instaflex nano gel - Diclofenac (1.16% w/w) + Linseed Oil (3% w/w) medicine

Diclovis Gel: Comprehensive Guide to Uses, Dosage, and Safety

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🏭 Innovcare Lifesciences Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 26, 2026
⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not established from the available information. Topical diclofenac should be used with caution during pregnancy, especially in the third trimester, as NSAIDs may cause premature closure of the ductus arteriosus. Consult your doctor before use. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for topical diclofenac in musculoskeletal pain; linseed oil evidence is limited.
Reviewed by
SaathiMed Expert Panel | Sep 26, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Severe skin rash or blistering

If experiencing severe symptoms, call emergency services immediately.

What is instaflex nano gel used for?

This medicine is a topical gel containing diclofenac and linseed oil, used to relieve pain and inflammation in conditions like osteoarthritis, sprains, and muscle aches. It works by blocking pain-causing chemicals in the body. Apply a thin layer to the affected area 3-4 times daily, and wash your hands after use.

  • Generic Name: Diclofenac (1.16% w/w) + Linseed Oil (3% w/w)
  • Manufacturer: Innovcare Lifesciences Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 instaflex nano gel के बारे में (Hindi Summary)

उपयोग: यह दवा एक टॉपिकल जेल है जिसमें डाइक्लोफेनाक और अलसी का तेल होता है। यह जोड़ों और मांसपेशियों के दर्द और सूजन को कम करने के लिए उपयोग की जाती है। यह ऑस्टियोआर्थराइटिस, रुमेटॉइड आर्थराइटिस, मोच, और मांसपेशियों के दर्द में प्रभावी है। इसे प्रभावित क्षेत्र पर दिन में 3-4 बार लगाएं।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में त्वचा पर जलन, लालिमा, खुजली, या दाने शामिल हैं। ये आमतौर पर हल्के होते हैं और अपने आप ठीक हो जाते हैं। दुर्लभ मामलों में, गंभीर त्वचा प्रतिक्रियाएं, पेट की समस्याएं, या गुर्दे की समस्याएं हो सकती हैं। यदि आपको गंभीर लक्षण दिखाई दें तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को लगाने से पहले और बाद में अपने हाथ धोएं। इसे केवल स्वस्थ त्वचा पर लगाएं। आंखों, मुंह, और घाव वाली त्वचा के संपर्क से बचें। इसे कपड़े से न ढकें या हीटिंग पैड का उपयोग न करें। यदि 7 दिनों तक उपयोग के बाद भी दर्द में सुधार न हो, तो डॉक्टर से मिलें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से परामर्श करें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 instaflex nano gel Uses & Benefits

[{"condition":"Osteoarthritis","description":"Relieves pain and improves joint mobility in knee, hip, and hand osteoarthritis when applied topically.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Provides localized pain relief and reduces inflammation in affected joints.","evidence":"Moderate"},{"condition":"Soft tissue injuries","description":"Helps reduce pain and swelling associated with sprains, strains, and sports injuries.","evidence":"Well-established"},{"condition":"Localized musculoskeletal pain","description":"Effective for back pain, neck pain, and muscle aches.","evidence":"Well-established"},{"condition":"Tendinitis and bursitis","description":"Reduces pain and inflammation in tendon and bursa conditions.","evidence":"Limited"}]

Off-label uses: [{"condition":"Migraine prophylaxis","description":"Sometimes prescribed off-label for migraine prevention, but evidence is limited.","evidence":"Limited"},{"condition":"Postherpetic neuralgia","description":"Topical NSAIDs may be used off-label for nerve pain after shingles, but evidence is insufficient.","evidence":"Insufficient"}]

Primary treatment for: Osteoarthritis

Also treats: Rheumatoid arthritis, Soft tissue injuries, Localized musculoskeletal pain, Tendinitis, Bursitis

📋 Drug Information

Generic Name(s)Diclofenac (1.16% w/w) + Linseed Oil (3% w/w)
Brand Nameinstaflex nano gel
ManufacturerInnovcare Lifesciences Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action Class
Route of AdministrationTopical
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Do not freeze.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Apply this medicine to clean, dry skin and wash your hands afterward to avoid spreading it to other areas.
2
Do not use this medicine on broken skin or open wounds, as it can increase absorption and side effects.
3
Avoid covering the treated area with tight bandages or heating pads, as this can enhance drug absorption.
4
If you experience skin irritation, stop using the gel and consult your doctor.
5
Use the lowest effective dose for the shortest duration to minimize side effects.
6
Inform your doctor if you are taking blood thinners or other NSAIDs, as interactions may occur.
7
Do not use this medicine for more than 7 days without medical advice if pain persists.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chronic joint pain
This medicine is commonly prescribed for this.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
✅
Muscle sprain
This medicine can help reduce pain and swelling.
Likely Use
❌
Headache
This medicine is not intended for headaches.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDiclofenac is absorbed through the skin when applied topically. The extent of absorption depends on the amount applied, the size of the treated area, and the integrity of the skin. Typically, only a small fraction of the applied dose reaches the systemic circulation, resulting in low plasma concentrations compared to oral diclofenac. Linseed oil is not significantly absorbed systemically.
DistributionAfter absorption, diclofenac is highly bound to plasma proteins (approximately 99%) and distributes into synovial fluid and other tissues. It crosses the placenta and is excreted in breast milk in small amounts. Linseed oil components are metabolized locally or absorbed minimally.
Protein BindingDiclofenac is approximately 99% bound to plasma proteins, primarily albumin.
MetabolismDiclofenac is metabolized in the liver by cytochrome P450 enzymes, mainly CYP2C9, to several metabolites, including 4'-hydroxydiclofenac and 5-hydroxydiclofenac. These metabolites are largely inactive.
Half-LifeThe elimination half-life of diclofenac from plasma is approximately 1-2 hours. However, the local therapeutic effect in the joint may last longer due to slow clearance from synovial fluid.
ExcretionDiclofenac and its metabolites are excreted primarily in the urine (about 65%) and bile/feces (about 35%).
BioavailabilityThe systemic bioavailability of topical diclofenac is low, typically less than 10% of the applied dose, depending on the formulation and application site.
Onset of ActionPain relief may begin within 30 minutes to 1 hour after application, but full anti-inflammatory effects may take several days of regular use.
Peak Plasma TimePeak plasma concentrations of diclofenac after topical application are generally reached within 1-4 hours, but are much lower than those achieved with oral dosing.
Duration of ActionThe pain-relieving effect of a single application typically lasts for 4-6 hours, but the anti-inflammatory effect may persist longer with repeated use.

How It Works

This medicine works by delivering diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), directly to the site of pain and inflammation. Diclofenac inhibits the activity of cyclooxygenase (COX) enzymes, which are responsible for converting arachidonic acid into prostaglandins. Prostaglandins are chemicals that sensitize nerve endings and promote inflammation. By blocking COX enzymes, diclofenac reduces the production of prostaglandins, thereby decreasing pain and swelling. Linseed oil, the other active ingredient, contains omega-3 fatty acids and has emollient properties that help soothe and moisturize the skin, potentially enhancing the penetration of diclofenac and providing additional anti-inflammatory benefits.

Mechanism Steps

1
Application and absorption: The gel is applied to the skin over the affected area, and diclofenac penetrates through the skin layers to reach the underlying inflamed tissues.
2
Inhibition of COX enzymes: Diclofenac binds to and inhibits the COX-1 and COX-2 enzymes, blocking the conversion of arachidonic acid to prostaglandins.
3
Reduction of prostaglandins: With reduced prostaglandin levels, the sensitization of pain receptors and the inflammatory response are diminished.
4
Linseed oil effect: Linseed oil provides emollient and soothing effects on the skin, and its omega-3 fatty acids may contribute to reduced inflammation.

💡 How to Take instaflex nano gel

Strength: Gel containing Diclofenac 1.16% w/w and Linseed Oil 3% w/w.

1Wash your hands thoroughly before applying the gel.
2Clean and dry the affected area.
3Squeeze a small amount of gel onto your fingertips or directly onto the affected area.
4Gently rub the gel into the skin until it is absorbed.
5Wash your hands after application unless your hands are the treated area.
6Do not cover the area with a bandage or heating pad.
7Avoid contact with eyes, mouth, and other mucous membranes.

Dosage Information

Adult DosageApply a thin layer of this medicine to the affected area 3 to 4 times daily, or as directed by your doctor. The amount needed depends on the size of the area being treated. Typically, a 2-4 cm length of gel is sufficient for an area of about 10 cm x 10 cm. Gently rub it into the skin until absorbed. Wash your hands after application unless the hands are the treated area. The dose must be individualized by a qualified clinician based on the indication, severity of pain, and patient response. Do not exceed the recommended frequency or duration of use without medical advice.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more susceptible to the side effects of NSAIDs. Use the lowest effective dose for the shortest duration necessary. No specific dose adjustment is required for topical use, but caution is advised.
Renal ImpairmentNo dose adjustment is typically required for topical use in patients with mild to moderate kidney impairment. However, caution is advised in severe kidney disease, and prolonged use should be avoided.
Hepatic ImpairmentNo dose adjustment is typically required for topical use in patients with mild to moderate liver impairment. Caution is advised in severe liver disease.
Maximum Daily DoseThe maximum recommended daily dose for topical diclofenac gel is not well established, but generally, application should not exceed 3-4 times daily or cover more than a limited area. Follow your doctor's instructions.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

No specific food interactions
Not applicable
This medicine is applied topically and does not interact with food.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Apply the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of instaflex nano gel

✅ Common Side Effects

Application site irritation (Common (1-10%))
Usually resolves on its own. If it persists or worsens, consult your doctor.
Redness or rash (Common (1-10%))
Discontinue use if severe and consult a doctor.
Itching (Common (1-10%))
Avoid scratching. If itching is severe, stop use and seek medical advice.
Dry skin (Uncommon (0.1-1%))
Moisturize the area after the gel has dried. If it persists, consult a doctor.

🚨 Serious Side Effects

Severe skin reactions (e.g., blistering, peeling) (Rare (<0.1%))
Stop using the medicine immediately and seek medical attention.
Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black stools, vomiting blood, or severe abdominal pain.
Kidney problems (Rare (<0.1%))
Report decreased urine output, swelling, or fatigue to your doctor promptly.
Cardiovascular events (e.g., chest pain, shortness of breath) (Rare (<0.1%))
Seek emergency medical help immediately.

⚠️ Rare Side Effects

Allergic reactions (e.g., hives, swelling of face/lips/throat)
Seek emergency medical attention.
Photosensitivity
Avoid sun exposure and use sunscreen. Consult a doctor if reaction occurs.
Bronchospasm in aspirin-sensitive asthma
Seek immediate medical help if breathing difficulty occurs.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Ibuprofen Major
Aspirin Major
Clopidogrel Major
ACE inhibitors Moderate
Diuretics Moderate
Lithium Moderate
Methotrexate Moderate
Corticosteroids Major
Cyclosporine Moderate

🚨 Major Interactions

  • Oral NSAIDs (e.g., ibuprofen, naproxen)
  • Anticoagulants (e.g., warfarin)
  • Antiplatelet drugs (e.g., clopidogrel)
  • Corticosteroids

⚡ Moderate Interactions

  • ACE inhibitors and ARBs
  • Diuretics
  • Lithium
  • Methotrexate

🍷 Alcohol Interaction

Alcohol does not directly interact with topically applied diclofenac, but excessive alcohol consumption may increase the risk of gastrointestinal bleeding and liver problems, especially if the medicine is absorbed systemically. It is advisable to limit alcohol intake while using this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known allergy to diclofenac, linseed oil, or any other ingredients","History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs","Application to broken skin, open wounds, or areas with dermatitis","Third trimester of pregnancy","Severe kidney or liver disease","Active gastrointestinal bleeding or peptic ulcer"]

⚠️ Warnings & Precautions

["For external use only. Do not ingest.","Avoid contact with eyes and mucous membranes.","Do not apply to large areas of skin or use for prolonged periods without medical advice.","Do not use with occlusive dressings or heating pads.","Discontinue if skin irritation develops.","Use with caution in elderly patients and those with kidney or liver impairment.","Avoid sun exposure to treated areas to prevent photosensitivity.","Keep out of reach of children."]

🤱 Lactation Safety

Diclofenac is excreted in breast milk in small amounts. Topical application is unlikely to result in significant systemic absorption, but it is recommended to avoid applying the gel to the breast area and to consult a doctor before use during breastfeeding.

💊 Overdose Management

Overdose with topical diclofenac is unlikely due to low systemic absorption. If accidental ingestion occurs, seek medical attention immediately. Symptoms of systemic NSAID overdose may include nausea, vomiting, abdominal pain, drowsiness, and in severe cases, gastrointestinal bleeding, kidney failure, or seizures. Treatment is supportive and symptomatic.

⏰ Missed Dose

If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Always wash your hands thoroughly before and after applying this medicine, unless your hands are the treated area. Apply a thin layer of the gel to the affected area and gently rub it in until it is absorbed. Do not cover the area with airtight dressings or heating pads, as this can increase absorption and the risk of side effects. Avoid contact with eyes, mucous membranes, and broken skin. If accidental contact occurs, rinse thoroughly with water. Do not use this medicine for more than the recommended duration without consulting a doctor. If your pain persists or worsens after 7 days of use, stop using it and speak to a healthcare professional. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Also, tell your doctor about all other medications you are taking, especially oral NSAIDs, blood thinners, or steroids, as interactions may occur. Keep this medicine out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the effects of NSAIDs, including topical forms. Use with caution and monitor for signs of gastrointestinal bleeding, kidney problems, or skin reactions. The lowest effective dose for the shortest duration is recommended.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before using this medicine. NSAIDs may affect ovulation and are generally not recommended during pregnancy, especially in the third trimester.

🏥 Post-Surgery Considerations

Consult your doctor before using this medicine after surgery. It may be used for post-operative pain relief in some cases, but ensure the surgical site is fully closed and there is no risk of infection.

🦷 Dental Procedures

This medicine is not typically used for dental pain. Inform your dentist if you are using this medicine, as it may interact with other medications used during dental procedures.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce joint stress.
🥗
Regular low-impact exercise like swimming or cycling can help improve joint mobility.
😴
Practice good posture to prevent muscle strain.
💧
Include anti-inflammatory foods in your diet, such as fruits, vegetables, and omega-3 rich fish.
🧘
Get adequate sleep to support your body's natural healing processes.
🌞
Apply heat or cold packs to the affected area as needed for additional relief.

🏋️ Exercise Considerations

While using this medicine, you can continue with your regular exercise routine, but avoid strenuous activities that may exacerbate your pain. Listen to your body and rest if pain worsens. Low-impact exercises like walking, swimming, and stretching are generally safe and beneficial.

🥗 Diet Recommendations

Include omega-3 rich foods like salmon, flaxseeds, and walnuts.
Reduce intake of processed foods and refined sugars.
Stay well hydrated by drinking plenty of water.
Eat a balanced diet rich in fruits and vegetables to support overall health.

💼 Impact on Daily Work & Life

This medicine is applied topically and is unlikely to affect your ability to drive or operate machinery. However, if you experience dizziness or drowsiness (rare), avoid these activities until you feel alert. You can continue your normal work and daily activities while using this medicine.

🛑 When to Stop This Medicine

Stop using this medicine and consult your doctor if your pain persists or worsens after 7 days of use, if you develop skin irritation or an allergic reaction, or if you experience any serious side effects. Do not stop suddenly if you have been using it for a long time without medical advice.

📅 Long-Term Use Effects

Long-term use of this medicine is generally safe when used as directed. However, prolonged use over large areas may increase systemic absorption and the risk of NSAID-related side effects such as gastrointestinal, kidney, or cardiovascular problems. Regular monitoring may be needed if used for extended periods, especially in elderly patients or those with underlying health conditions. It is advisable to use the lowest effective dose for the shortest duration necessary.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain and improve joint function.

Evidence: Well-established
Hot and cold therapy

Applying heat or cold packs can help reduce pain and inflammation.

Evidence: Moderate
Acupuncture

May provide pain relief for some individuals with musculoskeletal pain.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. You can receive vaccinations while using this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling with this medicine, keep it in its original packaging and carry a copy of your prescription. Store it at room temperature and protect it from direct sunlight. If you are flying, pack it in your carry-on luggage if you need it during the flight. For international travel, check the customs regulations of your destination country regarding topical medications. No time zone adjustments are needed for topical use, but maintain your regular application schedule as much as possible.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with chronic knee pain
Started this medicine as prescribed for osteoarthritis. Within 2 weeks noticed significant improvement in morning stiffness. Emphasized taking with food to prevent stomach upset.
💡 Lesson: Consistency with prescribed dose and taking with food improves both efficacy and tolerability.
👤 A 60-year-old retired teacher with lower back pain
Used this medicine gel twice daily for 10 days. Experienced mild skin redness initially, which resolved after a few days. Pain reduced significantly, allowing better sleep and mobility.
💡 Lesson: Mild skin reactions are common and often temporary. If they persist, consult a doctor.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: You may start feeling pain relief within 30 minutes to 1 hour after application, but the full anti-inflammatory effect may take several days of regular use.

Q: Can I use this medicine on my face?

A: No, this medicine is not recommended for use on the face. It is intended for application on joints and muscles of the body.

Q: Is it safe to use during pregnancy?

A: Consult your doctor before using this medicine during pregnancy, especially in the third trimester, as NSAIDs may pose risks to the fetus.

Q: Can I use this medicine with oral painkillers?

A: Using topical diclofenac with oral NSAIDs may increase the risk of side effects. Consult your doctor before combining them.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for instaflex nano gel

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: Topical pain gels are completely safe and have no side effects.
    Fact: Topical gels can cause skin irritation and, if absorbed systemically, may lead to stomach or kidney problems. They should be used as directed.
  • Myth: You can apply diclovis gel to any part of the body, including broken skin.
    Fact: This medicine should only be applied to intact skin. Applying it to broken skin can increase absorption and the risk of side effects.
  • Myth: More gel means faster pain relief.
    Fact: Using more than the recommended amount does not improve efficacy and may increase the risk of side effects. Follow the dosage instructions.

🔄 Alternative Options

Generic Alternatives

  • Diclofenac gel
  • Diclofenac topical gel
  • Diclofenac and linseed oil gel

Brand Alternatives

  • Voltaren
  • Voveran
  • Diclomol
  • Dynapar
  • Nac
  • Reactin

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","active_ingredient":"Diclofenac + Linseed Oil","route":"Topical","common_use":"Osteoarthritis, soft tissue injuries","onset":"30-60 minutes"},{"medicine":"Ibuprofen gel","active_ingredient":"Ibuprofen","route":"Topical","common_use":"Muscle pain, sprains","onset":"30-60 minutes"},{"medicine":"Ketoprofen gel","active_ingredient":"Ketoprofen","route":"Topical","common_use":"Osteoarthritis, tendonitis","onset":"30-60 minutes"}]

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