coaltoz-kz shampoo - Ketoconazole (2% w/v) + Salicylic Acid (2% w/v) medicine

coaltoz-kz shampoo

4.3 (8 reviews)
๐Ÿญ Cytoz Pharmaceuticals ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 22, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 22, 2026

What is coaltoz-kz shampoo used for?

Acvaketo S Shampoo (Ketoconazole + Salicylic Acid) is used to treat DERMA. It contains Ketoconazole (2% w/v) + Salicylic Acid (2% w/v), which Ketoconazole inhibits fungal ergosterol synthesis; Salicylic acid dissolves inte. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Ketoconazole + Salicylic Acid
  • Manufacturer: Cytoz Pharmaceuticals
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š coaltoz-kz shampoo Uses & Benefits

Dandruff, seborrheic dermatitis, tinea versicolor

Off-label uses: Tinea capitis, Pityriasis rosea

๐Ÿ“‹ Drug Information

Generic Name(s)Ketoconazole + Salicylic Acid
Brand NameAcvaketo S Shampoo
ManufacturerCytoz Pharmaceuticals
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action ClassAntifungal + Keratolytic
Route of AdministrationTopical (shampoo)
StorageStore at 20-25ยฐC (68-77ยฐF); keep tightly closed
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionMinimal systemic absorption through intact skin; increased absorption through damaged skin
DistributionLimited systemic distribution; primarily local action on scalp
Protein BindingKetoconazole: 99% bound to plasma proteins; Salicylic Acid: 50-80% bound
MetabolismKetoconazole: Hepatic via CYP3A4; Salicylic Acid: Hepatic conjugation
Half-LifeKetoconazole: 2-8 hours; Salicylic Acid: 2-3 hours
ExcretionKetoconazole: Feces (57%) and urine (13%); Salicylic Acid: Renal
BioavailabilityNegligible systemic bioavailability after topical application
Onset of ActionWithin 1-2 weeks of regular use
Peak Plasma TimeNot applicable for topical use
Duration of ActionLasts for 24-48 hours after application

How It Works

Ketoconazole inhibits fungal ergosterol synthesis; Salicylic acid dissolves intercellular cement and desquamates stratum corneum

Mechanism Steps

1Ketoconazole binds to 14-alpha-demethylase, inhibiting conversion of lanosterol to ergosterol
2Depletion of ergosterol disrupts fungal cell membrane integrity
3Salicylic acid dissolves intercellular cement in stratum corneum

๐Ÿ’ก How to Take coaltoz-kz shampoo

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of coaltoz-kz shampoo

โœ… Common Side Effects

  • Local irritation
  • Dryness
  • Itching
  • Stinging

๐Ÿšจ Serious Side Effects

  • Allergic contact dermatitis
  • Hepatotoxicity (rare)

โš ๏ธ Rare Side Effects

  • Hair discoloration
  • Hair loss

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk due to systemic absorption of salicylic acid
CYP3A4 substrates Major Increased plasma levels of CYP3A4 substrates if significant systemic absorption
Antacids Moderate Reduced absorption of ketoconazole if taken orally; not relevant for topical use
Alcohol Minor Possible skin irritation if applied with alcohol-based products

๐Ÿšจ Major Interactions

  • Warfarin
  • CYP3A4 substrates (e.g., midazolam, triazolam)

โšก Moderate Interactions

  • Antacids
  • H2 antagonists
  • Proton pump inhibitors

โ„น๏ธ Minor Interactions

  • Alcohol
  • Corticosteroids

๐Ÿฝ๏ธ Food Interactions

No significant food interactions for topical use

๐Ÿท Alcohol Interaction

No known interaction with topical use

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to any component; broken or inflamed skin

๐Ÿ“Š Monitoring Parameters

Clinical improvement of scaling and itching; liver function tests if prolonged use

๐Ÿคฑ Lactation Safety

Use with caution; minimal systemic absorption expected

๐Ÿ’Š Overdose Management

Rinse thoroughly with water; symptomatic treatment if ingested

โฐ Missed Dose

Apply as soon as remembered; skip if almost time for next dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

๐Ÿ”— View Profile

โญ User Reviews

Happy Patient Jul 10, 2026

Effective and reliable. Worked as expected.

Verified User Jul 10, 2026

Found this to be a helpful product. Good results.

Certified Buyer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Regular Customer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Verified User Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

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