comtrix s 1000 mg/500 mg injection - Uses, Price, Side Effects & Substitutes
What is comtrix s 1000 mg/500 mg injection used for?
Accuzon Plus 1.5gm Injection (Ceftriaxone + Sulbactam) is used to treat ANTI INFECTIVES. It contains Ceftriaxone (1000mg) + Sulbactam (500mg), which Ceftriaxone inhibits bacterial cell wall synthesis by binding to penicillin-bind. Always consult your doctor before use. Take as prescribed.
- Generic Name: Ceftriaxone + Sulbactam
- Manufacturer: Comed Chemicals Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ comtrix s 1000 mg/500 mg injection Uses & Benefits
Lower respiratory tract infections, urinary tract infections, skin and soft tissue infections, intra-abdominal infections, septicemia, meningitis, bone and joint infections
Off-label uses: Gonorrhea, Lyme disease, pelvic inflammatory disease
๐ Drug Information
| Generic Name(s) | Ceftriaxone + Sulbactam |
| Brand Name | Accuzon Plus 1.5gm Injection |
| Manufacturer | Comed Chemicals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporin + Beta-lactamase inhibitor |
| Route of Administration | Intravenous (IV) or Intramuscular (IM) |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light; reconstituted solution stable for 24 hours at room temperature or 3 days refrigerated |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Ceftriaxone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs); Sulbactam irreversibly inhibits beta-lactamases, protecting ceftriaxone from degradation.
Mechanism Steps
๐ก How to Take comtrix s 1000 mg/500 mg injection
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of comtrix s 1000 mg/500 mg injection
โ Common Side Effects
- Diarrhea
- Injection site reactions
- Rash
- Eosinophilia
๐จ Serious Side Effects
- Anaphylaxis
- Stevens-Johnson syndrome
- Clostridioides difficile colitis
- Hemolytic anemia
- Seizures
โ ๏ธ Rare Side Effects
- Pseudomembranous colitis
- Biliary sludge
- Interstitial nephritis
- Agranulocytosis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Alcohol | Major | Disulfiram-like reaction |
| Aminoglycosides | Major | Increased nephrotoxicity |
| Probenecid | Moderate | Decreased renal excretion of ceftriaxone |
| Loop diuretics | Moderate | Increased nephrotoxicity risk |
| NSAIDs | Moderate | Increased bleeding risk |
| Live vaccines | Minor | Reduced vaccine efficacy |
| BCG | Minor | Reduced therapeutic effect |
๐จ Major Interactions
- Warfarin
- Alcohol (disulfiram-like reaction)
- Aminoglycosides (nephrotoxicity)
โก Moderate Interactions
- Probenecid
- Loop diuretics
- NSAIDs
โน๏ธ Minor Interactions
- Live vaccines
- BCG
๐ฝ๏ธ Food Interactions
None known
๐ท Alcohol Interaction
May cause disulfiram-like reaction (nausea, vomiting, headache)
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to cephalosporins or beta-lactam antibiotics; history of anaphylaxis to penicillins
๐ Monitoring Parameters
Renal function, hepatic function, CBC, signs of superinfection, bleeding tendencies
๐คฑ Lactation Safety
Excreted in breast milk in low amounts; generally considered compatible
๐ Overdose Management
Supportive care; hemodialysis may remove ceftriaxone but not sulbactam
โฐ Missed Dose
Administer as soon as remembered; if near next dose, skip missed dose; do not double dose