clofresh ot cream
What is clofresh ot cream used for?
Avoderm Plus Cream (Terbinafine + Clobetasol) is used to treat DERMA. It contains Terbinafine (1% w/w) + Clobetasol (0.05% w/w), which Terbinafine inhibits squalene epoxidase, disrupting ergosterol synthesis; Clobet. Always consult your doctor before use. Take as prescribed.
- Generic Name: Terbinafine + Clobetasol
- Manufacturer: Smart Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ clofresh ot cream Uses & Benefits
Tinea pedis, tinea cruris, tinea corporis with inflammatory symptoms.
Off-label uses: Seborrheic dermatitis, Psoriasis
๐ Drug Information
| Generic Name(s) | Terbinafine + Clobetasol |
| Brand Name | Avoderm Plus Cream |
| Manufacturer | Smart Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | DERMA |
| Action Class | Antifungal + Corticosteroid |
| Route of Administration | Topical |
| Storage | Store at 20-25ยฐC (68-77ยฐF); keep tightly closed. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Terbinafine inhibits squalene epoxidase, disrupting ergosterol synthesis; Clobetasol binds to glucocorticoid receptors, suppressing inflammation.
Mechanism Steps
๐ก How to Take clofresh ot cream
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of clofresh ot cream
โ Common Side Effects
- Application site irritation
- Pruritus
- Burning
๐จ Serious Side Effects
- Skin atrophy
- Hypothalamic-pituitary-adrenal axis suppression
- Allergic contact dermatitis
โ ๏ธ Rare Side Effects
- Hypertrichosis
- Perioral dermatitis
- Acneiform eruptions
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| CYP3A4 inhibitors | Major | Increased systemic exposure of clobetasol |
| CYP3A4 inducers | Major | Decreased efficacy of clobetasol |
| Warfarin | Moderate | Potential increased INR |
| Cyclosporine | Moderate | Increased risk of nephrotoxicity |
๐จ Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole)
- CYP3A4 inducers (e.g., rifampin)
โก Moderate Interactions
- Warfarin
- Cyclosporine
โน๏ธ Minor Interactions
- Antacids
- Cimetidine
๐ฝ๏ธ Food Interactions
No significant food interactions for topical use.
๐ท Alcohol Interaction
No known interaction.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to any component; viral skin infections (e.g., herpes); fungal nail infections (monotherapy).
๐ Monitoring Parameters
Skin improvement; signs of skin atrophy or systemic effects with prolonged use.
๐คฑ Lactation Safety
Use with caution; avoid application to breast area.
๐ Overdose Management
Unlikely with topical use; if ingested, symptomatic treatment.
โฐ Missed Dose
Apply as soon as remembered; skip if almost time for next dose.
๐จโโ๏ธ Reviewed by Expert
โญ User Reviews
Effective and reliable. Worked as expected.
Effective and reliable. Worked as expected.
Effective and reliable. Worked as expected.
Good quality medicine. Satisfied with the outcome.
Good quality medicine. Satisfied with the outcome.