ocular Device Pvt Ltd ₹46.88 34.3% CHEAPER
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intavisc v injectionIntas Pharmaceuticals Ltd ₹51.97 27.2% CHEAPER
-
melose injectionOptho Pharma Pvt Ltd ₹60.00 16% CHEAPER
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hyprosol injectionSunways India Pvt Ltd ₹62.10 13% CHEAPER
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hymelose intra ocular ophthalmic solutionKlar Sehen Pvt Ltd ₹62.25 12.8% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is an eye drop that patients can use at home.
Fact: This medicine is an injectable surgical aid that must be administered by an ophthalmic surgeon during a procedure. - Myth: This medicine treats eye infections.
Fact: This medicine does not treat infections; it is used to maintain space and protect tissues during eye surgery.
🔄 Alternative Options
Generic Alternatives
- Hydroxypropylmethylcellulose 2% w/v ophthalmic injection