comtrix l tablet - Uses, Price, Side Effects & Substitutes
What is comtrix l tablet used for?
Alencef LZ 200mg/600mg Tablet (Cefixime + Linezolid) is used to treat ANTI INFECTIVES. It contains Cefixime (200mg) + Linezolid (600mg), which Cefixime inhibits bacterial cell wall synthesis; Linezolid inhibits bacterial pr. Always consult your doctor before use. Take as prescribed.
- Generic Name: Cefixime + Linezolid
- Manufacturer: Comed Chemicals Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ comtrix l tablet Uses & Benefits
Treatment of complicated skin and soft tissue infections, respiratory tract infections, urinary tract infections, and other mixed infections caused by susceptible organisms.
Off-label uses: Some gram-positive infections resistant to other antibiotics.
๐ Drug Information
| Generic Name(s) | Cefixime + Linezolid |
| Brand Name | Alencef LZ 200mg/600mg Tablet |
| Manufacturer | Comed Chemicals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporin antibiotic + Oxazolidinone antibiotic |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Cefixime inhibits bacterial cell wall synthesis; Linezolid inhibits bacterial protein synthesis by binding to 50S ribosomal subunit.
Mechanism Steps
๐ก How to Take comtrix l tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of comtrix l tablet
โ Common Side Effects
- Diarrhea
- Nausea
- Headache
- Vomiting
- Abdominal pain
- Dyspepsia
- Flatulence
๐จ Serious Side Effects
- Pseudomembranous colitis
- Seizures
- Serotonin syndrome
- Bone marrow suppression
- Peripheral neuropathy
- Optic neuropathy
- Lactic acidosis
- Anaphylaxis
โ ๏ธ Rare Side Effects
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- Hemolytic anemia
- Interstitial nephritis
- Hepatotoxicity
- QT prolongation
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased INR and bleeding risk |
| Methotrexate | Major | Increased methotrexate toxicity |
| Probenecid | Major | Decreased renal excretion of cefixime |
| MAOIs | Major | Increased risk of serotonin syndrome with linezolid |
| SSRIs | Major | Increased risk of serotonin syndrome |
| Tyramine-rich foods | Major | Hypertensive crisis with linezolid |
| Oral contraceptives | Moderate | Reduced contraceptive efficacy |
| Antacids | Moderate | Decreased absorption of cefixime |
| Iron supplements | Moderate | Decreased absorption of cefixime |
| Calcium supplements | Moderate | Decreased absorption of cefixime |
| Alcohol | Minor | Possible disulfiram-like reaction |
| Caffeine | Minor | No significant interaction |
๐จ Major Interactions
- Warfarin
- Methotrexate
- Probenecid
- MAOIs
- SSRIs
- Tyramine-rich foods
โก Moderate Interactions
- Oral contraceptives
- Antacids
- Iron supplements
- Calcium supplements
โน๏ธ Minor Interactions
- Alcohol
- Caffeine
๐ฝ๏ธ Food Interactions
Cefixime: Food delays absorption; Linezolid: Avoid tyramine-rich foods.
๐ท Alcohol Interaction
Avoid alcohol; may increase risk of disulfiram-like reaction with cefixime.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to cephalosporins or linezolid; MAOI therapy; uncontrolled hypertension; pheochromocytoma; carcinoid syndrome; thyrotoxicosis; concurrent use of serotonergic drugs.
๐ Monitoring Parameters
Complete blood count (CBC) weekly for linezolid; renal function; signs of superinfection; bleeding time if on warfarin.
๐คฑ Lactation Safety
Cefixime: Excreted in milk, use caution; Linezolid: Excreted in milk, avoid.
๐ Overdose Management
Supportive care; hemodialysis may help remove linezolid.
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose. Do not double dose.