clozob-b lotion - Beclometasone (1% w/v) + Clotrimazole (0.025% w/v) medicine

clozob-b lotion

No reviews yet
🏭 Malvern Pharma 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 21, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Oct 21, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

What is clozob-b lotion used for?

This medicine contains Beclometasone (1% w/v) + Clotrimazole (0.025% w/v) and is used to treat DERMA. Beclometasone reduces inflammation by suppressing cytokines and immune response; Clotrimazole inhibi. Always consult your doctor before use.

  • Generic Name: Beclometasone + Clotrimazole
  • Manufacturer: Malvern Pharma
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 clozob-b lotion Uses & Benefits

Treatment of inflammatory dermatoses with secondary fungal infections, e.g., eczema with candidiasis.

Off-label uses: Seborrheic dermatitis, Intertrigo

📋 Drug Information

Generic Name(s)Beclometasone + Clotrimazole
Brand NameBeclo C Lotion
ManufacturerMalvern Pharma
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action ClassCorticosteroid + Antifungal
Route of AdministrationTopical
StorageStore at room temperature (15-30°C); keep tightly closed.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionTopical absorption is minimal; systemic absorption may occur with prolonged use on large areas or damaged skin.
DistributionDistributes locally in skin layers; systemic distribution limited.
Protein BindingBeclometasone: ~87% bound to plasma proteins; Clotrimazole: ~90% bound.
MetabolismBeclometasone: Hepatic via CYP3A4; Clotrimazole: Hepatic to inactive metabolites.
Half-LifeBeclometasone: ~6.5 hours; Clotrimazole: ~3-6 hours.
ExcretionBeclometasone: Urine and feces; Clotrimazole: Feces (biliary) and urine.
BioavailabilityLow systemic bioavailability due to topical application.
Onset of ActionWithin a few days of regular application.
Peak Plasma TimeNot applicable for topical use; systemic levels minimal.
Duration of ActionDepends on frequency of application; typically 12-24 hours.

How It Works

Beclometasone reduces inflammation by suppressing cytokines and immune response; Clotrimazole inhibits fungal ergosterol synthesis, disrupting cell membrane.

Mechanism Steps

1Beclometasone binds to glucocorticoid receptors in skin cells.
2Receptor complex translocates to nucleus, modulating gene transcription.
3Decreases production of pro-inflammatory cytokines (e.g., IL-1, TNF-α).
4Inhibits phospholipase A2, reducing arachidonic acid release.
5Clotrimazole inhibits fungal lanosterol 14α-demethylase.
6Blocks conversion of lanosterol to ergosterol.
7Disrupts fungal cell membrane integrity and function.

💡 How to Take clozob-b lotion

Follow your doctor's prescription exactly.

⚠️ Side Effects of clozob-b lotion

✅ Common Side Effects

Burning
itching
irritation
dryness

🚨 Serious Side Effects

Skin atrophy
telangiectasia
adrenal suppression
allergic contact dermatitis

⚠️ Rare Side Effects

Hypertrichosis
perioral dermatitis
hypopigmentation

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
CYP3A4 inhibitors (e.g., ketoconazole) Major Increased systemic beclometasone exposure
CYP3A4 inducers (e.g., rifampin) Major Decreased beclometasone efficacy
Warfarin Moderate Possible enhanced anticoagulant effect
Insulin Moderate May increase blood glucose levels

🚨 Major Interactions

  • CYP3A4 inhibitors
  • CYP3A4 inducers

⚡ Moderate Interactions

  • Anticoagulants
  • Antidiabetic agents

🍷 Alcohol Interaction

No known interaction.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to components, untreated bacterial or viral skin infections, fungal infections not responsive to clotrimazole.

🤱 Lactation Safety

Use with caution; avoid application to breast area.

💊 Overdose Management

Topical overdose unlikely; if ingested, symptomatic treatment.

⏰ Missed Dose

Apply as soon as remembered; skip if almost time for next dose.

😊 Was this information helpful?

Browse Medicines A-Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Back to Medicines Directory