cinpine 1gm injection - Imipenem (500mg) + Cilastatin (500mg) medicine

cinpine 1gm injection - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Asterisk Laboratories India Pvt Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jul 2, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jul 02, 2026

What is cinpine 1gm injection used for?

Avim C 500mg/500mg Injection (Imipenem + Cilastatin) is used to treat ANTI INFECTIVES. It contains Imipenem (500mg) + Cilastatin (500mg), which Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Imipenem + Cilastatin
  • Manufacturer: Asterisk Laboratories India Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

๐Ÿ’Š cinpine 1gm injection Uses & Benefits

Treatment of serious infections including intra-abdominal, urinary tract, respiratory tract, skin and soft tissue, bone and joint, and septicemia

Off-label uses: Febrile neutropenia, Empiric therapy in critically ill patients

๐Ÿ“‹ Drug Information

Generic Name(s)Imipenem + Cilastatin
Brand NameAvim C 500mg/500mg Injection
ManufacturerAsterisk Laboratories India Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassCarbapenem antibiotic with renal dehydropeptidase inhibitor
Route of AdministrationIntravenous
StorageStore at 20-25ยฐC; protect from freezing
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionIntravenous administration results in complete bioavailability
DistributionWidely distributed into tissues and body fluids including CSF when meninges inflamed
Protein BindingApproximately 20%
MetabolismImipenem is metabolized by renal dehydropeptidase; cilastatin inhibits this enzyme
Half-LifeImipenem: ~1 hour; Cilastatin: ~0.8 hour
ExcretionPrimarily renal (70-80% unchanged)
Bioavailability100% (IV)
Onset of ActionRapid (within 30 minutes)
Peak Plasma TimeEnd of infusion
Duration of Action6-8 hours

How It Works

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs)

Mechanism Steps

1Imipenem binds to penicillin-binding proteins (PBPs) on bacterial cell wall
2Inhibits transpeptidase activity, preventing cross-linking of peptidoglycan
3Activates autolytic enzymes, leading to cell lysis and death

๐Ÿ’ก How to Take cinpine 1gm injection

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of cinpine 1gm injection

โœ… Common Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Rash
  • Phlebitis at injection site

๐Ÿšจ Serious Side Effects

  • Seizures
  • Clostridioides difficile colitis
  • Anaphylaxis
  • Stevens-Johnson syndrome

โš ๏ธ Rare Side Effects

  • Agranulocytosis
  • Hemolytic anemia
  • Interstitial nephritis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Valproic acid Major Decreased valproic acid levels, increased seizure risk
Ganciclovir Major Increased risk of seizures
Probenecid Major Increased imipenem levels
Methotrexate Moderate Increased methotrexate toxicity
Cyclosporine Moderate Increased nephrotoxicity risk
Warfarin Moderate Enhanced anticoagulant effect
Oral contraceptives Minor Reduced contraceptive efficacy

๐Ÿšจ Major Interactions

  • Valproic acid
  • Ganciclovir
  • Probenecid

โšก Moderate Interactions

  • Methotrexate
  • Cyclosporine
  • Warfarin

โ„น๏ธ Minor Interactions

  • Oral contraceptives

๐Ÿฝ๏ธ Food Interactions

No significant food interactions

๐Ÿท Alcohol Interaction

Avoid alcohol; may increase risk of disulfiram-like reaction

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to imipenem, cilastatin, or other carbapenems; severe hypersensitivity to beta-lactams

๐Ÿ“Š Monitoring Parameters

Renal function, liver function, CBC, signs of superinfection

๐Ÿคฑ Lactation Safety

Caution; excreted in breast milk in low amounts

๐Ÿ’Š Overdose Management

Supportive care; hemodialysis may help remove imipenem/cilastatin

โฐ Missed Dose

Administer as soon as remembered; do not double dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jul 02, 2026

๐Ÿ”— View Profile

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