Nodimox Plus 500 Capsule: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat.
- Severe or persistent diarrhea, especially with blood or mucus.
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain.
- Unusual bleeding or bruising, or signs of infection like fever and sore throat.
- Seizures or confusion, especially in patients with kidney disease.
- Decreased urine output or swelling in the legs.
If experiencing severe symptoms, call emergency services immediately.
What is indclox lb capsule used for?
This medicine is a prescription antibiotic combining amoxycillin and cloxacillin, used to treat bacterial infections of the skin, respiratory tract, bones, and teeth. It works by killing bacteria and must be taken exactly as prescribed.
- Generic Name: Amoxycillin (250mg) + Cloxacillin (250mg)
- Manufacturer: Ind Swift Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 indclox lb capsule के बारे में (Hindi Summary)
उपयोग: यह दवा एमोक्सिसिलिन और क्लोक्सासिलिन का संयोजन है, जिसका उपयोग बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। यह त्वचा, श्वसन तंत्र, हड्डियों और दांतों के संक्रमण में प्रभावी है। यह केवल डॉक्टर के पर्चे पर ही ली जानी चाहिए और पूरा कोर्स पूरा करना आवश्यक है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट दर्द और त्वचा पर चकत्ते शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, गंभीर दस्त, यकृत की समस्या और रक्त विकार हो सकते हैं। किसी भी गंभीर लक्षण पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। कोर्स पूरा करें, बीच में न छोड़ें। भोजन के साथ लेने से पेट की परेशानी कम हो सकती है। शराब न पिएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। दवा को ठंडी, सूखी जगह पर रखें।
💊 indclox lb capsule Uses & Benefits
[{"condition":"Skin and soft tissue infections","description":"Used to treat bacterial infections of the skin and underlying tissues, including cellulitis, abscesses, and wound infections, especially when Staphylococcus aureus is suspected.","evidence":"Well-established"},{"condition":"Respiratory tract infections","description":"May be prescribed for upper and lower respiratory tract infections such as sinusitis, pharyngitis, and pneumonia when caused by susceptible bacteria.","evidence":"Established"},{"condition":"Bone and joint infections","description":"Used in the management of osteomyelitis and septic arthritis caused by susceptible organisms, often as part of a broader treatment plan.","evidence":"Established"},{"condition":"Dental infections","description":"Prescribed for dental abscesses and other odontogenic infections to cover both streptococci and staphylococci.","evidence":"Established"},{"condition":"Postoperative prophylaxis","description":"Sometimes used to prevent surgical site infections in certain procedures, based on the clinician's judgment.","evidence":"Limited"}]
Off-label uses: [{"condition":"Eradication of Helicobacter pylori","description":"Amoxycillin is part of some H. pylori eradication regimens, but the combination with cloxacillin is not standard for this indication.","evidence":"Limited"},{"condition":"Lyme disease","description":"Amoxycillin is used for early Lyme disease, but the addition of cloxacillin is not typically recommended.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Skin and soft tissue infections, Respiratory tract infections, Bone and joint infections, Dental infections
📋 Drug Information
| Generic Name(s) | Amoxycillin (250mg) + Cloxacillin (250mg) |
| Brand Name | indclox lb capsule |
| Manufacturer | Ind Swift Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F) in a dry place. Protect from light and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise specified on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two penicillin antibiotics that inhibit bacterial cell wall synthesis. Amoxycillin is a broad-spectrum aminopenicillin that binds to penicillin-binding proteins (PBPs) and inhibits the cross-linking of peptidoglycan chains, leading to bacterial lysis. Cloxacillin is a penicillinase-resistant isoxazolyl penicillin that also binds to PBPs but is specifically designed to resist degradation by beta-lactamase enzymes produced by Staphylococcus aureus. Together, they provide coverage against a wider range of bacteria, including many streptococci, staphylococci, and some gram-negative organisms.
Mechanism Steps
💡 How to Take indclox lb capsule
Strength: Capsule containing 250 mg amoxycillin and 250 mg cloxacillin.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one capsule (containing 250 mg amoxycillin and 250 mg cloxacillin) taken orally every 6 to 8 hours, depending on the severity and type of infection. For skin and soft tissue infections, the typical duration is 5 to 10 days. For bone and joint infections, longer courses may be required. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing based on weight and indication. |
| Elderly Dosage | Elderly patients may have reduced renal function and are at higher risk of side effects. Dose adjustment may be necessary based on renal function. Monitor closely for signs of toxicity. |
| Renal Impairment | In patients with renal impairment, dose adjustment is required. For creatinine clearance (CrCl) 10-30 mL/min, consider extending the dosing interval to every 12 hours. For CrCl less than 10 mL/min, dosing interval may need to be extended to every 24 hours. Consult a clinician for precise dosing. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment, but use with caution and monitor liver function tests, especially with cloxacillin. |
| Maximum Daily Dose | The maximum recommended daily dose is not established from available information. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of indclox lb capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Allopurinol | Moderate | |
| Probenecid | Moderate | |
| Tetracyclines | Moderate | |
| Oral contraceptives | Moderate | |
| Antacids | Minor | |
| Aminoglycosides | Moderate |
🚨 Major Interactions
- Warfarin
- Methotrexate
- Allopurinol
- Oral contraceptives
⚡ Moderate Interactions
- Probenecid
- Tetracyclines
- Aminoglycosides
🍷 Alcohol Interaction
Alcohol may worsen gastrointestinal side effects such as nausea and stomach pain. It is advisable to avoid alcohol while taking this medicine, especially if you have liver disease.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to penicillins or cephalosporins.","History of severe allergic reaction (e.g., anaphylaxis) to beta-lactam antibiotics.","Infectious mononucleosis (risk of rash).","Concurrent use with methotrexate (relative).","Severe renal impairment without dose adjustment."]
⚠️ Warnings & Precautions
["Before starting, inform your doctor about any allergies, especially to antibiotics.","Use with caution in patients with renal impairment; dose adjustment may be needed.","Use with caution in patients with hepatic impairment; monitor liver function.","May reduce the efficacy of oral contraceptives; use additional contraception.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.","Do not use for viral infections; it is ineffective and promotes resistance.","Complete the full course as prescribed, even if symptoms improve.","If a rash or other allergic reaction occurs, stop the medicine and consult your doctor immediately."]
🤱 Lactation Safety
Amoxycillin and cloxacillin are excreted in breast milk in small amounts. They are generally considered safe during breastfeeding, but monitor the infant for diarrhea, thrush, or rash. Consult your doctor before use.
💊 Overdose Management
Overdose may cause nausea, vomiting, diarrhea, and abdominal pain. In severe cases, especially in renal impairment, seizures and crystalluria may occur. Treatment is supportive and symptomatic. Maintain adequate hydration. Hemodialysis may be considered in severe cases. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop the course early, even if you feel better, as this can lead to antibiotic resistance and recurrence of infection. Take the capsule with a full glass of water, with or without food, but taking it with food may reduce stomach upset. Inform your doctor if you have a history of allergies, asthma, kidney or liver disease, or if you are pregnant or breastfeeding. Avoid alcohol while taking this medicine, as it may worsen stomach upset and liver effects. Do not share this medicine with others, even if they have similar symptoms. Store the capsules in a cool, dry place away from direct sunlight and out of reach of children. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. If you experience any signs of a severe allergic reaction, such as rash, itching, swelling, dizziness, or trouble breathing, seek emergency medical help immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function and may require dose adjustment. They are also at higher risk of cloxacillin-induced liver injury. Monitor closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. It is generally considered safe but should be used only when clearly needed.
🏥 Post-Surgery Considerations
This medicine may be prescribed after surgery to prevent or treat surgical site infections. Follow your surgeon's instructions carefully.
🦷 Dental Procedures
This medicine is often prescribed for dental infections and before certain dental procedures in patients at risk of infective endocarditis. Inform your dentist if you are taking it.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
You can continue light exercise if you feel well, but avoid strenuous activity if you have fever or are feeling unwell. If you experience dizziness or fatigue, rest and consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. If affected, avoid driving or operating heavy machinery. Otherwise, you can continue your normal activities as tolerated.
🛑 When to Stop This Medicine
Stop taking this medicine only after completing the full prescribed course or if your doctor advises you to stop. If you experience a severe allergic reaction or other serious side effect, stop immediately and seek medical help.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance, overgrowth of non-susceptible organisms, and rarely, liver or kidney problems. It is not intended for prolonged use unless specifically directed by a doctor. Regular monitoring of liver and kidney function may be required if used for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Broader spectrum coverage including beta-lactamase producing bacteria.
Evidence: Well-establishedAlternative for skin infections in penicillin-allergic patients (with caution).
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Antibiotics do not interfere with most vaccines. However, if you are scheduled for a live bacterial vaccine (e.g., typhoid), consult your doctor as antibiotics may reduce its efficacy.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid temperature extremes. If crossing time zones, adjust dosing intervals as advised by your doctor. Store at room temperature and protect from light and moisture. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 2-3 days, but it is important to complete the full course as prescribed.
A: Yes, you can take it with or without food. Taking it with food may reduce stomach upset.
A: Take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: It is generally considered safe (Category B), but you should consult your doctor before use.
A: No, you must complete the full course to prevent recurrence and resistance.
🤔 Common Patient Concerns
🔄 Substitutes for indclox lb capsule
View AllAlternative brands with exact same active ingredient:
-
amyclox 250 mg/250 mg capsuleInd Swift Laboratories Ltd ₹3.20 84.8% CHEAPER
-
gp clox capsuleClox Pharma Pvt Ltd ₹4.98 76.4% CHEAPER
-
ceemox syrupAbbott ₹9.84 53.3% CHEAPER
-
moxiclox 250mg/250mg injectionPrem Pharmaceuticals Pvt Ltd ₹12.10 42.6% CHEAPER
-
zynaclox 250mg/250mg injectionZee Laboratories ₹12.48 40.8% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the common cold.
Fact: This medicine is an antibiotic and is only effective against bacterial infections. It does not treat viral infections. - Myth: You can stop taking this medicine as soon as you feel better.
Fact: You must complete the full course as prescribed, even if symptoms improve, to prevent recurrence and resistance. - Myth: This medicine is safe to take without a prescription.
Fact: This is a prescription medicine and should only be taken under a doctor's supervision.
🔄 Alternative Options
Generic Alternatives
- Amoxycillin and Cloxacillin Capsules