comtrix o 100mg/60million spores tablet - Cefixime (100mg) + Lactobacillus (60Million spores) medicine

Aelxim-100 LB Dry Syrup: Complete Medicine Guide

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🏭 Comed Chemicals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 22, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for approved indications.
Reviewed by
SaathiMed Expert Panel | Oct 22, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Severe allergic reaction (rash, swelling, difficulty breathing)
  • Bloody or severe diarrhea
  • Persistent vomiting
  • Signs of dehydration (decreased urine, dry mouth)
  • Yellowing of skin or eyes
  • Unusual bleeding or bruising

If experiencing severe symptoms, call emergency services immediately.

What is comtrix o 100mg/60million spores tablet used for?

This medicine is a combination of cefixime, an antibiotic, and lactobacillus, a probiotic. It is used to treat bacterial infections while helping to prevent antibiotic-associated diarrhea.

  • Generic Name: Cefixime + Lactobacillus
  • Manufacturer: Comed Chemicals Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 comtrix o 100mg/60million spores tablet के बारे में (Hindi Summary)

उपयोग: यह दवा सेफिक्सिम और लैक्टोबैसिलस का संयोजन है, जिसका उपयोग बैक्टीरियल संक्रमण जैसे कान का संक्रमण, गले का संक्रमण, ब्रोंकाइटिस और मूत्र मार्ग संक्रमण के इलाज के लिए किया जाता है। लैक्टोबैसिलस पेट के अच्छे बैक्टीरिया को बनाए रखने में मदद करता है।

साइड इफेक्ट्स: आम दुष्प्रभावों में दस्त, जी मिचलाना, पेट दर्द और हल्की परेशानी शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, गंभीर दस्त या रक्त विकार हो सकते हैं। यदि कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक पूरी करें, बीच में न छोड़ें। उपयोग से पहले बोतल को अच्छी तरह हिलाएं और मापने वाले कप से सही मात्रा लें। भोजन के साथ या बिना भोजन के लें। यदि आपको गुर्दे या यकृत की समस्या है या एंटीबायोटिक से एलर्जी है तो डॉक्टर को बताएं।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 comtrix o 100mg/60million spores tablet Uses & Benefits

[{"condition":"Acute otitis media","description":"Used to treat middle ear infections caused by susceptible bacteria such as Streptococcus pneumoniae and Haemophilus influenzae.","evidence":"Well-established"},{"condition":"Pharyngitis and tonsillitis","description":"Effective against streptococcal throat infections when penicillin is not suitable.","evidence":"Well-established"},{"condition":"Acute bronchitis","description":"May be used for bacterial bronchitis exacerbations, though viral causes are more common.","evidence":"Moderate"},{"condition":"Uncomplicated urinary tract infections","description":"Used for UTIs caused by susceptible strains of Escherichia coli and Klebsiella species.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Traveler's diarrhea","description":"Sometimes prescribed off-label for severe traveler's diarrhea caused by susceptible bacteria.","evidence":"Limited"}]

Primary treatment for: Bacterial infections

Also treats: Otitis media, Pharyngitis, Tonsillitis, Bronchitis, Urinary tract infections

📋 Drug Information

Generic Name(s)Cefixime + Lactobacillus
Brand NameAfix 200mg Tablet
ManufacturerComed Chemicals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassThird-generation cephalosporin antibiotic + Probiotic
Route of AdministrationOral
StorageStore below 30°C in a dry place. Protect from light. After reconstitution, store in refrigerator and use within 7 days.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always complete the full course of antibiotics even if symptoms improve.
2
Take with food if it causes stomach upset.
3
Shake the bottle well before each dose.
4
Use a proper measuring device for accurate dosing.
5
Report any severe diarrhea or allergic reactions immediately.
6
Do not share this medicine with others.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Ear pain
This medicine is commonly prescribed for ear infections.
Likely Use
✅
Sore throat
Used for bacterial pharyngitis.
Likely Use
❌
Fever
This medicine is not a primary fever reducer but may help if fever is due to bacterial infection.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionCefixime is absorbed from the gastrointestinal tract, with approximately 40-50% bioavailability. Food does not significantly affect absorption.
DistributionCefixime distributes widely into body tissues and fluids, including middle ear fluid, tonsils, sinuses, and urine.
Protein BindingCefixime is approximately 65% bound to plasma proteins.
MetabolismCefixime is not significantly metabolized and is excreted largely unchanged.
Half-LifeThe elimination half-life of cefixime is approximately 3-4 hours in healthy adults.
ExcretionCefixime is primarily excreted unchanged in the urine (about 50%) and in bile.
BioavailabilityApproximately 40-50%.
Onset of ActionOnset of action is typically within 1-2 hours after oral administration.
Peak Plasma TimePeak plasma concentrations are reached 2-4 hours after oral administration.
Duration of ActionThe duration of action is approximately 12-24 hours, allowing once or twice daily dosing.

How It Works

Cefixime is a third-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to bacterial cell death. Lactobacillus is a probiotic that helps maintain gut flora balance during antibiotic therapy.

Mechanism Steps

1
Binding to penicillin-binding proteins: Cefixime binds to specific penicillin-binding proteins on the bacterial cell membrane, inhibiting cell wall synthesis.
2
Inhibition of cell wall cross-linking: This prevents the cross-linking of peptidoglycan chains, weakening the bacterial cell wall.
3
Bacterial cell lysis: The weakened cell wall leads to osmotic lysis and death of the bacteria.
4
Probiotic effect of lactobacillus: Lactobacillus colonizes the gut and helps restore normal flora, reducing the risk of antibiotic-associated diarrhea.

💡 How to Take comtrix o 100mg/60million spores tablet

Strength: Dry syrup containing cefixime 100 mg and lactobacillus 60 million spores per 5 mL after reconstitution.

1Shake the bottle well before each use.
2Measure the dose accurately using the provided measuring cup or syringe.
3Take with or without food, but with food if stomach upset occurs.
4Complete the full course as prescribed by your doctor.
5Do not skip doses or stop early.

Dosage Information

Adult DosageThe usual adult dose of cefixime is 200-400 mg per day, taken as a single dose or in two divided doses, depending on the type and severity of infection. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may require dose adjustment based on renal function. Consult a doctor.
Renal ImpairmentIn patients with renal impairment (creatinine clearance <20 mL/min), the dose should be reduced to 200 mg once daily. Consult a doctor for individualized dosing.
Hepatic ImpairmentNo specific dose adjustment is recommended for hepatic impairment, but caution is advised.
Maximum Daily Dose400 mg per day for adults.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
No known interaction
Not applicable.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of comtrix o 100mg/60million spores tablet

✅ Common Side Effects

Diarrhea (Common (5-10%))
Usually resolves on its own. Maintain hydration. Consult doctor if persistent.
Nausea (Common (3-5%))
Take with food to reduce nausea. Consult doctor if severe.
Abdominal pain (Common (3-5%))
Usually temporary. Consult doctor if severe or persistent.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience rash, swelling, difficulty breathing.
Clostridium difficile-associated diarrhea (Rare (<0.1%))
Seek medical attention if you develop severe, persistent diarrhea or blood in stool.
Blood disorders (e.g., neutropenia, thrombocytopenia) (Rare (<0.1%))
Report unusual bruising or bleeding to your doctor.

⚠️ Rare Side Effects

Seizures
Seek immediate medical attention.
Interstitial nephritis
Report decreased urine output or swelling to your doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Carbamazepine Major
Probenecid Moderate
Oral contraceptives Moderate
Antacids Minor

🚨 Major Interactions

  • Warfarin
  • Carbamazepine

⚡ Moderate Interactions

  • Probenecid
  • Oral contraceptives

🍷 Alcohol Interaction

Alcohol may increase the risk of stomach upset and should be avoided during treatment.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known allergy to cephalosporins or penicillins","Previous severe allergic reaction to beta-lactam antibiotics"]

⚠️ Warnings & Precautions

["Use with caution in patients with renal impairment; dose adjustment may be required.","Prolonged use may lead to overgrowth of non-susceptible organisms.","May cause false-positive results in urine glucose tests.","Avoid in patients with a history of colitis."]

🤱 Lactation Safety

Cefixime is excreted in breast milk in small amounts and is generally considered safe during breastfeeding. Lactobacillus is safe. Consult your doctor.

💊 Overdose Management

Overdose may cause nausea, vomiting, and diarrhea. Seek immediate medical attention. Treatment is symptomatic and supportive. Hemodialysis may be considered in severe cases.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop early, even if you feel better. Shake the bottle well before each use and measure the dose with the provided measuring device. Take with or without food, but taking with food may reduce stomach upset. Inform your doctor if you have kidney problems, liver problems, or a history of allergies to antibiotics. Do not share this medicine with others. Keep out of reach of children. Store as directed on the label.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may have reduced kidney function and may require dose adjustment. Monitor renal function.

🤰 Pregnancy Planning (TTC)

Consult your doctor if you are planning pregnancy or are pregnant. Cefixime is generally considered safe but should be used only when clearly needed.

🏥 Post-Surgery Considerations

Inform your surgeon if you are taking this medicine before surgery. It may interact with other medications used during surgery.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine. It may affect the choice of antibiotics for dental procedures.

💚 Lifestyle Tips for Better Results

🏃
Stay hydrated to help flush out the infection.
🥗
Get plenty of rest to support your immune system.
😴
Eat a balanced diet rich in probiotics and fiber.
💧
Practice good hygiene to prevent reinfection.
🧘
Avoid close contact with others if you have a contagious infection.

🏋️ Exercise Considerations

No specific exercise restrictions, but rest if you feel unwell.

🥗 Diet Recommendations

Include yogurt and fermented foods to support gut health.
Stay well hydrated.
Avoid spicy and oily foods if you have stomach upset.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or tiredness in some people. If affected, avoid driving or operating heavy machinery until you know how it affects you.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor, even if you feel better. Complete the full prescribed course.

📅 Long-Term Use Effects

Long-term use of antibiotics can lead to bacterial resistance and disruption of gut flora. This medicine includes lactobacillus to help mitigate gut flora disruption. Use only as prescribed and for the recommended duration.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Probiotic supplements

Can help maintain gut health during antibiotic therapy.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Antibiotics may reduce the effectiveness of live bacterial vaccines like typhoid vaccine. Consult your doctor about vaccination timing.

📦 Storage Guide

✅ DO

Store below 30°C in a dry place

❌ DON'T

Do not refrigerate before reconstitution

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

After reconstitution, store in refrigerator and use within 7 days

❌ DON'T

Do not use after 7 days of reconstitution

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Keep it in a cool, dry place away from direct sunlight. If traveling with a reconstituted syrup, keep it refrigerated and use within 7 days. Check customs regulations for carrying medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 5-year-old child with ear infection
The child was prescribed this medicine for acute otitis media. The parents administered it with food twice daily. The child's fever and ear pain improved within 3 days, and the full course was completed without diarrhea.
💡 Lesson: Taking the full course and using the probiotic combination helped prevent diarrhea.
👤 An adult with urinary tract infection
A 30-year-old woman was prescribed this medicine for a UTI. She took it as directed and felt better in 2 days but continued for 7 days as advised. She experienced mild nausea, which was reduced by taking it with meals.
💡 Lesson: Completing the course prevents recurrence, and taking with food reduces side effects.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: You may start feeling better within 2-3 days, but you must complete the full course as prescribed.

Q: Can I take it with food?

A: Yes, you can take it with or without food. Taking with food may reduce stomach upset.

Q: What if I miss a dose?

A: Take it as soon as you remember, but if it's almost time for the next dose, skip the missed dose and continue with your regular schedule.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine with other medications?
  • What if I miss a dose?
  • How long does it take to work?
  • Is it safe for pregnant women?
  • Can I drink alcohol while taking this?

🔄 Substitutes for comtrix o 100mg/60million spores tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: Antibiotics can cure viral infections like the flu.
    Fact: Antibiotics only work against bacteria, not viruses.
  • Myth: You can stop taking antibiotics once you feel better.
    Fact: You must complete the full course to prevent recurrence and resistance.

🔄 Alternative Options

Generic Alternatives

  • Cefixime + Lactobacillus dry syrup (generic)

Brand Alternatives

  • Aelxim-100 LB Dry Syrup

📊 Comparison with Similar Medicines

[{"medicine":"Cefixime alone","difference":"Lacks probiotic, may cause more diarrhea."},{"medicine":"Cefixime + Clavulanic acid","difference":"Broader spectrum but higher risk of diarrhea."}]

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