clomark gm cream

4.7 (13 reviews)

Clobetasol (0.05% w/w) Miconazole (2% w/w)

🏭 Wellmark Lifesciences Private Limited 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is clomark gm cream used for?

Agmaderm Cream (Clobetasol + Miconazole) is used to treat DERMA. It contains Clobetasol (0.05% w/w) + Miconazole (2% w/w), which Clobetasol: Anti-inflammatory via glucocorticoid receptor; Miconazole: Inhibits . Always consult your doctor before use. Take as prescribed.

Generic Name: Clobetasol + Miconazole
Manufacturer: Wellmark Lifesciences Private Limited
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 clomark gm cream Uses & Benefits

Treatment of inflammatory dermatoses with fungal infection, e.g., tinea, candidiasis, eczema with secondary infection.

Off-label uses: Psoriasis, Lichen planus

📋 Drug Information

Generic Name(s)	Clobetasol + Miconazole
Brand Name	Agmaderm Cream
Manufacturer	Wellmark Lifesciences Private Limited
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	DERMA
Action Class	Corticosteroid + Antifungal
Route of Administration	Topical
Storage	Store at 20-25°C; avoid freezing.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionPercutaneous absorption varies; increased with inflamed skin or occlusion.

DistributionDistributes locally; systemic absorption minimal with intact skin.

Protein BindingClobetasol: 96-99%; Miconazole: ~90%

MetabolismClobetasol: Hepatic via CYP3A4; Miconazole: Hepatic extensively.

Half-LifeClobetasol: ~2-3 hours; Miconazole: ~20-24 hours.

ExcretionClobetasol: Renal and biliary; Miconazole: Feces (major) and urine.

BioavailabilityLow systemic bioavailability due to topical application.

Onset of ActionWithin a few days of regular application.

Peak Plasma TimeNot well defined for topical; systemic peak varies.

Duration of ActionSustained effect with twice-daily application.

How It Works

Clobetasol: Anti-inflammatory via glucocorticoid receptor; Miconazole: Inhibits ergosterol synthesis disrupting fungal cell membrane.

Mechanism Steps

1Clobetasol binds to glucocorticoid receptor, modulating gene expression to reduce inflammation.

2Miconazole inhibits lanosterol 14α-demethylase, blocking ergosterol synthesis.

3Ergosterol depletion disrupts fungal cell membrane integrity, leading to cell death.

💡 How to Take clomark gm cream

Follow your doctor's prescription exactly.

⚠️ Side Effects of clomark gm cream

✅ Common Side Effects

Burning
Itching
Irritation
Dryness

🚨 Serious Side Effects

Adrenal suppression
Cushing's syndrome
Skin atrophy
Allergic contact dermatitis

⚠️ Rare Side Effects

Perioral dermatitis
Hypertrichosis
Hypopigmentation

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased bleeding risk
Ketoconazole	Major	Increased systemic corticosteroid effects
Insulin	Moderate	May alter blood glucose levels

🚨 Major Interactions

CYP3A4 inhibitors
Anticoagulants

⚡ Moderate Interactions

Antidiabetic agents
Diuretics

ℹ️ Minor Interactions

NSAIDs
Vaccines

🍽️ Food Interactions

No significant food interactions

🍷 Alcohol Interaction

No known interaction

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to components; untreated bacterial or viral infections; rosacea; perioral dermatitis.

📊 Monitoring Parameters

Assess skin response; monitor for signs of systemic absorption (adrenal suppression) with prolonged use.

🤱 Lactation Safety

Use with caution; avoid application to breast area.

💊 Overdose Management

Acute overdose unlikely; chronic overuse may cause systemic corticosteroid effects; treat symptomatically.

⏰ Missed Dose

Apply as soon as remembered; skip if almost time for next dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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⭐ User Reviews

Certified Buyer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Regular Customer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Trusted Reviewer Jul 10, 2026

Effective and reliable. Worked as expected.