Dehydroepiandrosterone (Micronized) (25mg) + Folic Acid (1.5mg) (Medical Monograph)

Overview

A fixed-dose combination supplement containing micronized Dehydroepiandrosterone (DHEA), a prohormone precursor to androgens and estrogens, and Folic Acid (Vitamin B9). Micronization enhances DHEA's dissolution and absorption. This combination is primarily used to address age-related decline in DHEA levels and support metabolic, immune, and cognitive functions, with folic acid added to support homocysteine metabolism and methylation processes, which may be synergistic in certain clinical contexts like mood and cardiovascular health.

DHEA serves as a precursor for the synthesis of sex steroids (androgens and estrogens) in peripheral tissues, acting as a prohormone. It exerts both direct effects via binding to neurosteroid receptors (e.g., GABA-A, NMDA, sigma-1) and indirect effects via its metabolites. Folic acid is converted to active coenzymes essential for DNA synthesis, repair, methylation, and amino acid metabolism, including the conversion of homocysteine to methionine.