Amconazole 100 Capsule (Itraconazole 400mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of the skin or eyes (jaundice)
- Dark urine or pale stools
- Severe fatigue or weakness
- Swelling of the ankles, feet, or legs
- Sudden weight gain or shortness of breath
- Severe abdominal pain
- Numbness, tingling, or burning in hands or feet
- Hearing loss or ringing in the ears
- Severe rash with blisters or peeling skin
- Swelling of the face, lips, or throat
If experiencing severe symptoms, call emergency services immediately.
What is ibitra 400mg tablet sr used for?
This medicine is an antifungal capsule used to treat fungal infections of the skin, nails, mouth, throat, and internal organs. It works by breaking down the fungal cell membrane. It must be taken with food and exactly as prescribed.
- Generic Name: Itraconazole (400mg)
- Manufacturer: Indiabulls pharmaceutical ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ibitra 400mg tablet sr के बारे में (Hindi Summary)
उपयोग: यह दवा एक एंटीफंगल कैप्सूल है जिसका उपयोग त्वचा, नाखून, मुंह, गले और शरीर के आंतरिक अंगों के फंगल संक्रमण के इलाज के लिए किया जाता है। यह फंगस की कोशिका झिल्ली को नष्ट करके काम करती है। इसे भोजन के साथ लेना चाहिए और डॉक्टर के निर्देशानुसार पूरा कोर्स करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, सिरदर्द और चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें लीवर की समस्या, दिल की विफलता, गंभीर एलर्जी प्रतिक्रिया और तंत्रिका क्षति शामिल हो सकती है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ लें ताकि अवशोषण बेहतर हो और पेट की परेशानी कम हो। एंटासिड या एसिड कम करने वाली दवाओं को इस दवा से 2 घंटे पहले या बाद में लें। शराब न पिएं। अपने डॉक्टर को सभी दवाओं के बारे में बताएं। गर्भवती महिलाएं इस दवा का सेवन न करें।
💊 ibitra 400mg tablet sr Uses & Benefits
- [{"condition":"Onychomycosis (fungal nail infection)","description":"This medicine is used to treat fungal infections of the fingernails and toenails caused by dermatophytes and yeasts.
- It helps clear the infection and allows healthy nail to grow back.","evidence":"Well-established"},{"condition":"Tinea corporis, tinea cruris, and tinea pedis (ringworm, jock itch, athlete's foot)","description":"This medicine is effective for extensive or resistant skin fungal infections that have not responded to topical treatments.","evidence":"Well-established"},{"condition":"Oropharyngeal and esophageal candidiasis","description":"This medicine is used to treat yeast infections of the mouth and throat, especially in patients with weakened immune systems.","evidence":"Well-established"},{"condition":"Systemic fungal infections","description":"This medicine is used for invasive fungal infections such as histoplasmosis, blastomycosis, and aspergillosis in appropriate patients.","evidence":"Well-established"},{"condition":"Prophylaxis in immunocompromised patients","description":"This medicine may be prescribed to prevent fungal infections in patients with prolonged neutropenia or those undergoing certain transplants.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Seborrheic dermatitis","description":"Sometimes used off-label for severe seborrheic dermatitis that has not responded to standard treatments.","evidence":"Limited"},{"condition":"Allergic bronchopulmonary aspergillosis","description":"Occasionally used as part of a treatment regimen for this condition, but not a first-line therapy.","evidence":"Limited"}]
Primary treatment for: Fungal infections
Also treats: Onychomycosis, Tinea infections, Candidiasis, Histoplasmosis, Blastomycosis, Aspergillosis
📋 Drug Information
| Generic Name(s) | Itraconazole (400mg) |
| Brand Name | ibitra 400mg tablet sr |
| Manufacturer | Indiabulls pharmaceutical ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | OPHTHAL |
| Action Class | Fungal ergosterol synthesis inhibitor |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting the fungal enzyme cytochrome P450 14-alpha-demethylase, which is responsible for converting lanosterol to ergosterol. Ergosterol is a critical component of the fungal cell membrane. When this enzyme is blocked, the fungal cell membrane becomes weak and leaky, leading to cell death. This medicine is selective for the fungal enzyme over the human equivalent, which reduces but does not eliminate the risk of side effects in humans.
Mechanism Steps
💡 How to Take ibitra 400mg tablet sr
Strength: Itraconazole 400 mg immediate-release capsule
Dosage Information
| Adult Dosage | The dose of this medicine depends on the type and severity of the fungal infection being treated. For skin infections, a common dose is 200 mg once daily for 7 days, but this may vary. For nail infections, a pulse dosing regimen of 200 mg twice daily for 1 week per month for 2 to 3 months may be used. For systemic infections, doses may be higher and duration longer. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Always follow your doctor's prescription exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine. Dose selection should be cautious, and liver and kidney function should be monitored. No specific dose adjustment is established, but individualization by a clinician is essential. |
| Renal Impairment | Dose adjustment may be necessary in patients with severe kidney impairment. Monitor renal function and adjust dose as clinically indicated. Consult your doctor for specific guidance. |
| Hepatic Impairment | This medicine is contraindicated in patients with severe liver disease. In patients with mild to moderate liver impairment, use with caution and monitor liver function closely. Dose adjustment may be required. |
| Maximum Daily Dose | The maximum daily dose depends on the indication. For most indications, the maximum recommended dose is 400 mg per day. However, higher doses may be used in certain serious infections under close medical supervision. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ibitra 400mg tablet sr
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Cisapride | Major | |
| Warfarin | Major | |
| Simvastatin | Major | |
| Midazolam | Major | |
| Rifampicin | Major | |
| Omeprazole | Moderate | |
| Amlodipine | Moderate | |
| Glibenclamide | Moderate | |
| Antacids | Minor | |
| Sucralfate | Minor |
🚨 Major Interactions
- Cisapride, pimozide, quinidine, dofetilide
- Midazolam, triazolam
- Statins (simvastatin, lovastatin)
- Warfarin
- Rifampicin, rifabutin, phenytoin, carbamazepine
⚡ Moderate Interactions
- Calcium channel blockers (e.g., nifedipine, amlodipine)
- Oral hypoglycemics (e.g., glibenclamide)
- Proton pump inhibitors (e.g., omeprazole)
- H2 blockers (e.g., ranitidine)
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase the risk of liver damage and stomach bleeding, and may worsen side effects such as nausea and dizziness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to itraconazole or other azole antifungals","Pregnancy (except in life-threatening cases where benefit outweighs risk)","Women of childbearing potential not using effective contraception","Patients with evidence of ventricular dysfunction or heart failure","Concomitant use with cisapride, pimozide, quinidine, dofetilide, or levacetylmethadol","Severe liver disease"]
⚠️ Warnings & Precautions
["This medicine should be taken with food to ensure adequate absorption.","Avoid use in patients with a history of heart failure unless absolutely necessary.","Monitor liver function before and during treatment.","Use with caution in patients with kidney disease.","Inform your doctor about all other medications you are taking due to numerous drug interactions.","Do not use if you are pregnant or planning to become pregnant.","Avoid alcohol during treatment.","Do not share this medicine with others."]
🤱 Lactation Safety
This medicine is excreted in breast milk in small amounts. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother. Consult your doctor before breastfeeding.
💊 Overdose Management
There is no specific antidote for an overdose of this medicine. In case of overdose, seek immediate medical attention. Treatment should be symptomatic and supportive. Gastric lavage may be considered if the overdose is recent. Monitor vital signs and liver function.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop treatment early without medical advice. Swallow the capsule whole with a full glass of water, ideally after a meal, to improve absorption and reduce stomach upset. Avoid taking antacids or acid-reducing medicines within two hours of this medicine, as they can reduce its effectiveness. Do not drink alcohol while taking this medicine, as it can increase the risk of liver problems and stomach bleeding. Inform your doctor about all other medicines, supplements, and herbal products you are taking, because this medicine interacts with many drugs. If you have a history of heart failure, liver disease, or kidney disease, your doctor may need to monitor you more closely. Do not share this medicine with anyone else, even if they have similar symptoms. Keep this medicine out of the reach of children. If you miss a dose, take it as soon as you remember, but skip it if it is almost time for your next dose. Never double the dose to make up for a missed one. Contact your doctor immediately if you experience signs of an allergic reaction, liver problems, or heart failure.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to the side effects of this medicine, especially liver and heart toxicity. Dose selection should be cautious, and liver and kidney function should be monitored regularly.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended for use during pregnancy or in women planning to become pregnant. Use effective contraception during treatment and for at least two months after the last dose. If you become pregnant while taking this medicine, inform your doctor immediately.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist if you are taking this medicine before any surgery. It may interact with anesthetic agents and other medications used during surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may interact with medications used in dentistry and can affect healing.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause dizziness or fatigue in some people. Avoid strenuous exercise if you feel unsteady. If you experience muscle pain or weakness, consult your doctor before continuing exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue, which can affect your ability to drive or operate machinery. Avoid driving if you feel unsteady. Most people can continue their normal work activities, but take precautions if you experience side effects.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Stopping early can allow the infection to return and may lead to resistance. If you experience serious side effects, contact your doctor immediately; they will advise whether to stop or adjust the treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of liver toxicity, heart failure, and peripheral neuropathy. Regular monitoring of liver function and heart health is recommended for patients on prolonged therapy. The medicine can accumulate in tissues, so effects may persist after stopping. Always follow your doctor's guidance for duration of treatment.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For mild skin infections, topical creams may be sufficient and have fewer systemic side effects.
Evidence: Well-establishedTerbinafine or fluconazole may be alternatives depending on the type of fungal infection.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may interact with live vaccines. Consult your doctor before receiving any vaccinations while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, continue taking your doses at the same intervals as prescribed. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The time to work depends on the type of infection. For skin infections, improvement may be seen within 1 to 2 weeks. For nail infections, it may take several weeks to months.
A: Yes, this medicine should be taken with a full meal to improve absorption and reduce stomach upset.
A: Serious side effects include liver injury, heart failure, severe allergic reactions, and peripheral neuropathy. Seek immediate medical attention if you experience symptoms like jaundice, swelling, difficulty breathing, or numbness.
A: No, this medicine is not recommended during pregnancy as it may harm the developing baby. Use effective contraception during treatment and for at least two months after the last dose.
A: It is best to avoid alcohol as it can increase the risk of liver problems and stomach bleeding.
🤔 Common Patient Concerns
🔄 Substitutes for ibitra 400mg tablet sr
View AllAlternative brands with exact same active ingredient:
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itradila 400mg capsule srCadila Pharmaceuticals Ltd ₹93.75 56.5% CHEAPER
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afitra 400mg tabletRapross Pharmaceuticals Pvt Ltd ₹120.00 44.3% CHEAPER
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candirap 400mg capsuleRapross Pharmaceuticals Pvt Ltd ₹120.00 44.3% CHEAPER
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candiforce 400 tablet srMankind Pharma Ltd ₹146.25 32.2% CHEAPER
-
itracoe 400 sr tabletKoye Pharmaceuticals Pvt ltd ₹146.25 32.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken on an empty stomach.
Fact: This medicine should be taken with food to ensure proper absorption. - Myth: You can stop taking this medicine once symptoms improve.
Fact: You must complete the full course to prevent the infection from returning. - Myth: This medicine is safe to take with any other medication.
Fact: This medicine interacts with many drugs. Always inform your doctor about all medicines you take.
🔄 Alternative Options
Generic Alternatives
- Itraconazole 400 mg capsule
Brand Alternatives
- Amconazole 100 capsule