cycloaqua eye drop - Uses, Price, Side Effects & Substitutes
What is cycloaqua eye drop used for?
Arpimune ME 50mg Capsule (Ciclosporin) is used to treat OPHTHAL. It contains Ciclosporin (0.05% w/v), which Inhibits calcineurin, thereby preventing dephosphorylation and nuclear transloca. Always consult your doctor before use. Take as prescribed.
- Generic Name: Ciclosporin
- Manufacturer: Kinetic Lifescience (OPC) Pvt Ltd
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ cycloaqua eye drop Uses & Benefits
Prophylaxis of organ transplant rejection; rheumatoid arthritis; psoriasis; nephrotic syndrome; dry eye disease (ophthalmic).
Off-label uses: Severe atopic dermatitis; ulcerative colitis; aplastic anemia.
๐ Drug Information
| Generic Name(s) | Ciclosporin |
| Brand Name | Arpimune ME 50mg Capsule |
| Manufacturer | Kinetic Lifescience (OPC) Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | OPHTHAL |
| Action Class | Immunosuppressant- Calcineurin inhibitors |
| Route of Administration | Oral |
| Storage | Store at 15-30ยฐC in a dry place; protect from light. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Inhibits calcineurin, thereby preventing dephosphorylation and nuclear translocation of nuclear factor of activated T-cells (NF-AT), leading to reduced transcription of interleukin-2 and other cytokines, suppressing T-cell activation.
Mechanism Steps
๐ก How to Take cycloaqua eye drop
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cycloaqua eye drop
โ Common Side Effects
- Nephrotoxicity
- Hypertension
- Tremor
- Hirsutism
- Gingival hyperplasia
- Gastrointestinal disturbances
- Hyperlipidemia
๐จ Serious Side Effects
- Acute or chronic nephrotoxicity
- Hepatotoxicity
- Neurotoxicity (seizures, encephalopathy)
- Lymphoma
- Opportunistic infections
- Thrombotic microangiopathy
โ ๏ธ Rare Side Effects
- Anaphylaxis
- Hemolytic uremic syndrome
- Pancreatitis
- Myopathy
- Gynecomastia
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Potassium-sparing diuretics | Major | Increased risk of hyperkalemia |
| ACE inhibitors | Major | Increased risk of hyperkalemia and nephrotoxicity |
| NSAIDs | Major | Increased nephrotoxicity risk |
| Live vaccines | Major | Risk of disseminated infection |
| Ketoconazole | Moderate | Increased ciclosporin levels |
| Rifampin | Moderate | Decreased ciclosporin levels |
| Grapefruit juice | Minor | Increased ciclosporin levels |
๐จ Major Interactions
- Potassium-sparing diuretics
- ACE inhibitors
- ARBs
- Methotrexate
- Colchicine
- NSAIDs
- Live vaccines
โก Moderate Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
- CYP3A4 inducers (e.g., rifampin, phenytoin)
- Statins
- Digoxin
- Prednisolone
โน๏ธ Minor Interactions
- Grapefruit juice
- Calcium channel blockers (e.g., diltiazem, verapamil)
- Oral contraceptives
๐ฝ๏ธ Food Interactions
Grapefruit juice increases bioavailability; avoid. Food may decrease absorption; take consistently with or without food.
๐ท Alcohol Interaction
Alcohol may increase hepatotoxicity risk; avoid excessive consumption.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to ciclosporin; uncontrolled hypertension; active infections; malignancy; concurrent PUVA or UVB therapy.
๐ Monitoring Parameters
Blood pressure, renal function (serum creatinine, BUN), liver function tests, ciclosporin trough levels, electrolytes (especially potassium), lipid profile.
๐คฑ Lactation Safety
Contraindicated; excreted in breast milk.
๐ Overdose Management
Supportive care; monitor renal function, liver function, and electrolytes; no specific antidote.
โฐ Missed Dose
Take as soon as remembered unless near next dose; do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for cycloaqua eye drop
View AllAlternative brands with exact same active ingredient (Ciclosporin (0.05% w/v)):
-
imudrops eye dropCipla Ltd โน29.06 92.9% CHEAPER
-
iflo eye dropAjanta Pharma Ltd โน163.64 60.1% CHEAPER
-
xiclone 0.05% eye dropMaa Enterprise โน215.63 47.4% CHEAPER
-
hydroeyes 0.05% eye dropLupin Ltd โน232.00 43.4% CHEAPER
-
imudrops singules eye drop 0.5mlCipla Ltd โน245.00 40.2% CHEAPER
-
ecomune eye dropNri Vision Care India Limited โน328.13 20% CHEAPER
-
mitears eye dropShilpex Pharmysis โน348.00 15.1% CHEAPER
-
nano tears 0.05% eye dropSunways India Pvt Ltd โน357.19 12.9% CHEAPER
-
cyclo tears 0.05% eye dropEntod Pharmaceuticals Ltd โน365.50 10.9% CHEAPER
-
cyclodrop eye dropZydus Cadila โน403.90 1.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.