Amtas-M 25 Tablet: Comprehensive Guide to Uses, Side Effects, and Safety
When to Call Your Doctor IMMEDIATELY
- Severe dizziness or fainting
- Chest pain that is new or worsening
- Difficulty breathing or wheezing
- Swelling of face, lips, tongue, or throat
- Heart rate below 50 beats per minute
- Yellowing of skin or eyes
- Severe abdominal pain or dark urine
- Sudden weight gain or increased swelling in legs
If experiencing severe symptoms, call emergency services immediately.
What is corvadil m 5mg/25mg tablet used for?
This medicine is a combination of Amlodipine 5 mg and Metoprolol Succinate 25 mg used to treat high blood pressure and prevent angina. It works by relaxing blood vessels and slowing the heart rate. Take it once daily as prescribed, and do not stop suddenly.
- Generic Name: Amlodipine + Metoprolol Succinate
- Manufacturer: Torrent Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 corvadil m 5mg/25mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा अम्लोडिपिन 5 मिलीग्राम और मेटोप्रोलोल सक्सिनेट 25 मिलीग्राम का संयोजन है, जिसका उपयोग उच्च रक्तचाप (हाइपरटेंशन) और एंजाइना (सीने में दर्द) के इलाज के लिए किया जाता है। यह रक्त वाहिकाओं को आराम देकर और हृदय की गति को धीमा करके रक्तचाप को कम करती है। यह दवा डॉक्टर के परामर्श से नियमित रूप से लेनी चाहिए। इसे अचानक बंद न करें, क्योंकि इससे एंजाइना या दिल का दौरा पड़ सकता है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में चक्कर आना, थकान, सिरदर्द, पैरों में सूजन, धीमी हृदय गति और हाथ-पैर ठंडे होना शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभावों में बहुत कम रक्तचाप, दिल की विफलता का बिगड़ना, सांस लेने में कठिनाई, और एलर्जी प्रतिक्रिया शामिल हैं। यदि आपको सांस लेने में तकलीफ, सीने में दर्द, बेहोशी, या चेहरे, होंठ या गले में सूजन हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। दवा की खुराक बदलें या बंद करने से पहले डॉक्टर से सलाह लें। इस दवा से चक्कर आ सकते हैं, इसलिए वाहन चलाने या मशीन चलाने से बचें जब तक आपको पता न चल जाए कि यह दवा आप पर कैसा असर करती है। बैठने या लेटने से उठते समय धीरे-धीरे उठें। यदि आपको अस्थमा, सीओपीडी, मधुमेह, लीवर या किडनी की बीमारी है, तो डॉक्टर को बताएं। शराब न पिएं। नियमित रूप से रक्तचाप और हृदय गति की जांच कराएं।
💊 corvadil m 5mg/25mg tablet Uses & Benefits
- [{"condition":"Hypertension","description":"This medicine is used to lower high blood pressure in adults, reducing the risk of stroke, heart attack, and kidney problems.
- It is often prescribed when a single medicine does not control blood pressure adequately.","evidence":"Well-established"},{"condition":"Angina Pectoris","description":"This medicine helps prevent chest pain (angina) by reducing the heart's workload and improving blood flow to the heart muscle.
- It is used for chronic stable angina.","evidence":"Well-established"},{"condition":"Heart Rate Control","description":"The metoprolol component helps control fast heart rates in conditions such as atrial fibrillation or other supraventricular tachycardias, when appropriate.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine Prophylaxis","description":"Sometimes prescribed off-label to prevent migraines, especially in patients who also have hypertension. The evidence is limited and it is not a first-line treatment.","evidence":"Limited"},{"condition":"Anxiety with Palpitations","description":"May be used off-label to reduce heart rate and palpitations associated with anxiety disorders, but this is not a standard approved use.","evidence":"Limited"}]
Primary treatment for: Hypertension
Also treats: Angina pectoris, Heart rate control in atrial fibrillation
📋 Drug Information
| Generic Name(s) | Amlodipine + Metoprolol Succinate |
| Brand Name | Amtas-M 50 Tablet PR |
| Manufacturer | Torrent Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Antihypertensive combination (Calcium channel blocker + Beta-blocker) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Amlodipine is a dihydropyridine calcium channel blocker that inhibits the influx of calcium ions into vascular smooth muscle cells and cardiac muscle cells. This leads to relaxation and widening of peripheral arterioles, reducing peripheral vascular resistance and lowering blood pressure. Metoprolol Succinate is a cardioselective beta-1 adrenergic receptor blocker. It reduces heart rate, myocardial contractility, and cardiac output, thereby decreasing myocardial oxygen demand and lowering blood pressure. The combination provides additive blood pressure reduction and anti-anginal effects.
Mechanism Steps
💡 How to Take corvadil m 5mg/25mg tablet
Strength: Amlodipine 5 mg and Metoprolol Succinate 25 mg extended-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet of Amlodipine 5 mg and Metoprolol Succinate 25 mg taken orally once daily, preferably in the morning. The dose may be adjusted by your doctor based on your blood pressure response and tolerability. The maximum recommended dose is one tablet of Amlodipine 10 mg and Metoprolol Succinate 50 mg once daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially dizziness and hypotension. Start with a low dose and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No dose adjustment is needed for amlodipine in renal impairment. For metoprolol, dose adjustment may be required in severe renal impairment. Consult your doctor for individualized dosing. |
| Hepatic Impairment | In patients with hepatic impairment, the clearance of amlodipine and metoprolol may be reduced. Start with a low dose and titrate slowly. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is Amlodipine 10 mg and Metoprolol Succinate 50 mg once daily. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of corvadil m 5mg/25mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Moderate | |
| Clarithromycin | Major | |
| Fluoxetine | Major | |
| Verapamil | Major | |
| Ibuprofen | Moderate | |
| Digoxin | Moderate | |
| Rifampicin | Moderate | |
| Cimetidine | Moderate | |
| Clonidine | Major | |
| St. John's Wort | Minor |
🚨 Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir)
- CYP2D6 inhibitors (e.g., paroxetine, fluoxetine, quinidine)
- Verapamil or diltiazem
- Clonidine
- Monoamine oxidase inhibitors (MAOIs)
⚡ Moderate Interactions
- NSAIDs (e.g., ibuprofen, naproxen)
- Alpha-blockers (e.g., prazosin)
- Digoxin
- Rifampicin
- Cimetidine
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can increase the blood pressure-lowering effect and add to dizziness, drowsiness, and the risk of fainting. It can also worsen the side effects of metoprolol, such as fatigue and slow heart rate. If you choose to drink alcohol, do so in moderation and consult your doctor first.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe hypotension","Second or third-degree heart block without a pacemaker","Severe heart failure (NYHA class IV)","Cardiogenic shock","Sick sinus syndrome without a pacemaker","Severe peripheral arterial disease","Known hypersensitivity to amlodipine, metoprolol, or other beta-blockers","Severe liver disease"]
⚠️ Warnings & Precautions
["Do not stop this medicine abruptly, as it can worsen angina or cause a heart attack.","Use with caution in patients with asthma or COPD; metoprolol can cause bronchospasm.","May mask symptoms of hypoglycemia in diabetic patients.","Use with caution in patients with liver or kidney disease; dose adjustment may be needed.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol while taking this medicine.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Tell your doctor about all other medications you are taking, including over-the-counter and herbal products."]
🤱 Lactation Safety
Amlodipine and metoprolol are excreted in breast milk. There is limited information on the effects on breastfed infants. Consult your doctor before breastfeeding; alternative medications may be preferred.
💊 Overdose Management
Overdose of this medicine can cause severe hypotension, bradycardia, heart failure, bronchospasm, and cardiogenic shock. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and may include intravenous fluids, atropine for bradycardia, vasopressors for hypotension, and glucagon for beta-blocker toxicity. Hemodialysis is not effective for removing amlodipine or metoprolol.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without consulting your doctor first. This medicine can cause dizziness or fatigue, especially when you start treatment or when the dose is increased. Avoid driving or operating heavy machinery until you know how this medicine affects you. Stand up slowly from a sitting or lying position to prevent dizziness. Inform your doctor if you have asthma, chronic obstructive pulmonary disease (COPD), diabetes, liver disease, kidney disease, or heart failure. If you have diabetes, this medicine may mask the symptoms of low blood sugar (such as rapid heartbeat), so monitor your blood sugar regularly. Do not drink alcohol while taking this medicine, as it can increase dizziness and low blood pressure. Keep all appointments with your doctor and laboratory for monitoring of blood pressure, heart rate, and other parameters. Store this medicine at room temperature, away from moisture and direct sunlight. Keep it out of reach of children. If you are pregnant, planning to become pregnant, or breastfeeding, inform your doctor before taking this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients (above 65 years) may be more sensitive to the blood pressure-lowering and heart rate-slowing effects of this medicine. Start with a low dose and monitor closely for dizziness, falls, and hypotension. Regular monitoring of renal and hepatic function is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Both amlodipine and metoprolol may not be safe during pregnancy. Your doctor may switch you to a safer alternative. Use effective contraception while taking this medicine unless otherwise advised.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. Beta-blockers may interact with anesthetic agents and can affect heart rate and blood pressure during surgery. Do not stop the medicine before surgery unless instructed by your doctor. Continue taking it as prescribed, and monitor your heart rate and blood pressure closely after surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, especially if you are undergoing dental surgery or procedures that may cause bleeding. Beta-blockers can interact with local anesthetics containing epinephrine, potentially causing severe hypertension. Your dentist may need to adjust the anesthetic used.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Regular exercise is beneficial for blood pressure control, but avoid sudden strenuous activities, especially if you have angina. Warm up and cool down gradually. If you experience chest pain, dizziness, or shortness of breath during exercise, stop and consult your doctor. Beta-blockers can reduce your maximum heart rate, so use perceived exertion rather than target heart rate to gauge exercise intensity.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. If your job involves shift work, consult your doctor about the best time to take your dose. Most people can continue their normal work activities once they adjust to the medicine.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as severe dizziness, fainting, difficulty breathing, or a very slow heart rate, contact your doctor immediately. Your doctor may adjust the dose or switch you to a different medicine. Abrupt withdrawal can worsen angina or cause a heart attack.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe and effective for managing hypertension and angina. Regular monitoring of blood pressure, heart rate, and kidney and liver function is recommended. Prolonged use may lead to tolerance or reduced effectiveness in some patients, requiring dose adjustment. Do not stop the medicine without medical advice. Long-term beta-blockade may increase the risk of developing diabetes or worsen glucose control in predisposed individuals. Regular follow-up with your doctor is essential.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, weight loss, and stress reduction can help lower blood pressure and may reduce the need for medication.
Evidence: Well-establishedACE inhibitors, ARBs, diuretics, or other calcium channel blockers may be alternatives if this medicine is not suitable.
Evidence: Well-establishedMay be considered in certain patients with heart failure, but not a direct alternative for hypertension alone.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you have a history of severe allergic reactions, inform your healthcare provider before receiving any vaccine. Continue taking your medicine as usual unless advised otherwise by your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. If crossing time zones, consult your doctor about adjusting the timing of your dose. Store at room temperature and avoid leaving it in a hot car or checked luggage. Carry enough supply for your entire trip and a few extra days in case of delays. Check local customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts to lower blood pressure within 24 to 48 hours, but the full effect may take 1 to 2 weeks. It may take a few weeks to achieve optimal blood pressure control.
A: No, you should not stop taking this medicine without consulting your doctor. High blood pressure often has no symptoms, and stopping suddenly can cause dangerous rebound hypertension or angina.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: Only if prescribed by your doctor. Combining with other blood pressure medicines can increase the risk of low blood pressure. Always inform your doctor about all medicines you are taking.
🤔 Common Patient Concerns
🔄 Substitutes for corvadil m 5mg/25mg tablet
View AllAlternative brands with exact same active ingredient:
-
davaindia amlodipine+metoprolol succinate 5mg/25mg tablet prDavaindia Generic Pharmacy ₹16.00 70.9% CHEAPER
-
m prol-am 5mg/25mg tabletUnison Pharmaceuticals Pvt Ltd ₹31.60 42.5% CHEAPER
-
opmet am 5mg/25mg tabletOpsiscare Lifesciences Pvt Ltd ₹32.00 41.8% CHEAPER
-
metaloc am 5mg/25mg tabletEris Lifesciences Ltd ₹33.00 40% CHEAPER
-
cadprol am 5mg/25mg tabletCaddes Life Sciences ₹35.20 36% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be stopped once blood pressure is normal.
Fact: High blood pressure often has no symptoms and requires long-term treatment. Stopping suddenly can cause dangerous rebound hypertension or angina. - Myth: This medicine causes kidney damage.
Fact: This medicine is not directly harmful to the kidneys. It actually helps protect the kidneys by controlling blood pressure. - Myth: You can take this medicine only when you feel unwell.
Fact: This medicine must be taken regularly as prescribed, even if you feel fine, to control blood pressure and prevent complications.
🔄 Alternative Options
Generic Alternatives
- Amlodipine 5 mg + Metoprolol Succinate 25 mg extended-release tablet (generic)
Brand Alternatives
- Amtas-M 25 Tablet PR (Intas Pharmaceuticals Ltd)