Antrima 400mg/80mg Tablet: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Severe skin rash, blistering, or peeling of the skin
- Fever, sore throat, or unusual bleeding or bruising
- Yellowing of the eyes or skin, dark urine, or abdominal pain
- Decreased urine output or swelling in the legs or feet
- Difficulty breathing, swelling of the face, lips, or throat
- Severe diarrhea that is watery or bloody
- Persistent headache, confusion, or seizures
If experiencing severe symptoms, call emergency services immediately.
What is danatrim 400mg/80mg tablet used for?
This medicine is a combination antibiotic containing sulfamethoxazole and trimethoprim. It is used to treat various bacterial infections, including urinary tract infections, respiratory infections, and skin infections. It works by blocking two steps in the bacterial folate synthesis pathway, stopping bacterial growth.
- Generic Name: Sulfamethoxazole (400mg) + Trimethoprim (80mg)
- Manufacturer: Dana Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 danatrim 400mg/80mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा सल्फामेथोक्साज़ोल और ट्राइमेथोप्रिम का संयोजन है, जिसका उपयोग विभिन्न जीवाणु संक्रमणों के इलाज के लिए किया जाता है। यह मूत्र मार्ग संक्रमण, श्वसन तंत्र संक्रमण, त्वचा संक्रमण और निमोनिया के कुछ प्रकारों के इलाज में प्रभावी है। यह जीवाणुओं के फोलेट संश्लेषण को रोककर उनकी वृद्धि को रोकती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, दस्त, भूख न लगना, सिरदर्द और त्वचा पर चकत्ते शामिल हैं। गंभीर दुष्प्रभावों में त्वचा की गंभीर प्रतिक्रियाएं, रक्त विकार, गुर्दे और यकृत की समस्याएं शामिल हो सकती हैं। यदि आपको चकत्ते, छाले, बुखार, गले में खराश, असामान्य रक्तस्राव, पीलिया या पेशाब में कमी महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक न छोड़ें और कोर्स पूरा करें। पर्याप्त पानी पिएं। धूप से बचें और सनस्क्रीन का उपयोग करें। यदि आपको गुर्दे या यकृत की समस्या है, अस्थमा है, या सल्फा से एलर्जी है, तो डॉक्टर को बताएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। शराब का सेवन न करें।
💊 danatrim 400mg/80mg tablet Uses & Benefits
- [{"condition":"Urinary tract infections","description":"This medicine is commonly used to treat uncomplicated urinary tract infections caused by susceptible bacteria such as Escherichia coli.","evidence":"Well-established"},{"condition":"Respiratory tract infections","description":"It is used for acute exacerbations of chronic bronchitis and other respiratory infections when caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"This medicine can treat infections like cellulitis and abscesses caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Pneumocystis jirovecii pneumonia (PCP)","description":"It is a first-line treatment and prophylaxis for PCP in immunocompromised patients, such as those with HIV/AIDS.","evidence":"Well-established"},{"condition":"Traveler's diarrhea","description":"It may be used to treat diarrhea caused by susceptible bacteria, including some strains of E.
- coli.","evidence":"Moderate"},{"condition":"Otitis media","description":"It can be used for middle ear infections in children when caused by susceptible bacteria.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Community-acquired pneumonia","description":"Sometimes used off-label for mild community-acquired pneumonia when other antibiotics are not suitable.","evidence":"Limited"},{"condition":"Prostatitis","description":"May be used off-label for chronic bacterial prostatitis caused by susceptible organisms.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Urinary tract infections, Respiratory tract infections, Skin infections, Pneumocystis jirovecii pneumonia, Traveler's diarrhea
📋 Drug Information
| Generic Name(s) | Sulfamethoxazole (400mg) + Trimethoprim (80mg) |
| Brand Name | danatrim 400mg/80mg tablet |
| Manufacturer | Dana Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. However, this medicine is included in the WHO Model List of Essential Medicines for the treatment of several bacterial infections. |
| ICMR Guideline | Not established from the available information. Consult local guidelines for appropriate use. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting two sequential steps in the bacterial folate synthesis pathway. Sulfamethoxazole is a structural analog of para-aminobenzoic acid (PABA) and competitively inhibits dihydropteroate synthase, preventing the formation of dihydrofolic acid. Trimethoprim inhibits dihydrofolate reductase, blocking the conversion of dihydrofolic acid to tetrahydrofolic acid. This sequential blockade results in synergistic antibacterial activity, as bacteria cannot synthesize the folate they need for DNA and protein synthesis.
Mechanism Steps
💡 How to Take danatrim 400mg/80mg tablet
Strength: Each tablet contains sulfamethoxazole 400 mg and trimethoprim 80 mg.
Dosage Information
| Adult Dosage | The usual adult dose for most infections is one tablet (400 mg sulfamethoxazole and 80 mg trimethoprim) every 12 hours for 7 to 10 days. For severe infections, the dose may be increased. For Pneumocystis jirovecii pneumonia, higher doses are used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. For children over 2 months, dosing is typically based on weight and the specific infection. This medicine is not recommended for infants under 2 months of age. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially if they have reduced kidney function. Dose adjustment may be necessary based on renal function. Monitor closely for side effects. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. For creatinine clearance 15-30 mL/min, reduce dose by 50%. For creatinine clearance less than 15 mL/min, use is not recommended unless benefits outweigh risks. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose adjustment may be necessary. Monitor liver function tests regularly. |
| Maximum Daily Dose | The maximum recommended daily dose for adults is 1600 mg sulfamethoxazole and 320 mg trimethoprim (four tablets per day) for severe infections. For prophylaxis, lower doses are used. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of danatrim 400mg/80mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Major | |
| Phenytoin | Major | |
| Sulfonylureas | Major | |
| Amantadine | Moderate | |
| Digoxin | Moderate | |
| Rifampin | Moderate | |
| Dapsone | Moderate | |
| Procainamide | Moderate |
🚨 Major Interactions
- Warfarin
- Methotrexate
- ACE inhibitors (e.g., lisinopril)
- Phenytoin
- Sulfonylureas (e.g., glipizide)
⚡ Moderate Interactions
- Amantadine
- Digoxin
- Rifampin
- Dapsone
- Procainamide
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase the risk of liver damage and may worsen side effects such as nausea and dizziness. It can also reduce the effectiveness of the antibiotic.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to sulfamethoxazole, trimethoprim, or any component of the formulation","Known allergy to sulfonamides","Pregnancy at term or during labor","Nursing mothers of infants less than 2 months old or with jaundice","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["Serious skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis have been reported. Discontinue at first sign of rash.","Fatalities associated with hypersensitivity reactions, agranulocytosis, aplastic anemia, and other blood dyscrasias have occurred.","Use with caution in patients with renal or hepatic impairment; dose adjustment may be needed.","May cause hypoglycemia, especially in patients with renal impairment or on sulfonylureas.","May increase risk of hyperkalemia, particularly in patients on ACE inhibitors or with renal impairment.","Avoid in patients with G6PD deficiency due to risk of hemolysis.","May cause photosensitivity; advise sun protection.","Not recommended for prophylactic use in recurrent urinary tract infections unless specifically indicated."]
🤱 Lactation Safety
This medicine is excreted in breast milk. It should be used with caution in nursing mothers, especially if the infant is premature, jaundiced, or has glucose-6-phosphate dehydrogenase (G6PD) deficiency. Consult your doctor before use.
💊 Overdose Management
Overdose may cause nausea, vomiting, dizziness, headache, and mental depression. In severe cases, bone marrow suppression, liver toxicity, and kidney failure may occur. Treatment is supportive and symptomatic. Gastric lavage may be considered if ingestion is recent. Monitor blood counts, liver and kidney function. Folinic acid may be administered to counteract the effects of trimethoprim on folate metabolism. Contact a poison control center or emergency department immediately.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop early. Drink plenty of water to help prevent kidney stones. Avoid prolonged sun exposure and use sunscreen, as this medicine can make your skin more sensitive to sunlight. Inform your doctor if you have kidney or liver problems, asthma, or a history of allergies. Do not take this medicine if you are allergic to sulfa drugs. If you are pregnant or breastfeeding, consult your doctor before use. Avoid alcohol while taking this medicine. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function, which can increase the risk of side effects. Dose adjustment may be necessary. They should be monitored closely for signs of blood dyscrasias, skin reactions, and hyperkalemia. Adequate hydration is especially important.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It is generally avoided during pregnancy, especially in the first trimester and near term. Your doctor may recommend an alternative antibiotic if needed.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon that you are taking this medicine. It may interact with other medications used during surgery. Your doctor may advise you to stop the medicine before surgery or adjust the dose.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may interact with other medications or affect healing. Your dentist may recommend postponing non-urgent procedures until you complete the course.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause dizziness or fatigue in some people. Avoid strenuous exercise if you feel unwell. Listen to your body and rest when needed. If you experience joint pain or swelling, consult your doctor before resuming exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, headache, or fatigue in some people. If you experience these side effects, avoid driving or operating heavy machinery until you know how the medicine affects you. Most people can continue their normal activities, but it is important to take the medicine as prescribed and not skip doses.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor, even if you feel better. Stopping early can lead to a recurrence of the infection and antibiotic resistance. If you experience serious side effects such as a severe rash, difficulty breathing, or yellowing of the skin, stop the medicine and seek immediate medical attention.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to bone marrow suppression, folate deficiency, and increased risk of infections. It can also cause kidney stones and liver toxicity. Regular monitoring of blood counts, kidney and liver function is recommended for prolonged use. When used for prophylaxis, the dose is usually lower and the duration is determined by the underlying condition.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Drinking plenty of water can help flush out bacteria in urinary tract infections.
Evidence: Well-establishedMay help prevent urinary tract infections, but not a treatment for active infection.
Evidence: LimitedCan help restore gut flora during and after antibiotic treatment.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you are taking it for an active infection, you should postpone vaccination until you have recovered, unless your doctor advises otherwise.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If you are crossing time zones, adjust your dosing schedule to maintain 12-hour intervals as closely as possible. Check the customs regulations of your destination country regarding prescription medications. Always carry enough supply for your entire trip and a little extra in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 1-2 days, but it may take up to 3-5 days for full effect. Complete the full course as prescribed.
A: Yes, you can take it with or without food. Taking it with food may help reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: This medicine is generally avoided during pregnancy, especially in the first trimester and near term. Consult your doctor for individualized advice.
A: It is best to avoid alcohol while taking this medicine, as it can increase the risk of liver toxicity and worsen side effects.
A: Store at room temperature between 15°C and 30°C, away from light and moisture. Keep in the original container.
🤔 Common Patient Concerns
🔄 Substitutes for danatrim 400mg/80mg tablet
View AllAlternative brands with exact same active ingredient:
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sepnil 400mg/80mg tabletTOSC International Pvt Ltd ₹5.63 31% CHEAPER
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Sulphan SS 400mg/80mg TabletTherawin Formulations ₹5.65 30.8% CHEAPER
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salgatran 400mg/80mg tabletBevit Pharmaceuticals Ltd ₹5.81 28.8% CHEAPER
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otrim 400mg/80mg tabletBiochem Pharmaceutical Industries ₹5.90 27.7% CHEAPER
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kombina 400mg/80mg tabletDeys Medical ₹5.91 27.6% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the common cold.
Fact: This medicine is an antibiotic and only works against bacterial infections. It is not effective against viruses. - Myth: You can stop taking this medicine as soon as you feel better.
Fact: You must complete the full course as prescribed to prevent the infection from returning and to reduce antibiotic resistance. - Myth: This medicine is safe for everyone.
Fact: It is not safe for people with sulfa allergies, pregnant women near term, infants under 2 months, and those with severe kidney or liver disease. - Myth: This medicine can be used to prevent all infections.
Fact: It is only used for specific bacterial infections and should not be used indiscriminately.
🔄 Alternative Options
Generic Alternatives
- Sulfamethoxazole + Trimethoprim 400 mg + 80 mg tablet
Brand Alternatives
- Bactrim
- Septran
- Cotrim
- Sulfatrim