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cutifluc 200 tablet

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Fluconazole (200mg)

🏭 Cutis Biotech 📦 Varies by brand 💊 Allopathy 📅 Updated: Jul 5, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Jul 05, 2026

What is cutifluc 200 tablet used for?

AF 150 Tablet DT (Fluconazole) is used to treat ANTI INFECTIVES. It contains Fluconazole (200mg), which Inhibits fungal cytochrome P450 14α-demethylase, preventing conversion of lanos. Always consult your doctor before use. Take as prescribed.

Generic Name: Fluconazole
Manufacturer: Cutis Biotech
Form: Allopathy
Pregnancy Category: D
Prescription Required: Yes

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 cutifluc 200 tablet Uses & Benefits

Vaginal candidiasis, oropharyngeal candidiasis, esophageal candidiasis, systemic candidiasis, cryptococcal meningitis, prophylaxis in immunocompromised patients

Off-label uses: Coccidioidomycosis, histoplasmosis, blastomycosis, dermatophytosis, onychomycosis

📋 Drug Information

Generic Name(s)	Fluconazole
Brand Name	AF 150 Tablet DT
Manufacturer	Cutis Biotech
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI INFECTIVES
Action Class	Fungal ergosterol synthesis inhibitor
Route of Administration	Oral
Storage	Store at 20-25°C (68-77°F); protect from light and moisture
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed after oral administration; bioavailability >90%

DistributionWidely distributed into body tissues and fluids, including CSF

Protein Binding11-12%

MetabolismHepatic metabolism via CYP2C9 and CYP3A4

Half-Life30 hours (range 20-50 hours)

ExcretionPrimarily renal (80% unchanged)

Bioavailability>90%

Onset of ActionRapid; therapeutic levels achieved within 1-2 hours

Peak Plasma Time1-2 hours

Duration of Action24 hours

How It Works

Inhibits fungal cytochrome P450 14α-demethylase, preventing conversion of lanosterol to ergosterol, disrupting fungal cell membrane synthesis

Mechanism Steps

1Fluconazole enters fungal cell via diffusion

2Binds to fungal cytochrome P450 14α-demethylase (CYP51)

3Inhibits demethylation of lanosterol to ergosterol

💡 How to Take cutifluc 200 tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of cutifluc 200 tablet

✅ Common Side Effects

Headache
Nausea
Abdominal pain
Diarrhea
Dizziness
Rash

🚨 Serious Side Effects

Hepatotoxicity
QT prolongation
Torsades de pointes
Stevens-Johnson syndrome
Anaphylaxis
Exfoliative dermatitis

⚠️ Rare Side Effects

Alopecia
Seizures
Thrombocytopenia
Leukopenia
Agranulocytosis
Hypertriglyceridemia
Hypokalemia

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased bleeding risk
Phenytoin	Major	Increased phenytoin levels, toxicity
Sulfonylureas	Major	Hypoglycemia
Cisapride	Major	QT prolongation, arrhythmias
Terfenadine	Major	QT prolongation, arrhythmias
Astemizole	Major	QT prolongation, arrhythmias
Rifampin	Major	Decreased fluconazole efficacy
Rifabutin	Major	Increased rifabutin levels, uveitis
Tacrolimus	Major	Increased tacrolimus levels, nephrotoxicity
Sirolimus	Major	Increased sirolimus levels
Alfentanil	Major	Increased alfentanil levels, respiratory depression
Midazolam	Major	Increased midazolam levels, sedation
Triazolam	Major	Increased triazolam levels, sedation
Nifedipine	Major	Increased nifedipine levels, hypotension
Verapamil	Major	Increased verapamil levels, bradycardia
Atorvastatin	Major	Increased statin levels, myopathy
Simvastatin	Major	Increased statin levels, myopathy
Losartan	Major	Decreased losartan efficacy
Methadone	Major	Increased methadone levels, QT prolongation
Celecoxib	Major	Increased celecoxib levels
Flurbiprofen	Major	Increased flurbiprofen levels
Naproxen	Major	Increased naproxen levels
Ibuprofen	Major	Increased ibuprofen levels
Oral contraceptives	Major	Decreased contraceptive efficacy
Pimozide	Major	QT prolongation, arrhythmias
Quinidine	Major	QT prolongation, arrhythmias
Tolbutamide	Major	Hypoglycemia
Zidovudine	Major	Increased zidovudine levels
Cyclosporine	Moderate	Increased cyclosporine levels
Theophylline	Moderate	Increased theophylline levels, toxicity
Hydrochlorothiazide	Moderate	Increased fluconazole levels
Cimetidine	Minor	Decreased fluconazole absorption
Antacids	Minor	Decreased fluconazole absorption
Sucralfate	Minor	Decreased fluconazole absorption
Didanosine	Minor	Decreased fluconazole absorption
Ritonavir	Minor	Increased fluconazole levels
Saquinavir	Minor	Increased saquinavir levels

🚨 Major Interactions

Warfarin
Phenytoin
Sulfonylureas
Cisapride
Terfenadine
Astemizole
Rifampin
Rifabutin
Tacrolimus
Sirolimus
Alfentanil
Benzodiazepines (midazolam, triazolam)
Calcium channel blockers (nifedipine, verapamil)
HMG-CoA reductase inhibitors (atorvastatin, simvastatin)
Losartan
Methadone
NSAIDs (celecoxib, flurbiprofen, naproxen, ibuprofen)
Oral contraceptives
Pimozide
Quinidine
Tolbutamide
Warfarin
Zidovudine

⚡ Moderate Interactions

Cyclosporine
Theophylline
Hydrochlorothiazide
Phenytoin
Rifampin
Rifabutin
Tacrolimus
Sirolimus
Alfentanil
Benzodiazepines (midazolam, triazolam)
Calcium channel blockers (nifedipine, verapamil)
HMG-CoA reductase inhibitors (atorvastatin, simvastatin)
Losartan
Methadone
NSAIDs (celecoxib, flurbiprofen, naproxen, ibuprofen)
Oral contraceptives
Pimozide
Quinidine
Tolbutamide
Warfarin
Zidovudine

ℹ️ Minor Interactions

Cimetidine
Antacids
Sucralfate
Didanosine
Ritonavir
Saquinavir
Zidovudine

🍽️ Food Interactions

No significant food interactions; absorption not affected by food

🍷 Alcohol Interaction

Avoid alcohol; may increase hepatotoxicity risk

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to fluconazole or azoles; concomitant use with terfenadine, astemizole, cisapride, pimozide, quinidine

📊 Monitoring Parameters

Liver function tests, renal function, signs of hepatotoxicity, QT interval if risk factors

🤱 Lactation Safety

Excreted in breast milk; use with caution

💊 Overdose Management

Symptomatic and supportive; hemodialysis may enhance elimination

⏰ Missed Dose

Take as soon as remembered; if near next dose, skip missed dose. Do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Jul 05, 2026

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🔄 Substitutes for cutifluc 200 tablet

View All

Alternative brands with exact same active ingredient (Fluconazole (200mg)):

Medical Note: Always consult your doctor before switching medications.

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📌 Quick Facts

Storage	Store at 20-25°C (68-77°F); protect from light and moisture
Route	Oral
Pregnancy	Category D
Breastfeeding	Excreted in breast milk; use with caution
Alcohol	Avoid alcohol; may increase hepatotoxicity risk
Onset of Action	Rapid; therapeutic levels achieved within 1-2 hours
Half-Life	30 hours (range 20-50 hours)
Prescription	✅ Required

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