clotrima lotion

4.7 (12 reviews)

Clotrimazole (NA)

🏭 Parry Pharma Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is clotrima lotion used for?

Af -c dusting powder (Clotrimazole) is used to treat DERMA. It contains Clotrimazole (NA), which Inhibits fungal cytochrome P450 14α-demethylase, disrupting ergosterol synthesi. Always consult your doctor before use. Take as prescribed.

Generic Name: Clotrimazole
Manufacturer: Parry Pharma Pvt Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 clotrima lotion Uses & Benefits

Treatment of fungal skin infections such as athlete's foot, ringworm, jock itch, and candidal diaper rash.

Off-label uses: Pityriasis versicolor, Seborrheic dermatitis

📋 Drug Information

Generic Name(s)	Clotrimazole
Brand Name	Af -c dusting powder
Manufacturer	Parry Pharma Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	DERMA
Action Class	Fungal ergosterol synthesis inhibitor
Route of Administration	Topical (dusting powder).
Storage	Store at room temperature (20-25°C); keep container tightly closed.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionMinimal systemic absorption after topical application; absorption through intact skin is less than 0.5%.

DistributionNot well characterized; primarily remains in the stratum corneum after topical application.

Protein BindingNot applicable for topical use; systemic protein binding is approximately 90% if absorbed.

MetabolismHepatic metabolism via CYP450 enzymes to inactive metabolites.

Half-LifeNot applicable for topical use; systemic half-life is approximately 3-6 hours.

ExcretionPrimarily via feces (biliary excretion) and urine as metabolites.

BioavailabilityNegligible systemic bioavailability after topical application.

Onset of ActionWithin 24-48 hours of application.

Peak Plasma TimeNot applicable for topical use.

Duration of ActionUp to 24 hours after single application.

How It Works

Inhibits fungal cytochrome P450 14α-demethylase, disrupting ergosterol synthesis and fungal cell membrane integrity.

Mechanism Steps

1Clotrimazole binds to fungal CYP51 (lanosterol 14α-demethylase).

2Inhibits the conversion of lanosterol to ergosterol.

3Depletes ergosterol in fungal cell membrane.

💡 How to Take clotrima lotion

Follow your doctor's prescription exactly.

⚠️ Side Effects of clotrima lotion

✅ Common Side Effects

Skin irritation
Burning
Stinging
Redness

🚨 Serious Side Effects

Allergic contact dermatitis
Angioedema (rare)

⚠️ Rare Side Effects

Urticaria
Blistering
Exfoliation

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased INR and bleeding risk with systemic absorption (rare with topical use).
CYP3A4 substrates	Major	Potential for increased systemic levels of substrates if significant absorption occurs.
Oral hypoglycemics	Moderate	Possible enhanced hypoglycemic effect.
Phenytoin	Moderate	Possible increased phenytoin levels.
Antacids	Minor	Reduced absorption if taken orally (not applicable to topical).
H2 antagonists	Minor	Reduced absorption if taken orally (not applicable to topical).

🚨 Major Interactions

Warfarin
CYP3A4 substrates

⚡ Moderate Interactions

Oral hypoglycemics
Phenytoin

ℹ️ Minor Interactions

Antacids
H2 antagonists

🍽️ Food Interactions

No significant food interactions for topical use.

🍷 Alcohol Interaction

No known interaction.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to clotrimazole or any component.

📊 Monitoring Parameters

Clinical improvement of skin lesions; signs of irritation or allergic reaction.

🤱 Lactation Safety

Likely safe; minimal systemic absorption. Avoid application to breast area.

💊 Overdose Management

Unlikely with topical use; if ingested, symptomatic and supportive care.

⏰ Missed Dose

Apply as soon as remembered; skip if almost time for next dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for clotrima lotion

View All

Alternative brands with exact same active ingredient (Clotrimazole (NA)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Verified User Jul 10, 2026

Good quality medicine. Satisfied with the outcome.