clearof shampoo - Ketoconazole (2% w/v) + Zinc pyrithione (1% w/v) medicine

clearof shampoo - Uses, Price, Side Effects & Substitutes

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๐Ÿญ La Med India ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 28, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 28, 2026

What is clearof shampoo used for?

Af-K Lotion (Ketoconazole + Zinc Pyrithione) is used to treat DERMA. It contains Ketoconazole (2% w/v) + Zinc pyrithione (1% w/v), which Ketoconazole inhibits fungal ergosterol synthesis; Zinc pyrithione disrupts fung. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Ketoconazole + Zinc Pyrithione
  • Manufacturer: La Med India
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

๐Ÿ’Š clearof shampoo Uses & Benefits

Dandruff, seborrheic dermatitis, tinea versicolor

Off-label uses: Tinea capitis, pityriasis rosea

๐Ÿ“‹ Drug Information

Generic Name(s)Ketoconazole + Zinc Pyrithione
Brand NameAf-K Lotion
ManufacturerLa Med India
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action ClassAntifungal + Antidandruff
Route of AdministrationTopical
StorageStore at room temperature (20-25ยฐC), protect from light
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionMinimal systemic absorption when applied topically
DistributionLocalized to skin and scalp; negligible systemic distribution
Protein BindingNot applicable (topical)
MetabolismNot significantly metabolized systemically
Half-LifeNot applicable (topical)
ExcretionNot applicable (topical)
BioavailabilityNegligible systemic bioavailability
Onset of ActionWithin a few days to weeks
Peak Plasma TimeNot applicable (topical)
Duration of ActionLasts for several days after application

How It Works

Ketoconazole inhibits fungal ergosterol synthesis; Zinc pyrithione disrupts fungal cell membrane and has antibacterial activity

Mechanism Steps

1Ketoconazole inhibits lanosterol 14ฮฑ-demethylase, blocking ergosterol synthesis in fungi
2Zinc pyrithione disrupts fungal cell membrane integrity and inhibits fungal growth
3Combination reduces fungal load and inflammation on scalp

๐Ÿ’ก How to Take clearof shampoo

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of clearof shampoo

โœ… Common Side Effects

  • Skin irritation
  • Dryness
  • Pruritus

๐Ÿšจ Serious Side Effects

  • Allergic reaction
  • Contact dermatitis

โš ๏ธ Rare Side Effects

  • Hair discoloration
  • Oiliness or dryness of hair

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

๐Ÿฝ๏ธ Food Interactions

None

๐Ÿท Alcohol Interaction

None

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to any component

๐Ÿ“Š Monitoring Parameters

Clinical improvement, skin irritation

๐Ÿคฑ Lactation Safety

Use with caution; limited data

๐Ÿ’Š Overdose Management

Rinse with water; symptomatic treatment

โฐ Missed Dose

Apply as soon as remembered; skip if almost time for next dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 28, 2026

๐Ÿ”— View Profile

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