conozol 2% soap - Ketoconazole (2% w/w) medicine

conozol 2% soap - Uses, Price, Side Effects & Substitutes

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๐Ÿญ R B Pharmaceuticals ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 27, 2026
โš ๏ธ Hepatotoxicity Risk ๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 27, 2026

What is conozol 2% soap used for?

Arcolane 2% Scalp Solution (Ketoconazole) is used to treat DERMA. It contains Ketoconazole (2% w/w), which Inhibits fungal cytochrome P450 14ฮฑ-demethylase, blocking ergosterol synthesis . Always consult your doctor before use. Take as prescribed.

  • Generic Name: Ketoconazole
  • Manufacturer: R B Pharmaceuticals
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

๐Ÿ’Š conozol 2% soap Uses & Benefits

Treatment of seborrheic dermatitis of the scalp; dandruff; tinea versicolor; pityriasis capitis.

Off-label uses: Tinea capitis, Candidal intertrigo, Malassezia folliculitis

๐Ÿ“‹ Drug Information

Generic Name(s)Ketoconazole
Brand NameArcolane 2% Scalp Solution
ManufacturerR B Pharmaceuticals
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action ClassFungal ergosterol synthesis inhibitor
Route of AdministrationTopical (scalp solution)
StorageStore at 20-25ยฐC (68-77ยฐF); protect from light and heat.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionMinimal systemic absorption when applied topically; less than 1% of dose absorbed through scalp skin.
DistributionDistributes into skin layers, hair follicles, and sebaceous glands; negligible systemic distribution.
Protein BindingApproximately 99% bound to plasma proteins (mainly albumin) if absorbed systemically.
MetabolismHepatic via CYP3A4; extensive first-pass metabolism if absorbed.
Half-LifeTopical: not applicable; systemic: 2-8 hours.
ExcretionPrimarily feces (biliary) and urine (renal) for absorbed fraction.
BioavailabilityNegligible systemic bioavailability (<1%) due to topical application.
Onset of ActionWithin 1-2 weeks of regular use.
Peak Plasma TimeNot applicable for topical use; systemic absorption minimal.
Duration of ActionContinuous use required; effects persist as long as treatment continues.

How It Works

Inhibits fungal cytochrome P450 14ฮฑ-demethylase, blocking ergosterol synthesis and disrupting fungal cell membrane.

Mechanism Steps

1Ketoconazole binds to fungal CYP51 (lanosterol 14ฮฑ-demethylase).
2Inhibition of CYP51 prevents conversion of lanosterol to ergosterol.
3Depletion of ergosterol disrupts fungal cell membrane integrity.

๐Ÿ’ก How to Take conozol 2% soap

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of conozol 2% soap

โœ… Common Side Effects

  • Scalp irritation
  • Dryness
  • Pruritus
  • Oiliness
  • Hair discoloration
  • Contact dermatitis

๐Ÿšจ Serious Side Effects

  • Severe allergic reaction (angioedema, anaphylaxis)
  • Hepatotoxicity (rare with topical use)

โš ๏ธ Rare Side Effects

  • Bullous dermatitis
  • Urticaria
  • Hair loss

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased INR and bleeding risk
Cisapride Major Increased risk of cardiac arrhythmias
Pimozide Major Increased risk of QT prolongation
Quinidine Major Increased risk of QT prolongation
Lovastatin Major Increased risk of rhabdomyolysis
Simvastatin Major Increased risk of rhabdomyolysis
Midazolam Major Increased sedation and respiratory depression
Triazolam Major Increased sedation and respiratory depression
Oral hypoglycemics Moderate Increased hypoglycemic effect
Phenytoin Moderate Altered phenytoin levels
Rifampin Moderate Decreased ketoconazole efficacy
Isoniazid Moderate Decreased ketoconazole efficacy
Antacids Moderate Decreased ketoconazole absorption (if ingested)
H2 blockers Moderate Decreased ketoconazole absorption (if ingested)
Proton pump inhibitors Moderate Decreased ketoconazole absorption (if ingested)
Caffeine Minor Increased caffeine levels
Alcohol Minor Possible disulfiram-like reaction (systemic)
Oral contraceptives Minor Possible reduced contraceptive efficacy

๐Ÿšจ Major Interactions

  • Warfarin
  • CYP3A4 substrates (e.g., midazolam, triazolam)
  • Cisapride
  • Pimozide
  • Quinidine
  • Lovastatin
  • Simvastatin

โšก Moderate Interactions

  • Oral hypoglycemics
  • Phenytoin
  • Rifampin
  • Isoniazid
  • Antacids
  • H2 blockers
  • Proton pump inhibitors

โ„น๏ธ Minor Interactions

  • Caffeine
  • Alcohol
  • Oral contraceptives

๐Ÿฝ๏ธ Food Interactions

Grapefruit juice (may increase systemic absorption if ingested, but topical use minimal)

๐Ÿท Alcohol Interaction

No significant interaction with topical use; disulfiram-like reaction possible with systemic use but not relevant here.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to ketoconazole or any component; avoid use on broken or inflamed skin.

๐Ÿ“Š Monitoring Parameters

Clinical improvement of scalp condition; signs of irritation or allergic reaction; liver function tests if prolonged use or systemic absorption suspected.

๐Ÿคฑ Lactation Safety

Likely safe; minimal systemic absorption; caution if applied to breast area.

๐Ÿ’Š Overdose Management

Unlikely with topical use; accidental ingestion: symptomatic and supportive care; gastric lavage if large amount ingested.

โฐ Missed Dose

Apply as soon as remembered; if near next dose, skip missed dose; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 27, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for conozol 2% soap

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Alternative brands with exact same active ingredient (Ketoconazole (2% w/w)):

Medical Note: Always consult your doctor before switching medications.

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