Athfix 200mg/5ml Dry Syrup (Cefixime) - Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain or cramps
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Seizures or convulsions
- Severe skin rash with blistering or peeling
If experiencing severe symptoms, call emergency services immediately.
What is hicef 200 dry syrup used for?
This medicine is a cephalosporin antibiotic used to treat bacterial infections such as respiratory tract infections, urinary tract infections, and ear infections. It works by killing bacteria and is available as a dry syrup that is reconstituted into a liquid suspension.
- Generic Name: Cefixime (200mg/5ml)
- Manufacturer: Best Biotech
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 hicef 200 dry syrup के बारे में (Hindi Summary)
उपयोग: यह दवा सेफिक्साइम नामक एंटीबायोटिक है, जिसका उपयोग बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। यह श्वसन तंत्र, मूत्र मार्ग, कान, गले और त्वचा के संक्रमणों में प्रभावी है। यह दवा बैक्टीरिया की कोशिका भित्ति को नष्ट करके उन्हें मार देती है। यह वायरल संक्रमणों जैसे सर्दी-जुकाम या फ्लू के लिए प्रभावी नहीं है। इसका उपयोग डॉक्टर के पर्चे के अनुसार ही करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दस्त, जी मिचलाना, पेट दर्द और सिरदर्द शामिल हैं। ये आमतौर पर हल्के और अस्थायी होते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी प्रतिक्रिया, गंभीर दस्त, और दौरे पड़ सकते हैं। यदि कोई गंभीर या लगातार दुष्प्रभाव हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को बताएं यदि आपको सेफिक्साइम, अन्य सेफलोस्पोरिन या पेनिसिलिन से एलर्जी है। इस दवा का उपयोग वायरल संक्रमणों के लिए न करें। दवा को डॉक्टर के पर्चे के अनुसार ही लें, और कोर्स पूरा करें। रीकॉन्स्टिट्यूटेड सस्पेंशन को फ्रिज में रखें और 14 दिनों के बाद बची हुई दवा फेंक दें। एंटासिड या आयरन सप्लीमेंट के साथ इस दवा को लेने से बचें, कम से कम 2 घंटे का अंतराल रखें। यदि आप गर्भवती हैं, स्तनपान करा रही हैं, या गुर्दे की बीमारी है, तो डॉक्टर को बताएं।
💊 hicef 200 dry syrup Uses & Benefits
[{"condition":"Upper respiratory tract infections","description":"Used to treat bacterial infections such as pharyngitis, tonsillitis, and sinusitis caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Lower respiratory tract infections","description":"Effective against community-acquired pneumonia and acute exacerbations of chronic bronchitis.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Used for uncomplicated and complicated urinary tract infections caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Otitis media","description":"Treats middle ear infections in children caused by susceptible strains of bacteria.","evidence":"Well-established"},{"condition":"Uncomplicated gonorrhea","description":"Single-dose therapy for uncomplicated urethral, cervical, or rectal gonorrhea.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Used for mild to moderate skin infections such as cellulitis and abscesses.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Lyme disease","description":"Sometimes used as an alternative to doxycycline in patients who cannot take tetracyclines.","evidence":"Limited"},{"condition":"Typhoid fever","description":"May be used in areas where resistance patterns permit, but not first-line.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Respiratory tract infections, Urinary tract infections, Otitis media, Skin infections, Gonorrhea
📋 Drug Information
| Generic Name(s) | Cefixime (200mg/5ml) |
| Brand Name | hicef 200 dry syrup |
| Manufacturer | Best Biotech |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporins: 3 generation |
| Route of Administration | Oral |
| Storage | Store the dry powder at room temperature (15-30°C) in a tightly closed container, away from light and moisture. After reconstitution, store the suspension in the refrigerator (2-8°C) and discard any unused portion after 14 days. Do not freeze. |
| Shelf Life | The shelf life of the dry powder is typically 24 months from the date of manufacture. After reconstitution, the suspension should be used within 14 days if stored in the refrigerator. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine contains cefixime, a third-generation cephalosporin antibiotic that exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. It binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby blocking the cross-linking of peptidoglycan chains that provide structural integrity to the cell wall. This inhibition leads to weakening of the cell wall, cell lysis, and ultimately bacterial death. Cefixime is stable against hydrolysis by many beta-lactamases, which are enzymes produced by some bacteria that would otherwise inactivate penicillin-like antibiotics. However, it can be hydrolyzed by extended-spectrum beta-lactamases (ESBLs) and AmpC beta-lactamases, limiting its activity against certain resistant strains.
Mechanism Steps
💡 How to Take hicef 200 dry syrup
Strength: This medicine is a dry syrup that, when reconstituted, provides a suspension containing 200 mg of cefixime per 5 mL.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 200 mg to 400 mg per day, which can be given as a single daily dose or divided into two doses every 12 hours. For uncomplicated gonorrhea, a single 400 mg dose is recommended. The dose must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function. In patients with renal impairment, the dose may need to be reduced. Always follow your doctor's prescription exactly. |
| Pediatric Dosage | For children, the usual dose is 8 mg/kg/day, which can be given as a single daily dose or divided into two doses every 12 hours. The maximum pediatric dose should not exceed 400 mg per day. This medicine is not recommended for infants less than 6 months of age. Pediatric dosing is not established from available information for all age groups. Consult a pediatrician for appropriate dosing. |
| Elderly Dosage | Elderly patients may have reduced renal function, which can affect the elimination of cefixime. Dosage should be adjusted based on creatinine clearance. No specific dosage adjustments are recommended solely based on age, but renal function should be assessed before initiating therapy. |
| Renal Impairment | In patients with creatinine clearance (CrCl) of 20-60 mL/min, the dose should be reduced to 300 mg per day. For CrCl less than 20 mL/min, the dose should be reduced to 200 mg per day. Cefixime is not removed by hemodialysis, so no supplemental dose is needed after dialysis. Close monitoring is advised. |
| Hepatic Impairment | No specific dosage adjustment is required for patients with hepatic impairment, as cefixime is not significantly metabolized by the liver. However, caution is advised in patients with both hepatic and renal impairment. |
| Maximum Daily Dose | The maximum recommended daily dose is 400 mg for adults and 400 mg for children, regardless of the formulation. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of hicef 200 dry syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Carbamazepine | Major | |
| Antacids | Moderate | |
| Iron supplements | Moderate | |
| Probenecid | Moderate | |
| Oral contraceptives | Minor | |
| Loop diuretics | Minor |
🚨 Major Interactions
- Warfarin
- Carbamazepine
⚡ Moderate Interactions
- Antacids (aluminum/magnesium hydroxide)
- Iron supplements
- Probenecid
🍷 Alcohol Interaction
Alcohol does not directly interact with cefixime, but it may worsen gastrointestinal side effects such as nausea and diarrhea. It is advisable to avoid alcohol during antibiotic treatment to reduce the risk of dehydration and to support recovery.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to cefixime or any other cephalosporin antibiotic.","History of severe allergic reaction to penicillins (cross-reactivity possible).","Use in patients with carnitine deficiency (due to pivalate-containing formulations, but not applicable to cefixime alone)."]
⚠️ Warnings & Precautions
["Before starting therapy, inquire about previous hypersensitivity reactions to cephalosporins, penicillins, or other drugs.","Use with caution in patients with renal impairment; dosage adjustment may be needed.","Prolonged use may result in overgrowth of non-susceptible organisms, including fungi.","Clostridioides difficile-associated diarrhea has been reported; consider this diagnosis in patients who present with diarrhea subsequent to antibiotic use.","Do not use in patients with a history of seizures, especially with renal impairment, as cefixime may accumulate and lower seizure threshold.","Safety and efficacy in children under 6 months of age have not been established.","As with other antibiotics, cefixime may reduce the efficacy of oral contraceptives; advise additional precautions."]
🤱 Lactation Safety
Cefixime is excreted in human breast milk in low concentrations. It is generally considered safe during breastfeeding, but monitor the infant for diarrhea, thrush, or rash. Consult your doctor before use.
💊 Overdose Management
Overdosage of cefixime may cause nausea, vomiting, abdominal pain, diarrhea, and seizures. There is no specific antidote. Treatment should be symptomatic and supportive. In cases of recent ingestion, activated charcoal may be administered to reduce absorption. Cefixime is not significantly removed by hemodialysis or peritoneal dialysis. In case of overdose, contact a poison control center or emergency room immediately.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Before taking this medicine, inform your doctor if you are allergic to cefixime, other cephalosporins, or penicillins. Do not use this medicine to treat viral infections. Take the medicine exactly as prescribed, and do not skip doses or stop early. Shake the reconstituted suspension well before each use. Store the dry powder at room temperature and the reconstituted suspension in the refrigerator, discarding any unused portion after 14 days. Avoid taking antacids or iron supplements within 2 hours of this medicine, as they may reduce its absorption. If you have kidney disease, your doctor may need to adjust your dose. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not share this medicine with others, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function, which can affect the elimination of this medicine. Dosage adjustment may be necessary based on creatinine clearance. Monitor for signs of toxicity and ensure adequate hydration.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It is classified as Pregnancy Category B, meaning it is generally considered safe, but should be used only if clearly needed. Discuss any potential risks and benefits with your healthcare provider.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon that you are taking this medicine. It may need to be stopped before certain procedures, or your surgeon may adjust your dose. This medicine is sometimes used to prevent surgical site infections, but this should be determined by your healthcare team.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may interact with other medications used during dental work, and your dentist may need to adjust your treatment plan. Good oral hygiene is important while on antibiotics.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause dizziness or fatigue in some individuals. Avoid strenuous exercise or activities requiring mental alertness until you know how the medicine affects you. If you experience dizziness, do not drive or operate heavy machinery.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. If affected, avoid driving or operating machinery. Otherwise, you can continue your normal daily activities as tolerated. Take the medicine at the same time each day to maintain consistent levels.
🛑 When to Stop This Medicine
Do not stop taking this medicine before completing the full prescribed course, even if you feel better. Stopping early can lead to recurrence of infection and antibiotic resistance. If you experience severe side effects, contact your doctor before stopping. Your doctor will advise if and when it is safe to discontinue.
📅 Long-Term Use Effects
Long-term use of this medicine is not typically recommended unless for a specific chronic infection under close medical supervision. Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi, and may increase the risk of antibiotic resistance. Regular monitoring of renal and hepatic function may be advised if used for extended periods. Discontinue and consult your doctor if you experience persistent diarrhea or other significant side effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help prevent antibiotic-associated diarrhea when taken alongside this medicine.
Evidence: ModerateHelps flush out bacteria in urinary tract infections and maintains hydration.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you are scheduled to receive a live vaccine, inform your doctor, as antibiotics may affect the immune response to certain vaccines. Generally, antibiotics do not contraindicate vaccination.
📦 Storage Guide
✅ DO
Store dry powder at room temperature (15-30°C)
❌ DON'T
Do not refrigerate the dry powder
✅ DO
Store reconstituted suspension in refrigerator (2-8°C)
❌ DON'T
Do not freeze the reconstituted suspension
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Discard reconstituted suspension after 14 days
❌ DON'T
Do not use beyond the discard date
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging along with a copy of your prescription. For air travel, keep the dry powder in your carry-on luggage to avoid temperature extremes in checked baggage. If you have already reconstituted the suspension, store it in a cool, insulated bag and keep it refrigerated as soon as possible. Be aware of customs regulations regarding prescription medications in your destination country. If crossing time zones, adjust your dosing schedule gradually, but consult your doctor for specific advice.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours, but it is important to complete the full course as prescribed.
A: Yes, you can take it with or without food. Taking it with food may help reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: Yes, it is commonly used in children, but the dose is based on weight. It is not recommended for infants under 6 months of age.
A: No, you must complete the full prescribed course to prevent the infection from returning and to avoid antibiotic resistance.
🤔 Common Patient Concerns
🔄 Substitutes for hicef 200 dry syrup
View AllAlternative brands with exact same active ingredient:
-
emix kid 200mg/5ml dry syrupPharma Fabrikon ₹35.16 71.9% CHEAPER
-
cefstat 200mg/5ml dry syrupKaiser Drugs Pvt Ltd ₹40.80 67.4% CHEAPER
-
athfix 200mg/5ml dry syrupAthens Labs Ltd ₹40.97 67.2% CHEAPER
-
cefifurt 200mg/5ml dry syrupFrankfurt Pharma Pvt Ltd ₹46.41 62.9% CHEAPER
-
creo 200mg/5ml suspensionThrift Pharmaceuticals ₹46.88 62.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Antibiotics can cure viral infections like the common cold.
Fact: This medicine is effective only against bacterial infections. It does not treat viral infections. - Myth: You can stop taking antibiotics once you feel better.
Fact: You must complete the full prescribed course to prevent bacterial resistance and ensure complete eradication of the infection. - Myth: Antibiotics weaken the immune system.
Fact: Antibiotics do not weaken the immune system; they target bacteria. However, they can disrupt normal gut flora, which may have temporary effects.
🔄 Alternative Options
Generic Alternatives
- Cefixime 200 mg/5 mL dry syrup (various manufacturers)
Brand Alternatives
- Taxim-O
- Zifi
- Cefolac
- Omnicef
- Suprax