clark eye drop - Chloramphenicol (0.5% w/v) + Hydroxypropylmethylcellulose (0.25% w/v) medicine

clark eye drop

No reviews yet
🏭 Pax Healthcare 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 24, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Oct 24, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

What is clark eye drop used for?

This medicine contains Chloramphenicol (0.5% w/v) + Hydroxypropylmethylcellulose (0.25% w/v) and is used to treat OPHTHAL. Chloramphenicol inhibits bacterial protein synthesis by binding to 50S ribosomal subunit; Hydroxypro. Always consult your doctor before use.

  • Generic Name: Chloramphenicol + Hydroxypropylmethylcellulose
  • Manufacturer: Pax Healthcare
  • Form: Allopathy
  • Pregnancy Category: Category C
  • Prescription Required: Yes
💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 clark eye drop Uses & Benefits

Treatment of bacterial conjunctivitis, keratitis, and other superficial ocular infections; relief of dry eye symptoms

Off-label uses: Prophylaxis in ocular surgery (not standard)

📋 Drug Information

Generic Name(s)Chloramphenicol + Hydroxypropylmethylcellulose
Brand NameClark Eye Drop
ManufacturerPax Healthcare
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassOPHTHAL
Action ClassAntibiotic + Lubricant
Route of AdministrationOphthalmic (topical)
StorageStore at room temperature (15-30°C); protect from light; keep tightly closed
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionMinimal systemic absorption after ophthalmic administration
DistributionPrimarily local in ocular tissues
Protein BindingChloramphenicol: 50-60%
MetabolismChloramphenicol: Hepatic via glucuronidation
Half-LifeChloramphenicol: 1.5-4 hours (systemic)
ExcretionChloramphenicol: Renal (90%)
BioavailabilityLow systemic bioavailability due to topical application
Onset of ActionRapid (within hours for antibacterial effect)
Peak Plasma TimeNot applicable for topical ophthalmic use
Duration of Action6-8 hours

How It Works

Chloramphenicol inhibits bacterial protein synthesis by binding to 50S ribosomal subunit; Hydroxypropylmethylcellulose acts as a lubricant and tear substitute

Mechanism Steps

1Chloramphenicol binds to the 50S ribosomal subunit of bacteria
2Inhibits peptide bond formation
3Prevents bacterial protein synthesis
4Exerts bacteriostatic effect
5Hydroxypropylmethylcellulose forms a protective film over the cornea
6Lubricates and moisturizes the ocular surface

💡 How to Take clark eye drop

Follow your doctor's prescription exactly.

⚠️ Side Effects of clark eye drop

✅ Common Side Effects

Transient stinging
Blurred vision
Eye irritation

🚨 Serious Side Effects

Bone marrow suppression (aplastic anemia)
Hypersensitivity reactions

⚠️ Rare Side Effects

Optic neuritis
Peripheral neuropathy

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major Increased bleeding risk due to inhibition of warfarin metabolism
Phenytoin Major Increased phenytoin levels and toxicity
Phenobarbital Major Decreased chloramphenicol efficacy
Rifampin Major Decreased chloramphenicol efficacy

🚨 Major Interactions

  • Warfarin
  • Phenytoin
  • Phenobarbital
  • Rifampin

⚡ Moderate Interactions

  • Oral contraceptives
  • Sulfonylureas

🍷 Alcohol Interaction

None known

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to chloramphenicol or any component

🤱 Lactation Safety

Caution advised; small amounts may be excreted in breast milk

💊 Overdose Management

Rinse eye with water; symptomatic treatment

⏰ Missed Dose

Apply as soon as remembered; skip if almost time for next dose

🔄 Substitutes for clark eye drop

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

😊 Was this information helpful?

Browse Medicines A-Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Back to Medicines Directory