clincheek cream - Tretinoin (NA) medicine

clincheek cream

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Tretinoin (NA)
🏭 Micro Labs Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Oct 23, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
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What is clincheek cream used for?

This medicine contains Tretinoin (NA) and is used to treat DERMA. Binds to retinoic acid receptors (RARs) in the skin, normalizing follicular keratinization and reduc. Always consult your doctor before use.

  • Generic Name: Tretinoin
  • Manufacturer: Micro Labs Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 clincheek cream Uses & Benefits

Acne vulgaris; photoaging (off-label); fine wrinkles (off-label).

Off-label uses: Photoaging, Fine wrinkles, Melasma

📋 Drug Information

Generic Name(s)Tretinoin
Brand NameA-Ret 0.05% Gel
ManufacturerMicro Labs Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action ClassRetinoids- First generation
Route of AdministrationTopical
StorageStore at 20-25°C (68-77°F); protect from light and heat.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionMinimal percutaneous absorption; systemic absorption is low when applied topically.
DistributionDistributes locally in the skin; systemic distribution is negligible.
Protein Binding>95% bound to plasma proteins (mainly albumin) if absorbed.
MetabolismMetabolized in the liver via CYP450 enzymes, primarily CYP2C8 and CYP2C9.
Half-LifeApproximately 0.5-2 hours for systemic tretinoin; topical application has minimal systemic half-life
ExcretionExcreted in urine and feces as metabolites.
BioavailabilityLow systemic bioavailability due to minimal percutaneous absorption.
Onset of Action2-3 weeks for visible improvement in acne.
Peak Plasma TimeNot applicable for topical use; systemic peak not relevant.
Duration of ActionEffects persist with continued use; improvement may take up to 12 weeks.

How It Works

Binds to retinoic acid receptors (RARs) in the skin, normalizing follicular keratinization and reducing comedone formation.

Mechanism Steps

1Binds to retinoic acid receptors (RARs) in keratinocytes.
2Modulates gene expression involved in cell differentiation and proliferation.
3Normalizes follicular keratinization, reducing comedone formation.
4Increases epidermal turnover, promoting shedding of comedones.
5Decreases inflammation by inhibiting neutrophil chemotaxis.

💡 How to Take clincheek cream

Follow your doctor's prescription exactly.

⚠️ Side Effects of clincheek cream

✅ Common Side Effects

Skin redness
Peeling
Dryness
Stinging
Burning sensation

🚨 Serious Side Effects

Severe skin irritation
Allergic reaction
Photosensitivity

⚠️ Rare Side Effects

Hyperpigmentation
Hypopigmentation
Scarring

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Other topical retinoids Major Increased risk of skin irritation and peeling.
Benzoyl peroxide Major May cause excessive skin irritation if used together.
Topical corticosteroids Moderate May reduce efficacy of tretinoin.
Topical resorcinol Moderate Increased skin irritation.
Topical sulfur Moderate Increased skin irritation.

🚨 Major Interactions

  • Other topical retinoids
  • Benzoyl peroxide (concomitant use may cause irritation)

⚡ Moderate Interactions

  • Topical corticosteroids
  • Topical resorcinol
  • Topical sulfur

🍷 Alcohol Interaction

No known interaction.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to tretinoin or any component; pregnancy; breastfeeding; eczema; sunburn.

🤱 Lactation Safety

Safety not established; avoid use during breastfeeding.

💊 Overdose Management

Overdose unlikely with topical use; if ingested, treat symptomatically.

⏰ Missed Dose

Apply as soon as remembered; if near next dose, skip missed dose and resume regular schedule.

🔄 Substitutes for clincheek cream

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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