Clofresh Advance Cream: A Comprehensive Guide to Uses, Side Effects, and Safety
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction: swelling of face, lips, throat, difficulty breathing.
- Signs of adrenal suppression: extreme fatigue, weakness, weight loss, nausea.
- Severe skin reactions: blistering, peeling, or severe rash.
- Worsening of infection: increased redness, swelling, pus, or pain.
- No improvement after 2 weeks of use.
- New or unusual symptoms appear.
If experiencing severe symptoms, call emergency services immediately.
What is clofresh advance cream used for?
This medicine is a topical cream combining mometasone, a corticosteroid, and terbinafine, an antifungal. It is used to treat inflammatory fungal skin infections like ringworm, jock itch, and athlete's foot. Apply a thin film to the affected area as directed by your doctor, usually once or twice daily. Do not use for longer than prescribed.
- Generic Name: Mometasone + Terbinafine
- Manufacturer: Smart Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 clofresh advance cream के बारे में (Hindi Summary)
उपयोग: यह दवा एक टॉपिकल क्रीम है जिसमें मोमेटासोन (एक स्टेरॉयड) और टर्बिनाफाइन (एक एंटीफंगल) शामिल हैं। इसका उपयोग त्वचा के फंगल संक्रमण जैसे दाद, खुजली और एथलीट फुट के इलाज के लिए किया जाता है, जिसमें सूजन, लालिमा और खुजली भी होती है। यह क्रीम फंगस को मारती है और साथ ही सूजन और खुजली को कम करती है। इसे डॉक्टर के निर्देशानुसार ही लगाएं।
साइड इफेक्ट्स: आम दुष्प्रभावों में लगाने की जगह पर हल्की जलन, खुजली, सूखापन या लालिमा शामिल हैं। ये आमतौर पर हल्के और अस्थायी होते हैं। लंबे समय तक उपयोग से त्वचा पतली हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर आपको गंभीर एलर्जी, सांस लेने में कठिनाई, या चेहरे पर सूजन हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस क्रीम को प्रभावित हिस्से पर पतली परत में लगाएं और डॉक्टर के निर्देशानुसार हल्के से मलें। लगाने से पहले और बाद में हाथ धोएं। आंखों, मुंह और अन्य श्लेष्मा झिल्ली से संपर्क से बचें। बिना निर्देश के पट्टी न लगाएं। निर्धारित अवधि से अधिक इस्तेमाल न करें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। बच्चों के पहुंच से दूर रखें।
💊 clofresh advance cream Uses & Benefits
- [{"condition":"Inflammatory tinea corporis (ringworm of the body)","description":"This medicine is used to treat ringworm infections of the body that have significant inflammation, itching, and redness.
- The antifungal component kills the fungus while the corticosteroid reduces inflammation.","evidence":"Well-established"},{"condition":"Inflammatory tinea cruris (jock itch)","description":"This medicine is used for jock itch with marked inflammation.
- It helps relieve itching and redness while treating the fungal infection.","evidence":"Well-established"},{"condition":"Inflammatory tinea pedis (athlete's foot)","description":"This medicine is used for athlete's foot with significant inflammatory symptoms.
- It provides relief from itching and burning while eradicating the fungus.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Inflammatory dermatophytosis of other sites","description":"Sometimes used off-label for other fungal skin infections with inflammation, such as tinea manuum, when prescribed by a dermatologist.","evidence":"Limited"}]
Primary treatment for: Inflammatory fungal skin infections
Also treats: Tinea corporis, Tinea cruris, Tinea pedis
📋 Drug Information
| Generic Name(s) | Mometasone + Terbinafine |
| Brand Name | Clofresh Advance Cream |
| Manufacturer | Smart Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | DERMA |
| Action Class | Corticosteroid + Antifungal |
| Route of Administration | Topical |
| Storage | Store at room temperature (15-30°C). Protect from light and moisture. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients. Mometasone is a synthetic corticosteroid that binds to glucocorticoid receptors in the skin, leading to reduced production of inflammatory mediators and suppression of local immune responses. This reduces itching, redness, swelling, and irritation. Terbinafine is an allylamine antifungal that inhibits squalene epoxidase, an enzyme essential for fungal cell membrane synthesis. This leads to accumulation of squalene and deficiency of ergosterol, causing fungal cell death.
Mechanism Steps
💡 How to Take clofresh advance cream
Strength: Cream containing mometasone (NA) and terbinafine (NA).
Dosage Information
| Adult Dosage | Apply a thin film of this medicine to the affected area and gently rub it in once or twice daily, or as directed by your doctor. The duration of treatment depends on the type and severity of the infection, but typically should not exceed 2 to 4 weeks. Dose must be individualized by a qualified clinician based on indication, age, and response to treatment. Do not use for longer than prescribed. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dosage adjustments are required for elderly patients. However, they may be more susceptible to skin thinning and systemic effects. Use with caution and monitor closely. |
| Renal Impairment | No dosage adjustment is required for renal impairment when used topically as directed. |
| Hepatic Impairment | No dosage adjustment is required for hepatic impairment when used topically as directed. |
| Maximum Daily Dose | Not established from the available information. Use only as prescribed by your doctor. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of clofresh advance cream
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Other topical corticosteroids | Major | |
| CYP2D6 inhibitors | Moderate | |
| Rifampicin | Moderate | |
| Cimetidine | Moderate |
🚨 Major Interactions
- Other topical corticosteroids
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
⚡ Moderate Interactions
- Rifampicin
- Cimetidine
🍷 Alcohol Interaction
No known interaction with alcohol when used topically. However, alcohol may worsen certain skin conditions. Consult your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to mometasone, terbinafine, or any component of the formulation","Bacterial or viral skin infections (e.g., impetigo, herpes simplex)","Acne vulgaris, rosacea, perioral dermatitis","Use on the face, groin, or underarms unless directed by a doctor","Children under 12 years unless prescribed by a doctor"]
⚠️ Warnings & Precautions
["For external use only. Do not swallow.","Avoid contact with eyes, mouth, and mucous membranes.","Do not use on open wounds or broken skin.","Do not cover with occlusive dressings unless instructed.","Prolonged use may cause skin thinning, stretch marks, and adrenal suppression.","Consult a doctor if symptoms persist or worsen after 2 weeks of use.","Do not use for bacterial or viral infections.","Keep out of reach of children."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Consult your doctor before use. Do not apply to the breast area if breastfeeding.
💊 Overdose Management
Overdose with topical application is unlikely. If accidental ingestion occurs, seek medical attention immediately. Symptoms of overdose may include nausea, vomiting, and abdominal pain. Treatment is supportive and symptomatic.
⏰ Missed Dose
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.
Additional Safety Advice
Apply a thin film of this medicine to the affected area and gently rub it in as directed by your doctor. Wash your hands before and after application unless your hands are the treated area. Avoid contact with eyes, mouth, and other mucous membranes. Do not cover the treated area with bandages or dressings unless instructed. Do not use this medicine for longer than prescribed, as prolonged use of topical corticosteroids can cause skin thinning and other effects. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not use this medicine on children under 12 years unless prescribed by a doctor. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to skin thinning and systemic effects of corticosteroids. Use with caution and monitor for side effects.
🤰 Pregnancy Planning (TTC)
Consult your doctor before using this medicine if you are planning to become pregnant. The safety of this medicine during pregnancy is not fully established.
🏥 Post-Surgery Considerations
Consult your doctor before using this medicine on surgical wounds. It should not be applied to open wounds or broken skin.
🦷 Dental Procedures
No specific considerations for dental procedures. Inform your dentist about all medicines you are using.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
No specific exercise restrictions. However, if the infection is on the feet, avoid barefoot walking in public areas to prevent spread. Keep the area dry after exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is applied topically and is unlikely to affect your ability to drive or operate machinery. However, if you experience any skin irritation or allergic reaction, avoid these activities until you feel better.
🛑 When to Stop This Medicine
Stop using this medicine and consult your doctor if your symptoms worsen, if you experience severe side effects, or if you do not see improvement after 2 weeks. Do not stop abruptly if you have been using it for a long time without consulting your doctor.
📅 Long-Term Use Effects
Prolonged use of this medicine, especially over large areas or with occlusive dressings, can lead to skin thinning, stretch marks, and adrenal suppression. It may also increase the risk of secondary infections. Use only as prescribed and for the recommended duration. Regular monitoring by a doctor is advised if long-term use is necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For fungal infections without significant inflammation, a topical antifungal alone may be sufficient.
Evidence: Well-establishedFor extensive or resistant infections, oral antifungals may be prescribed.
Evidence: Well-establishedKeeping the skin clean and dry helps prevent fungal infections.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interactions with vaccines. However, if you are scheduled for vaccination, inform your doctor about this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case of customs checks. Store at room temperature and protect from extreme heat or cold. No time zone adjustments are needed for topical application. If traveling to a hot climate, keep the cream away from direct sunlight.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may notice improvement in itching and redness within a few days. The fungal infection typically resolves within 1 to 2 weeks of regular use.
A: No, unless specifically directed by your doctor. It can cause skin thinning and other side effects on the face.
A: Pediatric dosing is not established. Consult a pediatrician before use in children.
A: Consult your doctor before use. The safety of this medicine during pregnancy is not fully established.
A: Apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose.
🤔 Common Patient Concerns
🔄 Substitutes for clofresh advance cream
View AllAlternative brands with exact same active ingredient:
-
Terbex M CreamSynokem Pharmaceuticals Ltd ₹69.00 156% COSTLIER
-
tekfinem creamAdips Laboratories Ltd ₹92.81 244.4% COSTLIER
-
mezo t creamAGIO Pharmaceuticals Ltd ₹100.31 272.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This cream can be used for any skin rash.
Fact: This medicine is specifically for inflammatory fungal infections. It should not be used for bacterial or viral skin infections. - Myth: More cream means faster healing.
Fact: Applying more than a thin film does not speed up healing and may increase side effects. - Myth: It is safe to use indefinitely.
Fact: Prolonged use can cause skin thinning and other side effects. Use only as prescribed.
🔄 Alternative Options
Generic Alternatives
- Mometasone + Terbinafine cream (generic)