intaprost t eye drop - Bimatoprost (0.3mg/ml) + Timolol (5mg/ml) medicine

Ganfort Eye Drop: Comprehensive Guide to Uses, Side Effects, and Safety

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🏭 Intas Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 26, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for the combination in open-angle glaucoma and ocular hypertension.
Reviewed by
SaathiMed Expert Panel | Sep 26, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Sudden decrease in vision
  • Severe eye pain or redness
  • Difficulty breathing or wheezing
  • Unusually slow heartbeat or fainting
  • Swelling of face, lips, or throat
  • Severe headache with nausea
  • Eye discharge or signs of infection

If experiencing severe symptoms, call emergency services immediately.

What is intaprost t eye drop used for?

This medicine is a combination eye drop containing bimatoprost and timolol. It is used to lower high pressure inside the eye in adults with open-angle glaucoma or ocular hypertension. It works by increasing fluid drainage and decreasing fluid production in the eye. Use one drop in the affected eye(s) once daily in the evening, as prescribed by your eye doctor.

  • Generic Name: Bimatoprost (0.3mg/ml) + Timolol (5mg/ml)
  • Manufacturer: Intas Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 intaprost t eye drop के बारे में (Hindi Summary)

उपयोग: यह दवा आंखों की एक विशेष ड्रॉप है जिसका उपयोग ग्लूकोमा (काला मोतिया) और आंखों के उच्च दबाव (ऑकुलर हाइपरटेंशन) के इलाज के लिए किया जाता है। यह आंखों के अंदर के तरल पदार्थ के बहाव को बढ़ाकर और उसके उत्पादन को कम करके आंखों के दबाव को कम करती है। इसे आमतौर पर शाम को दिन में एक बार आंख में डाला जाता है। यह दवा डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में आंखों का लाल होना, खुजली, जलन, धुंधली दृष्टि, पलकों का बढ़ना और पलकों की त्वचा का काला पड़ना शामिल हैं। कुछ लोगों में आंख की पुतली का रंग बदल सकता है, जो स्थायी हो सकता है। दुर्लभ मामलों में सांस लेने में कठिनाई, धड़कन का धीमा होना, या गंभीर एलर्जी हो सकती है। अगर आपको कोई भी गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा का उपयोग करने से पहले अपने हाथ धो लें। आंख में डालने के बाद आंख के भीतरी कोने को 1-2 मिनट तक दबाए रखें ताकि दवा शरीर में कम अवशोषित हो। ड्रॉपर की नोक को आंख या किसी सतह से न छुएं। यदि आप कॉन्टैक्ट लेंस पहनते हैं, तो दवा डालने से पहले उन्हें निकाल लें और 15 मिनट बाद ही वापस लगाएं। इस दवा को बच्चों और अन्य लोगों से दूर रखें। अपने डॉक्टर से नियमित जांच कराते रहें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 intaprost t eye drop Uses & Benefits

[{"condition":"Open-angle glaucoma","description":"This medicine is used to lower elevated intraocular pressure in patients with open-angle glaucoma when a single agent does not provide sufficient control.","evidence":"Well-established"},{"condition":"Ocular hypertension","description":"It is indicated for the reduction of intraocular pressure in patients with ocular hypertension who require combination therapy.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Angle-closure glaucoma","description":"Sometimes used off-label after laser iridotomy or in combination with other treatments, but not a standard first-line option.","evidence":"Limited"},{"condition":"Pediatric glaucoma","description":"Rarely used off-label in children under close specialist supervision; safety and efficacy are not well established.","evidence":"Limited"}]

Primary treatment for: Open-angle glaucoma

Also treats: Ocular hypertension

📋 Drug Information

Generic Name(s)Bimatoprost (0.3mg/ml) + Timolol (5mg/ml)
Brand Nameintaprost t eye drop
ManufacturerIntas Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassOPHTHAL
Action Class
Route of AdministrationOphthalmic
StorageStore at 2°C to 8°C (36°F to 46°F) before opening. After opening, store at room temperature (15°C to 25°C) for up to 4 weeks. Protect from light and keep the bottle tightly closed when not in use.
Shelf Life24 months from the date of manufacture. Discard 4 weeks after opening.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Instruct patients to press the nasolacrimal duct for 1–2 minutes after instillation to minimise systemic absorption.
2
Advise patients to remove contact lenses before use and wait 15 minutes before reinsertion.
3
Warn patients about potential permanent iris colour change and eyelash growth.
4
Monitor heart rate and blood pressure in patients with cardiovascular disease.
5
Avoid concomitant use with oral beta-blockers unless benefits outweigh risks.
6
Educate patients on proper drop technique to avoid contamination.
7
Schedule regular follow-up to monitor intraocular pressure and visual fields.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Elevated intraocular pressure
This medicine is commonly prescribed for this.
Likely Use
❌
Red eye
This medicine may cause red eye as a side effect, but it is not used to treat red eye.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionAfter topical ocular administration, bimatoprost and timolol are absorbed through the cornea and conjunctiva into the aqueous humour. Systemic absorption occurs via the nasolacrimal duct and can lead to measurable plasma concentrations, although these are generally low.
DistributionBoth drugs distribute into ocular tissues. Timolol is widely distributed in the body and can cross the blood-brain barrier and placenta. Bimatoprost is highly protein-bound in plasma.
Protein BindingBimatoprost is approximately 88% bound to plasma proteins. Timolol is minimally bound to plasma proteins (less than 10%).
MetabolismBimatoprost undergoes oxidation, N-deethylation, and glucuronidation in the liver. Timolol is extensively metabolised in the liver, primarily by CYP2D6, to inactive metabolites.
Half-LifeThe elimination half-life of bimatoprost is approximately 45 minutes after intravenous administration, but ocular effects last much longer. Timolol has a plasma half-life of about 2.5 to 4 hours.
ExcretionBimatoprost metabolites are excreted mainly in the urine. Timolol and its metabolites are excreted primarily in the urine.
BioavailabilitySystemic bioavailability of timolol after ocular administration is approximately 60% compared to oral dosing. Bimatoprost systemic bioavailability is not well established from available information.
Onset of ActionThe intraocular pressure-lowering effect begins within 2 hours after instillation, but the maximum effect may take several hours to develop.
Peak Plasma TimePeak plasma concentrations of timolol occur about 1 to 2 hours after ocular administration. Bimatoprost peak plasma time is not well established.
Duration of ActionThe intraocular pressure reduction lasts for at least 24 hours, allowing once-daily dosing.

How It Works

This medicine lowers intraocular pressure by two complementary mechanisms. Bimatoprost, a prostamide analogue, increases the outflow of aqueous humour through the trabecular meshwork and uveoscleral pathways. Timolol, a non-selective beta-adrenergic receptor blocker, reduces the production of aqueous humour by the ciliary epithelium. The combined effect is a greater reduction in intraocular pressure than either agent alone.

Mechanism Steps

1
Bimatoprost increases aqueous outflow: Bimatoprost binds to FP prostaglandin receptors in the ciliary muscle and trabecular meshwork, remodelling the extracellular matrix and enhancing both uveoscleral and trabecular outflow of aqueous humour.
2
Timolol reduces aqueous production: Timolol blocks beta-adrenergic receptors on the ciliary epithelium, decreasing cyclic AMP production and thereby reducing the secretion of aqueous humour into the anterior chamber.
3
Combined IOP reduction: The simultaneous increase in outflow and decrease in inflow of aqueous humour leads to a greater and more sustained reduction in intraocular pressure than either agent alone.

💡 How to Take intaprost t eye drop

Strength: Ophthalmic solution containing bimatoprost 0.3 mg/mL and timolol 5 mg/mL.

1Wash your hands thoroughly with soap and water.
2Shake the bottle gently before use.
3Tilt your head back and pull down your lower eyelid to form a small pocket.
4Look up and gently squeeze one drop into the pocket.
5Close your eye and press the inner corner near your nose for 1–2 minutes.
6Wipe away any excess liquid with a clean tissue.
7Replace the cap tightly and wash your hands again.

Dosage Information

Adult DosageThe usual adult dose is one drop in the affected eye(s) once daily in the evening. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed one drop per day in each eye, as more frequent dosing may reduce the intraocular pressure-lowering effect. If you are using other eye drops, wait at least 5 minutes between instillations.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageNo specific dose adjustment is required for elderly patients, but they should be monitored for systemic side effects such as bradycardia and hypotension.
Renal ImpairmentNo specific dose adjustment is recommended for renal impairment, but use with caution in severe renal impairment.
Hepatic ImpairmentNo specific dose adjustment is recommended for hepatic impairment, but use with caution in severe hepatic impairment.
Maximum Daily DoseOne drop in each affected eye once daily.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

⏰ What to Do If You Miss a Dose

📌 Less than 12 hours have passed since the missed dose
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than 12 hours have passed since the missed dose
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of intaprost t eye drop

✅ Common Side Effects

Conjunctival redness (Very common (>10%))
This usually lessens over time. If it persists or becomes severe, consult your eye doctor.
Eye itching (Common (5-10%))
Try not to rub your eyes. If itching is bothersome, speak to your doctor.
Increased eyelash growth (Common (5-10%))
This is a known effect and may be cosmetic. It reverses slowly after stopping the medicine.
Darkening of eyelid skin (Common (5-10%))
This may be permanent. Discuss with your doctor if concerned.
Blurred vision (Common (5-10%))
Wait until vision clears before driving or operating machinery. If persistent, consult your doctor.

🚨 Serious Side Effects

Bronchospasm (Rare (<0.1%))
Seek immediate medical attention if you experience difficulty breathing, wheezing, or chest tightness.
Heart block (Rare (<0.1%))
Go to the emergency room if you feel faint, dizzy, or have an unusually slow heartbeat.
Severe allergic reaction (Rare (<0.1%))
Call emergency services if you notice swelling of the face, lips, or throat, or difficulty breathing.

⚠️ Rare Side Effects

Iris colour change
This change may be permanent. Inform your doctor if you notice your eye colour changing.
Macular edema
Report any sudden decrease in vision to your ophthalmologist immediately.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Propranolol Major
Verapamil Major
Digoxin Major
Fluoxetine Moderate
Reserpine Moderate

🚨 Major Interactions

  • Oral beta-blockers (e.g., propranolol, metoprolol)
  • Calcium channel blockers (e.g., verapamil, diltiazem)
  • Digitalis glycosides (e.g., digoxin)

⚡ Moderate Interactions

  • CYP2D6 inhibitors (e.g., quinidine, fluoxetine, paroxetine)
  • Adrenergic psychotropic drugs (e.g., reserpine)

🍷 Alcohol Interaction

Alcohol may enhance the blood pressure-lowering effect of timolol and increase dizziness. It is advisable to limit alcohol consumption while using this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to bimatoprost, timolol, or any component of the formulation","Bronchial asthma or a history of bronchial asthma","Severe chronic obstructive pulmonary disease (COPD)","Sinus bradycardia, sick sinus syndrome, sinoatrial block, second- or third-degree atrioventricular block not controlled with a pacemaker","Overt cardiac failure","Cardiogenic shock"]

⚠️ Warnings & Precautions

["This medicine may cause changes to the iris colour, eyelid skin, and eyelashes; these changes may be permanent.","Systemic absorption of timolol can cause bradycardia, hypotension, and bronchospasm; monitor patients with cardiovascular or respiratory disease.","Remove contact lenses before use and wait 15 minutes before reinsertion.","Do not touch the dropper tip to any surface to avoid contamination.","If you have a history of angle-closure glaucoma, use with caution and only after appropriate treatment.","Patients with diabetes may experience masking of hypoglycemia symptoms due to timolol.","Use with caution in patients with myasthenia gravis or other neuromuscular disorders."]

🤱 Lactation Safety

Timolol is excreted in human breast milk. Bimatoprost excretion in breast milk is not known. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother.

💊 Overdose Management

Overdose with this medicine is unlikely due to its topical route. If accidental ingestion occurs, seek immediate medical attention. Symptoms of timolol overdose may include bradycardia, hypotension, bronchospasm, and heart failure. Treatment is supportive and symptomatic. Contact a poison control centre if needed.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Use this medicine only in the affected eye(s) and exactly as prescribed by your ophthalmologist. Wash your hands before and after instilling the drops. To reduce systemic absorption, gently press the inner corner of your eye (near the nose) for 1–2 minutes after putting in the drop. This simple step can minimise side effects like slow heart rate and low blood pressure. Do not touch the dropper tip to your eye or any surface, as this can contaminate the solution. If you wear contact lenses, remove them before using this medicine and wait at least 15 minutes before reinserting them, because the preservative may be absorbed by soft lenses. Do not use this medicine if you have asthma, severe COPD, or certain heart conditions unless your doctor has specifically approved it. Inform all your healthcare providers, including your dentist and pharmacist, that you are using this medicine. Keep all follow-up appointments to monitor your eye pressure and check for side effects. Never share your eye drops with anyone else.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more susceptible to systemic side effects such as bradycardia and hypotension. Monitor heart rate and blood pressure regularly. No specific dose adjustment is required, but caution is advised.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before continuing this medicine. Alternative treatments may be considered. Use effective contraception if advised.

🏥 Post-Surgery Considerations

If you are undergoing eye surgery, inform your surgeon that you are using this medicine. It may need to be temporarily stopped before surgery. Follow your surgeon's instructions.

🦷 Dental Procedures

Inform your dentist that you are using this medicine, as it may interact with certain medications used during dental procedures. No specific precautions are usually needed, but your dentist may want to monitor your heart rate.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce overall health risks.
🥗
Engage in regular, moderate exercise as approved by your doctor.
😴
Avoid rubbing your eyes to prevent irritation.
💧
Follow a balanced diet rich in fruits and vegetables.
🧘
Get adequate sleep to support eye health.
🌞
Manage stress through relaxation techniques.

🏋️ Exercise Considerations

Exercise is generally safe while using this medicine. However, if you experience dizziness or blurred vision after instilling the drops, avoid strenuous activities until your vision is clear. Consult your doctor before starting any new exercise regimen.

🥗 Diet Recommendations

Include foods rich in omega-3 fatty acids, such as fish and flaxseed.
Eat plenty of leafy green vegetables.
Stay well hydrated.
Limit caffeine and alcohol as they may affect eye pressure.

💼 Impact on Daily Work & Life

This medicine may cause temporary blurred vision after instillation. Wait until your vision is clear before driving or operating heavy machinery. Otherwise, it should not significantly impact your daily work or lifestyle.

🛑 When to Stop This Medicine

Do not stop using this medicine without consulting your eye doctor. Stopping suddenly can lead to a rapid increase in eye pressure and potential vision loss. If you experience severe side effects, contact your doctor immediately for alternative treatment options.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to increased pigmentation of the iris, eyelid skin, and eyelashes. These changes may be permanent. Regular monitoring of intraocular pressure and visual fields is necessary to ensure adequate control of glaucoma. Systemic effects such as bradycardia and hypotension may also occur with prolonged use.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Laser trabeculoplasty

A laser procedure that can improve aqueous outflow and lower eye pressure.

Evidence: Well-established
Surgical trabeculectomy

A surgical procedure to create a new drainage pathway for aqueous humour.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific interactions between this medicine and vaccines have been reported. Continue with your regular vaccination schedule as advised by your doctor.

📦 Storage Guide

✅ DO

Store in the refrigerator (2°C to 8°C) before opening.

❌ DON'T

Do not freeze.

✅ DO

After opening, store at room temperature (15°C to 25°C) for up to 4 weeks.

❌ DON'T

Do not use after 4 weeks of opening.

✅ DO

Keep the bottle tightly closed when not in use.

❌ DON'T

Do not touch the dropper tip to any surface.

✈️ Traveling with This Medicine

Carry this medicine in your hand luggage with the original prescription label. Keep it in a cool, dry place, and use an insulated pouch if travelling to hot climates. If crossing time zones, continue with your usual evening dose schedule; consult your doctor if unsure. Declare the medicine at customs if required. Always carry enough supply for your entire trip.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 62-year-old man with open-angle glaucoma
He was prescribed this medicine after his eye pressure remained high on a single agent. Within a few weeks, his intraocular pressure dropped significantly. He initially experienced red eyes, which lessened over time. He learned to press the inner corner of his eye after instilling the drop, which reduced his systemic symptoms.
💡 Lesson: Proper administration technique can minimise side effects and improve tolerability.
👤 A 55-year-old woman with ocular hypertension
She noticed her eyelashes growing longer and darker after a few months of use. Her eye pressure was well controlled. She was reassured that these changes are common and not dangerous, but she should inform her doctor if she notices any iris colour change.
💡 Lesson: Cosmetic side effects are common but reversible; patients should be informed beforehand.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: The eye pressure-lowering effect begins within 2 hours, but it may take a few weeks to achieve the full effect.

Q: Can I use this medicine if I wear contact lenses?

A: Remove contact lenses before using this medicine and wait at least 15 minutes before reinserting them.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I use this medicine long-term?
  • Will it change my eye colour?
  • Can I drive after using this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I use it with other eye drops?

🔄 Substitutes for intaprost t eye drop

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure glaucoma.
    Fact: This medicine does not cure glaucoma; it only helps control intraocular pressure to prevent further vision loss.
  • Myth: You can stop using this medicine once your eye pressure is normal.
    Fact: Glaucoma is a chronic condition; stopping the medicine can lead to a rise in eye pressure and potential vision loss. Always consult your doctor before stopping.
  • Myth: Using more drops will lower eye pressure faster.
    Fact: Using more than one drop per day may actually reduce the effectiveness and increase side effects. Follow your doctor's instructions exactly.

🔄 Alternative Options

Generic Alternatives

  • Bimatoprost + Timolol ophthalmic solution (generic)

Brand Alternatives

  • Ganfort eye drop

📊 Comparison with Similar Medicines

[{"medicine":"Bimatoprost + Timolol","class":"Prostamide + Beta-blocker","frequency":"Once daily","common_side_effects":"Red eye, eyelash growth, itching"},{"medicine":"Latanoprost + Timolol","class":"Prostaglandin + Beta-blocker","frequency":"Once daily","common_side_effects":"Red eye, eyelash growth, blurred vision"},{"medicine":"Dorzolamide + Timolol","class":"Carbonic anhydrase inhibitor + Beta-blocker","frequency":"Twice daily","common_side_effects":"Bitter taste, eye stinging, blurred vision"}]

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