Hydrazide 25 Tablet (Hydrochlorothiazide 25 mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe dizziness or fainting
- Irregular or rapid heartbeat
- Muscle weakness or cramps that are severe
- Confusion or difficulty concentrating
- Decreased urine output or no urine
- Severe abdominal pain with nausea and vomiting
- Swelling of face, lips, tongue, or throat
- Difficulty breathing or chest pain
- Severe skin rash or blistering
- Eye pain or blurred vision
If experiencing severe symptoms, call emergency services immediately.
What is hydride 25mg tablet used for?
This medicine contains hydrochlorothiazide 25 mg, a thiazide diuretic used to treat high blood pressure and fluid retention. It works by helping the kidneys remove excess salt and water, which lowers blood pressure and reduces swelling. It is also used to prevent calcium kidney stones and manage diabetes insipidus.
- Generic Name: Hydrochlorothiazide (25mg)
- Manufacturer: Micro Labs Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 hydride 25mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा हाइड्रोक्लोरोथियाजाइड 25 मिलीग्राम युक्त एक थियाजाइड मूत्रवर्धक है। इसका उपयोग उच्च रक्तचाप (हाई ब्लड प्रेशर) को कम करने और शरीर में अतिरिक्त तरल पदार्थ (सूजन) को कम करने के लिए किया जाता है। यह गुर्दे पर कार्य करके सोडियम और पानी को बाहर निकालने में मदद करती है, जिससे रक्तचाप कम होता है। यह कैल्शियम युक्त गुर्दे की पथरी को रोकने और डायबिटीज इन्सिपिडस के इलाज में भी सहायक है। इस दवा का सेवन डॉक्टर के निर्देशानुसार ही करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में चक्कर आना, सिरदर्द, कमजोरी और बार-बार पेशाब आना शामिल हैं। कुछ लोगों में पोटैशियम या सोडियम की कमी, ब्लड शुगर और यूरिक एसिड का स्तर बढ़ सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, अग्न्याशय की सूजन, त्वचा पर गंभीर दाने या दृष्टि में बदलाव हो सकते हैं। यदि आपको मांसपेशियों में ऐंठन, असामान्य थकान, भ्रम या तेज धड़कन महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। दवा की खुराक बदलें या बंद करने से पहले डॉक्टर से सलाह लें। इस दवा से चक्कर आ सकते हैं, इसलिए वाहन चलाने या मशीनरी चलाने से बचें जब तक आपको इसका असर पता न चल जाए। पर्याप्त पानी पिएं और शराब से बचें। नियमित रूप से रक्तचाप, गुर्दे की कार्यप्रणाली और इलेक्ट्रोलाइट्स की जांच कराएं। यदि आप गर्भवती हैं, गर्भधारण की योजना बना रही हैं या स्तनपान करा रही हैं, तो डॉक्टर से परामर्श करें।
💊 hydride 25mg tablet Uses & Benefits
[{"condition":"Hypertension","description":"Lowers blood pressure by promoting sodium and water excretion, reducing fluid volume and vascular resistance.","evidence":"Well-established"},{"condition":"Edema","description":"Helps remove excess fluid in conditions such as heart failure, liver cirrhosis, and kidney disease.","evidence":"Well-established"},{"condition":"Calcium kidney stones","description":"Reduces urinary calcium excretion, which can help prevent recurrent calcium stone formation.","evidence":"Well-established"},{"condition":"Diabetes insipidus","description":"Can reduce urine output in nephrogenic diabetes insipidus by promoting sodium and water reabsorption.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Osteoporosis","description":"Sometimes used off-label because thiazides reduce urinary calcium loss and may help preserve bone density.","evidence":"Limited"},{"condition":"Ménière's disease","description":"Occasionally prescribed off-label to reduce fluid retention associated with inner ear pressure.","evidence":"Limited"}]
Primary treatment for: Hypertension
Also treats: Edema, Heart failure, Liver cirrhosis, Kidney disorders, Calcium kidney stones, Diabetes insipidus
📋 Drug Information
| Generic Name(s) | Hydrochlorothiazide (25mg) |
| Brand Name | hydride 25mg tablet |
| Manufacturer | Micro Labs Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Low-ceiling Diuretics (Inhibitors of Na+Cl symport) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F) in a dry place. Protect from light and moisture. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Thiazide diuretics are recommended by the World Health Organization as first-line treatment for hypertension in adults, either alone or in combination with other antihypertensive agents. |
| ICMR Guideline | The Indian Council of Medical Research recommends thiazide diuretics as one of the first-line options for the management of hypertension in India, especially in combination with other drugs. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine inhibits the sodium-chloride symporter in the distal convoluted tubule of the nephron. By blocking this transporter, it reduces sodium and chloride reabsorption, leading to increased excretion of sodium, chloride, and water. The resulting diuresis reduces plasma volume and, with continued use, lowers peripheral vascular resistance. It also increases calcium reabsorption in the distal tubule, which decreases urinary calcium excretion. These actions together lower blood pressure and reduce edema.
Mechanism Steps
💡 How to Take hydride 25mg tablet
Strength: Hydrochlorothiazide 25 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual adult dose for hypertension is 12.5 mg to 50 mg once daily, with a maximum of 50 mg per day for hypertension. For edema, the dose may range from 25 mg to 100 mg daily, given as a single dose or in divided doses. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to therapy. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially dizziness and electrolyte imbalances. Start with a lower dose and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with renal impairment, the dose may need to be reduced or the medicine avoided if creatinine clearance is below 30 mL/min. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose adjustment may be necessary. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | For hypertension, the maximum recommended daily dose is 50 mg. For edema, up to 100 mg daily may be used in some cases, but only under medical supervision. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of hydride 25mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Lithium | Major | |
| Digoxin | Major | |
| ACE inhibitors | Major | |
| ARBs | Major | |
| Corticosteroids | Major | |
| NSAIDs | Moderate | |
| Metformin | Moderate | |
| Insulin | Moderate | |
| Cholestyramine | Moderate | |
| Colestipol | Moderate |
🚨 Major Interactions
- Lithium
- Digoxin
- Angiotensin-converting enzyme (ACE) inhibitors
- Angiotensin II receptor blockers (ARBs)
- Corticosteroids
⚡ Moderate Interactions
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Metformin
- Insulin
- Cholestyramine
- Colestipol
🍷 Alcohol Interaction
Alcohol can enhance the blood pressure-lowering and dizzy effects of this medicine. It is advisable to avoid or limit alcohol consumption while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Allergy to hydrochlorothiazide or other sulfonamide-derived medicines","Anuria (absence of urine production)","Severe renal impairment (e.g., creatinine clearance
⚠️ Warnings & Precautions
["This medicine can cause dizziness; avoid driving or operating machinery until you know how it affects you.","Monitor for signs of electrolyte imbalance such as muscle cramps, weakness, confusion, or irregular heartbeat.","Use with caution in patients with diabetes, gout, lupus, or a history of kidney stones.","Avoid alcohol while taking this medicine as it can worsen dizziness and low blood pressure.","Do not take potassium supplements or salt substitutes containing potassium without consulting your doctor.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","This medicine may increase sensitivity to sunlight; use sunscreen and protective clothing.","Regular monitoring of blood pressure, kidney function, and electrolytes is recommended."]
🤱 Lactation Safety
Hydrochlorothiazide is excreted in breast milk in small amounts. High doses may suppress lactation. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose may cause excessive diuresis, electrolyte depletion, and hypotension. Seek immediate medical attention. Treatment is supportive and symptomatic, including electrolyte replacement and fluid management as needed.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without medical advice. This medicine can cause dizziness, so avoid driving or operating heavy machinery until you know how it affects you. Drink enough water to stay hydrated, but follow your doctor's advice if you have heart or kidney problems that require fluid restriction. Avoid alcohol because it can worsen dizziness and low blood pressure. Have your blood pressure, kidney function, and electrolyte levels checked regularly as advised by your doctor. Inform your doctor if you have diabetes, gout, lupus, or a history of kidney stones. Do not take potassium supplements or salt substitutes containing potassium without consulting your doctor. If you are pregnant, planning pregnancy, or breastfeeding, talk to your doctor before using this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the effects of this medicine, particularly dizziness, electrolyte imbalances, and low blood pressure. Start with a lower dose and monitor closely. Regular monitoring of renal function and electrolytes is especially important.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. Thiazide diuretics are generally not recommended during pregnancy for routine hypertension because safer alternatives are available. Your doctor may switch you to a different medicine.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may need to be temporarily stopped before surgery due to its effects on blood pressure and electrolytes. Follow your doctor's instructions regarding perioperative management.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may cause dry mouth or dizziness during dental procedures. Your dentist may recommend monitoring blood pressure and hydration during the visit.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause dizziness and low blood pressure, especially during the initial days of treatment. Avoid strenuous exercise or sudden changes in posture until you know how the medicine affects you. Stay hydrated during exercise, but follow any fluid restrictions advised by your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, especially when standing up quickly. Avoid driving or operating heavy machinery until you know how it affects you. Frequent urination may require breaks during work hours. Adjusting the dose timing to the morning can help minimize disruption to your work and sleep.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects such as allergic reactions, severe electrolyte imbalance, or pancreatitis, seek immediate medical attention and follow your doctor's advice regarding discontinuation.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to electrolyte imbalances, increased blood sugar, increased uric acid, and reduced kidney function in some patients. Regular monitoring of blood pressure, electrolytes, renal function, and blood glucose is recommended. It may also increase the risk of skin cancer, particularly squamous cell carcinoma, with prolonged use. Discuss with your doctor about regular skin checks and sun protection.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Dietary changes, exercise, and weight loss can help lower blood pressure and reduce the need for medication.
Evidence: Well-establishedACE inhibitors, ARBs, calcium channel blockers, or beta-blockers may be used as alternatives or in combination.
Evidence: Well-establishedMay be used to avoid potassium loss, but have different side effect profiles.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, inform your healthcare provider about all medicines you are taking before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, consult your doctor about adjusting the timing of your dose. Carry enough supply for the entire trip and a few extra days in case of delays. Check local customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The diuretic effect begins within 2 hours, but the full blood pressure-lowering effect may take several days to weeks.
A: Yes, you can take it with or without food, but taking it with food may reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: No, do not stop taking this medicine without consulting your doctor. High blood pressure often has no symptoms, and stopping suddenly can cause it to rise again.
A: Yes, increased urination is a common effect, especially when starting treatment. Taking the dose in the morning can help avoid nighttime urination.
🤔 Common Patient Concerns
🔄 Substitutes for hydride 25mg tablet
View AllAlternative brands with exact same active ingredient:
-
hydrazide 25 tabletCipla Ltd ₹15.75 3.8% CHEAPER
-
bpzide 25mg tabletStadmed Pvt Ltd ₹16.50 0.7% COSTLIER
-
thiazide 25mg tabletOrdain Health Care Global Pvt Ltd ₹16.59 1.3% COSTLIER
-
hyzide 25mg tabletEast West Pharma ₹17.11 4.5% COSTLIER
-
hydronol 25 tabletKnoll Pharmaceuticals Ltd ₹17.33 5.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Hydrochlorothiazide is a blood thinner.
Fact: This medicine is a diuretic, not a blood thinner. It does not affect blood clotting. - Myth: You can stop taking it once your blood pressure is normal.
Fact: High blood pressure often has no symptoms, and stopping the medicine can cause it to rise again. Always consult your doctor before stopping. - Myth: It causes kidney damage in everyone.
Fact: When used as prescribed and monitored, it is generally safe. Regular monitoring helps prevent kidney problems. - Myth: It is safe to take during pregnancy.
Fact: Thiazide diuretics are generally not recommended during pregnancy for routine hypertension because safer alternatives exist. Consult your doctor.
🔄 Alternative Options
Generic Alternatives
- Hydrochlorothiazide 25 mg tablet (various manufacturers)
Brand Alternatives
- Hydrazide 25 tablet (Cipla Ltd)