Trofil 60mg/100mg/2mg Tablet: Complete Information
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of face, lips, or throat
- Difficulty breathing or wheezing
- Severe skin rash with blistering or peeling
- High fever with severe headache and confusion
- Seizures or loss of consciousness
- Yellowing of eyes or skin
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is esnotone plus tablet used for?
This medicine is a combination of Guaifenesin (an expectorant) and Diethylcarbamazine (an antifilarial agent). It is used to treat lymphatic filariasis and to relieve cough with thick mucus. It works by thinning mucus and killing filarial worms. It should be taken only under medical supervision.
- Generic Name: Guaifenesin (60mg) + Diethylcarbamazine (100mg)
- Manufacturer: Sarmain Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 esnotone plus tablet के बारे में (Hindi Summary)
उपयोग: यह दवा गुआइफेनेसिन और डाइएथिलकार्बामाज़ीन का संयोजन है। इसका उपयोग लिम्फैटिक फाइलेरिया (हाथी पांव) और बलगम वाली खांसी के इलाज में किया जाता है। गुआइफेनेसिन बलगम को पतला करता है जिससे खांसी में आराम मिलता है, और डाइएथिलकार्बामाज़ीन फाइलेरिया के कीड़ों को मारता है। यह दवा डॉक्टर की सलाह के बिना नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, चक्कर आना, सिरदर्द और पेट में परेशानी शामिल हैं। कुछ लोगों को बुखार, जोड़ों में दर्द और त्वचा पर चकत्ते भी हो सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर सांस लेने में कठिनाई, चेहरे या गले में सूजन, या गंभीर दाने हों तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अपनी मर्जी से खुराक न बढ़ाएं या कम न करें। इसे पानी के साथ निगलें। अगर पेट में परेशानी हो तो इसे भोजन के साथ लें। दवा लेने के बाद चक्कर आने पर वाहन न चलाएं। शराब का सेवन न करें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। बच्चों से दूर रखें।
💊 esnotone plus tablet Uses & Benefits
- [{"condition":"Lymphatic filariasis","description":"Diethylcarbamazine is effective against Wuchereria bancrofti, Brugia malayi, and Brugia timori, the parasites that cause lymphatic filariasis.
- It helps reduce microfilariae in the blood and alleviates symptoms.","evidence":"Well-established"},{"condition":"Tropical pulmonary eosinophilia","description":"A condition caused by hypersensitivity to filarial parasites, characterized by severe cough and wheezing.
- Diethylcarbamazine is the treatment of choice.","evidence":"Well-established"},{"condition":"Productive cough with thick mucus","description":"Guaifenesin helps thin and loosen mucus in the airways, making it easier to cough out.
- It is used for symptomatic relief of respiratory conditions with excessive or thick secretions.","evidence":"Well-established"},{"condition":"Loiasis (African eye worm)","description":"Diethylcarbamazine is used to treat infection with Loa loa, although caution is needed due to risk of severe reactions.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Onchocerciasis (river blindness)","description":"Diethylcarbamazine has been used in some regimens, but it is not the preferred treatment due to risk of severe reactions. Ivermectin is preferred.","evidence":"Limited"},{"condition":"Bronchial asthma with mucus plugging","description":"Guaifenesin may be used as an adjunct to help clear mucus, but it does not treat the underlying inflammation.","evidence":"Limited"}]
Primary treatment for: Lymphatic filariasis
Also treats: Tropical pulmonary eosinophilia, Loiasis, Productive cough with thick mucus
📋 Drug Information
| Generic Name(s) | Guaifenesin (60mg) + Diethylcarbamazine (100mg) |
| Brand Name | esnotone plus tablet |
| Manufacturer | Sarmain Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Diethylcarbamazine is included in WHO guidelines for the treatment of lymphatic filariasis, often in combination with other antifilarial drugs. However, this specific combination product is not specifically mentioned in WHO guidelines. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Guaifenesin is an expectorant that works by increasing the volume and reducing the viscosity of bronchial secretions. It stimulates gastric mucosal receptors, which reflexively increase respiratory tract fluid output, making coughs more productive. Diethylcarbamazine is an antifilarial agent. It immobilizes and kills microfilariae and adult worms by altering their surface membranes, making them more susceptible to host immune defenses. It also inhibits arachidonic acid metabolism in the parasite, leading to parasite death. The combination is designed to address both mucus clearance and filarial infection when both are present.
Mechanism Steps
💡 How to Take esnotone plus tablet
Strength: Each tablet contains Guaifenesin 60 mg and Diethylcarbamazine 100 mg.
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function. For lymphatic filariasis, diethylcarbamazine is typically given in a dose of 6 mg/kg/day for 12 days, but the exact regimen varies. For tropical pulmonary eosinophilia, a similar dose may be used. Guaifenesin is usually dosed at 200-400 mg every 4 hours, but this combination provides only 60 mg per tablet. Therefore, the dosing frequency and duration should be strictly as prescribed by your doctor. Do not self-medicate. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced kidney function, which can affect the elimination of diethylcarbamazine. Dose adjustment may be necessary. Consult your doctor for appropriate dosing. |
| Renal Impairment | In patients with renal impairment, diethylcarbamazine may accumulate. Dose reduction or longer dosing intervals may be required. Consult your doctor for specific guidance. |
| Hepatic Impairment | In patients with hepatic impairment, both ingredients may be metabolized more slowly. Caution is advised, and dose adjustment may be needed. Consult your doctor. |
| Maximum Daily Dose | The maximum daily dose should be determined by your doctor based on the indication and patient factors. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of esnotone plus tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ivermectin | Major | |
| Suramin | Major | |
| Warfarin | Moderate | |
| Alcohol | Moderate | |
| Benzodiazepines | Moderate | |
| Antacids | Minor | |
| Diuretics | Minor |
🚨 Major Interactions
- Ivermectin
- Suramin
⚡ Moderate Interactions
- CNS depressants (e.g., alcohol, benzodiazepines)
- Anticoagulants (e.g., warfarin)
🍷 Alcohol Interaction
Avoid consuming alcohol while taking this medicine. Alcohol can increase the risk of dizziness, drowsiness, and stomach upset. It may also worsen liver side effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to guaifenesin or diethylcarbamazine","Severe renal impairment","Active peptic ulcer disease","Children under 2 years of age (unless directed by a doctor)","Pregnancy (unless clearly needed and prescribed)"]
⚠️ Warnings & Precautions
["Do not exceed the recommended dose.","Avoid driving or operating machinery if you feel dizzy or drowsy.","Avoid alcohol while taking this medicine.","Inform your doctor if you have kidney or liver disease.","Inform your doctor if you are pregnant or breastfeeding.","Diethylcarbamazine can cause a Mazzotti reaction; your doctor may prescribe medications to manage this.","Use with caution in patients with a history of seizures.","Keep out of reach of children."]
🤱 Lactation Safety
Both guaifenesin and diethylcarbamazine are excreted in breast milk. There is limited information on their effects on the breastfed infant. Consult your doctor before breastfeeding while on this medicine.
💊 Overdose Management
Overdose may cause nausea, vomiting, dizziness, and drowsiness. In severe cases, it can lead to seizures or difficulty breathing. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not increase or decrease the dose on your own. Swallow the tablet whole with a glass of water. It can be taken with or without food, but taking it with food may reduce stomach upset. Avoid driving or operating heavy machinery if you feel dizzy or drowsy after taking this medicine. Do not consume alcohol while on this medicine, as it may worsen side effects like dizziness and stomach irritation. Inform your doctor if you have kidney or liver problems, or if you are pregnant or breastfeeding. Keep this medicine out of reach of children. Store it at room temperature, away from moisture and direct sunlight. Do not use it after the expiry date. If you miss a dose, take it as soon as you remember, but skip it if it is almost time for the next dose. Never double the dose.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced kidney function, which can affect the elimination of diethylcarbamazine. Dose adjustment may be necessary. They may also be more susceptible to side effects like dizziness and confusion. Close monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Both ingredients may pose risks to the fetus. Effective contraception should be used during treatment. Discuss alternative treatments if needed.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may interact with other medications used during surgery. Your doctor may advise you to stop it temporarily.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may cause dry mouth or interact with local anesthetics. No specific precautions are established, but it is important to disclose all medications.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you feel dizzy or fatigued. Light activity is fine, but listen to your body. If you have swelling in your legs due to filariasis, elevate your legs and avoid prolonged standing.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how it affects you. It is advisable to take rest if you experience side effects. Inform your employer if you need to take time off.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Complete the full course as prescribed. If you experience severe side effects, contact your doctor immediately; they will advise whether to stop.
📅 Long-Term Use Effects
Long-term use of this medicine should be under medical supervision. Prolonged use may require monitoring of liver and kidney function. Diethylcarbamazine can cause cumulative toxicity, and guaifenesin is generally safe for short-term use. Do not use for extended periods without consulting your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another antifilarial medicine often used in combination for lymphatic filariasis.
Evidence: Well-establishedUsed in combination with other antifilarials for lymphatic filariasis.
Evidence: Well-establishedFor lymphedema management, including elevation and compression.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. There are no known interactions with vaccines. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If you are crossing time zones, adjust your dosing schedule as advised by your doctor. Check the customs regulations of your destination country regarding prescription medicines. Always carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The expectorant effect may start within 30 minutes to 1 hour. The antifilarial effect takes longer, with microfilariae reduction seen within days. Clinical improvement may take a few weeks.
A: Inform your doctor about all other medications you are taking, as this medicine can interact with some drugs like ivermectin, warfarin, and alcohol.
A: Mild side effects like nausea and dizziness usually go away. If you experience severe symptoms like difficulty breathing, severe rash, or confusion, seek immediate medical help.
🤔 Common Patient Concerns
🔄 Substitutes for esnotone plus tablet
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a general cough syrup.
Fact: This medicine contains diethylcarbamazine, an antifilarial agent, and is not a simple cough syrup. It should be used only for specific indications as prescribed by a doctor. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full course as prescribed to ensure the infection is fully treated and to prevent recurrence. - Myth: This medicine is safe for everyone.
Fact: It is not safe for people with certain conditions like severe kidney disease or active peptic ulcer. Always consult a doctor.
🔄 Alternative Options
Generic Alternatives
- Guaifenesin + Diethylcarbamazine (generic versions may be available)
Brand Alternatives
- Trofil 60mg/100mg/2mg Tablet