clitz 100mg/100mg/100mg soft gelatin capsule - Uses, Price, Side Effects & Substitutes
What is clitz 100mg/100mg/100mg soft gelatin capsule used for?
Clitz (Clindamycin + Clotrimazole) is used to treat DERMA. It contains Clindamycin (100mg) + Clotrimazole (100mg), which Clindamycin inhibits bacterial protein synthesis by binding to 50S ribosomal sub. Always consult your doctor before use. Take as prescribed.
- Generic Name: Clindamycin + Clotrimazole
- Manufacturer: Merganzer Pharma Private Limited
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ clitz 100mg/100mg/100mg soft gelatin capsule Uses & Benefits
Bacterial vaginosis, vaginal candidiasis, mixed vaginal infections.
Off-label uses: Acne vulgaris, periodontal infections (clindamycin component).
๐ Drug Information
| Generic Name(s) | Clindamycin + Clotrimazole |
| Brand Name | Clitz |
| Manufacturer | Merganzer Pharma Private Limited |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | DERMA |
| Action Class | Antibiotic + Antifungal |
| Route of Administration | Oral (soft gelatin capsule) |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from moisture and light. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Clindamycin inhibits bacterial protein synthesis by binding to 50S ribosomal subunit; Clotrimazole inhibits fungal ergosterol synthesis by inhibiting 14ฮฑ-demethylase.
Mechanism Steps
๐ก How to Take clitz 100mg/100mg/100mg soft gelatin capsule
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of clitz 100mg/100mg/100mg soft gelatin capsule
โ Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Metallic taste
๐จ Serious Side Effects
- Pseudomembranous colitis
- Severe allergic reactions
- Stevens-Johnson syndrome
โ ๏ธ Rare Side Effects
- Hepatotoxicity
- Nephrotoxicity
- Blood dyscrasias
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Neuromuscular blockers | Major | Enhanced neuromuscular blockade |
| Macrolides | Major | Antagonism of clindamycin effect |
| CYP3A4 inhibitors | Major | Increased clindamycin levels |
| Warfarin | Moderate | Increased INR |
| Oral contraceptives | Moderate | Reduced contraceptive efficacy |
| Cyclosporine | Moderate | Increased nephrotoxicity risk |
| Antacids | Minor | Reduced clindamycin absorption |
| Kaolin | Minor | Reduced clindamycin absorption |
๐จ Major Interactions
- Neuromuscular blocking agents
- Macrolide antibiotics
- CYP3A4 inhibitors
โก Moderate Interactions
- Oral contraceptives
- Warfarin
- Cyclosporine
โน๏ธ Minor Interactions
- Antacids
- Kaolin
- Bismuth subsalicylate
๐ฝ๏ธ Food Interactions
Clindamycin absorption is not significantly affected by food; clotrimazole absorption is minimal.
๐ท Alcohol Interaction
No significant interaction, but alcohol may reduce treatment adherence.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to clindamycin, lincomycin, clotrimazole, or any excipients; history of antibiotic-associated colitis.
๐ Monitoring Parameters
Signs of superinfection, diarrhea, liver function tests, renal function.
๐คฑ Lactation Safety
Clindamycin is excreted in breast milk; use with caution. Clotrimazole is not absorbed systemically.
๐ Overdose Management
Gastric lavage, supportive care; no specific antidote.
โฐ Missed Dose
Take as soon as remembered; skip if almost time for next dose; do not double.