Pipzo 1.125 gm Injection: A Comprehensive Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Severe, persistent diarrhea or abdominal pain
- Seizures or convulsions
- Rash with blisters or peeling skin
- Unusual bleeding or bruising
- Decreased urine output or swelling in the legs
- Yellowing of the skin or eyes
- High fever with chills that does not improve
If experiencing severe symptoms, call emergency services immediately.
What is infocer 1000mg/125mg injection used for?
This medicine is a combination antibiotic containing piperacillin and tazobactam, used to treat serious bacterial infections. It works by killing bacteria and is given intravenously in a hospital setting.
- Generic Name: Piperacillin (1000mg) + Tazobactum (125mg)
- Manufacturer: Little Greave Pharmaceutical Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 infocer 1000mg/125mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा पाइपरासिलिन और टैज़ोबैक्टम का संयोजन है, जिसका उपयोग गंभीर जीवाणु संक्रमणों के इलाज के लिए किया जाता है। यह अस्पताल में डॉक्टर द्वारा इंजेक्शन के माध्यम से दी जाती है। यह निमोनिया, पेट के संक्रमण, त्वचा के संक्रमण, मूत्र मार्ग के संक्रमण और रक्त के संक्रमण के इलाज में प्रभावी है। यह वायरल संक्रमण जैसे सर्दी-जुकाम के लिए प्रभावी नहीं है।
साइड इफेक्ट्स: आम दुष्प्रभावों में दस्त, मतली, उल्टी, सिरदर्द, अनिद्रा, दाने और इंजेक्शन स्थल पर दर्द या सूजन शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, गंभीर दस्त, दौरे और रक्त विकार शामिल हो सकते हैं। यदि आपको कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल डॉक्टर या नर्स द्वारा दी जानी चाहिए। स्वयं इंजेक्शन न लगाएं। अपने डॉक्टर को अपनी सभी दवाओं और एलर्जी के बारे में बताएं। गुर्दे की कार्यप्रणाली की निगरानी की आवश्यकता हो सकती है। गंभीर दस्त होने पर बिना डॉक्टर की सलाह के दस्त रोकने की दवा न लें। उपचार के दौरान शराब से बचें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से परामर्श करें।
💊 infocer 1000mg/125mg injection Uses & Benefits
[{"condition":"Intra-abdominal infections","description":"Used for complicated appendicitis, peritonitis, and other abdominal infections caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Hospital-acquired pneumonia","description":"Effective against many gram-negative and gram-positive bacteria causing lung infections in hospitalized patients.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats serious skin infections including cellulitis, abscesses, and diabetic foot infections.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Used for complicated urinary tract infections and pyelonephritis caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Gynecological infections","description":"Treats pelvic inflammatory disease and postpartum endometritis.","evidence":"Well-established"},{"condition":"Bloodstream infections","description":"Used for bacteremia and sepsis when caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Febrile neutropenia","description":"Empiric therapy for fever in patients with low white blood cell counts.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Meningitis","description":"Sometimes used off-label for bacterial meningitis when other options are not suitable, but not first-line.","evidence":"Limited"},{"condition":"Prosthetic joint infections","description":"May be used as part of combination therapy for infected joint replacements.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Intra-abdominal infections, Hospital-acquired pneumonia, Skin and soft tissue infections, Complicated urinary tract infections, Gynecological infections, Bloodstream infections, Febrile neutropenia
📋 Drug Information
| Generic Name(s) | Piperacillin (1000mg) + Tazobactum (125mg) |
| Brand Name | infocer 1000mg/125mg injection |
| Manufacturer | Little Greave Pharmaceutical Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Parenteral (intravenous or intramuscular) |
| Storage | Store the unreconstituted vials at room temperature (20°C to 25°C). Protect from light and moisture. Once reconstituted, the solution should be used immediately or stored as per the manufacturer's instructions, typically refrigerated (2°C to 8°C) and used within 24 hours. Do not freeze. |
| Shelf Life | The shelf life of the unreconstituted product is typically 24 months from the date of manufacture. Check the expiry date on the vial. Once reconstituted, use within the time specified by the manufacturer. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting bacterial cell wall synthesis. Piperacillin binds to specific penicillin-binding proteins (PBPs) inside the bacterial cell wall, preventing the cross-linking of peptidoglycan chains. This weakens the cell wall and leads to bacterial lysis and death. Tazobactam is a beta-lactamase inhibitor that protects piperacillin from degradation by many beta-lactamase enzymes produced by bacteria. By irreversibly binding to these enzymes, tazobactam extends the spectrum of piperacillin to include many beta-lactamase-producing organisms.
Mechanism Steps
💡 How to Take infocer 1000mg/125mg injection
Strength: This medicine is available as a sterile powder for injection in vials containing 1.125 g (1000 mg piperacillin + 125 mg tazobactam), 2.25 g, 3.375 g, and 4.5 g. The specific strength is 1000 mg + 125 mg.
Dosage Information
| Adult Dosage | The usual adult dose for serious infections is 3.375 g (3 g piperacillin + 0.375 g tazobactam) every 6 hours or 4.5 g every 6 to 8 hours, administered intravenously. For nosocomial pneumonia, the recommended dose is 4.5 g every 6 hours. For complicated urinary tract infections, the dose may be 3.375 g every 6 hours. The duration of therapy depends on the type and severity of infection and clinical response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. For children 2 months to 12 years, the usual dose is 90 mg/kg (piperacillin component) every 6 to 8 hours, but this must be confirmed by a pediatrician. Safety and efficacy in children under 2 months have not been established. |
| Elderly Dosage | Elderly patients (65 years and older) may have decreased renal function, which can increase the risk of toxicity. Dose should be adjusted based on renal function. Monitor renal function closely. No specific dose adjustment is recommended solely based on age, but renal function should guide dosing. |
| Renal Impairment | Dose adjustment is required for patients with renal impairment. For creatinine clearance (CrCl) greater than 40 mL/min, no adjustment is needed. For CrCl 20-40 mL/min, the recommended dose is 2.25 g every 6 hours. For CrCl less than 20 mL/min, the dose is 2.25 g every 8 hours. For patients on hemodialysis, the dose is 2.25 g every 12 hours, with an additional dose after each dialysis session. For peritoneal dialysis, the dose is 2.25 g every 12 hours. These are general guidelines; individual dosing must be determined by a clinician. |
| Hepatic Impairment | No specific dose adjustment is recommended for hepatic impairment alone. However, if hepatic impairment is accompanied by renal impairment, dose adjustment based on renal function is necessary. Monitor liver enzymes during therapy. |
| Maximum Daily Dose | The maximum recommended daily dose is 18 g of piperacillin (with 2.25 g tazobactam) per day, given as 4.5 g every 6 hours. Doses should not exceed this without careful consideration by a clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of infocer 1000mg/125mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Probenecid | Moderate | |
| Gentamicin | Major | |
| Vecuronium | Moderate | |
| Oral contraceptives | Moderate | |
| Allopurinol | Moderate | |
| Furosemide | Moderate | |
| Heparin | Moderate | |
| Rifampin | Minor |
🚨 Major Interactions
- Warfarin
- Methotrexate
- Probenecid
- Aminoglycosides (e.g., gentamicin)
- Vecuronium
⚡ Moderate Interactions
- Oral contraceptives
- Allopurinol
- Loop diuretics (e.g., furosemide)
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine. Alcohol can increase the risk of liver toxicity and may worsen side effects such as nausea, vomiting, and dizziness. It can also impair the immune response, potentially slowing recovery from infection.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe hypersensitivity to piperacillin, tazobactam, or any other penicillin or beta-lactam antibiotic.","History of severe allergic reaction (e.g., anaphylaxis) to any beta-lactam antibiotic.","Concurrent use with other beta-lactam antibiotics that may increase risk of toxicity.","Not for use in patients with viral infections (e.g., common cold)."]
⚠️ Warnings & Precautions
["Serious and occasionally fatal hypersensitivity reactions (anaphylaxis) have been reported. Before starting therapy, inquire about previous hypersensitivity to penicillins, cephalosporins, or other allergens. If a reaction occurs, discontinue immediately and institute emergency treatment.","Clostridioides difficile-associated diarrhea (CDAD) has been reported. If diarrhea develops, evaluate for CDAD. Use of antibacterial agents may alter normal flora and lead to superinfection.","Seizures may occur in patients with renal impairment if doses are not adjusted. Monitor renal function and adjust dose accordingly.","Hematologic effects: leukopenia, neutropenia, thrombocytopenia, and anemia have been reported. Monitor blood counts during prolonged therapy.","Renal impairment: dose adjustment is required. Monitor renal function. Interstitial nephritis may occur.","Hepatotoxicity: elevations in liver enzymes have been observed. Monitor if symptoms occur.","Use in pregnancy: Category B. Use only if clearly needed.","Use in lactation: Excreted in breast milk. Caution advised.","Pediatric use: Safety and efficacy in children under 2 months have not been established.","Elderly: Higher risk of renal impairment; dose adjustment may be needed based on renal function."]
🤱 Lactation Safety
Piperacillin and tazobactam are excreted in human milk in low concentrations. Caution should be exercised when administered to a nursing woman. Consult your doctor to weigh the benefits and risks. If used, monitor the infant for diarrhea, thrush, or rash.
💊 Overdose Management
Overdose with this medicine is unlikely due to its administration by healthcare professionals. In case of overdose, treatment should be symptomatic and supportive. Piperacillin and tazobactam are both dialyzable; hemodialysis may be considered in severe cases, especially in patients with renal failure. Monitor vital signs and electrolytes. Contact a poison control center for guidance.
⏰ Missed Dose
This medicine is given by a healthcare professional in a hospital or clinic setting. If you miss a scheduled dose, contact your healthcare provider as soon as possible. Do not attempt to self-administer a double dose. Your provider will determine the best course of action based on the timing of the missed dose and your dosing schedule.
Additional Safety Advice
This medicine must be given only by a healthcare professional. Do not attempt to self-administer. Inform your doctor if you have a history of allergies to penicillins, cephalosporins, or other beta-lactam antibiotics. Tell your doctor about all other medicines you are taking, especially blood thinners, methotrexate, probenecid, or other antibiotics. Your kidney function may need to be monitored during treatment, especially if you have pre-existing kidney disease or are taking other kidney-damaging drugs. If you develop severe diarrhea, tell your doctor before taking any anti-diarrheal medication, as it could be a sign of a serious gut infection. Avoid alcohol during treatment as it may worsen side effects. If you are pregnant or breastfeeding, discuss the risks and benefits with your doctor. Do not skip doses or stop treatment early, even if you feel better, as this can lead to resistance and recurrence of infection.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have decreased renal function, which can increase the risk of side effects such as seizures. Dose adjustment based on creatinine clearance is essential. Monitor renal function closely. Elderly patients may also be more susceptible to Clostridioides difficile infection. Use with caution and monitor for signs of superinfection.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting this medicine. It is classified as Pregnancy Category B, meaning animal studies show no risk, but human studies are lacking. Use only if clearly needed. If you become pregnant while on this medicine, inform your doctor immediately.
🏥 Post-Surgery Considerations
This medicine is often used after surgery to prevent or treat surgical site infections. It is administered intravenously in the hospital. Your surgeon will determine the appropriate dose and duration based on the type of surgery and your risk of infection. Monitor for signs of infection at the surgical site.
🦷 Dental Procedures
This medicine is not typically used for dental procedures. If you have a dental infection, your dentist may prescribe oral antibiotics. If you are receiving this medicine for another infection and need dental work, inform your dentist. No specific precautions are required, but maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While on this medicine, you may feel tired or dizzy. Avoid strenuous exercise until you have fully recovered. Light activities like walking are fine if you feel up to it. Consult your doctor before resuming intense workouts.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital or clinic, so you may need to take time off work during treatment. You may experience fatigue, dizziness, or diarrhea, which can affect your ability to work. Avoid driving or operating machinery if you feel dizzy. Discuss with your employer about sick leave as needed.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. The full course must be completed to ensure the infection is fully treated and to prevent resistance. If you experience severe side effects, your doctor may decide to stop the medicine and switch to an alternative. Always follow your doctor's instructions.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to antibiotic resistance, superinfections (such as fungal infections or Clostridioides difficile), and rarely, blood disorders or kidney problems. Prolonged therapy should be avoided unless necessary. Regular monitoring of renal function, liver enzymes, and blood counts may be required during extended treatment. If you experience any unusual symptoms during or after treatment, consult your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the infection and culture results, other antibiotics such as cephalosporins, carbapenems, or fluoroquinolones may be used.
Evidence: Well-establishedFor abscesses or infected collections, surgical drainage may be necessary in addition to antibiotics.
Evidence: Well-establishedRest, hydration, and fever control are important adjuncts to antibiotic therapy.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the effectiveness of live vaccines. Avoid receiving live vaccines during treatment. Inactivated vaccines are generally safe but may have a reduced response. Consult your doctor regarding vaccination timing.
📦 Storage Guide
✅ DO
Store unreconstituted vials at room temperature (20-25°C)
❌ DON'T
Do not freeze the vials
✅ DO
Protect from light and moisture
❌ DON'T
Do not store in bathroom
✅ DO
Use reconstituted solution within the recommended time
❌ DON'T
Do not use if the solution is cloudy or has particles
✈️ Traveling with This Medicine
This medicine is administered in a healthcare setting, so travel advice is limited. If you are traveling after treatment, carry a copy of your prescription and medical records. If you need to continue treatment while traveling, arrange for administration at a healthcare facility at your destination. Store the medicine as directed, and do not expose it to extreme temperatures. Check customs regulations for carrying prescription medications.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working quickly after intravenous administration. You may start feeling better within 24 to 48 hours, but it is important to complete the full course as prescribed.
A: No, you should not take this medicine if you are allergic to penicillin or other beta-lactam antibiotics, as it contains piperacillin, a penicillin. Inform your doctor about any allergies.
A: This medicine is classified as Pregnancy Category B. It should be used during pregnancy only if clearly needed. Consult your doctor to weigh the benefits and risks.
A: This medicine may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how it affects you.
A: Report any side effects to your doctor immediately. Mild side effects like nausea or diarrhea may resolve, but severe reactions require urgent medical attention.
🤔 Common Patient Concerns
🔄 Substitutes for infocer 1000mg/125mg injection
View AllAlternative brands with exact same active ingredient:
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cidal 1000mg/125mg injectionNeon Laboratories Ltd ₹67.50 31.4% CHEAPER
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blucillin tazo 1000 mg/125 mg injectionBlue Cross Laboratories Ltd ₹68.25 30.6% CHEAPER
-
dazopip np 1000mg/125mg injectionDr. D Pharma ₹80.63 18% CHEAPER
-
Sanotaz 1000mg/125mg InjectionArvincare Pharma ₹80.63 18% CHEAPER
-
lazocin 1.125gm injectionAllenge India ₹80.72 17.9% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any infection.
Fact: This medicine is only effective against certain bacterial infections. It does not work for viral infections like the flu or common cold. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full course as prescribed to prevent recurrence and resistance, even if symptoms improve. - Myth: This medicine is safe to take without a doctor's supervision.
Fact: This medicine must be given by a healthcare professional and requires a prescription. It is not for self-administration. - Myth: This medicine is the same as other antibiotics.
Fact: This medicine is a specific combination of piperacillin and tazobactam with a unique spectrum of activity. It is not interchangeable with other antibiotics.
🔄 Alternative Options
Generic Alternatives
- Piperacillin and Tazobactam Injection
Brand Alternatives
- Pipzo 1.125 gm Injection
- Tazact 1.125 gm Injection
- Zosyn 1.125 gm Injection
- Piptaz 1.125 gm Injection
- Tazoper 1.125 gm Injection