comtrix o tablet - Uses, Price, Side Effects & Substitutes
What is comtrix o tablet used for?
Afix 200mg Tablet (Cefixime + Lactobacillus) is used to treat ANTI INFECTIVES. It contains Cefixime (200mg) + Lactobacillus (60Million spores), which Cefixime inhibits bacterial cell wall synthesis by binding to penicillin-binding. Always consult your doctor before use. Take as prescribed.
- Generic Name: Cefixime + Lactobacillus
- Manufacturer: Comed Chemicals Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ comtrix o tablet Uses & Benefits
Upper respiratory tract infections, lower respiratory tract infections, urinary tract infections, otitis media, gonorrhea, typhoid fever.
Off-label uses: Prophylaxis in surgery, Lyme disease, Shigellosis
๐ Drug Information
| Generic Name(s) | Cefixime + Lactobacillus |
| Brand Name | Afix 200mg Tablet |
| Manufacturer | Comed Chemicals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Third-generation cephalosporin antibiotic + Probiotic |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Cefixime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). Lactobacillus restores gut flora.
Mechanism Steps
๐ก How to Take comtrix o tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of comtrix o tablet
โ Common Side Effects
- Diarrhea
- Nausea
- Vomiting
- Abdominal pain
- Headache
- Dizziness
- Rash
๐จ Serious Side Effects
- Pseudomembranous colitis
- Severe allergic reactions (anaphylaxis)
- Stevens-Johnson syndrome
- Seizures
- Hemolytic anemia
โ ๏ธ Rare Side Effects
- Hepatitis
- Interstitial nephritis
- Thrombocytopenia
- Agranulocytosis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Probenecid | Major | Decreased renal excretion of cefixime, increased toxicity |
| Live typhoid vaccine | Major | Reduced vaccine efficacy |
| BCG vaccine | Moderate | Reduced vaccine efficacy |
| Cholera vaccine | Moderate | Reduced vaccine efficacy |
| Oral contraceptives | Moderate | Reduced contraceptive efficacy |
| Antacids | Minor | Possible reduced absorption of cefixime |
| Iron supplements | Minor | Possible reduced absorption |
| Zinc supplements | Minor | Possible reduced absorption |
๐จ Major Interactions
- Warfarin
- Probenecid
- Live typhoid vaccine
โก Moderate Interactions
- BCG vaccine
- Cholera vaccine
- Oral contraceptives
โน๏ธ Minor Interactions
- Antacids
- Iron supplements
- Zinc supplements
๐ฝ๏ธ Food Interactions
No significant food interactions.
๐ท Alcohol Interaction
Avoid alcohol; may increase risk of disulfiram-like reaction (rare).
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to cephalosporins or penicillins; severe renal impairment (CrCl <20 mL/min) without dose adjustment.
๐ Monitoring Parameters
Renal function, liver function, CBC, signs of superinfection, diarrhea.
๐คฑ Lactation Safety
Cefixime excreted in breast milk in low amounts; caution. Lactobacillus considered safe.
๐ Overdose Management
Supportive care; hemodialysis may remove cefixime.
โฐ Missed Dose
Take as soon as remembered; skip if almost time for next dose; do not double.