clobiderm gz cream - Uses, Price, Side Effects & Substitutes
What is clobiderm gz cream used for?
Cosvate-GM Cream (Clobetasol + Gentamicin) is used to treat DERMA. It contains Clobetasol (0.05% w/w) + Gentamicin (0.1% w/w), which Clobetasol: Anti-inflammatory via glucocorticoid receptor binding; Gentamicin: B. Always consult your doctor before use. Take as prescribed.
- Generic Name: Clobetasol + Gentamicin
- Manufacturer: Gary Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ clobiderm gz cream Uses & Benefits
Inflammatory dermatoses with secondary bacterial infection, e.g., eczema, psoriasis, contact dermatitis.
Off-label uses: Lichen planus, discoid lupus erythematosus.
๐ Drug Information
| Generic Name(s) | Clobetasol + Gentamicin |
| Brand Name | Cosvate-GM Cream |
| Manufacturer | Gary Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | DERMA |
| Action Class | Corticosteroid + Antibiotic |
| Route of Administration | Topical |
| Storage | Store at 20-25ยฐC; protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Clobetasol: Anti-inflammatory via glucocorticoid receptor binding; Gentamicin: Bactericidal by binding to 30S ribosomal subunit.
Mechanism Steps
๐ก How to Take clobiderm gz cream
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of clobiderm gz cream
โ Common Side Effects
- Burning
- itching
- irritation
- dryness
๐จ Serious Side Effects
- Adrenal suppression
- Cushing's syndrome
- Skin atrophy
- Secondary infection
โ ๏ธ Rare Side Effects
- Allergic contact dermatitis
- Hypopigmentation
- Perioral dermatitis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Aminoglycosides | Major | Increased nephrotoxicity and ototoxicity risk |
| Neuromuscular blocking agents | Major | Enhanced neuromuscular blockade |
| Loop diuretics | Moderate | Increased ototoxicity risk |
| Amphotericin B | Moderate | Increased nephrotoxicity risk |
| Other topical corticosteroids | Minor | Additive local effects |
๐จ Major Interactions
- Aminoglycosides
- Neuromuscular blocking agents
โก Moderate Interactions
- Loop diuretics
- Amphotericin B
โน๏ธ Minor Interactions
- Other topical corticosteroids
๐ฝ๏ธ Food Interactions
None known.
๐ท Alcohol Interaction
No known interaction.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to components, untreated bacterial/fungal/viral infections, skin ulcers, rosacea, perioral dermatitis.
๐ Monitoring Parameters
Skin condition, signs of infection, adrenal suppression with prolonged use.
๐คฑ Lactation Safety
Use with caution; avoid application to breast area.
๐ Overdose Management
Topical overdose unlikely; discontinue use and treat symptomatically.
โฐ Missed Dose
Apply as soon as remembered; skip if near next dose.