Divret Tablet PR (Indapamide 1.5mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe dizziness or fainting
- Irregular heartbeat or palpitations
- Muscle cramps or weakness
- Swelling of face, lips, tongue, or throat
- Difficulty breathing
- Severe abdominal pain with nausea and vomiting
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bruising or bleeding
If experiencing severe symptoms, call emergency services immediately.
What is indepin 1.5 sr tablet used for?
This medicine contains Indapamide 1.5mg, a thiazide-like diuretic used to treat high blood pressure and fluid retention. It works by helping the kidneys remove excess salt and water, and by relaxing blood vessels. It is usually taken once daily in the morning.
- Generic Name: Indapamide (1.5mg)
- Manufacturer: Johnlee Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 indepin 1.5 sr tablet के बारे में (Hindi Summary)
उपयोग: यह दवा इंडापामाइड 1.5mg से बनी है और मुख्य रूप से उच्च रक्तचाप (हाई ब्लड प्रेशर) और शरीर में पानी के जमाव (सूजन) के इलाज के लिए इस्तेमाल की जाती है। यह किडनी को अतिरिक्त नमक और पानी बाहर निकालने में मदद करती है, जिससे रक्तचाप कम होता है और सूजन कम होती है। यह दवा आमतौर पर दिन में एक बार सुबह लेने की सलाह दी जाती है। इसे डॉक्टर की सलाह के बिना बंद या शुरू न करें।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में चक्कर आना, सिरदर्द, कमजोरी और बार-बार पेशाब आना शामिल हैं। कुछ लोगों में पोटैशियम या सोडियम की कमी हो सकती है, जिससे मांसपेशियों में ऐंठन, भ्रम या दिल की धड़कन अनियमित हो सकती है। अगर आपको चेहरे, होंठ या जीभ में सूजन, सांस लेने में कठिनाई, या गंभीर दाने दिखें तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं के बारे में बताएं, खासकर किडनी या लिवर की बीमारी, डायबिटीज, गाउट या ल्यूपस। अपने डॉक्टर को अपनी सभी दवाओं के बारे में बताएं। इस दवा के साथ शराब न लें। पर्याप्त पानी पिएं। डॉक्टर समय-समय पर खून की जांच करने की सलाह दे सकते हैं। गर्भवती या स्तनपान कराने वाली महिलाएं बिना डॉक्टर की सलाह के यह दवा न लें।
💊 indepin 1.5 sr tablet Uses & Benefits
[{"condition":"Hypertension","description":"This medicine is used to lower high blood pressure, reducing the risk of stroke, heart attack, and kidney problems.","evidence":"Well-established"},{"condition":"Edema","description":"It helps relieve fluid retention (edema) associated with heart failure, liver cirrhosis, or kidney disease.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Calcium nephrolithiasis","description":"Sometimes prescribed off-label to reduce calcium excretion in people with recurrent calcium kidney stones.","evidence":"Limited"},{"condition":"Diabetes insipidus","description":"Rarely used off-label to reduce urine output in nephrogenic diabetes insipidus.","evidence":"Limited"}]
Primary treatment for: Hypertension
Also treats: Edema due to heart failure, Edema due to liver cirrhosis, Edema due to kidney disease
📋 Drug Information
| Generic Name(s) | Indapamide (1.5mg) |
| Brand Name | indepin 1.5 sr tablet |
| Manufacturer | Johnlee Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Low-ceiling Diuretics (Inhibitors of Na+Cl symport) |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works primarily by inhibiting the reabsorption of sodium and chloride in the distal convoluted tubule of the kidney. This action increases the excretion of sodium, chloride, and water, leading to diuresis and a reduction in blood volume. Additionally, it causes vasodilation by opening potassium channels, which directly relaxes blood vessels. These combined effects lower blood pressure and reduce edema.
Mechanism Steps
💡 How to Take indepin 1.5 sr tablet
Strength: This medicine is available as a 1.5 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 1.5 mg taken orally once daily, preferably in the morning. The dose may be adjusted by your doctor based on your blood pressure response and kidney function. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially dizziness and electrolyte imbalances. Start with a low dose and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with mild to moderate renal impairment, no dose adjustment is usually needed. However, in severe renal impairment (creatinine clearance <30 mL/min), this medicine is contraindicated. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | In patients with mild to moderate hepatic impairment, use with caution. In severe hepatic impairment, this medicine is contraindicated. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is 1.5 mg. Higher doses do not provide additional antihypertensive benefit but increase the risk of side effects. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of indepin 1.5 sr tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Lithium | Major | |
| NSAIDs | Moderate | |
| Corticosteroids | Major | |
| Digoxin | Moderate | |
| Oral antidiabetic drugs | Moderate | |
| Cholestyramine | Minor | |
| Calcium supplements | Minor | |
| Other antihypertensives | Major | |
| Alcohol | Moderate | |
| Licorice | Minor |
🚨 Major Interactions
- Lithium
- Other antihypertensive drugs
- Corticosteroids
⚡ Moderate Interactions
- NSAIDs
- Digoxin
- Oral antidiabetic drugs
🍷 Alcohol Interaction
Alcohol may increase the blood pressure lowering effect of this medicine, leading to dizziness, lightheadedness, and fainting. It is advisable to avoid alcohol or limit its consumption while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to indapamide or other sulfonamide-derived drugs","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["This medicine may cause electrolyte imbalances. Regular monitoring of blood electrolytes is recommended.","It can cause dizziness and low blood pressure. Avoid driving or operating machinery until you know how it affects you.","It may worsen glucose tolerance and increase blood sugar levels in diabetic patients.","It can increase uric acid levels and precipitate gout attacks.","It may cause photosensitivity reactions. Avoid excessive sun exposure and use sunscreen.","It can cause acute angle-closure glaucoma. Seek immediate medical attention if you experience eye pain or blurred vision.","It may cause severe skin reactions. Stop the medicine and seek medical help if you develop a rash."]
🤱 Lactation Safety
This medicine is excreted in breast milk. It is not recommended during breastfeeding as it may cause serious adverse effects in the nursing infant. Consult your doctor for alternative treatments.
💊 Overdose Management
Overdose of this medicine can cause excessive diuresis, leading to dehydration, electrolyte imbalances, and hypotension. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic, including fluid and electrolyte replacement. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Before taking this medicine, inform your doctor about all your medical conditions, especially kidney or liver disease, diabetes, gout, or lupus. Tell your doctor about all other medicines you are taking, including over-the-counter drugs and herbal supplements, as this medicine can interact with many substances. Avoid alcohol while taking this medicine, as it can increase dizziness and low blood pressure. Stay well hydrated, but do not drink excessive amounts of water unless advised. Your doctor may recommend regular blood tests to monitor your kidney function, electrolyte levels, and blood sugar. Do not use this medicine if you are pregnant or planning to become pregnant without consulting your doctor. If you miss a dose, take it as soon as you remember, but skip it if it is almost time for your next dose; never double the dose. Keep this medicine out of reach of children and store it as directed.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the effects of this medicine, especially dizziness, electrolyte imbalances, and kidney function changes. Start with a low dose and monitor closely. Regular blood tests are recommended.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy. Consult your doctor to switch to a safer alternative before conception.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may need to be stopped before surgery to avoid electrolyte imbalances and low blood pressure during the procedure.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may cause dry mouth or dizziness. Maintain good oral hygiene and stay hydrated during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause dizziness and low blood pressure, especially when standing up quickly. Avoid strenuous exercise initially until you know how the medicine affects you. Stay hydrated during exercise. If you feel dizzy or weak, stop and rest.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or lightheadedness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause increased urination, so plan your work schedule accordingly. Most people can continue their normal activities with some adjustments.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects like allergic reactions, severe dizziness, or irregular heartbeat, seek immediate medical attention. Your doctor may adjust the dose or switch to a different medicine if needed.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to electrolyte imbalances, increased blood sugar, and increased uric acid levels. Regular monitoring of blood tests is recommended. It may also reduce kidney function over time, especially in patients with pre-existing kidney disease. Periodic review with your doctor is essential to adjust the dose and monitor for side effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, and weight loss can help control blood pressure and reduce the need for medication.
Evidence: Well-establishedACE inhibitors, ARBs, calcium channel blockers, or beta-blockers may be used as alternatives or in combination.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, inform your healthcare provider about this medicine before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, continue taking your dose at the same local time as usual, but consult your doctor if you are unsure. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The diuretic effect starts within 1-2 hours, but the full blood pressure lowering effect may take several weeks.
A: Yes, you can take it with or without food. Taking it with food may reduce stomach upset.
A: If you remember within 12 hours, take it. Otherwise, skip the missed dose and continue with your regular schedule. Do not double dose.
A: It is not recommended during pregnancy. Consult your doctor for alternative treatments.
A: No, do not stop without consulting your doctor. Stopping suddenly can cause blood pressure to rise again.
🤔 Common Patient Concerns
🔄 Substitutes for indepin 1.5 sr tablet
View AllAlternative brands with exact same active ingredient:
-
natritor 1.5mg tablet srIpca Laboratories Ltd ₹37.41 53.6% CHEAPER
-
in 1.5mg tablet srSystopic Laboratories Pvt Ltd ₹37.50 53.5% CHEAPER
-
insuretis 1.5mg tabletDruto Laboratories ₹46.53 42.3% CHEAPER
-
natridac 1.5mg tablet srZydus Cadila ₹49.00 39.2% CHEAPER
-
excrete 1.5mg tablet srCardia Life Care Pvt Ltd ₹50.00 38% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure high blood pressure permanently.
Fact: This medicine controls high blood pressure but does not cure it. You may need to take it long-term. - Myth: You can stop taking this medicine once your blood pressure is normal.
Fact: Stopping suddenly can cause blood pressure to rise again. Always consult your doctor before stopping. - Myth: This medicine is safe for everyone.
Fact: It is not safe for people with certain conditions like severe kidney or liver disease, or during pregnancy.
🔄 Alternative Options
Generic Alternatives
- Indapamide 1.5mg Tablet
Brand Alternatives
- Divret Tablet PR