coxwin zh 450 mg/300 mg tablet - Uses, Price, Side Effects & Substitutes
What is coxwin zh 450 mg/300 mg tablet used for?
Akt 2 Tablet (Rifampicin + Isoniazid) is used to treat ANTI INFECTIVES. It contains Rifampicin (450mg) + Isoniazid (300mg), which Rifampicin inhibits DNA-dependent RNA polymerase; Isoniazid inhibits mycolic aci. Always consult your doctor before use. Take as prescribed.
- Generic Name: Rifampicin + Isoniazid
- Manufacturer: Marc Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ coxwin zh 450 mg/300 mg tablet Uses & Benefits
Tuberculosis (first-line treatment)
Off-label uses: Leprosy (rifampicin), atypical mycobacterial infections
๐ Drug Information
| Generic Name(s) | Rifampicin + Isoniazid |
| Brand Name | Akt 2 Tablet |
| Manufacturer | Marc Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Antimycobacterials |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC, protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Rifampicin inhibits DNA-dependent RNA polymerase; Isoniazid inhibits mycolic acid synthesis
Mechanism Steps
๐ก How to Take coxwin zh 450 mg/300 mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of coxwin zh 450 mg/300 mg tablet
โ Common Side Effects
- Nausea
- Vomiting
- Anorexia
- Abdominal pain
- Headache
- Dizziness
- Rash
- Reddish-orange discoloration of urine/tears/sweat (rifampicin)
๐จ Serious Side Effects
- Hepatotoxicity
- Thrombocytopenia
- Hemolytic anemia
- Acute renal failure
- Peripheral neuropathy (isoniazid)
- Stevens-Johnson syndrome
โ ๏ธ Rare Side Effects
- Agranulocytosis
- Lupus-like syndrome
- Gynecomastia
- Psychosis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Reduced anticoagulant effect |
| Oral contraceptives | Major | Reduced contraceptive efficacy |
| Phenytoin | Major | Reduced phenytoin levels |
| Theophylline | Major | Reduced theophylline levels |
| Ketoconazole | Major | Reduced ketoconazole levels |
| Antiretroviral protease inhibitors | Major | Reduced antiretroviral levels |
| Corticosteroids | Moderate | Reduced corticosteroid effect |
| Cyclosporine | Moderate | Reduced cyclosporine levels |
| Diltiazem | Moderate | Reduced diltiazem levels |
| Verapamil | Moderate | Reduced verapamil levels |
| Digoxin | Moderate | Reduced digoxin levels |
| Sulfonylureas | Moderate | Reduced hypoglycemic effect |
| Antacids | Minor | Reduced absorption of isoniazid |
| Alcohol | Minor | Increased hepatotoxicity risk |
| Food (high-fat) | Minor | Delayed absorption |
๐จ Major Interactions
- Warfarin
- Oral contraceptives
- Phenytoin
- Theophylline
- Ketoconazole
- Antiretroviral protease inhibitors
โก Moderate Interactions
- Corticosteroids
- Cyclosporine
- Diltiazem
- Verapamil
- Digoxin
- Sulfonylureas
โน๏ธ Minor Interactions
- Antacids
- Alcohol
- Food (high-fat meals)
๐ฝ๏ธ Food Interactions
High-fat meals may delay absorption; avoid tyramine-rich foods with isoniazid
๐ท Alcohol Interaction
Avoid alcohol; increases hepatotoxicity risk
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, acute liver disease, history of drug-induced hepatitis
๐ Monitoring Parameters
Liver function tests, sputum culture, chest X-ray, signs of hepatitis
๐คฑ Lactation Safety
Both drugs excreted in breast milk; use with caution
๐ Overdose Management
Gastric lavage, activated charcoal, supportive care; monitor liver function
โฐ Missed Dose
Take as soon as remembered unless near next dose; do not double dose